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Home Amines 1159840-61-5
1159840-61-5,MFCD31619251
Catalog No.:AA003AM5

1159840-61-5 | 1H-Imidazo[4,5-c]quinoline-1-ethanol, 4-amino-2-[(ethylamino)methyl]-α,α-dimethyl-, 2,2,2-trifluoroacetate (1:2)

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$16.00   $11.00
- +
5mg
98%
in stock  
$39.00   $28.00
- +
10mg
98%
in stock  
$64.00   $45.00
- +
25mg
98%
in stock  
$112.00   $78.00
- +
50mg
98%
in stock  
$190.00   $133.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA003AM5
Chemical Name:
1H-Imidazo[4,5-c]quinoline-1-ethanol, 4-amino-2-[(ethylamino)methyl]-α,α-dimethyl-, 2,2,2-trifluoroacetate (1:2)
CAS Number:
1159840-61-5
Molecular Formula:
C21H25F6N5O5
Molecular Weight:
541.4441
MDL Number:
MFCD31619251
SMILES:
OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.CCNCc1nc2c(n1CC(O)(C)C)c1ccccc1nc2N
Properties
Computed Properties
 
Complexity:
488  
Covalently-Bonded Unit Count:
3  
Heavy Atom Count:
37  
Hydrogen Bond Acceptor Count:
15  
Hydrogen Bond Donor Count:
5  
Rotatable Bond Count:
5  

Downstream Synthesis Route
1159840-61-5   
CASUnavailable 
  1229024-37-6 

[1]Locationinpatent:experimentalpartShukla,NikunjM.;Malladi,SubbalakshmiS.;Mutz,ColeA.;Balakrishna,Rajalakshmi;David,SunilA.[JournalofMedicinalChemistry,2010,vol.53,#11,p.4450-4465]

[1]Locationinpatent:experimentalpartShukla,NikunjM.;Malladi,SubbalakshmiS.;Mutz,ColeA.;Balakrishna,Rajalakshmi;David,SunilA.[JournalofMedicinalChemistry,2010,vol.53,#11,p.4450-4465]

[1]Locationinpatent:experimentalpartShukla,NikunjM.;Malladi,SubbalakshmiS.;Mutz,ColeA.;Balakrishna,Rajalakshmi;David,SunilA.[JournalofMedicinalChemistry,2010,vol.53,#11,p.4450-4465]

1159840-61-5   
CASUnavailable 
  1229024-44-5 

[1]Locationinpatent:experimentalpartShukla,NikunjM.;Malladi,SubbalakshmiS.;Mutz,ColeA.;Balakrishna,Rajalakshmi;David,SunilA.[JournalofMedicinalChemistry,2010,vol.53,#11,p.4450-4465]

[1]Locationinpatent:experimentalpartShukla,NikunjM.;Malladi,SubbalakshmiS.;Mutz,ColeA.;Balakrishna,Rajalakshmi;David,SunilA.[JournalofMedicinalChemistry,2010,vol.53,#11,p.4450-4465]

Literature

Title: Buitendijk M, et al. Gardiquimod: a Toll-like receptor-7 agonist that inhibits HIV type 1 infection of human macrophages and activated T cells. AIDS Res Hum Retroviruses. 2013 Jun;29(6):907-18.

Title: Ma F, et al. The TLR7 agonists imiquimod and gardiquimod improve DC-based immunotherapy for melanoma in mice. Cell Mol Immunol. 2010 Sep;7(5):381-8.

Title: Zhou Z, et al. TLR7/8 agonists promote NK-DC cross-talk to enhance NK cell anti-tumor effects in hepatocellular carcinoma. Cancer Lett. 2015 Dec 28;369(2):298-306.

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SDS
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Tags:1159840-61-5 Molecular Formula|1159840-61-5 MDL|1159840-61-5 SMILES|1159840-61-5 1H-Imidazo[4,5-c]quinoline-1-ethanol, 4-amino-2-[(ethylamino)methyl]-α,α-dimethyl-, 2,2,2-trifluoroacetate (1:2)