Home Other Building Blocks 1192500-31-4
1192500-31-4,MFCD30478396
Catalog No.:AA008TAU

1192500-31-4 | Avibactam free acid

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
99%
in stock  
$132.00   $93.00
- +
25mg
99%
in stock  
$275.00   $193.00
- +
100mg
99%
in stock  
$585.00   $409.00
- +
1g
99%
in stock  
$2,029.00   $1,420.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA008TAU
Chemical Name:
Avibactam free acid
CAS Number:
1192500-31-4
Molecular Formula:
C7H11N3O6S
Molecular Weight:
265.2437
MDL Number:
MFCD30478396
SMILES:
NC(=O)[C@@H]1CC[C@@H]2CN1C(=O)N2OS(=O)(=O)O
Properties

Downstream Synthesis Route

[1]CurrentPatentAssignee:PFIZERINC-US2012/323010,2012,A1

[2]Wang,Tao;Du,Liang-Dong;Wan,Ding-Jian;Li,Xiang;Chen,Xin-Zhi;Wu,Guo-Feng[OrganicProcessResearchandDevelopment,2018,vol.22,#3,p.267-272]

[1]Patent:US2012/323010,2012,A1

[2]Patent:US2012/323010,2012,A1

[3]Patent:US2012/323010,2012,A1

[4]Patent:US2012/323010,2012,A1

[1]Patent:US2012/323010,2012,A1

[2]Patent:US2012/323010,2012,A1

[1]OrganicProcessResearchandDevelopment,2016,vol.20,p.1799-1805

1192500-31-4    14866-33-2   
C7H10N3O6S(1-)*C32H68N(1+) 

[1]Patent:CN107417686,2017,A.Locationinpatent:Paragraph0036;0041

Literature

Title: Ehmann DE, et al. Avibactam is a covalent, reversible, non-β-lactam β-lactamase inhibitor. Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11663-8.

Title: Livermore DM, et al. Characterization of β-lactamase and porin mutants of Enterobacteriaceae selected with ceftaroline + avibactam (NXL104). J Antimicrob Chemother. 2012 Jun;67(6):1354-8.

Title: Berkhout J, et al. Pharmacokinetics and penetration of ceftazidime and avibactam into epithelial lining fluid in thigh- and lung-infected mice. Antimicrob Agents Chemother. 2015 Apr;59(4):2299-304.

Title: Zhang W, et al. In vitro and in vivo bactericidal activity of ceftazidime-avibactam against Carbapenemase-producing Klebsiella pneumoniae. Antimicrob Resist Infect Control. 2018 Nov 21;7:142.

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