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119410-08-1,MFCD00878381
Catalog No.:AA000IOA

119410-08-1 | 8-Chloro-11-(piperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-3-ol

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1mg
≥98%
in stock  
$170.00   $119.00
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5mg
≥98%
in stock  
$598.00   $418.00
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10mg
≥98%
in stock  
$1,088.00   $761.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA000IOA
Chemical Name:
8-Chloro-11-(piperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-3-ol
CAS Number:
119410-08-1
Molecular Formula:
C19H19ClN2O
Molecular Weight:
326.8200
MDL Number:
MFCD00878381
SMILES:
Oc1cnc2c(c1)CCc1c(C2=C2CCNCC2)ccc(c1)Cl
Properties
Computed Properties
 
Complexity:
458  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
XLogP3:
4.1  

Literature

Title: Prevalence of desloratadine poor metabolizer phenotype in healthy Jordanian males.

Journal: Biopharmaceutics & drug disposition 20120101

Title: Pharmacokinetic and safety profile of rupatadine when coadministered with azithromycin at steady-state levels: a randomized, open-label, two-way, crossover, Phase I study.

Journal: Clinical therapeutics 20080901

Title: Simultaneous determination of desloratadine and its active metabolite 3-hydroxydesloratadine in human plasma by LC/MS/MS and its application to pharmacokinetics and bioequivalence.

Journal: Journal of pharmaceutical and biomedical analysis 20071130

Title: Influence of food on the oral bioavailability of rupatadine tablets in healthy volunteers: a single-dose, randomized, open-label, two-way crossover study.

Journal: Clinical therapeutics 20070501

Title: Orthogonal extraction/chromatography and UPLC, two powerful new techniques for bioanalytical quantitation of desloratadine and 3-hydroxydesloratadine at 25 pg/mL.

Journal: Journal of pharmaceutical and biomedical analysis 20060224

Title: Pharmacokinetics/pharmacodynamics of desloratadine and fluoxetine in healthy volunteers.

Journal: Journal of clinical pharmacology 20041101

Title: Identification of human UDP-glucuronosyltransferase enzyme(s) responsible for the glucuronidation of 3-hydroxydesloratadine.

Journal: Biopharmaceutics & drug disposition 20040901

Title: Validation of a sensitive and automated 96-well solid-phase extraction liquid chromatography-tandem mass spectrometry method for the determination of desloratadine and 3-hydroxydesloratadine in human plasma.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030725

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Tags:119410-08-1 Molecular Formula|119410-08-1 MDL|119410-08-1 SMILES|119410-08-1 8-Chloro-11-(piperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-3-ol |Heterocyclic_Building_Blocks