Title: The melanocortin-4 receptor as target for obesity treatment: a systematic review of emerging pharmacological therapeutic options.
Journal: International journal of obesity (2005) 20140201
Title: Food intake reductions and increases in energetic responses by hindbrain leptin and melanotan II are enhanced in mice with POMC-specific PTP1B deficiency.
Journal: American journal of physiology. Endocrinology and metabolism 20120901
Title: Melanocortin receptor 4 deficiency affects body weight regulation, grooming behavior, and substrate preference in the rat.
Journal: Obesity (Silver Spring, Md.) 20120301
Title: Anatomical dissociation of melanocortin receptor agonist effects on taste- and gut-sensitive feeding processes.
Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20111001
Title: Assessment of voluntary ethanol consumption and the effects of a melanocortin (MC) receptor agonist on ethanol intake in mutant C57BL/6J mice lacking the MC-4 receptor.
Journal: Alcoholism, clinical and experimental research 20110601
Title: Systemic but not central nervous system nitric oxide synthase inhibition exacerbates the hypertensive effects of chronic melanocortin-3/4 receptor activation.
Journal: Hypertension (Dallas, Tex. : 1979) 20110301
Title: Activation of the melanocortin-4 receptor causes enhanced excitation in presympathetic paraventricular neurons in obese Zucker rats.
Journal: Regulatory peptides 20110117
Title: Central melanocortin stimulation increases phosphorylated perilipin A and hormone-sensitive lipase in adipose tissues.
Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20100701
Title: Melanocortin activity in the amygdala controls appetite for dietary fat.
Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20100201
Title: Distinct effects of leptin and a melanocortin receptor agonist injected into medial hypothalamic nuclei on glucose uptake in peripheral tissues.
Journal: Diabetes 20091201
Title: Melanocortins may stimulate reproduction by activating orexin neurons in the dorsomedial hypothalamus and kisspeptin neurons in the preoptic area of the ewe.
Journal: Endocrinology 20091201
Title: Substitution of arginine with proline and proline derivatives in melanocyte-stimulating hormones leads to selectivity for human melanocortin 4 receptor.
Journal: Journal of medicinal chemistry 20090625
Title: Melanocortin-4 receptor mRNA expressed in sympathetic outflow neurons to brown adipose tissue: neuroanatomical and functional evidence.
Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20080801
Title: Reflex penile erection in anesthetized mice: an exploratory study.
Journal: Neuroscience 20080731
Title: 5-HT(2C) receptor activation is a common mechanism on proerectile effects of apomorphine, oxytocin and melanotan-II in rats.
Journal: European journal of pharmacology 20080728
Title: Presynaptic melanocortin-4 receptors on vagal afferent fibers modulate the excitability of rat nucleus tractus solitarius neurons.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20080507
Title: Structure-activity relationships of cyclic lactam analogues of alpha-melanocyte-stimulating hormone (alpha-MSH) targeting the human melanocortin-3 receptor.
Journal: Journal of medicinal chemistry 20080124
Title: Functional evaluation of THIQ, a melanocortin 4 receptor agonist, in models of food intake and inflammation.
Journal: Basic & clinical pharmacology & toxicology 20071201
Title: Differential activation of the sympathetic innervation of adipose tissues by melanocortin receptor stimulation.
Journal: Endocrinology 20071101
Title: Melanocortins and agouti-related protein modulate the excitability of two arcuate nucleus neuron populations by alteration of resting potassium conductances.
Journal: The Journal of physiology 20070115
Title: A liquid chromatographic/tandem mass spectroscopic method for quantification of the cyclic peptide melanotan-II. Plasma and brain tissue concentrations following administration in mice.
Journal: Rapid communications in mass spectrometry : RCM 20070101
Title: Design, synthesis, and biological evaluation of new cyclic melanotropin peptide analogues selective for the human melanocortin-4 receptor.
Journal: Journal of medicinal chemistry 20061116
Title: The melanocortin agonist, melanotan II, enhances proceptive sexual behaviors in the female rat.
Journal: Pharmacology, biochemistry, and behavior 20061101
Title: Cell signaling and trafficking of human melanocortin receptors in real time using two-photon fluorescence and confocal laser microscopy: differentiation of agonists and antagonists.
Journal: Chemical biology & drug design 20061001
Title: Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities.
Journal: Journal of medicinal chemistry 20060323
Title: Reduced anorexigenic efficacy of leptin, but not of the melanocortin receptor agonist melanotan-II, predicts diet-induced obesity in rats.
Journal: Endocrinology 20051201
Title: Intracerebroventricular administration of melanotan II increases insulin sensitivity of glucose disposal in mice.
Journal: Diabetologia 20050801
Title: Effects of melanocortin receptor activation and blockade on ethanol intake: a possible role for the melanocortin-4 receptor.
Journal: Alcoholism, clinical and experimental research 20050601
Title: Pharmacotherapy for erectile dysfunction.
Journal: The journal of sexual medicine 20040901
Title: The melanocortin agonist melanotan II increases insulin sensitivity in OLETF rats.
Journal: Peptides 20040801
Title: Unabated anorexic and enhanced thermogenic responses to melanotan II in diet-induced obese rats despite reduced melanocortin 3 and 4 receptor expression.
Journal: The Journal of endocrinology 20040701
Title: Adrenalectomy alters the sensitivity of the central nervous system melanocortin system.
Journal: Diabetes 20031201
Title: MTII-induced reduction of voluntary ethanol drinking is blocked by pretreatment with AgRP-(83-132).
Journal: Neuropeptides 20031201
Title: Extensive structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5.
Journal: The journal of peptide research : official journal of the American Peptide Society 20031101
Title: Structure-activity relationship of cyclic peptide penta-c[Asp-His(6)-DPhe(7)-Arg(8)-Trp(9)-Lys]-NH(2) at the human melanocortin-1 and -4 receptors: His(6) substitution.
Journal: Bioorganic & medicinal chemistry letters 20030407
Title: Structure-activity relationships of the melanocortin tetrapeptide Ac-His-D-Phe-Arg-Trp-NH2 at the mouse melanocortin receptors. 4. Modifications at the Trp position.
Journal: Journal of medicinal chemistry 20021219
Title: Structure-activity relationships of the melanocortin tetrapeptide Ac-His-DPhe-Arg-Trp-NH(2) at the mouse melanocortin receptors: part 2 modifications at the Phe position.
Journal: Journal of medicinal chemistry 20020704
Title: The leptin-like effects of 3-d peripheral administration of a melanocortin agonist are more marked in genetically obese Zucker (fa/fa) than in lean rats.
Journal: Endocrinology 20020601
Title: [New medications for treatment of erectile dysfunction].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20020601
Title: The role of melanocortins in body weight regulation: opportunities for the treatment of obesity.
Journal: European journal of pharmacology 20020412
Title: Activation of central melanocortin receptors by MT-II increases cavernosal pressure in rabbits by the neuronal release of NO.
Journal: British journal of pharmacology 20011201
Title: Molecular determinants of ligand binding to the human melanocortin-4 receptor.
Journal: Biochemistry 20001205
Title: Characterization of melanocortin receptor ligands on cloned brain melanocortin receptors and on grooming behavior in the rat.
Journal: European journal of pharmacology 19990813
Title: Evaluation of melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase-I clinical study.
Journal: Life sciences 19960101
Title: Topographical modification of melanotropin peptide analogues with beta-methyltryptophan isomers at position 9 leads to differential potencies and prolonged biological activities.
Journal: Journal of medicinal chemistry 19951110
Title: Design of potent linear alpha-melanotropin 4-10 analogues modified in positions 5 and 10.
Journal: Journal of medicinal chemistry 19890101
Title: Breindahl T, et al. Identification and characterization by LC-UV-MS/MS of melanotan II skin-tanning products sold illegally on the Internet. Drug Test Anal. 2015 Feb;7(2):164-72.
Title: Giuliano F, et al. Melanotan-II: Investigation of the inducer and facilitator effects on penile erection in anaesthetized rat. Neuroscience. 2006;138(1):293-301.
Title: Ter Laak MP, et al. The potent melanocortin receptor agonist melanotan-II promotes peripheral nerve regeneration and has neuroprotective properties in the rat. Eur J Pharmacol. 2003 Feb 21;462(1-3):179-83.
Title: Wessells H, et al. Melanocortin receptor agonists, penile erection, and sexual motivation: human studies with Melanotan II. Int J Impot Res. 2000 Oct;12 Suppl 4:S74-9.
Title: De Jonghe BC, et al. Food intake reductions and increases in energetic responses by hindbrain leptin and melanotan II are enhanced in mice with POMC-specific PTP1B deficiency. Am J Physiol Endocrinol Metab. 2012 Sep 1;303(5):E644-51.
