Home Carboxes 122018-58-0
122018-58-0,MFCD01311153
Catalog No.:AA01EAQA

122018-58-0 | (Ser140)-Myelin Proteolipid Protein (139-151) (depalmitoylated) (human, bovine, dog, mouse, rat) trifluoroacetate salt H-His-Ser-Leu-Gly-Lys-Trp-Leu-Gly-His-Pro-Asp-Lys-Phe-OH trifluoroacetate salt

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
in stock  
$383.00   $268.00
- +
5mg
in stock  
$1,506.00   $1,054.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA01EAQA
Chemical Name:
(Ser140)-Myelin Proteolipid Protein (139-151) (depalmitoylated) (human, bovine, dog, mouse, rat) trifluoroacetate salt H-His-Ser-Leu-Gly-Lys-Trp-Leu-Gly-His-Pro-Asp-Lys-Phe-OH trifluoroacetate salt
CAS Number:
122018-58-0
Molecular Formula:
C72H104N20O17
Molecular Weight:
1521.7200
MDL Number:
MFCD01311153
SMILES:
NCCCC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1ccccc1)CCCCN)CC(=O)O)Cc1c[nH]cn1)CC(C)C)Cc1c[nH]c2c1cccc2)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]cn1)N)CO)CC(C)C
Properties
Computed Properties
 
Complexity:
3040  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
11  
Heavy Atom Count:
109  
Hydrogen Bond Acceptor Count:
22  
Hydrogen Bond Donor Count:
20  
Rotatable Bond Count:
47  
XLogP3:
-5.7  

Literature

Title: SIRT1 activating compounds reduce oxidative stress and prevent cell death in neuronal cells.

Journal: Frontiers in cellular neuroscience 20120101

Title: Reversible neural stem cell niche dysfunction in a model of multiple sclerosis.

Journal: Annals of neurology 20110501

Title: Alteration of T cell cytokine production in PLPp-139-151-induced EAE in SJL mice by an immunostimulatory CpG oligonucleotide.

Journal: Journal of neuroinflammation 20110101

Title: Combination treatment of mice with CRx-153 (nortriptyline and desloratadine) decreases the severity of experimental autoimmune encephalomyelitis.

Journal: Cellular immunology 20110101

Title: Glatiramer acetate reduces Th-17 inflammation and induces regulatory T-cells in the CNS of mice with relapsing-remitting or chronic EAE.

Journal: Journal of neuroimmunology 20100825

Title: TGF-beta-induced myelin peptide-specific regulatory T cells mediate antigen-specific suppression of induction of experimental autoimmune encephalomyelitis.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20100615

Title: S-nitrosoglutathione a physiologic nitric oxide carrier attenuates experimental autoimmune encephalomyelitis.

Journal: Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 20100601

Title: Rapamycin inhibits relapsing experimental autoimmune encephalomyelitis by both effector and regulatory T cells modulation.

Journal: Journal of neuroimmunology 20100330

Title: Immune response to controlled release of immunomodulating peptides in a murine experimental autoimmune encephalomyelitis (EAE) model.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20100125

Title: Oral administration of triptolide ameliorates the clinical signs of experimental autoimmune encephalomyelitis (EAE) by induction of HSP70 and stabilization of NF-kappaB/IkappaBalpha transcriptional complex.

Journal: Journal of neuroimmunology 20091210

Title: Nicotinic attenuation of central nervous system inflammation and autoimmunity.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20090201

Title: Decreased severity of experimental autoimmune encephalomyelitis during resveratrol administration is associated with increased IL-17+IL-10+ T cells, CD4(-) IFN-gamma+ cells, and decreased macrophage IL-6 expression.

Journal: International immunopharmacology 20090101

Title: 15-deoxy-Delta(12,14)-prostaglandin J(2) and curcumin modulate the expression of toll-like receptors 4 and 9 in autoimmune T lymphocyte.

Journal: Journal of clinical immunology 20080901

Title: Bowman-Birk inhibitor suppresses autoimmune inflammation and neuronal loss in a mouse model of multiple sclerosis.

Journal: Journal of the neurological sciences 20080815

Title: Brain derived neurotrophic factor treatment reduces inflammation and apoptosis in experimental allergic encephalomyelitis.

Journal: Journal of the neurological sciences 20080715

Title: Stem cells ameliorate EAE via an indoleamine 2,3-dioxygenase (IDO) mechanism.

Journal: Journal of neuroimmunology 20080101

Title: The PLPp-specific T-cell population promoted by pertussis toxin is characterized by high frequencies of IL-17-producing cells.

Journal: Cytokine 20071001

Title: Soluble mannosylated myelin peptide inhibits the encephalitogenicity of autoreactive T cells during experimental autoimmune encephalomyelitis.

Journal: The American journal of pathology 20070101

Title: Dipeptidyl peptidase IV (DP IV, CD26) and aminopeptidase N (APN, CD13) as regulators of T cell function and targets of immunotherapy in CNS inflammation.

Journal: International immunopharmacology 20061220

Title: 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor Atorvastatin mediated effects depend on the activation status of target cells in PLP-EAE.

Journal: Journal of autoimmunity 20061201

Title: The selective Rho-kinase inhibitor Fasudil is protective and therapeutic in experimental autoimmune encephalomyelitis.

Journal: Journal of neuroimmunology 20061101

Title: Diversified serum IgG response involving non-myelin CNS proteins during experimental autoimmune encephalomyelitis.

Journal: Journal of neuroimmunology 20061001

Title: Structural requirements for initiation of cross-reactivity and CNS autoimmunity with a PLP139-151 mimic peptide derived from murine hepatitis virus.

Journal: European journal of immunology 20061001

Title: Retinal ganglion cell loss induced by acute optic neuritis in a relapsing model of multiple sclerosis.

Journal: Multiple sclerosis (Houndmills, Basingstoke, England) 20061001

Title: Arvanil inhibits T lymphocyte activation and ameliorates autoimmune encephalomyelitis.

Journal: Journal of neuroimmunology 20060201

Title: Leptin neutralization interferes with pathogenic T cell autoreactivity in autoimmune encephalomyelitis.

Journal: The Journal of clinical investigation 20060201

Title: FTY720, sphingosine 1-phosphate receptor modulator, ameliorates experimental autoimmune encephalomyelitis by inhibition of T cell infiltration.

Journal: Cellular & molecular immunology 20051201

Title: Human bone marrow stromal cell treatment improves neurological functional recovery in EAE mice.

Journal: Experimental neurology 20050901

Title: 5-aminoimidazole-4-carboxamide ribonucleoside: a novel immunomodulator with therapeutic efficacy in experimental autoimmune encephalomyelitis.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20050701

Title: Citrullination of central nervous system proteins during the development of experimental autoimmune encephalomyelitis.

Journal: The Journal of comparative neurology 20050606

Title: Suppression of experimental autoimmune encephalomyelitis using estrogen receptor-selective ligands.

Journal: The Journal of endocrinology 20050501

Title: Mannosylated PLP(139-151) induces peptide-specific tolerance to experimental autoimmune encephalomyelitis.

Journal: Journal of neuroimmunology 20050301

Title: [Construction and expression of regulatable recombinant adenovirus vector for mouse PLP-Ig chimeric protein].

Journal: Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 20041101

Title: Sphingosine 1-phosphate receptor agonists attenuate relapsing-remitting experimental autoimmune encephalitis in SJL mice.

Journal: Journal of neuroimmunology 20040801

Title: Targeting kallikrein 6 proteolysis attenuates CNS inflammatory disease.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040501

Title: Differential effects of treatment with a small-molecule VLA-4 antagonist before and after onset of relapsing EAE.

Journal: Blood 20031215

Title: An immunomodulatory GpG oligonucleotide for the treatment of autoimmunity via the innate and adaptive immune systems.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20031101

Title: Early pregnancy factor treatment suppresses the inflammatory response and adhesion molecule expression in the spinal cord of SJL/J mice with experimental autoimmune encephalomyelitis and the delayed-type hypersensitivity reaction to trinitrochlorobenzene in normal BALB/c mice.

Journal: Journal of the neurological sciences 20030815

Title: Dysregulation of the hypothalamic-pituitary-gonadal axis in experimental autoimmune encephalomyelitis and multiple sclerosis.

Journal: Journal of neuroimmunology 20030701

Title: Analysis of protein induction in the CNS of SJL mice with experimental allergic encephalomyelitis by proteomic screening and immunohistochemistry.

Journal: Cellular and molecular biology (Noisy-le-Grand, France) 20030701

Title: Immunoregulation of a viral model of multiple sclerosis using the synthetic cannabinoid R+WIN55,212.

Journal: The Journal of clinical investigation 20030415

Title: Alpha lipoic acid inhibits T cell migration into the spinal cord and suppresses and treats experimental autoimmune encephalomyelitis.

Journal: Journal of neuroimmunology 20021001

Title: Novel synthetic amino acid copolymers that inhibit autoantigen-specific T cell responses and suppress experimental autoimmune encephalomyelitis.

Journal: The Journal of clinical investigation 20020615

Title: Thiopalmitoylation of myelin proteolipid protein epitopes enhances immunogenicity and encephalitogenicity.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20010601

Title: Tolerance induction by acylated peptides: suppression of EAE in the mouse with palmitoylated PLP peptides.

Journal: Journal of neuroimmunology 20010402

Title: An unexpected version of horror autotoxicus: anaphylactic shock to a self-peptide.

Journal: Nature immunology 20010301

Title: Kordopati GG, et al. Biologically relevant conformational features of linear and cyclic proteolipid protein (PLP) peptide analogues obtained by high-resolution nuclear magnetic resonance and molecular dynamics. J Comput Aided Mol Des. 2017 Jul 29.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:122018-58-0 Molecular Formula|122018-58-0 MDL|122018-58-0 SMILES|122018-58-0 (Ser140)-Myelin Proteolipid Protein (139-151) (depalmitoylated) (human, bovine, dog, mouse, rat) trifluoroacetate salt H-His-Ser-Leu-Gly-Lys-Trp-Leu-Gly-His-Pro-Asp-Lys-Phe-OH trifluoroacetate salt