Home Amines 125464-42-8
125464-42-8,MFCD00216817
Catalog No.:AA000NN4

125464-42-8 | 3-Amino-2-(4-chlorophenyl)propane-1-sulfonic acid

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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA000NN4
Chemical Name:
3-Amino-2-(4-chlorophenyl)propane-1-sulfonic acid
CAS Number:
125464-42-8
Molecular Formula:
C9H12ClNO3S
Molecular Weight:
249.7145
MDL Number:
MFCD00216817
SMILES:
NCC(c1ccc(cc1)Cl)CS(=O)(=O)O
Properties
Computed Properties
 
Complexity:
280  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
15  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
4  
Undefined Atom Stereocenter Count:
1  
XLogP3:
-1.7  

Literature

Title: Role for ventral pallidal GABAergic mechanisms in the regulation of ethanol self-administration.

Journal: Psychopharmacology 20120901

Title: Brainstem injection of lidocaine releases the descending pain-inhibitory mechanisms in a rat model of mononeuropathy.

Journal: Experimental neurology 20120901

Title: Spinal segmental and supraspinal mechanisms underlying the pain-relieving effects of spinal cord stimulation: an experimental study in a rat model of neuropathy.

Journal: Neuroscience 20120726

Title: Effects of GABA ligands injected into the nucleus accumbens shell on fear/anxiety-like and feeding behaviours in food-deprived rats.

Journal: Pharmacology, biochemistry, and behavior 20120301

Title: In vivo neurochemical evidence that newly synthesised GABA activates GABA(B), but not GABA(A), receptors on dopaminergic nerve endings in the nucleus accumbens of freely moving rats.

Journal: Neuropharmacology 20120201

Title: Striatal dopamine transmission is subtly modified in human A53Tα-synuclein overexpressing mice.

Journal: PloS one 20120101

Title: Time-dependent effect of GABA on glucose-stimulated insulin secretion from isolated islets in rat.

Journal: Scandinavian journal of clinical and laboratory investigation 20111001

Title: Insulin reduces neuronal excitability by turning on GABA(A) channels that generate tonic current.

Journal: PloS one 20110101

Title: Positive regulation by GABA(B)R1 subunit of leptin expression through gene transactivation in adipocytes.

Journal: PloS one 20110101

Title: Differential calcium dependence of axonal versus somatodendritic dopamine release, with characteristics of both in the ventral tegmental area.

Journal: Frontiers in systems neuroscience 20110101

Title: GABA-activated single-channel and tonic currents in rat brain slices.

Journal: Journal of visualized experiments : JoVE 20110101

Title: Transmitters and pathways mediating inhibition of spinal itch-signaling neurons by scratching and other counterstimuli.

Journal: PloS one 20110101

Title: Effect of an hyperbaric nitrogen narcotic ambience on arginine and citrulline levels, the precursor and co-product of nitric oxide, in rat striatum.

Journal: Medical gas research 20110101

Title: GABAergic actions on cholinergic laterodorsal tegmental neurons: implications for control of behavioral state.

Journal: Neuroscience 20101215

Title: GABA-A and GABA-B receptors mediate feeding elicited by the GABA-B agonist baclofen in the ventral tegmental area and nucleus accumbens shell in rats: reciprocal and regional interactions.

Journal: Brain research 20101008

Title: Orally administered soymorphins, soy-derived opioid peptides, suppress feeding and intestinal transit via gut mu(1)-receptor coupled to 5-HT(1A), D(2), and GABA(B) systems.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20100901

Title: Ferulic acid inhibits nitric oxide-induced apoptosis by enhancing GABA(B1) receptor expression in transient focal cerebral ischemia in rats.

Journal: Acta pharmacologica Sinica 20100801

Title: A pressurized nitrogen counterbalance to cortical glutamatergic pathway stimulation.

Journal: Neurochemical research 20100501

Title: Spinal GABA receptors mediate the suppressive effect of electroacupuncture on cold allodynia in rats.

Journal: Brain research 20100331

Title: 5-HT(1B) receptor regulation of serotonin (5-HT) release by endogenous 5-HT in the substantia nigra.

Journal: Neuroscience 20100113

Title: Effect of sildenafil on neuropathic pain and hemodynamics in rats.

Journal: Yonsei medical journal 20100101

Title: IH current generates the afterhyperpolarisation following activation of subthreshold cortical synaptic inputs to striatal cholinergic interneurons.

Journal: The Journal of physiology 20091215

Title: Human cord blood-derived hematopoietic and neural-like stem/progenitor cells are attracted by the neurotransmitter GABA.

Journal: Stem cells and development 20091101

Title: [Cardiovascular change induced by central hypertonic saline are accompanied by GABA release in awake rats].

Journal: Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20091101

Title: Tegmental pedunculopontine glutamate and GABA-B synapses mediate morphine reward.

Journal: Behavioral neuroscience 20090201

Title: Role of ventral medial prefrontal cortex in incubation of cocaine craving.

Journal: Neuropharmacology 20090101

Title: Nitric oxide modulates the firing rate of the rat supraoptic magnocellular neurons.

Journal: Neuroscience 20080813

Title: Suppression of detrusor-sphincter dysynergia by GABA-receptor activation in the lumbosacral spinal cord in spinal cord-injured rats.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20080701

Title: GABA receptor activation in the lumbosacral spinal cord decreases detrusor overactivity in spinal cord injured rats.

Journal: The Journal of urology 20080301

Title: GABAB receptors role in cell migration and positioning within the ventromedial nucleus of the hypothalamus.

Journal: Neuroscience 20080219

Title: GABAB receptors are required for galanin modulation of membrane properties of neurons in the arcuate nucleus of rats.

Journal: Brain research 20080129

Title: Expression of gamma-aminobutyric acid receptor (subtype A) in prostate cancer.

Journal: Acta oncologica (Stockholm, Sweden) 20080101

Title: A spinal muscarinic M2 receptor-GABAergic disinhibition pathway that modulates peripheral inflammation in mice.

Journal: Neuropharmacology 20071001

Title: GABA(B) receptor activation inhibits dopamine D1 receptor-mediated facilitation of [(3)H]GABA release in substantia nigra pars reticulata.

Journal: Neuropharmacology 20071001

Title: Enhanced activity of GABA receptors inhibits glutamate release induced by focal cerebral ischemia in rat striatum.

Journal: Neuroscience letters 20070613

Title: Pentobarbital enhances gamma-aminobutyric acid-mediated excitation without altering synaptic plasticity in rat hippocampus.

Journal: Anesthesia and analgesia 20070401

Title: Electrically evoked GABA release in rat hippocampus CA1 region and its changes during kindling epileptogenesis.

Journal: Brain research 20070302

Title: Opposite effects of presynaptic 5-HT3 receptor activation on spontaneous and action potential-evoked GABA release at hippocampal synapses.

Journal: Journal of neurochemistry 20070101

Title: Orexin A in the rostrolateral hypothalamic area induces feeding by modulating GABAergic transmission.

Journal: Brain research 20061213

Title: Baclofen, an agonist at peripheral GABAB receptors, induces antinociception via activation of TEA-sensitive potassium channels.

Journal: British journal of pharmacology 20061101

Title: GABA receptor subtype antagonists in the nucleus accumbens shell and ventral tegmental area differentially alter feeding responses induced by deprivation, glucoprivation and lipoprivation in rats.

Journal: Brain research 20060412

Title: Simultaneous NMDA-dependent long-term potentiation of EPSCs and long-term depression of IPSCs in cultured rat hippocampal neurons.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20060125

Title: Analysis of responses to kava kava in the feline pulmonary vascular bed.

Journal: Journal of medicinal food 20060101

Title: Involvement of spinal GABA receptors in the regulation of intraspinal acetylcholine release.

Journal: European journal of pharmacology 20051121

Title: GABAB-receptor-mediated suppression of sympathetic outflow from the spinal cord of neonatal rats.

Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20051101

Title: Analgesic properties of the novel compound M43068 in rat models of acute and neuropathic pain.

Journal: European journal of pharmacology 20051031

Title: Involvement of kv1 potassium channels in spreading acidification and depression in the cerebellar cortex.

Journal: Journal of neurophysiology 20050801

Title: Enantiomeric analysis of baclofen analogs by capillary zone electrophoresis, using highly sulfated cyclodextrins: Inclusion ionization constant pKa determination.

Journal: Electrophoresis 20050801

Title: GABAB receptors on central terminals of C-afferents mediate intersegmental Adelta-afferent evoked hypoalgesia.

Journal: European journal of pain (London, England) 20050601

Title: Interaction between gamma-aminobutyric acid GABAB and cannabinoid CB1 receptors in spinal pain pathways in rat.

Journal: European journal of pharmacology 20050509

Title: Functional GABA(B) receptors are expressed at the cone photoreceptor terminals in bullfrog retina.

Journal: Neuroscience 20050101

Title: Human follicular fluid stimulates the sperm acrosome reaction by interacting with the gamma-aminobutyric acid receptors.

Journal: Fertility and sterility 20041001

Title: Analysis of gamma-aminobutyric acid-mediated responses in the pulmonary vascular bed of the cat.

Journal: Anesthesia and analgesia 20040901

Title: Conversion into GABA (gamma-aminobutyric acid) may reduce the capacity of L-glutamine as an insulin secretagogue.

Journal: The Biochemical journal 20040501

Title: GABAergic synapses of the suprachiasmatic nucleus exhibit a diurnal rhythm of short-term synaptic plasticity.

Journal: The European journal of neuroscience 20040501

Title: GABA modulates presynaptic signalling mediated by dinucleotides on rat synaptic terminals.

Journal: The Journal of pharmacology and experimental therapeutics 20040301

Title: Dopaminergic ventral tegmental neurons modulated by methylphenidate.

Journal: Life sciences 20040213

Title: Activaton of GABAB receptor inhibits the excitability of rat small diameter trigeminal root ganglion neurons.

Journal: Neuroscience 20040101

Title: A study comparing the actions of gabapentin and pregabalin on the electrophysiological properties of cultured DRG neurones from neonatal rats.

Journal: BMC pharmacology 20040101

Title: Dual effect of GABA on descending monosynaptic excitatory postsynaptic potential in frog lumbar motoneurons.

Journal: Neuroscience 20040101

Title: Analysis of responses to St. John's Wort in the feline pulmonary vascular bed.

Journal: Journal of herbal pharmacotherapy 20040101

Title: Analysis of responses to valerian root extract in the feline pulmonary vascular bed.

Journal: Journal of alternative and complementary medicine (New York, N.Y.) 20031201

Title: Unmyelinated axons in the rat hippocampus hyperpolarize and activate an H current when spike frequency exceeds 1 Hz.

Journal: The Journal of physiology 20031015

Title: Modulation of olfactory learning in young rats through intrabulbar GABA(B) receptors.

Journal: The European journal of neuroscience 20031001

Title: Novel modulatory mechanisms revealed by the sustained application of nicotine in the guinea-pig hippocampus in vitro.

Journal: The Journal of physiology 20030901

Title: Analgesia and hyperalgesia from GABA-mediated modulation of the cerebral cortex.

Journal: Nature 20030717

Title: Lack of intersite GABA receptor subtype antagonist effects upon mu opioid receptor agonist-induced feeding elicited from either the ventral tegmental area or nucleus accumbens shell in rats.

Journal: Physiology & behavior 20030701

Title: Estrogen-induced autonomic effects are mediated by NMDA and GABAA receptors in the parabrachial nucleus.

Journal: Brain research 20030530

Title: Pharmacological characterisation of a cell line expressing GABA B1b and GABA B2 receptor subunits.

Journal: Biochemical pharmacology 20030401

Title: Spinal gabapentin and antinociception: mechanisms of action.

Journal: Journal of Korean medical science 20030401

Title: GABAB receptor-mediated presynaptic potentiation of ATP ionotropic receptors in rat midbrain synaptosomes.

Journal: Neuropharmacology 20030301

Title: Galphimine B modulates synaptic transmission on dopaminergic ventral tegmental area neurons.

Journal: Planta medica 20030101

Title: Pre- and postsynaptic GABA(B) receptors modulate rapid neurotransmission from suprachiasmatic nucleus to parvocellular hypothalamic paraventricular nucleus neurons.

Journal: Neuroscience 20030101

Title: Pentobarbital depressant effects are independent of GABA receptors in auditory thalamic neurons.

Journal: Journal of neurophysiology 20021201

Title: Kavalactones and dihydrokavain modulate GABAergic activity in a rat gastric-brainstem preparation.

Journal: Planta medica 20021201

Title: gamma-Aminobutyric acid (A) receptor agonists accelerate cutaneous barrier recovery and prevent epidermal hyperplasia induced by barrier disruption.

Journal: The Journal of investigative dermatology 20021101

Title: Comparison of antiepileptic drugs tiagabine, lamotrigine, and gabapentin in mouse models of acute, prolonged, and chronic nociception.

Journal: The Journal of pharmacology and experimental therapeutics 20020901

Title: Neurotransmitter mechanisms in gabapentin antinociception.

Journal: Pharmacology 20020801

Title: GABA is toxic for mouse striatal neurones through a transporter-mediated process.

Journal: Journal of neurochemistry 20020801

Title: Protection of malonate-induced GABA but not dopamine loss by GABA transporter blockade in rat striatum.

Journal: Experimental neurology 20020701

Title: International Union of Pharmacology. XXXIII. Mammalian gamma-aminobutyric acid(B) receptors: structure and function.

Journal: Pharmacological reviews 20020601

Title: Alterations in food intake elicited by GABA and opioid agonists and antagonists administered into the ventral tegmental area region of rats.

Journal: Physiology & behavior 20020501

Title: [The effects of intrathecally administered baclofen on somato-sympathetic reflex potentials].

Journal: Masui. The Japanese journal of anesthesiology 20020401

Title: Synaptic regulation of somatodendritic dopamine release by glutamate and GABA differs between substantia nigra and ventral tegmental area.

Journal: Journal of neurochemistry 20020401

Title: Gabapentin-mediated inhibition of voltage-activated Ca2+ channel currents in cultured sensory neurones is dependent on culture conditions and channel subunit expression.

Journal: Neuropharmacology 20020301

Title: Mechanism underlying gamma-aminobutyric acid-induced antihypertensive effect in spontaneously hypertensive rats.

Journal: European journal of pharmacology 20020301

Title: Gabapentin inhibits high-threshold calcium channel currents in cultured rat dorsal root ganglion neurones.

Journal: British journal of pharmacology 20020101

Title: GABA(B) receptor-mediated inhibition of mitral/tufted cell activity in the rat olfactory bulb: a whole-cell patch-clamp study in vitro.

Journal: Neuroscience 20020101

Title: Role of GABA(B) receptor in the regulation of excitatory synaptic transmission in trigeminal motoneurons.

Journal: Journal of biomedical science 20020101

Title: Biphasic effect of GABA on rat sperm acrosome reaction: involvement of GABA(A) and GABA(B) receptors.

Journal: Archives of andrology 20020101

Title: [The study of the role of the GABA A and GABA B receptors in presynaptic inhibition of primary afferents of spinal cord of the frog Rana ridibunda].

Journal: Zhurnal evoliutsionnoi biokhimii i fiziologii 20020101

Title: Role of GABA within the nucleus tractus solitarii in the hypoxic ventilatory decline of awake rats.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20011101

Title: Cholinergic synaptic potentials in the supragranular layers of auditory cortex.

Journal: Synapse (New York, N.Y.) 20010801

Title: GABA(B) receptors mediate motility signals for migrating embryonic cortical cells.

Journal: Cerebral cortex (New York, N.Y. : 1991) 20010801

Title: gamma-Aminobutyric acid receptor subtype antagonists differentially alter opioid-induced feeding in the shell region of the nucleus accumbens in rats.

Journal: Brain research 20010706

Title: Involvement of GABAergic systems in manifestation of pharmacological activity of desipramine.

Journal: Japanese journal of pharmacology 20010701

Title: Mechanism of action of baclofen in rat dorsal motor nucleus of the vagus.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20010601

Title: Polysynaptic excitatory pathways induce heterosynaptic depression in the rat auditory cortex.

Journal: Neuroscience research 20010501

Title: Gamma-vinyl GABA reduces paired pulse inhibition in the rat dentate gyrus in vivo and in vitro.

Journal: Epilepsy research 20010501

Title: Pretreatment of rat brain synaptosomes with GABA increases subsequent GABA uptake via GABA(B) receptor activation.

Journal: Neurochemical research 20010101

Title: The human GABA(B1b) and GABA(B2) heterodimeric recombinant receptor shows low sensitivity to phaclofen and saclofen.

Journal: British journal of pharmacology 20001101

Title: Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors.

Journal: Nature 19970320

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Tags:125464-42-8 Molecular Formula|125464-42-8 MDL|125464-42-8 SMILES|125464-42-8 3-Amino-2-(4-chlorophenyl)propane-1-sulfonic acid