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Home Other Building Blocks 1304630-27-0
1304630-27-0,MFCD28502195
Catalog No.:AA01EO3Y

1304630-27-0 | NGP555

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥95%
in stock  
$168.00   $117.00
- +
5mg
≥95%
in stock  
$456.00   $319.00
- +
10mg
≥95%
in stock  
$826.00   $578.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA01EO3Y
Chemical Name:
NGP555
CAS Number:
1304630-27-0
Molecular Formula:
C23H23FN4S
Molecular Weight:
406.5189
MDL Number:
MFCD28502195
SMILES:
CCc1cc(Nc2scc(n2)c2ccc(c(c2)F)n2cnc(c2)C)c(cc1C)C
Properties
Computed Properties
 
Complexity:
537  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
5  
XLogP3:
6.3  

Downstream Synthesis Route

[1]Bhattarai,Sanjay;Liu,Lei;Wolfe,MichaelS.[BioorganicandMedicinalChemistryLetters,2021,vol.54]

[1]Bhattarai,Sanjay;Liu,Lei;Wolfe,MichaelS.[BioorganicandMedicinalChemistryLetters,2021,vol.54]

[1]Bhattarai,Sanjay;Liu,Lei;Wolfe,MichaelS.[BioorganicandMedicinalChemistryLetters,2021,vol.54]

[1]Bhattarai,Sanjay;Liu,Lei;Wolfe,MichaelS.[BioorganicandMedicinalChemistryLetters,2021,vol.54]

[1]Bhattarai,Sanjay;Liu,Lei;Wolfe,MichaelS.[BioorganicandMedicinalChemistryLetters,2021,vol.54]

Literature

Title: A study of Pneumococcal merodiploids at the molecular level.

Journal: Genetics 19750901

Title: Kounnas MZ, et al. NGP 555, a γ-Secretase Modulator, Lowers the Amyloid Biomarker, Aβ42, in Cerebrospinal Fluid while Preventing Alzheimer's Disease Cognitive Decline in Rodents. Alzheimers Dement (N Y). 2017 Jan;3(1):65-73.

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