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13063-04-2,MFCD01659688
Catalog No.:AA000UNI

13063-04-2 | Nitidine Chloride

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10mg
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$50.00   $35.00
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25mg
95%
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$83.00   $58.00
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50mg
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$139.00   $97.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA000UNI
Chemical Name:
Nitidine Chloride
CAS Number:
13063-04-2
Molecular Formula:
C21H18ClNO4
Molecular Weight:
383.8249
MDL Number:
MFCD01659688
SMILES:
COc1cc2c[n+](C)c3c(c2cc1OC)ccc1c3cc2OCOc2c1.[Cl-]
NSC Number:
146397
Properties
Computed Properties
 
Complexity:
516  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
5  
Rotatable Bond Count:
2  

Downstream Synthesis Route

[1]JournaloftheChemicalSociety,1959,p.4012

[1]OrganicandBiomolecularChemistry,2011,vol.9,p.3133-3135

[2]Patent:CN109942590,2019,A.Locationinpatent:Paragraph0016;0020;0021

[3]ResearchonChemicalIntermediates,2019,vol.45,p.5399-5407

[4]JournaloftheChemicalSociety,1959,p.1840,1843    JournaloftheChemicalSociety,1959,p.4007,4009

[5]ChemicalandPharmaceuticalBulletin,1987,vol.35,p.2348-2354

[6]TetrahedronLetters,1984,vol.25,p.5169-5172

13063-04-2   
2,3-dimethoxy-12-methyl-12,13-dihydro-1,3dioxolo4',5':4,5benzo1,2-<i>c</i>phenanthridin-13-ol 

[1]CollectionofCzechoslovakChemicalCommunications,1972,vol.37,p.2746-2763

[1]JournalofOrganicChemistry,1978,vol.43,p.286-288

[1]ChemicalandPharmaceuticalBulletin,1984,vol.32,p.2984-2994

[2]TetrahedronLetters,1984,vol.25,p.5169-5172

[3]ChemicalandPharmaceuticalBulletin,1987,vol.35,p.2348-2354

[4]JournaloftheChemicalSociety,1959,p.1840,1843    JournaloftheChemicalSociety,1959,p.4007,4009

Literature

Title: Development and validation of an LC-ESI-MS/MS method for the determination of nitidine chloride in rat plasma.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120301

Title: Biological activities of nitidine, a potential anti-malarial lead compound.

Journal: Malaria journal 20120101

Title: Nitidine Chloride inhibits breast cancer cells migration and invasion by suppressing c-Src/FAK associated signaling pathway.

Journal: Cancer letters 20111227

Title: [Study on the alkaloids from the stem of Zanthoxylum dissitum].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20110401

Title: Formal synthesis of nitidine and NK109 via palladium-catalyzed domino direct arylation/N-arylation of aryl triflates.

Journal: Organic letters 20110318

Title: Distinct G-quadruplex structures of human telomeric DNA formed by the induction of sanguinarine and nitidine under salt-deficient condition.

Journal: Fitoterapia 20101201

Title: Tumor-selective cytotoxicity of benzo[c]phenanthridine derivatives from Toddalia asiatica Lam.

Journal: Cancer chemotherapy and pharmacology 20100301

Title: Gold(I)-catalyzed tandem reactions initiated by hydroamination of alkynyl carbamates: application to the synthesis of nitidine.

Journal: The Journal of organic chemistry 20091204

Title: [Studies on pharmacokinetics of nitidine chloride in rabbits].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090601

Title: DNA-binding affinities and sequence selectivity of quaternary benzophenanthridine alkaloids sanguinarine, chelerythrine, and nitidine.

Journal: Bioorganic & medicinal chemistry 20060815

Title: Synthesis and cytotoxic activity of benzo[c][1,7] and [1,8]phenanthrolines analogues of nitidine and fagaronine.

Journal: Bioorganic & medicinal chemistry 20040715

Title: Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia.

Journal: Journal of natural products 20040701

Title: Substituted benzo[i]phenanthridines as mammalian topoisomerase-targeting agents.

Journal: Bioorganic & medicinal chemistry 20030417

Title: Alkaloids, amides and antispasmodic activity of Zanthoxylum hyemale.

Journal: Planta medica 20020601

Title: [Determination of nitidine in different parts of Zanthoxylum nitidum].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20010901

Title: Comparison of in vitro activities of camptothecin and nitidine derivatives against fungal and cancer cells.

Journal: Antimicrobial agents and chemotherapy 19991201

Title: The role of the iminium bond in the inhibition of reverse transcriptase by quaternary benzophenanthridines.

Journal: The Journal of pharmacy and pharmacology 19981101

Title: Evaluation of natural products as inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase.

Journal: Journal of natural products 19910101

Title: Chen J, et al. Inhibition of STAT3 signaling pathway by nitidine chloride suppressed the angiogenesis and growth of human gastric cancer. Mol Cancer Ther. 2012 Feb;11(2):277-87.

Title: Wang Z, et al. Nitidine chloride inhibits LPS-induced inflammatory cytokines production via MAPK and NF-kappaB pathway in RAW 264.7 cells. J Ethnopharmacol. 2012 Oct 31;144(1):145-50.

Title: Pan X, et al. Nitidine Chloride inhibits breast cancer cells migration and invasion by suppressing c-Src/FAK associated signaling pathway. Cancer Lett. 2011 Dec 27;313(2):181-91.

Title: Fang Z, et al. Nitidine chloride induces apoptosis and inhibits tumor cell proliferation via suppressing ERK signaling pathway in renal cancer. Food Chem Toxicol. 2014 Apr;66:210-6.

Title: Liu LM, et al. DNA topoisomerase 1 and 2A function as oncogenes in liver cancer and may be direct targets of nitidine chloride. Int J Oncol. 2018 Nov;53(5):1897-1912.

Title: Bouquet J, et al. Biological activities of nitidine, a potential anti-malarial lead compound. Malar J. 2012 Mar 9;11:67.

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