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3895-92-9,MFCD00060717
Catalog No.:AA0032I2

3895-92-9 | Chelerythrine chloride

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Purity
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1mg
99%
in stock  
$8.00   $6.00
- +
50mg
98%(HPLC)
in stock  
$359.00   $252.00
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100mg
98%(HPLC)
in stock  
$564.00   $395.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA0032I2
Chemical Name:
Chelerythrine chloride
CAS Number:
3895-92-9
Molecular Formula:
C21H18ClNO4
Molecular Weight:
383.8249
MDL Number:
MFCD00060717
SMILES:
COc1c(OC)ccc2c1c[n+](C)c1c2ccc2c1cc1OCOc1c2.[Cl-]
Properties
Properties
 
Form:
Solid  
MP:
195-205 °C  
Storage:
Inert atmosphere;-20 ℃;  

Computed Properties
 
Complexity:
516  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
5  
Rotatable Bond Count:
2  

Downstream Synthesis Route

[1]JournaloftheChemicalSociety,1956,p.4535,4540

[1]JournaloftheChemicalSociety,1956,p.769

[2]ChemicalandPharmaceuticalBulletin,1984,vol.32,p.2984-2994

64-17-5    3895-92-9    64-19-7    100-63-0   
1,2-dimethoxy-12-methyl-13-(<i>N</i>'-phenyl-hydrazino)-12,13-dihydro-1,3dioxolo4',5':4,5benzo1,2-<i>c</i>phenanthridine 

[1]ActaChimicaAcademiaeScientiarumHungaricae,1957,vol.11,p.303,305    ZhurnalObshcheiKhimii,1957,vol.27,p.2108,2110,2111;engl.Ausg.S.2166,2167,2168

64-17-5    3895-92-9    64-19-7    100-63-0   
2,3-dimethoxy-6-(5-methylamino-naphtho2,3-<i>d</i>1,3dioxol-6-yl)-benzaldehyde-phenylhydrazone 

[1]ActaChimicaAcademiaeScientiarumHungaricae,1957,vol.11,p.303,305    ZhurnalObshcheiKhimii,1957,vol.27,p.2108,2110,2111;engl.Ausg.S.2166,2167,2168

[1]Tetrahedron,2011,vol.67,p.1320-1333

[2]ChemicalandPharmaceuticalBulletin,1984,vol.32,p.2984-2994

[3]Chemicalandpharmaceuticalbulletin,1971,vol.19,p.31-36

Literature

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Title: In vitro antifungal activity of sanguinarine and chelerythrine derivatives against phytopathogenic fungi.

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Title: Deoxycholic acid inhibits smooth muscle contraction via protein kinase C-dependent modulation of L-type Ca2+ channels in rat proximal colon.

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Title: Involvement of basal and calcium-activated protein kinase C in neurotransmitter secretion in mouse motor synapses.

Journal: Bulletin of experimental biology and medicine 20121001

Title: Luminescence and binding properties of two isoquinoline alkaloids chelerythrine and sanguinarine with ctDNA.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20120901

Title: Exercise preconditioning provides early cardioprotection against exhaustive exercise in rats: potential involvement of protein kinase C delta translocation.

Journal: Molecular and cellular biochemistry 20120901

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Title: Facilitation of neurotransmitter release in mouse motor synapses in different modes of protein kinase C activation.

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Title: Investigation of sanguinarine and chelerythrine effects on LPS-induced inflammatory gene expression in THP-1 cell line.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20120715

Title: Protein kinase C inhibitor prevents renal apoptotic and fibrotic changes in response to partial ureteric obstruction.

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Title: Protein kinase C-α mediates hypertonicity-stimulated increase in urea transporter phosphorylation in the inner medullary collecting duct.

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Title: Differential consequences of protein kinase C activation during early and late hepatic ischemic preconditioning.

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Title: Cardioprotection of electroacupuncture against myocardial ischemia-reperfusion injury by modulation of cardiac norepinephrine release.

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Title: Protective effect of urantide against ischemia-reperfusion injury via protein kinase C and phosphtidylinositol 3'-kinase - Akt pathway.

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Title: Protein kinase mζ is necessary for cocaine-induced synaptic potentiation in the ventral tegmental area.

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Title: Cellular pharmacology of protein kinase Mζ (PKMζ) contrasts with its in vitro profile: implications for PKMζ as a mediator of memory.

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Title: Testosterone modulates platelet aggregation and endothelial cell growth through nitric oxide pathway.

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Title: One-pot synthesis of isoquinolinium salts by rhodium-catalyzed C-H bond activation: application to the total synthesis of oxychelerythrine.

Journal: Angewandte Chemie (International ed. in English) 20120102

Title: Physiological effect of protein kinase C on ENaC-mediated lung liquid regulation in the adult rat lung.

Journal: American journal of physiology. Lung cellular and molecular physiology 20120101

Title: The proton-activated G protein coupled receptor OGR1 acutely regulates the activity of epithelial proton transport proteins.

Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20120101

Title: Pharmacological differences of endothelin receptors-mediated modulation in cultured interstitial cells of Cajal from the murine small and large intestine.

Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20120101

Title: Neuromedin S increases L-type Ca(2+) channel currents through G(i)α-protein and phospholipase C-dependent novel protein kinase C delta pathway in adult rat ventricular myocytes.

Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20120101

Title: Reactive oxygen species-independent rapid initiation of mitochondrial apoptotic pathway by chelerythrine.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20111201

Title: Formulation optimization of chelerythrine loaded O-carboxymethylchitosan microspheres using response surface methodology.

Journal: International journal of biological macromolecules 20111201

Title: The ERM protein, ezrin, regulates neutrophil transmigration by modulating the apical localization of MRP2 in response to the SipA effector protein during Salmonella Typhimurium infection.

Journal: Cellular microbiology 20111201

Title: Platelet-activating factor stimulates sodium-hydrogen exchange in ventricular myocytes.

Journal: American journal of physiology. Heart and circulatory physiology 20111201

Title: KMUP-1 inhibits L-type Ca²⁺ channels involved the protein kinase C in rat basilar artery myocytes.

Journal: The Kaohsiung journal of medical sciences 20111201

Title: Tumor necrosis factor-α downregulates sodium current in skeletal muscle by protein kinase C activation: involvement in critical illness polyneuromyopathy.

Journal: American journal of physiology. Cell physiology 20111101

Title: Parathyroid hormone and the regulation of cell cycle in colon adenocarcinoma cells.

Journal: Biochimica et biophysica acta 20111001

Title: Neurotensin inhibits background K+ channels and facilitates glutamatergic transmission in rat spinal cord dorsal horn.

Journal: The European journal of neuroscience 20111001

Title: Rat lymphocytes express NMDA receptors that take part in regulation of cytokine production.

Journal: Cell biochemistry and function 20111001

Title: β₁-adrenergic receptor up-regulation induced by nadolol is mediated via signal transduction pathway coupled to α₁-adrenergic receptors.

Journal: Brain research 20110926

Title: Agonist-induced periodic vasomotion in rat isolated pulmonary artery.

Journal: Fundamental & clinical pharmacology 20110801

Title: Activity of the chelerythrine, a quaternary benzo[c]phenanthridine alkaloid from Chelidonium majus L. on Dactylogyrus intermedius.

Journal: Parasitology research 20110701

Title: Thyroid hormones modulate GABA(A) receptor-mediated currents in hippocampal neurons.

Journal: Neuropharmacology 20110601

Title: Effects of chelerythrine, a specific inhibitor of cyclooxygenase-2, on acute inflammation in mice.

Journal: Fitoterapia 20110601

Title: PKCgamma in Vc and C1/C2 is involved in trigeminal neuropathic pain.

Journal: Journal of dental research 20110601

Title: Protein kinase C phosphorylates the cAMP response element binding protein in the hypothalamic paraventricular nucleus during morphine withdrawal.

Journal: British journal of pharmacology 20110601

Title: Chelerythrine perturbs lamellar actomyosin filaments by selective inhibition of myotonic dystrophy kinase-related Cdc42-binding kinase.

Journal: FEBS letters 20110506

Title: Antidepressant phenotype by inhibiting the phospholipase Cβ(1)--protein kinase Cγ pathway in the forced swim test.

Journal: Neuropharmacology 20110501

Title: Differential effect of the benzophenanthridine alkaloids sanguinarine and chelerythrine on glycine transporters.

Journal: Neurochemistry international 20110501

Title: The heart: a novel gonadotrophin-releasing hormone target.

Journal: Journal of neuroendocrinology 20110501

Title: Identification of benzo[c]phenanthridine metabolites in human hepatocytes by liquid chromatography with electrospray ion-trap and quadrupole time-of-flight mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110501

Title: Structural modification of sanguinarine and chelerythrine and their antibacterial activity.

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Title: Induction of apoptosis by chelerythrine chloride through mitochondrial pathway and Bcl-2 family proteins in human hepatoma SMMC-7721 cell.

Journal: Archives of pharmacal research 20110501

Title: Protein kinase M maintains long-term sensitization and long-term facilitation in aplysia.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20110427

Title: Microarray analysis of the chelerythrine-induced transcriptome of Mycobacterium tuberculosis.

Journal: Current microbiology 20110401

Title: Hypoxia-induced sensitization of transient receptor potential vanilloid 1 involves activation of hypoxia-inducible factor-1 alpha and PKC.

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Title: Kisspeptin-10 elicits triphasic cytosolic calcium responses in immortalized GT1-7 GnRH neurones.

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Title: Luteinizing hormone (LH) acts through PKA and PKC to modulate T-type calcium currents and intracellular calcium transients in mice Leydig cells.

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Title: Effects of the PKC inhibitors chelerythrine and bisindolylmaleimide I (GF 109203X) on delayed rectifier K+ currents.

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Title: Mechanism governing reversal of multidrug resistance in human breast carcinoma cells by chelerythrine.

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Title: Protein kinase C regulates urea permeability in the rat inner medullary collecting duct.

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Title: Protein kinase C activation modulates reversible increase in cortical blood-brain barrier permeability and tight junction protein expression during hypoxia and posthypoxic reoxygenation.

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Title: TRPC6 channels stimulated by angiotensin II are inhibited by TRPC1/C5 channel activity through a Ca2+- and PKC-dependent mechanism in native vascular myocytes.

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Title: Opioid peptide deltorphin II simulates the cardioprotective effect of ischemic preconditioning: role of δ₂-opioid receptors, protein kinase C, and K(ATP) channels.

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Title: Role of protein kinase Czeta in thrombin-induced RhoA activation and inter-endothelial gap formation of human dermal microvessel endothelial cell monolayers.

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Title: Mechanism of inhibition of acetylcholine secretion in newly formed mouse synapses involving Ca2+-dependent kinases and voltage-gated K+-channels.

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Title: Rho kinase activation and ROS production contributes to the cooling enhanced contraction in cutaneous equine digital veins.

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Title: The identification of inhibitors of Schistosoma mansoni miracidial transformation by incorporating a medium-throughput small-molecule screen.

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Title: Multiple kinase pathways regulate voltage-dependent Ca2+ influx and migration in oligodendrocyte precursor cells.

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Title: Role of progesterone on the regulation of vascular muscle cells proliferation, migration and apoptosis.

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Title: Rho kinase and protein kinase C involvement in vascular smooth muscle myofilament calcium sensitization in arteries from diabetic rats.

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Title: [Effects of a protein kinase C inhibitor combined with cisplatin on non-small cell lung cancer].

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Title: Role of Rho-kinase in mediating contraction of chicken embryo femoral arteries.

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Title: Regulation of K-Cl cotransport in erythrocytes of frog Rana temporaria by commonly used protein kinase and protein phosphatase inhibitors.

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Title: High glucose increases expression of cyclooxygenase-2, increases oxidative stress and decreases the generation of nitric oxide in mouse microvessel endothelial cells.

Journal: Journal of cellular physiology 20100301

Title: Critical involvement of postsynaptic protein kinase activation in long-term potentiation at hippocampal mossy fiber synapses on CA3 interneurons.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20100224

Title: Attenuation of renal ischemia-reperfusion injury by postconditioning involves adenosine receptor and protein kinase C activation.

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Title: Involvement of protein kinase C-CPI-17 in androgen modulation of angiotensin II-renal vasoconstriction.

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Title: Autophagy and protein kinase C are required for cardioprotection by sulfaphenazole.

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Title: Rift valley fever virus infection of human cells and insect hosts is promoted by protein kinase C epsilon.

Journal: PloS one 20100101

Title: Inactivation of the Ecs ABC transporter of Staphylococcus aureus attenuates virulence by altering composition and function of bacterial wall.

Journal: PloS one 20100101

Title: Antiproliferative and antiangiogenic effects of the benzophenanthridine alkaloid sanguinarine in melanoma.

Journal: Biochemical pharmacology 20091201

Title: The membrane cytoskeletal protein adducin is phosphorylated by protein kinase C in D1 neurons of the nucleus accumbens and dorsal striatum following cocaine administration.

Journal: Journal of neurochemistry 20091201

Title: PKC-permitted elevation of sarcolemmal KATP concentration may explain female-specific resistance to myocardial infarction.

Journal: The Journal of physiology 20091201

Title: Rapid use-dependent down-regulation of gamma-aminobutyric acid type A receptors in rat mesencephalic trigeminal neurons.

Journal: Journal of neuroscience research 20091101

Title: [Determination of chelerythrine in Chelidonium majus by RP-HPLC].

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Title: Cardiac Na+ current regulation by pyridine nucleotides.

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Title: Cardiac metabolic state and Brugada syndrome: a link revealed.

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Title: Structure-activity relationship of isoform selective inhibitors of Rac1/1b GTPase nucleotide binding.

Journal: Bioorganic & medicinal chemistry letters 20091001

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology 20091001

Title: Antifungal activity of the benzo[c]phenanthridine alkaloids from Chelidonium majus Linn against resistant clinical yeast isolates.

Journal: Journal of ethnopharmacology 20090925

Title: Selective sigma receptor agonist 2-(4-morpholinethyl)1-phenylcyclohexanecarboxylate (PRE084) promotes neuroprotection and neurite elongation through protein kinase C (PKC) signaling on motoneurons.

Journal: Neuroscience 20090804

Title: Effect of protease-activated receptor 2 activation on single TRPV1 channel activities in rat vagal pulmonary sensory neurons.

Journal: Experimental physiology 20090801

Title: Ragweed pollen-mediated IgE-independent release of biogenic amines from mast cells via induction of mitochondrial dysfunction.

Journal: Molecular immunology 20090801

Title: Regulation of store-operated Ca2+ entry in pulmonary artery smooth muscle cells.

Journal: Cell calcium 20090801

Title: Protective mechanisms of NO preconditioning against NO-induced apoptosis in H9c2 cells: role of PKC and COX-2.

Journal: Free radical research 20090801

Title: [Studies on chemical constituents of fructus broussonetiae].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20090801

Title: Role of mitochondrial ATP-sensitive potassium channels on fatigue in mouse muscle fibers.

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Title: The anti-arrhythmic peptide AAP10 remodels Cx43 and Cx40 expression and function.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20090701

Title: The role of nitric oxide and reactive oxygen species in the positive inotropic response to mechanical stretch in the mammalian myocardium.

Journal: Biochimica et biophysica acta 20090701

Title: Relaxin alters cardiac myofilament function through a PKC-dependent pathway.

Journal: American journal of physiology. Heart and circulatory physiology 20090701

Title: Delayed anti-arrhythmic effect of nitroglycerin in anesthetized rats: involvement of CGRP, PKC and mK ATP channels.

Journal: International journal of cardiology 20090626

Title: Water taste transduction pathway is calcium dependent in Drosophila.

Journal: Chemical senses 20090601

Title: Activation of peripheral delta2 opioid receptors increases cardiac tolerance to ischemia/reperfusion injury Involvement of protein kinase C, NO-synthase, KATP channels and the autonomic nervous system.

Journal: Life sciences 20090508

Title: Protein kinase C activity is associated with prefrontal cortical decline in aging.

Journal: Neurobiology of aging 20090501

Title: Direct evidence for the up-regulation of Vps34 regulated by PKCgamma during short-term treatment with morphine.

Journal: Synapse (New York, N.Y.) 20090501

Title: A retrograde apoptotic signal originating in NGF-deprived distal axons of rat sympathetic neurons in compartmented cultures.

Journal: Cell research 20090501

Title: Lysophosphatidic acid signaling promotes proliferation, differentiation, and cell survival in rat growth plate chondrocytes.

Journal: Biochimica et biophysica acta 20090501

Title: CapZ dynamics are altered by endothelin-1 and phenylephrine via PIP2- and PKC-dependent mechanisms.

Journal: American journal of physiology. Cell physiology 20090501

Title: Effects of desflurane and propofol on electrophysiological parameters during and recovery after hypoxia in rat hippocampal slice CA1 pyramidal cells.

Journal: Neuroscience 20090421

Title: Rapid component I(Kr) of cardiac delayed rectifier potassium currents in guinea-pig is inhibited by alpha(1)-adrenoreceptor activation via protein kinase A and protein kinase C-dependent pathways.

Journal: European journal of pharmacology 20090417

Title: Statins and fenofibrate affect skeletal muscle chloride conductance in rats by differently impairing ClC-1 channel regulation and expression.

Journal: British journal of pharmacology 20090401

Title: Analysis of alkaloids in Macleaya cordata (Willd.) R. Br. using high-performance liquid chromatography with diode array detection and electrospray ionization mass spectrometry.

Journal: Journal of chromatography. A 20090313

Title: Protein kinase C mediates amyloid beta-protein fragment 31-35-induced suppression of hippocampal late-phase long-term potentiation in vivo.

Journal: Neurobiology of learning and memory 20090301

Title: Improvement of deficient natural killer activity and delayed bactericidal activity by a thiol proteinase inhibitor, E-64-d, in leukocytes from Chediak-Higashi syndrome patients in vitro.

Journal: International immunopharmacology 20090301

Title: Role of oxidative stress in the natriuresis induced by central administration of angiotensin II.

Journal: Journal of the renin-angiotensin-aldosterone system : JRAAS 20090301

Title: Bradykinin regulates calpain and proinflammatory signaling through TRPM7-sensitive pathways in vascular smooth muscle cells.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20090201

Title: Obligatory role for phosphatidylinositol 4,5-bisphosphate in activation of native TRPC1 store-operated channels in vascular myocytes.

Journal: The Journal of physiology 20090201

Title: Effect of curcumin on acidic pH-induced expression of IL-6 and IL-8 in human esophageal epithelial cells (HET-1A): role of PKC, MAPKs, and NF-kappaB.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20090201

Title: Two PKC consensus sites on human acid-sensing ion channel 1b differentially regulate its function.

Journal: American journal of physiology. Cell physiology 20090201

Title: Synthesis and structure-activity relationships of novel, substituted 5,6-dihydrodibenzo[a,g]quinolizinium P2X7 antagonists.

Journal: Bioorganic & medicinal chemistry letters 20090201

Title: Contribution of RhoA kinase and protein kinase C to weak relaxant effect of pinacidil on carbachol-induced contractions in sensitized guinea-pig trachealis.

Journal: Archives of pharmacal research 20090201

Title: [The effect of chelerythrine on the hypertrophy of cardiac myocytes of neonatal rats induced by different glucose levels and its mechanism].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20090201

Title: [Mechanisms of gross saponins of Tribulus terrestris via activating PKCepsilon against myocardial apoptosis induced by oxidative stress].

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Title: Angiotensin II stimulates water and NaCl intake through separate cell signalling pathways in rats.

Journal: Experimental physiology 20090101

Title: Structural and functional similarity between the bacterial type III secretion system needle protein PrgI and the eukaryotic apoptosis Bcl-2 proteins.

Journal: PloS one 20090101

Title: Cholinergic excitation of dopaminergic cells depends on sequential activation of protein kinase C and the L-type calcium channel in ventral tegmental area slices.

Journal: Brain research 20081215

Title: The antimanic-like effect of tamoxifen: Behavioural comparison with other PKC-inhibiting and antiestrogenic drugs.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20081212

Title: Adenosine A2A and beta-adrenergic calcium transient and contractile responses in rat ventricular myocytes.

Journal: American journal of physiology. Heart and circulatory physiology 20081201

Title: Natural feed additive of Macleaya cordata: safety assessment in rats a 90-day feeding experiment.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20081201

Title: PKMzeta maintains spatial, instrumental, and classically conditioned long-term memories.

Journal: PLoS biology 20081201

Title: Iodine-mediated electrophilic cyclization of 2-alkynyl-1-methylene azide aromatics leading to highly substituted isoquinolines and its application to the synthesis of norchelerythrine.

Journal: Journal of the American Chemical Society 20081119

Title: Structure-activity relationship studies of phenanthridine-based Bcl-XL inhibitors.

Journal: Journal of medicinal chemistry 20081113

Title: Modulation of Na+-H+ exchange isoforms NHE1 and NHE3 by insulin-like growth factor-1 in isolated bovine articular chondrocytes.

Journal: Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20081101

Title: Impact of protein kinase C activation on epileptiform activity in the hippocampal slice.

Journal: Epilepsy research 20081101

Title: Effects of 18-glycyrrhetinic acid on serine 368 phosphorylation of connexin43 in rat neonatal cardiomyocytes.

Journal: Cell biology international 20081101

Title: Activation of the RAF/mitogen-activated protein/extracellular signal-regulated kinase kinase/extracellular signal-regulated kinase pathway mediates apoptosis induced by chelerythrine in osteosarcoma.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20081015

Title: Testosterone and dihydrotestosterone inhibit gallbladder motility through multiple signalling pathways.

Journal: Steroids 20081001

Title: Calcium sensitization in human esophageal muscle: role for RhoA kinase in maintenance of lower esophageal sphincter tone.

Journal: The Journal of pharmacology and experimental therapeutics 20081001

Title: Vasoactive intestinal peptide increases cystic fibrosis transmembrane conductance regulator levels in the apical membrane of Calu-3 cells through a protein kinase C-dependent mechanism.

Journal: The Journal of pharmacology and experimental therapeutics 20081001

Title: Site-specific binding of chelerythrine and sanguinarine to single pyrimidine bulges in hairpin DNA.

Journal: Analytical and bioanalytical chemistry 20081001

Title: Production of hydrogen peroxide and redox cycling can explain how sanguinarine and chelerythrine induce rapid apoptosis.

Journal: Archives of biochemistry and biophysics 20080901

Title: Comparison of the involvement of protein kinase C in agonist-induced contractions in mouse aorta and corpus cavernosum.

Journal: European journal of pharmacology 20080820

Title: N-oleoyldopamine, a novel endogenous capsaicin-like lipid, protects the heart against ischemia-reperfusion injury via activation of TRPV1.

Journal: American journal of physiology. Heart and circulatory physiology 20080801

Title: Nitric oxide induces heat shock protein 72 production and delayed protection against myocardial ischemia in rabbits via activating protein kinase C.

Journal: Chinese medical journal 20080620

Title: Insulin effects on cardiac Na+/Ca2+ exchanger activity: role of the cytoplasmic regulatory loop.

Journal: The Journal of biological chemistry 20080613

Title: Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).

Journal: Journal of medicinal chemistry 20080612

Title: Chelerythrine and dihydrochelerythrine induce G1 phase arrest and bimodal cell death in human leukemia HL-60 cells.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20080601

Title: Volume-sensitive NADPH oxidase activity and taurine efflux in NIH3T3 mouse fibroblasts.

Journal: American journal of physiology. Cell physiology 20080601

Title: Apelin decreases the SR Ca2+ content but enhances the amplitude of [Ca2+]i transient and contractions during twitches in isolated rat cardiac myocytes.

Journal: American journal of physiology. Heart and circulatory physiology 20080601

Title: Complex regulation of store-operated Ca2+ entry pathway by PKC-epsilon in vascular SMCs.

Journal: American journal of physiology. Cell physiology 20080601

Title: Role of PKCepsilon in PGF2alpha-stimulated MMP-2 secretion from human ciliary muscle cells.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20080601

Title: Macleaya cordata extract and Sangrovit genotoxicity. Assessment in vivo.

Journal: Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia 20080601

Title: Separation of sanguinarine and chelerythrine in Macleaya cordata (Willd) R. Br. based on methyl acrylate-co-divinylbenzene macroporous adsorbents.

Journal: Journal of chromatography. A 20080523

Title: Diverse properties of store-operated TRPC channels activated by protein kinase C in vascular myocytes.

Journal: The Journal of physiology 20080515

Title: The increase in retinal cells proliferation induced by FGF2 is mediated by tyrosine and PI3 kinases.

Journal: Neurochemical research 20080501

Title: Molecular interaction in the mouse PAG between NMDA and opioid receptors in morphine-induced acute thermal nociception.

Journal: Journal of neurochemistry 20080401

Title: Epinephrine increases phosphorylation of MAP-2c in rat pheochromocytoma cells (PC12 Cells) via a protein kinase C- and mitogen activated protein kinase-dependent mechanism.

Journal: Journal of proteome research 20080401

Title: A decisive role of mitochondria in defining rate and intensity of apoptosis induction by different alkaloids.

Journal: Toxicology letters 20080401

Title: Chelerythrine induces apoptosis through a Bax/Bak-independent mitochondrial mechanism.

Journal: The Journal of biological chemistry 20080328

Title: Chelerythrine treatment influences the balance of pro- and anti-apoptotic signaling pathways in the remote myocardium after infarction.

Journal: Molecular and cellular biochemistry 20080301

Title: Low-dose morphine induces hyperalgesia through activation of G alphas, protein kinase C, and L-type Ca 2+ channels in rats.

Journal: Journal of neuroscience research 20080201

Title: Differential effect of sanguinarine, chelerythrine and chelidonine on DNA damage and cell viability in primary mouse spleen cells and mouse leukemic cells.

Journal: Cell biology international 20080201

Title: Conventional protein kinase C isoenzymes undergo dephosphorylation in neutrophil-like HL-60 cells treated by chelerythrine or sanguinarine.

Journal: Cell biology and toxicology 20080101

Title: Cardioprotection induced by hydrogen sulfide preconditioning involves activation of ERK and PI3K/Akt pathways.

Journal: Pflugers Archiv : European journal of physiology 20080101

Title: Identification of a PKCepsilon-dependent regulation of myocardial contraction by epicatechin-3-gallate.

Journal: American journal of physiology. Heart and circulatory physiology 20080101

Title: H2S preconditioning-induced PKC activation regulates intracellular calcium handling in rat cardiomyocytes.

Journal: American journal of physiology. Cell physiology 20080101

Title: Sevoflurane enhances ethanol-induced cardiac preconditioning through modulation of protein kinase C, mitochondrial KATP channels, and nitric oxide synthase, in guinea pig hearts.

Journal: Anesthesia and analgesia 20080101

Title: [Changes in the DNA content in EGF-stimulated ciliate Tetrahymena pyriformis under effect of caffeine, KCl, and inhibitors of PLC and PKC].

Journal: Tsitologiia 20080101

Title: [Effect of ionising irradiation on outward potassium current in the aorta smooth muscle cells in rats: the role of protein kinase C].

Journal: Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) 20080101

Title: A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20071218

Title: Opening the calcium-activated potassium channel participates in the cardioprotective effect of puerarin.

Journal: European journal of pharmacology 20071128

Title: Disuse of rat muscle in vivo reduces protein kinase C activity controlling the sarcolemma chloride conductance.

Journal: The Journal of physiology 20071101

Title: Oxytocin and vasopressin stimulate anion secretion by human and porcine vas deferens epithelia.

Journal: Biology of reproduction 20070901

Title: Oxidative stress and increased eNOS and NADPH oxidase expression in mouse microvessel endothelial cells.

Journal: Journal of cellular physiology 20070901

Title: Ischemic preconditioning targets the reperfusion phase.

Journal: Basic research in cardiology 20070901

Title: Protein kinase C protects preconditioned rabbit hearts by increasing sensitivity of adenosine A2b-dependent signaling during early reperfusion.

Journal: Journal of molecular and cellular cardiology 20070901

Title: Berberine suppresses inflammatory agents-induced interleukin-1beta and tumor necrosis factor-alpha productions via the inhibition of IkappaB degradation in human lung cells.

Journal: Pharmacological research 20070901

Title: PKC activation sets an upper limit to the functional plasticity of GABAergic transmission induced by endogenous neurosteroids.

Journal: The European journal of neuroscience 20070901

Title: Signal transduction mechanisms of CD137 ligand in human monocytes.

Journal: Cellular signalling 20070901

Title: Involvement of the protein kinase Cgamma isoform in development of tolerance to nitrous oxide-induced antinociception in mice.

Journal: Neuroscience 20070824

Title: Urocortin prevents mitochondrial permeability transition in response to reperfusion injury indirectly by reducing oxidative stress.

Journal: American journal of physiology. Heart and circulatory physiology 20070801

Title: Localization of intracellular compartments that exchange Na,K-ATPase molecules with the plasma membrane in a hormone-dependent manner.

Journal: British journal of pharmacology 20070801

Title: A minor role for Ca2+ sensitization in sustained contraction through activation of muscarinic receptor in circular muscle of rat distal colon.

Journal: Pflugers Archiv : European journal of physiology 20070701

Title: Landiolol has cardioprotective effects against reperfusion injury in the rat heart via the PKCepsilon signaling pathway.

Journal: Free radical research 20070701

Title: Role of L-type calcium channels and PKC in active tone development in rabbit coronary artery.

Journal: American journal of physiology. Heart and circulatory physiology 20070601

Title: Protein kinase C regulates vascular myogenic tone through activation of TRPM4.

Journal: American journal of physiology. Heart and circulatory physiology 20070601

Title: Verrucotoxin inhibits KATP channels in cardiac myocytes through a muscarinic M3 receptor-PKC pathway.

Journal: European journal of pharmacology 20070601

Title: Delayed protection of tetramethylpyrazine on neonatal rat cardiomyocytes subjected to anoxia-reoxygenation injury.

Journal: Basic & clinical pharmacology & toxicology 20070601

Title: [Effect of Chelerythrine on glucosyltransferase and water-insoluble glucan of Streptococcus mutans].

Journal: Shanghai kou qiang yi xue = Shanghai journal of stomatology 20070601

Title: Effects of PKC on inhibition of delayed rectifier potassium currents by N/OFQ.

Journal: Biochemical and biophysical research communications 20070511

Title: PKC blockade differentially affects aversive but not appetitive gustatory memories.

Journal: Brain research 20070507

Title: M1 muscarinic receptor modulation of Kir2 channels enhances temporal summation of excitatory synaptic potentials in prefrontal cortex pyramidal neurons.

Journal: Journal of neurophysiology 20070501

Title: Taurodeoxycholate modulates apical Cl-/OH- exchange activity in Caco2 cells.

Journal: Digestive diseases and sciences 20070501

Title: Endothelin-1 accentuates the proatherosclerotic effects associated with C-reactive protein.

Journal: The Journal of thoracic and cardiovascular surgery 20070501

Title: The pH hypothesis of postconditioning: staccato reperfusion reintroduces oxygen and perpetuates myocardial acidosis.

Journal: Circulation 20070410

Title: Role of protein kinase C in aldosterone-induced non-genomic inhibition of basolateral potassium channels in human colonic crypts.

Journal: The Journal of steroid biochemistry and molecular biology 20070401

Title: Extracellular signal-regulated kinase 1/2-mediated transcriptional regulation of G-protein-coupled receptor kinase 3 expression in neuronal cells.

Journal: The Journal of pharmacology and experimental therapeutics 20070401

Title: A61603-induced contractions of the porcine meningeal artery are mediated by alpha1- and alpha2-adrenoceptors.

Journal: Basic & clinical pharmacology & toxicology 20070401

Title: Cardioprotective properties of humoral factors released from rat hearts subject to ischemic preconditioning.

Journal: Journal of cardiovascular pharmacology 20070401

Title: Receptor regulation of the volume-sensitive efflux of taurine and iodide from human SH-SY5Y neuroblastoma cells: differential requirements for Ca(2+) and protein kinase C.

Journal: The Journal of pharmacology and experimental therapeutics 20070301

Title: Variability in the yield of benzophenanthridine alkaloids in wildcrafted vs cultivated bloodroot (Sanguinaria canadensis L.).

Journal: Journal of agricultural and food chemistry 20070221

Title: (+/-)3,4-Methylenedioxyamphetamine elicits action potential bursts in a central snail neuron.

Journal: Experimental neurology 20070201

Title: Protein kinase C-mediated modulation of glutamate transporter activity in rat retina.

Journal: Current eye research 20070201

Title: [Effect of Chelerythrine on cell surface hydrophobicity and adherence of Streptococcus mutans].

Journal: Shanghai kou qiang yi xue = Shanghai journal of stomatology 20070201

Title: Activation of kappa-opioid receptor as a method for prevention of ischemic and reperfusion arrhythmias: role of protein kinase C and K(ATP) channels.

Journal: Bulletin of experimental biology and medicine 20070201

Title: Synaptic strength at the thalamocortical input to layer IV neonatal barrel cortex is regulated by protein kinase C.

Journal: Neuropharmacology 20070101

Title: Two distinct signaling pathways for regulation of spontaneous local Ca2+ release by phospholipase C in airway smooth muscle cells.

Journal: Pflugers Archiv : European journal of physiology 20070101

Title: Postjunctional synergism of norepinephrine with ATP and diadenosine tetraphosphate in Guinea pig vas deferens. Role of protein kinase C and Myosin light chain phosphatase.

Journal: Pharmacology 20070101

Title: [Effect of adrenocorticotropic hormone on the caspase-3 level and DNA fragmentation in hyperplasia tissue of human adrenals].

Journal: Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20070101

Title: Angiotensin II activates two cation conductances with distinct TRPC1 and TRPC6 channel properties in rabbit mesenteric artery myocytes.

Journal: The Journal of physiology 20061201

Title: Chelerythrine and sanguinarine dock at distinct sites on BclXL that are not the classic BH3 binding cleft.

Journal: Journal of molecular biology 20061201

Title: Positive inotropic effects of carbon monoxide-releasing molecules (CO-RMs) in the isolated perfused rat heart.

Journal: British journal of pharmacology 20061201

Title: Nucleotide regulation of the voltage-dependent nonselective cation conductance in murine colonic myocytes.

Journal: American journal of physiology. Cell physiology 20061101

Title: Characterization of beta-hexosaminidase secretion in rabbit lacrimal gland.

Journal: Experimental eye research 20061101

Title: The effect of chelerythrine on cell growth, apoptosis, and cell cycle in human normal and cancer cells in comparison with sanguinarine.

Journal: Cell biology and toxicology 20061101

Title: Bone marrow cells have a potent anti-ischemic effect against myocardial cell death in humans.

Journal: The Journal of thoracic and cardiovascular surgery 20061101

Title: Preconditioning by 17beta-estradiol in isolated rat heart depends on PI3-K/PKB pathway, PKC, and ROS.

Journal: American journal of physiology. Heart and circulatory physiology 20061001

Title: Signal transduction pathways involved in non-genomic action of estrone on vascular tissue.

Journal: Steroids 20061001

Title: FRET analysis reveals a critical conformational change within the Na,K-ATPase alpha1 subunit N-terminus during GPCR-dependent endocytosis.

Journal: FEBS letters 20060918

Title: Effects of hyposmotic stress on exocytosis in isolated turbot, Scophthalmus maximus, hepatocytes.

Journal: Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology 20060901

Title: Calcium channel and glutamate receptor activities regulate actin organization in salamander retinal neurons.

Journal: The Journal of physiology 20060901

Title: Quaternary benzo[c]phenathridine alkaloids sanguinarine and chelerythrine do not affect transcriptional activity of aryl hydrocarbon receptor: analyses in rat hepatoma cell line H4IIE.luc.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20060901

Title: Is protein kinase C (PKC) involved in nociception?

Journal: The International journal of neuroscience 20060901

Title: DNA-binding affinities and sequence selectivity of quaternary benzophenanthridine alkaloids sanguinarine, chelerythrine, and nitidine.

Journal: Bioorganic & medicinal chemistry 20060815

Title: Phosphorylation at the hydrophobic site of protein kinase C Apl II is increased during intermediate term facilitation.

Journal: Neuroscience 20060811

Title: Modulation of cardiac sarcoplasmic reticulum calcium release by aenosine: a protein kinase C- dependent pathway.

Journal: Molecular and cellular biochemistry 20060801

Title: Signalling pathways involved in hypertonicity- and acidification-induced activation of Na+/H+ exchange in trout hepatocytes.

Journal: The Journal of experimental biology 20060801

Title: [Protective effect of protein kinase C and mitogen-activated protein kinases and its mechanism in liver ischemic preconditioning].

Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20060801

Title: Elevated endothelin-1 levels impair nitric oxide homeostasis through a PKC-dependent pathway.

Journal: Circulation 20060704

Title: Relaxin family peptide receptors RXFP1 and RXFP2 modulate cAMP signaling by distinct mechanisms.

Journal: Molecular pharmacology 20060701

Title: Novel alpha1-adrenergic receptor signaling pathways: secreted factors and interactions with the extracellular matrix.

Journal: Molecular pharmacology 20060701

Title: Rho-kinase contributes to hypoxia/reoxygenation-induced cerebral endothelial dysfunction.

Journal: Journal of cardiovascular pharmacology 20060701

Title: Effects of sanguinarine and chelerythrine on the cell cycle and apoptosis.

Journal: Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia 20060701

Title: Protein kinase C zeta mediates epidermal growth factor-induced growth of head and neck tumor cells by regulating mitogen-activated protein kinase.

Journal: Cancer research 20060615

Title: Apoptotic response of uveal melanoma cells upon treatment with chelidonine, sanguinarine and chelerythrine.

Journal: Cancer letters 20060608

Title: Recent advances in targeting regulators of apoptosis in cancer cells for therapeutic gain.

Journal: Expert opinion on investigational drugs 20060601

Title: [Experimental study of the inhibitory effects of Chelidonium majus L. extractive on Streptococcus mutans in vitro].

Journal: Shanghai kou qiang yi xue = Shanghai journal of stomatology 20060601

Title: Activation of protein kinase C enhances 1-methyl-4-phenylpyridinium ion (MPP+)-induced hydroxylradical generation in rat striatum.

Journal: Neuroscience letters 20060501

Title: PI3K is required for insulin-stimulated but not EGF-stimulated ERK1/2 activation.

Journal: European journal of cell biology 20060501

Title: Infarct-sparing effect of myocardial postconditioning is dependent on protein kinase C signalling.

Journal: Cardiovascular research 20060501

Title: Postconditioning protects rabbit hearts through a protein kinase C-adenosine A2b receptor cascade.

Journal: Cardiovascular research 20060501

Title: Involvement of protein kinase C in 5-HT-evoked thermal hyperalgesia and spinal fos protein expression in the rat.

Journal: Pharmacology, biochemistry, and behavior 20060501

Title: The mitochondrial effects of small organic ligands of BCL-2: sensitization of BCL-2-overexpressing cells to apoptosis by a pyrimidine-2,4,6-trione derivative.

Journal: The Journal of biological chemistry 20060414

Title: Geranylgeranylacetone, a noninvasive heat shock protein inducer, induces protein kinase C and leads to neuroprotection against cerebral infarction in rats.

Journal: Neuroscience letters 20060403

Title: Role of protein kinase C in the effect of ATP on contractile function of the isolated strip from mouse diaphragm.

Journal: Bulletin of experimental biology and medicine 20060401

Title: The beneficial in vitro effects of lovastatin and chelerythrine on relaxatory response to acetylcholine in the perfused mesentric bed isolated from diabetic rats.

Journal: European journal of pharmacology 20060327

Title: Protein kinase C inhibitor chelerythrine attenuates the morphine-induced excitatory amino acid release and reduction of the antinociceptive effect of morphine in rats injected intrathecally with pertussis toxin.

Journal: Life sciences 20060313

Title: Angiotensin II acutely decreases myocardial stiffness: a novel AT1, PKC and Na+/H+ exchanger-mediated effect.

Journal: British journal of pharmacology 20060301

Title: Salviae miltiorrhizae radix increases dopamine release of rat and pheochromocytoma PC12 cells.

Journal: Phytotherapy research : PTR 20060301

Title: Effects of intravenous anesthetics on the activity of glutamate transporter EAAT3 expressed in Xenopus oocytes: evidence for protein kinase C involvement.

Journal: European journal of pharmacology 20060215

Title: Investigation of sanguinarine and chelerythrine effects on CYP1A1 expression and activity in human hepatoma cells.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20060201

Title: Reduction of infarct size with D-myo-inositol trisphosphate: role of PI3-kinase and mitochondrial K(ATP) channels.

Journal: American journal of physiology. Heart and circulatory physiology 20060201

Title: Protective effect of chelerythrine on gentamicin-induced nephrotoxicity.

Journal: Cell biochemistry and function 20060101

Title: Impact of inhibition of Qo site of mitochondrial complex III with myxothiazol on persistent sodium currents via superoxide and protein kinase C in rat hippocampal CA1 cells.

Journal: Neurobiology of disease 20060101

Title: Palmitate induces tumor necrosis factor-alpha expression in C2C12 skeletal muscle cells by a mechanism involving protein kinase C and nuclear factor-kappaB activation.

Journal: Endocrinology 20060101

Title: Regulation of cardiac inwardly rectifying potassium current IK1 and Kir2.x channels by endothelin-1.

Journal: Journal of molecular medicine (Berlin, Germany) 20060101

Title: Inhibition of experimental proliferative vitreoretinopathy with protein kinase C inhibitor (chelerythrine chloride) and melatonin.

Journal: Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde 20060101

Title: Human metallothionein gene expression is upregulated by beta-thujaplicin: possible involvement of protein kinase C and reactive oxygen species.

Journal: Biological & pharmaceutical bulletin 20060101

Title: Lysophosphatidylcholine augments Ca(v)3.2 but not Ca(v)3.1 T-type Ca(2+) channel current expressed in HEK-293 cells.

Journal: Pharmacology 20060101

Title: Analysis of secondary metabolites from eschscholtzia californica by high-performance liquid chromatography.

Journal: Phytochemical analysis : PCA 20060101

Title: Role of oxidative/nitrosative stress in the tolerance to ischemia/reperfusion injury in cardiomyopathic hamster heart.

Journal: Antioxidants & redox signaling 20060101

Title: Rapid determination of protopine, allocryptopine, sanguinarine and chelerythrine in fruits of Macleaya cordata by microwave-assisted solvent extraction and HPLC-ESI/MS.

Journal: Phytochemical analysis : PCA 20060101

Title: Site-specific binding of chelerythrine to single cytosine and thymine bulges in DNA hairpins.

Journal: Nucleic acids symposium series (2004) 20060101

Title: Gender differences in cardioprotection against ischemia/reperfusion injury in adult rat hearts: focus on Akt and protein kinase C signaling.

Journal: The Journal of pharmacology and experimental therapeutics 20051201

Title: Aldosterone and tight junctions: modulation of claudin-4 phosphorylation in renal collecting duct cells.

Journal: American journal of physiology. Cell physiology 20051201

Title: Pivotal role of NOX-2-containing NADPH oxidase in early ischemic preconditioning.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20051201

Title: Relative contribution of Rho kinase and protein kinase C to myogenic tone in rat cerebral arteries in hypertension.

Journal: American journal of physiology. Heart and circulatory physiology 20051101

Title: Activation of PKC modulates blood-brain barrier endothelial cell permeability changes induced by hypoxia and posthypoxic reoxygenation.

Journal: American journal of physiology. Heart and circulatory physiology 20051101

Title: Hepatic injury in rats with obstructive jaundice: roles of the protein kinase C signal pathway and cytoprotection of fructose.

Journal: Hepatobiliary & pancreatic diseases international : HBPD INT 20051101

Title: Effects of chronic exposure to ethanol on glutamate transporter EAAT3 expressed in Xenopus oocytes: evidence for protein kinase C involvement.

Journal: Alcoholism, clinical and experimental research 20051101

Title: Subcellular localization of iron regulatory proteins to Golgi and ER membranes.

Journal: Journal of cell science 20051001

Title: Divergent regulation of Pyk2/CAKbeta phosphorylation by Ca2+ and cAMP in the hippocampus.

Journal: Biochimica et biophysica acta 20050930

Title: Role of the protein kinase C-epsilon-Raf-1-MEK-1/2-p44/42 MAPK signaling cascade in the activation of signal transducers and activators of transcription 1 and 3 and induction of cyclooxygenase-2 after ischemic preconditioning.

Journal: Circulation 20050927

Title: Effects of the limited analyte solubility on its mobility and zone shape: electrophoretic behavior of sanguinarine and chelerythrine around pH 7.

Journal: Electrophoresis 20050901

Title: Pharmacological preconditioning with bradykinin affords myocardial protection through NO-dependent mechanisms.

Journal: International heart journal 20050901

Title: Mechanisms of erythropoietin-mediated cardioprotection during ischemia-reperfusion injury: role of protein kinase C and phosphatidylinositol 3-kinase signaling.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20050801

Title: Modulation of tumor necrosis factor-alpha and oxidative stress through protein kinase C and P42/44 mitogen-activated protein kinase in lead increases lipopolysaccharide-induced liver damage in rats.

Journal: Shock (Augusta, Ga.) 20050801

Title: Highly stable phenanthridinium frameworks as a new class of tunable DNA binding agents with cytotoxic properties.

Journal: Journal of medicinal chemistry 20050714

Title: NAD(P)H-dependent superoxide production in platelets: the role of angiotensin II and protein kinase C.

Journal: Clinical biochemistry 20050701

Title: AMPA receptor stimulation increases alpha5beta1 integrin surface expression, adhesive function and signaling.

Journal: Journal of neurochemistry 20050701

Title: Mechanisms of the protective effects of urocortin on coronary endothelial function during ischemia-reperfusion in rat isolated hearts.

Journal: British journal of pharmacology 20050601

Title: Annexin-1 peptide Anx-1(2-26) protects adult rat cardiac myocytes from cellular injury induced by simulated ischaemia.

Journal: British journal of pharmacology 20050601

Title: Cardioprotective effects of Ilex paraguariensis extract: evidence for a nitric oxide-dependent mechanism.

Journal: Clinical nutrition (Edinburgh, Scotland) 20050601

Title: The interaction of isoflurane and protein kinase C-activators on sarcolemmal KATP channels.

Journal: Anesthesia and analgesia 20050601

Title: Study of the inhibition of alpha-amylase by the benzo[c]phenanthridine alkaloids sanguinarine and chelerythrine.

Journal: Journal of enzyme inhibition and medicinal chemistry 20050601

Title: Protein kinase C is selectively involved in the mechanisms of long-term synaptic plasticity.

Journal: Bulletin of experimental biology and medicine 20050601

Title: Platelet-activating factor induces cardioprotection in isolated rat heart akin to ischemic preconditioning: role of phosphoinositide 3-kinase and protein kinase C activation.

Journal: American journal of physiology. Heart and circulatory physiology 20050501

Title: Remifentanil mimics cardioprotective effect of ischemic preconditioning via protein kinase C activation in open chest of rats.

Journal: Acta pharmacologica Sinica 20050501

Title: In vitro assessment of cytotoxic agent combinations for hormone-refractory prostate cancer treatment.

Journal: Anti-cancer drugs 20050401

Title: Antecedent ethanol ingestion prevents postischemic leukocyte adhesion and P-selectin expression by a protein kinase C-dependent mechanism.

Journal: Digestive diseases and sciences 20050401

Title: Induction of human leukemia HL-60 cell differentiation via a PKC/ERK pathway by helenalin, a pseudoguainolide sesquiterpene lactone.

Journal: European journal of pharmacology 20050328

Title: Staurosporine inhibits voltage-dependent K+ current through a PKC-independent mechanism in isolated coronary arterial smooth muscle cells.

Journal: Journal of cardiovascular pharmacology 20050301

Title: Global kinase screening. Applications of frontal affinity chromatography coupled to mass spectrometry in drug discovery.

Journal: Analytical chemistry 20050301

Title: Hypotonic shock mediation by p38 MAPK, JNK, PKC, FAK, OSR1 and SPAK in osmosensing chloride secreting cells of killifish opercular epithelium.

Journal: The Journal of experimental biology 20050301

Title: Protein kinase C zeta is required for epidermal growth factor-induced chemotaxis of human breast cancer cells.

Journal: Cancer research 20050215

Title: Signal transduction of the prophenoloxidase activating system of prawn haemocytes triggered by CpG oligodeoxynucleotides.

Journal: Fish & shellfish immunology 20050201

Title: Protein kinase C delta is not activated by caspase-3 and its inhibition is sufficient to induce apoptosis in the colon cancer line, COLO 205.

Journal: Cellular signalling 20050201

Title: alpha1A- but not alpha1B-adrenergic receptors precondition the ischemic heart by a staurosporine-sensitive, chelerythrine-insensitive mechanism.

Journal: Cardiovascular research 20050201

Title: Synergistic stimulatory effect of 12-O-tetradecanoylphorbol-13-acetate and capsaicin on macrophage differentiation in HL-60 and HL-525 human myeloid leukemia cells.

Journal: International journal of oncology 20050201

Title: Insulin-induced phosphorylation of ENaC correlates with increased sodium channel function in A6 cells.

Journal: American journal of physiology. Cell physiology 20050101

Title: An oxidative stress mechanism mediates chelerythrine-induced heparin-binding EGF-like growth factor ectodomain shedding.

Journal: Journal of cellular biochemistry 20050101

Title: Deferoxamine induces prolonged cardiac preconditioning via accumulation of oxygen radicals.

Journal: Free radical biology & medicine 20050101

Title: Synthesis of oxychelerythrine using lithiated toluamide-benzonitrile cycloaddition.

Journal: Chemical & pharmaceutical bulletin 20050101

Title: Protective effects of insulin during ischemia-reperfusion injury in hamster cheek pouch microcirculation.

Journal: Journal of vascular research 20050101

Title: Secretion of ATP from Schwann cells in response to uridine triphosphate.

Journal: The European journal of neuroscience 20050101

Title: Effect of pravastatin on impaired endothelium-dependent relaxation induced by lysophosphatidylcholine in rat aorta.

Journal: Acta pharmacologica Sinica 20050101

Title: Diazoxide ameliorates microcirculatory disturbances through PKC-dependent pathway in I/R-injured rat cremaster muscles.

Journal: Journal of biomedical science 20050101

Title: Roles of protein kinase C and fructose in hepatic injury caused by obstructive jaundice.

Journal: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20050101

Title: Metabolic arrest and its regulation in anoxic eel hepatocytes.

Journal: Physiological and biochemical zoology : PBZ 20050101

Title: Effects of angiotensin II on the pericyte-containing microvasculature of the rat retina.

Journal: The Journal of physiology 20041215

Title: Hypoxic pulmonary vasoconstriction and pulmonary artery tissue cytokine expression are mediated by protein kinase C.

Journal: American journal of physiology. Lung cellular and molecular physiology 20041201

Title: Dual concentration-dependent effects of phorbol 12, 13-dibutyrate on spontaneous and acetylcholine-induced electrical responses recorded from isolated circular smooth muscle of the guinea-pig stomach antrum.

Journal: Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 20041201

Title: Silent information regulator 2alpha, a longevity factor and class III histone deacetylase, is an essential endogenous apoptosis inhibitor in cardiac myocytes.

Journal: Circulation research 20041112

Title: Bmx, a member of the Tec family of nonreceptor tyrosine kinases, is a novel participant in pharmacological cardioprotection.

Journal: American journal of physiology. Heart and circulatory physiology 20041101

Title: Spontaneous activity and its cholinergic modulation in circular smooth muscle isolated from guinea-pig stomach antrum.

Journal: Pflugers Archiv : European journal of physiology 20041101

Title: Extracellular signal-regulated kinase (ERK) in glucose-induced and endothelin-mediated fibronectin synthesis.

Journal: Laboratory investigation; a journal of technical methods and pathology 20041101

Title: Protein kinase C inhibitors produce mitochondrial flavoprotein oxidation in cardiac myocytes.

Journal: Anesthesia and analgesia 20041101

Title: 17beta-estradiol reduces the effect of metabolic inhibition on gap junction intercellular communication in rat cardiomyocytes via the estrogen receptor.

Journal: Journal of molecular and cellular cardiology 20041101

Title: Chronic exercise improves myocardial inotropic reserve capacity through alpha1-adrenergic and protein kinase C-dependent effects in Senescent rats.

Journal: The journals of gerontology. Series A, Biological sciences and medical sciences 20041101

Title: Down-regulation of connexin43 in early myocardial ischemia and protective effect by ischemic preconditioning in rat hearts in vivo.

Journal: Japanese heart journal 20041101

Title: Endothelin-1 enhances the activity of Na+/Ca2+ exchanger type 1 in renal epithelial cells.

Journal: Journal of cardiovascular pharmacology 20041101

Title: Differential interplay between protein kinase C and Rho-kinase in the endothelin-1-induced and pressure-induced contractions of rat posterior cerebral artery.

Journal: Journal of cardiovascular pharmacology 20041101

Title: Protein kinase C overactivity impairs prefrontal cortical regulation of working memory.

Journal: Science (New York, N.Y.) 20041029

Title: Gene therapy of endothelial nitric oxide synthase and manganese superoxide dismutase restores delayed wound healing in type 1 diabetic mice.

Journal: Circulation 20041019

Title: Intermittent hypoxia protects the rat heart against ischemia/reperfusion injury by activating protein kinase C.

Journal: Life sciences 20041008

Title: Aggregation and other intermolecular interactions of biological buffers observed by capillary electrophoresis and UV photometry.

Journal: Journal of chromatography. A 20041008

Title: Reversible connexin 43 dephosphorylation during hypoxia and reoxygenation is linked to cellular ATP levels.

Journal: Circulation research 20041001

Title: Activation of protein kinase C contributes to the isoflurane-induced improvement of functional and metabolic recovery in isolated ischemic rat hearts.

Journal: Anesthesia and analgesia 20041001

Title: Arg-vasopressin increases proliferation of human osteoblast-like cells and decreases production of interleukin-6 and macrophage colony-stimulating factor.

Journal: Regulatory peptides 20040915

Title: Regulation of tumor necrosis factor-alpha in glioma cells by lead and lipopolysaccharide: involvement of common signaling pathway.

Journal: Toxicology letters 20040910

Title: Effect of protein kinase C blockade on phosphorylation of NR1 in dorsal horn and spinothalamic tract cells caused by intradermal capsaicin injection in rats.

Journal: Brain research 20040910

Title: Systemic regulation of vascular NAD(P)H oxidase activity and nox isoform expression in human arteries and veins.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20040901

Title: Investigation of signaling pathways that mediate the inotropic effect of urotensin-II in human heart.

Journal: Cardiovascular research 20040901

Title: Role of protein kinase C in the excitatory action of cholinergic nerve stimulation on spontaneous activity of circular smooth muscle isolated from the guinea-pig stomach antrum.

Journal: Pflugers Archiv : European journal of physiology 20040901

Title: Effects of alpha1-adrenergic stimulation on normal and hypertrophied mouse hearts. Relation to caveolin-3 expression.

Journal: Cardiovascular research 20040815

Title: Role of PKCalpha and PKCiota in phenylephrine-induced contraction of rat corpora cavernosa.

Journal: International journal of impotence research 20040801

Title: Substance P induces inward current and regulates pacemaker currents through tachykinin NK1 receptor in cultured interstitial cells of Cajal of murine small intestine.

Journal: European journal of pharmacology 20040708

Title: Chelerythrine and other benzophenanthridine alkaloids block the human P2X7 receptor.

Journal: British journal of pharmacology 20040701

Title: Chronic high pressure-induced arterial oxidative stress: involvement of protein kinase C-dependent NAD(P)H oxidase and local renin-angiotensin system.

Journal: The American journal of pathology 20040701

Title: IgA immune complex blunts the contraction of cultured mesangial cells through the inhibition of protein kinase C and intracellular calcium.

Journal: The Chinese journal of physiology 20040630

Title: Endothelial dysfunction in aortic rings and mesenteric beds isolated from deoxycorticosterone acetate hypertensive rats: possible involvement of protein kinase C.

Journal: European journal of pharmacology 20040628

Title: Capillary electrophoretic studies of acid-base properties of sanguinarine and chelerythrine alkaloids.

Journal: Journal of chromatography. A 20040618

Title: Experimental evidence for the limiting role of enzymatic reactions in chemoattractant-induced pseudopod extension in human neutrophils.

Journal: The Journal of biological chemistry 20040604

Title: Transient glucose deprivation causes upregulation of heme oxygenase-1 and cyclooxygenase-2 expression in cardiac fibroblasts.

Journal: Journal of molecular and cellular cardiology 20040601

Title: Mechanisms involved in carbachol-induced Ca(2+) sensitization of contractile elements in rat proximal and distal colon.

Journal: British journal of pharmacology 20040601

Title: Cytoskeletal restraints regulate homotypic ALCAM-mediated adhesion through PKCalpha independently of Rho-like GTPases.

Journal: Journal of cell science 20040601

Title: Regulation of proangiogenic factor CCN1 in cardiac muscle: impact of ischemia, pressure overload, and neurohumoral activation.

Journal: Circulation 20040511

Title: Involvement of protein kinase C-related anti-apoptosis signaling in radiation-induced apoptosis in murine thymic lymphoma(3SBH5) cells.

Journal: Radiation research 20040501

Title: Rapid change of glucose concentration promotes mesangial cell proliferation via VEGF: inhibitory effects of thiazolidinedione.

Journal: Biochemical and biophysical research communications 20040423

Title: Epidermal growth factor induces fibroblast contractility and motility via a protein kinase C delta-dependent pathway.

Journal: The Journal of biological chemistry 20040409

Title: Protein kinase C plays an essential role in sildenafil-induced cardioprotection in rabbits.

Journal: American journal of physiology. Heart and circulatory physiology 20040401

Title: Hypoxia selection of death-resistant cells. A role for Bcl-X(L).

Journal: The Journal of biological chemistry 20040305

Title: Exocytosis of a complement component C3-like protein by tunicate hemocytes.

Journal: Developmental and comparative immunology 20040301

Title: Opioid-mediated modulation of calcium currents in striatal and pallidal neurons following reserpine treatment: focus on kappa response.

Journal: Synapse (New York, N.Y.) 20040301

Title: Delayed preconditioning of the human myocardium: signal transduction and clinical implications.

Journal: Cardiovascular research 20040215

Title: Hypoxia increases calcium flux through cortical neuron glutamate receptors via protein kinase C.

Journal: Journal of neurochemistry 20040201

Title: Troglitazone acts by PPARgamma and PPARgamma-independent pathways on LLC-PK1-F+ acid-base metabolism.

Journal: American journal of physiology. Renal physiology 20040101

Title: Sanguinarine and chelerythrine: assessment of safety on pigs in ninety days feeding experiment.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20040101

Title: CD3 receptor modulation in Jurkat leukemic cell line.

Journal: Folia histochemica et cytobiologica 20040101

Title: Chelerythrine stimulates GSH transport by rat Mrp2 (Abcc2) expressed in canine kidney cells.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20031201

Title: Mechanisms of myocardial ischemic preconditioning are age related: PKC-epsilon does not play a requisite role in old rabbits.

Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20031201

Title: Nicotinic receptor-mediated regulation of the dopamine transporter in rat prefrontocortical slices following chronic in vivo administration of nicotine.

Journal: Schizophrenia research 20031201

Title: Influence of alpha2-autoreceptor stimulation on the facilitation by angiotensin II and bradykinin of noradrenaline release.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20031201

Title: Insulin-induced improvement of postischemic recovery is abolished by inhibition of protein kinase C in rat heart.

Journal: The Journal of thoracic and cardiovascular surgery 20031201

Title: Converting enzyme inhibitor temocaprilat prevents high glucose-mediated suppression of human aortic endothelial cell proliferation.

Journal: Journal of cardiovascular pharmacology 20031201

Title: Isoform-selectivity of PKC inhibitors acting at the regulatory and catalytic domain of mammalian PKC-alpha, -betaI, -delta, -eta and -zeta.

Journal: Journal of enzyme inhibition and medicinal chemistry 20031201

Title: Electrophoretic investigation of interactions of sanguinarine and chelerythrine with molecules containing mercapto group.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20031125

Title: The effects of protein kinase C activity on synaptic transmission in two areas of rat hippocampus.

Journal: Brain research 20031114

Title: Constitutive cytoplasmic localization of p21(Waf1/Cip1) affects the apoptotic process in monocytic leukaemia.

Journal: Leukemia 20031101

Title: Immunocytochemical detection of GLUT2 at the rat intestinal brush-border membrane.

Journal: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 20031101

Title: Cellular redistribution of inducible Hsp70 protein in the human and rabbit heart in response to the stress of chronic hypoxia: role of protein kinases,

Journal: The Journal of biological chemistry 20031031

Title: Signaling via histamine receptors in cat duodenal smooth muscle cells.

Journal: Molecules and cells 20031031

Title: Involvement of protein kinase C in the adaptive changes of cholinergic neurons to sympathetic denervation in the guinea pig myenteric plexus.

Journal: Life sciences 20031003

Title: Endothelin-1 limits vascular smooth muscle beta-adrenergic receptor sensitivity by a PKC-dependent pathway.

Journal: Journal of cardiovascular pharmacology 20031001

Title: HL-1 myocytes exhibit PKC and K(ATP) channel-dependent delta opioid preconditioning.

Journal: The Journal of surgical research 20031001

Title: Protein kinase C inhibition induces DNA fragmentation in COLO 205 cells which is blocked by cysteine protease inhibition but not mediated through caspase-3.

Journal: Experimental cell research 20030910

Title: Kinase-dependent loss of Na+ channel slow-inactivation in rat CA1 hippocampal pyramidal cell dendrites after brief exposure to convulsants.

Journal: The European journal of neuroscience 20030901

Title: Signaling pathway for aloe-emodin-induced apoptosis in human H460 lung nonsmall carcinoma cell.

Journal: International journal of cancer 20030810

Title: Protein kinase C modifications of VE-cadherin, p120, and beta-catenin contribute to endothelial barrier dysregulation induced by thrombin.

Journal: American journal of physiology. Lung cellular and molecular physiology 20030801

Title: Chelerythrin activates caspase-8, downregulates FLIP long and short, and overcomes resistance to tumour necrosis factor-related apoptosis-inducing ligand in KG1a cells.

Journal: British journal of haematology 20030801

Title: Human beta(3)-adrenoreceptors couple to KvLQT1/MinK potassium channels in Xenopus oocytes via protein kinase C phosphorylation of the KvLQT1 protein.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20030801

Title: Diverse regulation of atrial natriuretic peptide secretion by serotonin receptor subtypes.

Journal: Cardiovascular research 20030801

Title: Inhibition of alpha, betaI, delta, eta, and zeta protein kinase C isoforms by xanthonolignoids.

Journal: Journal of enzyme inhibition and medicinal chemistry 20030801

Title: Co-stimulation of mGluR5 and N-methyl-D-aspartate receptors is required for potentiation of excitatory synaptic transmission in hippocampal neurons.

Journal: The Journal of biological chemistry 20030725

Title: Alpha-2 adrenoceptor mediating the facilitatory effect of norepinephrine on the glycine response in the spinal dorsal horn neuron of the rat.

Journal: Life sciences 20030704

Title: Protein kinase C-delta mediates adenosine A3 receptor-induced delayed cardioprotection in mouse.

Journal: American journal of physiology. Heart and circulatory physiology 20030701

Title: Role of protein kinase C in geranylgeranylacetone-induced expression of heat-shock protein 72 and cardioprotection in the rat heart.

Journal: Journal of molecular and cellular cardiology 20030701

Title: Various inotropic effects of angiotensin II in post-ischaemic rat hearts depending on ischaemic time with possible involvement of protein kinase C.

Journal: Acta physiologica Scandinavica 20030701

Title: Inhibition of taurine transport by high concentration of glucose in cultured rat cardiomyocytes.

Journal: Metabolism: clinical and experimental 20030701

Title: A double-lumen intrathecal catheter for studies of modulation of spinal opiate tolerance.

Journal: Journal of neuroscience methods 20030630

Title: Ischaemic tolerance in aged mouse myocardium: the role of adenosine and effects of A1 adenosine receptor overexpression.

Journal: The Journal of physiology 20030615

Title: Identification of chelerythrine as an inhibitor of BclXL function.

Journal: The Journal of biological chemistry 20030606

Title: Differential regulation of early growth response gene-1 expression by insulin and glucose in vascular endothelial cells.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20030601

Title: Adenosine-mediated early preconditioning in mouse: protective signaling and concentration dependent effects.

Journal: Cardiovascular research 20030601

Title: Preischemic infusion of alpha-human atrial natriuretic peptide elicits myoprotective effects against ischemia reperfusion in isolated rat hearts.

Journal: Molecular and cellular biochemistry 20030601

Title: Differential activation of protein kinase C between ischemic and pharmacological preconditioning in the rabbit heart.

Journal: The Japanese journal of physiology 20030601

Title: PKC is required for activation of ROCK by RhoA in human endothelial cells.

Journal: Biochemical and biophysical research communications 20030516

Title: Properties of a constitutively active Ca2+-permeable non-selective cation channel in rabbit ear artery myocytes.

Journal: The Journal of physiology 20030515

Title: Activation of Mst1 causes dilated cardiomyopathy by stimulating apoptosis without compensatory ventricular myocyte hypertrophy.

Journal: The Journal of clinical investigation 20030515

Title: Reactive oxygen species are involved in smoking-induced dysfunction of nitric oxide biosynthesis and upregulation of endothelial nitric oxide synthase: an in vitro demonstration in human coronary artery endothelial cells.

Journal: Circulation 20030513

Title: Protein kinase C activation generates superoxide and contributes to impairment of cerebrovasodilation induced by G protein activation after brain injury.

Journal: Brain research 20030509

Title: Norepinephrine evoked by potassium depolarization increases interstitial adenosine concentration via activation of ecto-5'-nucleotidase in rat hearts.

Journal: The Journal of pharmacology and experimental therapeutics 20030501

Title: Modulation of protein kinase C (PKC)-mediated contraction and the possible role of PKC epsilon in rat mesenteric arteries.

Journal: Frontiers in bioscience : a journal and virtual library 20030501

Title: Tyrosine kinase is involved in hemin-induced pyresis.

Journal: Archives of pharmacal research 20030501

Title: Chelerythrine and bisindolylmaleimide I prolong cardiac action potentials by protein kinase C-independent mechanism.

Journal: European journal of pharmacology 20030411

Title: Inhibition of protein kinase C by synthetic xanthone derivatives.

Journal: Bioorganic & medicinal chemistry 20030403

Title: Dopaminergic inhibition of secretin-stimulated choleresis by increased PKC-gamma expression and decrease of PKA activity.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20030401

Title: Phosphorylation of protein kinase C sites in NBD1 and the R domain control CFTR channel activation by PKA.

Journal: The Journal of physiology 20030401

Title: Control of head morphogenesis in an invertebrate asexually produced larva-like bud ( Cassiopea andromeda; Cnidaria: Scyphozoa).

Journal: Development genes and evolution 20030401

Title: The induction of heat shock protein-72 attenuates cisplatin-induced acute renal failure in rats.

Journal: Pflugers Archiv : European journal of physiology 20030401

Title: Vasospasm following subarachnoid hemorrhage: evidence against functional upregulation of protein kinase C constrictor pathway.

Journal: Neurological research 20030401

Title: Effect of protein kinase C activation and inhibition on rat hepatic stellate cell activation.

Journal: Digestive diseases and sciences 20030401

Title: Lipoxin A4 stimulates a cytosolic Ca2+ increase in human bronchial epithelium.

Journal: The Journal of biological chemistry 20030328

Title: Vitamin E deficiency reduces surfactant lipid biosynthesis in alveolar type II cells.

Journal: Free radical biology & medicine 20030315

Title: Effects of a phorbol ester and cyclosporin A on hippocampal synaptic plasticity in streptozotocin-induced-diabetic rats: reduced sensitivity to phorbol esters.

Journal: Neuroscience letters 20030313

Title: [Effects of chelerythrine on cell proliferation and p27 expression of cardiac fibroblasts modulated by arginine vasopressin].

Journal: Zhonghua yi xue za zhi 20030310

Title: D-2-amino-5-phosphonopentanoic acid inhibits intrathecal pertussis toxin-induced thermal hyperalgesia and protein kinase Cgamma up-regulation.

Journal: Brain research 20030214

Title: The effect of chelerythrine on depolarization-induced force responses in skinned fast skeletal muscle fibres of the rat.

Journal: British journal of pharmacology 20030201

Title: Potentiation of glycine responses by dideoxyforskolin and tamoxifen in rat spinal neurons.

Journal: The European journal of neuroscience 20030201

Title: PMA decreases the proliferation of retinal cells in vitro: the involvement of acetylcholine and BDNF.

Journal: Neurochemistry international 20030101

Title: Natriuretic peptides suppress protein kinase C activity to reduce evoked dopamine efflux from pheochromocytoma (PC12) cells.

Journal: Endocrinology 20030101

Title: Role of protein kinase C in central muscarinic inhibitory mechanisms regulating voiding in rats.

Journal: Neuroscience 20030101

Title: A calcium/calmodulin kinase pathway connects brain-derived neurotrophic factor to the cyclic AMP-responsive transcription factor in the rat hippocampus.

Journal: Neuroscience 20030101

Title: Protein kinase C is involved in clozapine's facilitation of N-methyl-D-aspartate- and electrically evoked responses in pyramidal cells of the medial prefrontal cortex.

Journal: Neuroscience 20030101

Title: Adenosine suppresses the response of neurons to gaba in the superficial laminae of the rat spinal dorsal horn.

Journal: Neuroscience 20030101

Title: Quaternary benzo[c]phenanthridine alkaloids as inhibitors of dipeptidyl peptidase IV-like activity baring enzymes in human blood plasma and glioma cell lines.

Journal: Physiological research 20030101

Title: Attenuation of canine cerebral vasospasm after subarachnoid hemorrhage by protein kinase C inhibitors despite augmented phosphorylation of myosin light chain.

Journal: Journal of vascular research 20030101

Title: Pituitary adenylate cyclase-activating polypeptide (PACAP)-evoked increase in cyclic AMP production in chick cerebral cortex: lack of a role of the protein kinase C pathway.

Journal: Polish journal of pharmacology 20030101

Title: Modulation of CD40L antigen expression in Jurkat cells: involvement of protein kinase C activity.

Journal: Folia histochemica et cytobiologica 20030101

Title: [Effect of inhibiting protein kinase C on calcium sensitivity of contractile apparatus of vascular smooth muscle during vasospasms of different origins].

Journal: Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) 20030101

Title: Differential regulation by Ca(2+) of calmodulin- and PKC-dependent contractile pathways in cat lower oesophageal sphincter.

Journal: Autonomic & autacoid pharmacology 20030101

Title: The intracellular pathway of the acetylcholine-induced contraction in cat detrusor muscle cells.

Journal: British journal of pharmacology 20021201

Title: Differential mechanisms of morphine antinociceptive tolerance revealed in (beta)arrestin-2 knock-out mice.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20021201

Title: Involvement of 5-HT7 receptors in serotonergic effects on spike afterpotentials in presumed jaw-closing motoneurons of rats.

Journal: Brain research 20021108

Title: Phorbol ester stimulates a protein kinase C-mediated agatoxin-TK-sensitive calcium permeability pathway in human red blood cells.

Journal: Blood 20021101

Title: Upregulation of myocardial Na+/H+ exchanger induced by chronic treatment with a selective inhibitor.

Journal: Journal of molecular and cellular cardiology 20021101

Title: Neurotensin modulates the amplitude and frequency of voltage-activated Ca2+ currents in frog pituitary melanotrophs: implication of the inositol triphosphate/protein kinase C pathway.

Journal: The European journal of neuroscience 20021101

Title: Modulation of steroid hydroxylase activity in stably transfected V79MZh11B1 and V79MZh11B2 cells by PKC and PKD inhibitors.

Journal: Endocrine research 20021101

Title: Factors contributing to neurotrophin-independent survival of adult sensory neurons.

Journal: Brain research 20021025

Title: Interaction between alpha2-autoreceptors and receptors mediating the effects of angiotensin II and bradykinin in the heart of newborn rats.

Journal: European journal of pharmacology 20021025

Title: Protein kinase C activation induces phosphatidylserine exposure on red blood cells.

Journal: Biochemistry 20021015

Title: Regulation of mdm2 mRNA expression in human breast tumor-derived GI-101A cells.

Journal: Life sciences 20021004

Title: The role of serotonin in ischemic cellular damage and the infarct size-reducing effect of sarpogrelate, a 5-hydroxytryptamine-2 receptor blocker, in rabbit hearts.

Journal: Journal of the American College of Cardiology 20021002

Title: Different signal transduction pathways are involved during human sperm capacitation induced by biological and pharmacological agents.

Journal: Molecular human reproduction 20020901

Title: Regulation of NFkappaB in hepatic ischemic preconditioning.

Journal: Journal of the American College of Surgeons 20020901

Title: Inhibitory activity on binding of specific ligands to the human angiotensin II AT(1) and endothelin 1 ET(A) receptors: bioactive benzo[c]phenanthridine alkaloids from the root of Bocconia frutescens.

Journal: Planta medica 20020901

Title: Activation of glutamate receptors inhibits Na/K-ATPase of cerebellum granule cells.

Journal: Biochemistry. Biokhimiia 20020901

Title: Intestinal ischemia preconditions myocardium: role of protein kinase C and mitochondrial K(ATP) channel.

Journal: Cardiovascular research 20020815

Title: Remote preconditioning protects the heart by activating myocardial PKCepsilon-isoform.

Journal: Cardiovascular research 20020815

Title: Excitation of smooth muscles isolated from the guinea-pig gastric antrum in response to depolarization.

Journal: The Journal of physiology 20020815

Title: DNA adduct formation from quaternary benzo[c]phenanthridine alkaloids sanguinarine and chelerythrine as revealed by the 32P-postlabeling technique.

Journal: Chemico-biological interactions 20020815

Title: Two kinase activities are sufficient for sea urchin sperm chromatin decondensation in vitro.

Journal: Molecular reproduction and development 20020801

Title: Orphanin FQ/nociceptin-mediated desensitization of opioid receptor-like 1 receptor and mu opioid receptors involves protein kinase C: a molecular mechanism for heterologous cross-talk.

Journal: The Journal of pharmacology and experimental therapeutics 20020801

Title: Modulation of volume-sensitive chloride current by noradrenaline in rabbit portal vein myocytes.

Journal: The Journal of physiology 20020715

Title: Moderate alcohol consumption induces sustained cardiac protection by activating PKC-epsilon and Akt.

Journal: American journal of physiology. Heart and circulatory physiology 20020701

Title: ATP-inhibition of M current in frog sympathetic neurons involves phospholipase C but not Ins P(3), Ca(2+), PKC, or Ras.

Journal: Journal of neurophysiology 20020701

Title: Cardioprotection mediated by sphingosine-1-phosphate and ganglioside GM-1 in wild-type and PKC epsilon knockout mouse hearts.

Journal: American journal of physiology. Heart and circulatory physiology 20020601

Title: alpha-Adrenergic response and myofilament activity in mouse hearts lacking PKC phosphorylation sites on cardiac TnI.

Journal: American journal of physiology. Heart and circulatory physiology 20020601

Title: Dopamine-induced inhibition of Na+-K+-ATPase activity requires integrity of actin cytoskeleton in opossum kidney cells.

Journal: Acta physiologica Scandinavica 20020601

Title: Protein kinase C modulators enhance angiotensin II desensitization of guinea pig ileum via maxi-K+ channels.

Journal: European journal of pharmacology 20020503

Title: Inhibition of cAMP accumulation by kappa-receptor activation in isolated iris-ciliary bodies: role of phosphodiesterase and protein kinase C.

Journal: The Journal of pharmacology and experimental therapeutics 20020501

Title: Angiotensin II increases L-type Ca2+ current in gramicidin D-perforated adult rabbit ventricular myocytes: comparison with conventional patch-clamp method.

Journal: Pflugers Archiv : European journal of physiology 20020501

Title: Dual regulation of cardiac Na+-K+ pumps and CFTR Cl- channels by protein kinases A and C.

Journal: Pflugers Archiv : European journal of physiology 20020501

Title: Antagonists of protein kinase C inhibit rat retinal glutamate transport activity in situ.

Journal: Journal of neurochemistry 20020501

Title: Uptake of (3)H-1-methyl-4-phenylpyridinium ((3)H-MPP(+)) by human intestinal Caco-2 cells is regulated by phosphorylation/dephosphorylation mechanisms.

Journal: Biochemical pharmacology 20020415

Title: Preconditioning blocks cardiocyte apoptosis: role of K(ATP) channels and PKC-epsilon.

Journal: American journal of physiology. Heart and circulatory physiology 20020401

Title: Role of protein kinase C in control of ethanol-modulated beta-endorphin release from hypothalamic neurons in primary cultures.

Journal: The Journal of pharmacology and experimental therapeutics 20020401

Title: Protein kinase Mzeta is necessary and sufficient for LTP maintenance.

Journal: Nature neuroscience 20020401

Title: Memory enhancement and formation by atypical PKM activity in Drosophila melanogaster.

Journal: Nature neuroscience 20020401

Title: Voltage independence of vasomotion in isolated irideal arterioles of the rat.

Journal: The Journal of physiology 20020401

Title: Role of protein kinase C-epsilon in the development of kappa-opioid receptor tolerance to U50,488H in rat ventricular myocytes.

Journal: British journal of pharmacology 20020401

Title: Ethanol alters glutamate but not adenosine uptake in rat astrocytes: evidence for protein kinase C involvement.

Journal: Neurochemical research 20020401

Title: Effect of modulators of protein kinase C activity on Ca2+ transport in retinal rod microsomes.

Journal: Biochemistry. Biokhimiia 20020401

Title: Protective effects of protein kinase C during myocardial ischemia require activation of phosphatidyl-inositol specific phospholipase C.

Journal: The Annals of thoracic surgery 20020401

Title: Human urotensin II-induced aorta ring contractions are mediated by protein kinase C, tyrosine kinases and Rho-kinase: inhibition by somatostatin receptor antagonists.

Journal: European journal of pharmacology 20020308

Title: Endothelin-induced changes in the physiology of retinal pericytes.

Journal: Investigative ophthalmology & visual science 20020301

Title: Effects of fasting on corticosterone production by zona fasciculata-reticularis cells in ovariectomized rats.

Journal: Journal of investigative medicine : the official publication of the American Federation for Clinical Research 20020301

Title: Roles of protein kinase C and alpha-tocopherol in regulation of signal transduction for GATA-4 phosphorylation in HL-1 cardiac muscle cells.

Journal: Free radical biology & medicine 20020215

Title: Diverse inhibitors of intracellular signalling act as adenosine receptor antagonists.

Journal: Cellular signalling 20020201

Title: Altered PYK2 phosphorylation by ANG II in hypertensive vascular smooth muscle.

Journal: American journal of physiology. Heart and circulatory physiology 20020201

Title: myo-Inositol 1,4,5-trisphosphate and Ca(2+)/calmodulin-dependent factors mediate transduction of compression-induced signals in bovine articular chondrocytes.

Journal: The Biochemical journal 20020201

Title: Quaternary benzo[c]phenanthridine alkaloids as inhibitors of aminopeptidase N and dipeptidyl peptidase IV.

Journal: Phytotherapy research : PTR 20020201

Title: Antisense RNA-mediated suppression of benzophenanthridine alkaloid biosynthesis in transgenic cell cultures of California poppy.

Journal: Plant physiology 20020201

Title: Modulation of apoptosis by mitochondrial uncouplers: apoptosis-delaying features despite intrinsic cytotoxicity.

Journal: Biochemical pharmacology 20020201

Title: Interaction of chelerythrine with inositol phosphate metabolism.

Journal: Fundamental & clinical pharmacology 20020201

Title: Negative inotropic effects of angiotensin II, endothelin-1 and phenylephrine in indo-1 loaded adult mouse ventricular myocytes.

Journal: Life sciences 20020125

Title: In vivo evidence for a role of protein kinase C in peripheral nociceptive processing.

Journal: British journal of pharmacology 20020101

Title: Signalling pathways involved in the direct effects of IGFBP-5 on breast epithelial cell attachment and survival.

Journal: Journal of cellular biochemistry 20020101

Title: Antitumor activity of protein kinase C inhibitors and cisplatin in human head and neck squamous cell carcinoma lines.

Journal: Anti-cancer drugs 20020101

Title: PKC-delta inhibition does not block preconditioning-induced preservation in mitochondrial ATP synthesis and infarct size reduction in rats.

Journal: Basic research in cardiology 20020101

Title: Roles of the cytoskeleton and of protein phosphorylation events in the osmotic stress response in eel intestinal epithelium.

Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20020101

Title: [A role of protein kinase C in signal reactions in outer segments of the bovine retinal rods].

Journal: Biofizika 20020101

Title: A new phenylpropanoid ester from the bark of Zanthoxylum scandens (Rutaceae).

Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences 20020101

Title: Cytotoxicity of natural compounds in hepatocyte cell culture models. The case of quaternary benzo[c]phenanthridine alkaloids.

Journal: Toxicology letters 20011215

Title: Role of protein kinase C zeta isoform in Fas resistance of immature myeloid KG1a leukemic cells.

Journal: Blood 20011215

Title: Mechanism of alpha-adrenergic regulation of expressed hKv4.3 currents.

Journal: American journal of physiology. Heart and circulatory physiology 20011201

Title: Involvement of calcium, inositol-1,4,5 trisphosphate and diacylglycerol in the prothoracicotropic hormone-stimulated ecdysteroid synthesis and secretion in the prothoracic glands of Bombyx mori.

Journal: Zoological science 20011201

Title: Role of protein kinase C in opioid modulation of glycine-gated Cl(-) current in rat periaqueductal gray neuron.

Journal: European journal of pharmacology 20011116

Title: Adenosine A(2A) and A(2B) receptor activation of erythropoietin production.

Journal: American journal of physiology. Renal physiology 20011101

Title: Mechanisms of the apoptotic and necrotic actions of trimethyltin in cerebellar granule cells.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20011101

Title: Activation of PKC decreases myocardial O2 consumption and increases contractile efficiency in rats.

Journal: American journal of physiology. Heart and circulatory physiology 20011101

Title: Differentiation of bipolar CG-4 line oligodendrocytes is associated with regulation of CREB, MAP kinase and PKC signalling pathways.

Journal: Neuroscience research 20011101

Title: Role of spinal NMDA receptors, protein kinase C and nitric oxide synthase in the hyperalgesia induced by magnesium deficiency in rats.

Journal: British journal of pharmacology 20011101

Title: Acute alcohol-induced protection against infarction in rabbit hearts: differences from and similarities to ischemic preconditioning.

Journal: Journal of molecular and cellular cardiology 20011101

Title: Dual signaling via protein kinase C and phosphatidylinositol 3'-kinase/Akt contributes to bradykinin B2 receptor-induced cardioprotection in guinea pig hearts.

Journal: Journal of molecular and cellular cardiology 20011101

Title: Regulation by endothelin-1 of Na+-Ca2+ exchange current (I(NaCa)) from guinea-pig isolated ventricular myocytes.

Journal: Cell calcium 20011101

Title: Investigation of the inhibitory effects of chelerythrine chloride on the translocation of the protein kinase C betaI, betaII, zeta in human neutrophils.

Journal: Farmaco (Societa chimica italiana : 1989) 20011101

Title: Mechanisms of Ca2+ overload induced by extracellular H2O2 in quiescent isolated rat cardiomyocytes.

Journal: Basic research in cardiology 20011101

Title: Second messengers in platelet aggregation evoked by serotonin and A23187, a calcium ionophore.

Journal: Life sciences 20011026

Title: Stimulatory effect of phenylephrine on the secretion of beta-endorphin from rat adrenal medulla in vitro.

Journal: Autonomic neuroscience : basic & clinical 20011008

Title: Regulation and distribution of MAdCAM-1 in endothelial cells in vitro.

Journal: American journal of physiology. Cell physiology 20011001

Title: Role of Na(+)/H(+) exchanger during O(2) deprivation in mouse CA1 neurons.

Journal: American journal of physiology. Cell physiology 20011001

Title: Death by protein kinase C inhibitor: a stressful event.

Journal: Journal of molecular and cellular cardiology 20011001

Title: Chelerythrine rapidly induces apoptosis through generation of reactive oxygen species in cardiac myocytes.

Journal: Journal of molecular and cellular cardiology 20011001

Title: Protein kinase C regulation of cell spreading in the molluscan Biomphalaria glabrata embryonic (Bge) cell line.

Journal: Biochimica et biophysica acta 20010926

Title: Protein kinase C regulates dopamine D4 receptor-mediated phospholipid methylation.

Journal: European journal of pharmacology 20010914

Title: Induction of osteoblast differentiation indexes by PTHrP in MG-63 cells involves multiple signaling pathways.

Journal: American journal of physiology. Endocrinology and metabolism 20010901

Title: Regulation of ATP-sensitive K(+) channels by protein kinase C in murine colonic myocytes.

Journal: American journal of physiology. Cell physiology 20010901

Title: Src and multiple MAP kinase activation in cardiac hypertrophy and congestive heart failure under chronic pressure-overload: comparison with acute mechanical stretch.

Journal: Journal of molecular and cellular cardiology 20010901

Title: The lysophospholipids sphingosine-1-phosphate and lysophosphatidic acid enhance survival during hypoxia in neonatal rat cardiac myocytes.

Journal: Journal of molecular and cellular cardiology 20010901

Title: Inhibition of acetylcholine-activated K(+) current by chelerythrine and bisindolylmaleimide I in atrial myocytes from mice.

Journal: European journal of pharmacology 20010727

Title: Chelerythrine and genistein inhibit the endothelin-1-induced increase in myofilament Ca(2+) sensitivity in rabbit ventricular myocytes.

Journal: European journal of pharmacology 20010720

Title: Post-ischemic PKC inhibition impairs myocardial calcium handling and increases contractile protein calcium sensitivity.

Journal: Cardiovascular research 20010701

Title: ANG II-mediated inhibition of neuronal delayed rectifier K+ current: role of protein kinase C-alpha.

Journal: American journal of physiology. Cell physiology 20010701

Title: Heat shock prevents simulated ischemia-induced apoptosis in renal tubular cells via a PKC-dependent mechanism.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20010701

Title: Histamine increases interstitial adenosine concentration via activation of ecto-5'-nucleotidase in rat hearts in vivo.

Journal: The Journal of pharmacology and experimental therapeutics 20010701

Title: Activation of extracellular signal-regulated kinase in trabecular meshwork cells.

Journal: Experimental eye research 20010701

Title: Evidence for a role of protein kinase C in FGF signal transduction in the developing chick limb bud.

Journal: Development (Cambridge, England) 20010701

Title: Inhibition of carbachol stimulated acid secretion by interleukin 1beta in rabbit parietal cells requires protein kinase C.

Journal: Gut 20010601

Title: Capsaicin potentiates 1,25-dihydoxyvitamin D3- and all-trans retinoic acid-induced differentiation of human promyelocytic leukemia HL-60 cells.

Journal: European journal of pharmacology 20010525

Title: Protein kinase C inhibition abrogates hepatic ischemic preconditioning responses.

Journal: The Journal of surgical research 20010515

Title: 17beta-oestradiol stimulates capacitative Ca2+ entry in human endometrial cells.

Journal: Molecular and cellular endocrinology 20010515

Title: Protein kinase C regulation of dopamine transporter initiated by nicotinic receptor activation in slices of rat prefrontal cortex.

Journal: Journal of neurochemistry 20010501

Title: Protein phosphorylation in mitochondria from human placenta.

Journal: Placenta 20010501

Title: Characterisation using FLIPR of human vanilloid VR1 receptor pharmacology.

Journal: European journal of pharmacology 20010406

Title: Ca2+-induced contraction of cat esophageal circular smooth muscle cells.

Journal: American journal of physiology. Cell physiology 20010401

Title: Angiotensin II stimulates cardiac L-type Ca(2+) current by a Ca(2+)- and protein kinase C-dependent mechanism.

Journal: American journal of physiology. Heart and circulatory physiology 20010401

Title: Antisense knockout of HOXB4 blocks 1,25-dihydroxyvitamin D3 inhibition of c-myc expression.

Journal: The Journal of endocrinology 20010401

Title: Protein kinase C isoform-dependent modulation of ATP-sensitive K+ channels during reoxygenation in guinea-pig ventricular myocytes.

Journal: The Journal of physiology 20010401

Title: Signalling pathways regulating the dephosphorylation of Ser729 in the hydrophobic domain of protein kinase Cepsilon upon cell passage.

Journal: The Journal of biological chemistry 20010330

Title: Amplification effect and mechanism of action of ET-1 in U-46619-induced vasoconstriction in pig skin.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20010301

Title: Transgenic incorporation of skeletal TnT into cardiac myofilaments blunts PKC-mediated depression of force.

Journal: American journal of physiology. Heart and circulatory physiology 20010301

Title: Essential activation of PKC-delta in opioid-initiated cardioprotection.

Journal: American journal of physiology. Heart and circulatory physiology 20010301

Title: Exercise directly enhances myocardial tolerance to ischaemia-reperfusion injury in the rat through a protein kinase C mediated mechanism.

Journal: Heart (British Cardiac Society) 20010301

Title: Use of protein kinase C inhibitors results in rapid [Mg(2+)](i) mobilization in primary cultured rat aortic smooth muscle cells: are certain kinase C isoforms natural homeostatic regulators of cystolic free Mg(2+).

Journal: European journal of pharmacology 20010216

Title: Protection of cardiac myocytes via delta(1)-opioid receptors, protein kinase C, and mitochondrial K(ATP) channels.

Journal: American journal of physiology. Heart and circulatory physiology 20010101

Title: Hemicholinium-3 mustard reveals two populations of cycling choline cotransporters in Limulus.

Journal: Neuroscience 20010101

Title: Opioid receptor stimulation acts as mediator of protection in ischaemic preconditioning.

Journal: Cardiovascular journal of South Africa : official journal for Southern Africa Cardiac Society [and] South African Society of Cardiac Practitioners 20010101

Title: Interaction of benzo[c]phenanthridine and protoberberine alkaloids with animal and yeast cells.

Journal: Cell biology and toxicology 20010101

Title: High calcium and dobutamine positive inotropy in the perfused mouse heart: myofilament calcium responsiveness, energetic economy, and effects of protein kinase C inhibition.

Journal: BMC physiology 20010101

Title: Specificity and mechanism of action of some commonly used protein kinase inhibitors.

Journal: The Biochemical journal 20001001

Title: Activation of potassium and chloride channels by tumor necrosis factor alpha. Role in liver cell death.

Journal: The Journal of biological chemistry 20000707

Title: Effects of long-term nitroglycerin treatment on endothelial nitric oxide synthase (NOS III) gene expression, NOS III-mediated superoxide production, and vascular NO bioavailability.

Journal: Circulation research 20000107

Title: Regulation of cytochrome P4501B1 (CYP1B1) in mouse embryo fibroblast (C3H10T1/2) cells by protein kinase C (PKC).

Journal: Biochemical pharmacology 19990315

Title: Morphine preconditioning attenuates neutrophil activation in rat models of myocardial infarction.

Journal: Cardiovascular research 19981201

Title: Protein kinase C activity is required for aryl hydrocarbon receptor pathway-mediated signal transduction.

Journal: Molecular pharmacology 19980401

Title: Evaluation of natural products as inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase.

Journal: Journal of natural products 19910101

Title: Aldosterone regulates rapid trafficking of epithelial sodium channel subunits in renal cortical collecting duct cells via protein kinase D activation.

Journal: Molecular endocrinology (Baltimore, Md.)

Title: Androgens induce nongenomic stimulation of colonic contractile activity through induction of calcium sensitization and phosphorylation of LC20 and CPI-17.

Journal: Molecular endocrinology (Baltimore, Md.)

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Tags:3895-92-9 Molecular Formula|3895-92-9 MDL|3895-92-9 SMILES|3895-92-9 Chelerythrine chloride