Home Thiazoles 135-07-9
135-07-9,MFCD00242610
Catalog No.:AA00HTRB

135-07-9 | Methyclothiazide

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5mg
98%(HPLC)
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$43.00   $30.00
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10mg
≥98%
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25mg
≥98%
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50mg
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100mg
98%(HPLC)
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00HTRB
Chemical Name:
Methyclothiazide
CAS Number:
135-07-9
Molecular Formula:
C9H11Cl2N3O4S2
Molecular Weight:
360.2373
MDL Number:
MFCD00242610
SMILES:
ClCC1Nc2cc(Cl)c(cc2S(=O)(=O)N1C)S(=O)(=O)N
Properties
Computed Properties
 
Complexity:
571  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
20  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
2  
Undefined Atom Stereocenter Count:
1  
XLogP3:
1.4  

Downstream Synthesis Route

[1]Close,W.J.etal.[JournaloftheAmericanChemicalSociety,1960,vol.82,p.1132-1135]

[1]Hennig;Moskalyk;Chatten;Chan[JournalofPharmaceuticalSciences,1981,vol.70,#3,p.317-319]

[1]Blaschke;Maibaum[JournalofPharmaceuticalSciences,1985,vol.74,#4,p.438-442]

[1]Close,W.J.etal.[JournaloftheAmericanChemicalSociety,1960,vol.82,p.1132-1135]

Literature

Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

Journal: PLoS computational biology 20111201

Title: Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

Journal: Journal of medicinal chemistry 20081113

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: [Home blood pressure monitoring in addition to office blood pressure determination is useful in patients with systolic hypertension before their inclusion into a drug trial].

Journal: Archives des maladies du coeur et des vaisseaux 20060101

Title: Direct vascular actions of methyclothiazide in remodeled mesenteric arteries from hypertensive patients.

Journal: American journal of hypertension 20011001

Title: Thiazide-induced hypercalcemia in vitamin D-treated hypoparathyroidism.

Journal: Annals of internal medicine 19721001

Title: Antihypertensive properties of cryptenamine used with reserpine and methyclothiazide.

Journal: Journal of pharmaceutical sciences 19710801

Title: Chlorothiazide-induced hypercalcemia in juvenile osteoporosis and hyperparathyroidism.

Journal: The New England journal of medicine 19690710

Title: Colas, B., et al., Mechanisms of methyclothiazide-induced inhibition of contractile responses in rat aorta. Eur J Pharmacol, 2000. 408(1): p. 63-7.

Title: Colas, B., et al., Direct vascular actions of methyclothiazide and indapamide in aorta of spontaneously hypertensive rats. Fundam Clin Pharmacol, 2000. 14(4): p. 363-8.

Title: Sasaki, S. and R.D. Bunag, Methyclothiazide attenuates salt-induced hypertension without affecting sympathetic responsiveness in Dahl rats. J Cardiovasc Pharmacol, 1983. 5(3): p. 378-83.

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SDS
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