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Home Other Building Blocks 1373615-35-0
1373615-35-0,MFCD22420827
Catalog No.:AA009CBE

1373615-35-0 | PF-5274857

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$14.00   $10.00
- +
5mg
98%
in stock  
$34.00   $24.00
- +
10mg
98%
in stock  
$50.00   $35.00
- +
25mg
98%
in stock  
$84.00   $59.00
- +
50mg
98%
in stock  
$142.00   $100.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA009CBE
Chemical Name:
PF-5274857
CAS Number:
1373615-35-0
Molecular Formula:
C20H25ClN4O3S
Molecular Weight:
436.9555
MDL Number:
MFCD22420827
SMILES:
Cc1cnc(c(c1)C)c1cc(ncc1Cl)N1CCN(CC1)C(=O)CCS(=O)(=O)C
Properties
Computed Properties
 
Complexity:
663  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
6  
Rotatable Bond Count:
5  
XLogP3:
1.8  

Downstream Synthesis Route

[1]Patent:WO2012/52948,2012,A1.Locationinpatent:Page/Pagecolumn50

[1]Patent:WO2012/52948,2012,A1

[1]Patent:WO2012/52948,2012,A1

(2,5-dichloropyridin-4-yl)boronicacid 
  1373615-35-0 

[1]Patent:WO2012/52948,2012,A1

[1]Patent:WO2012/52948,2012,A1

Literature

Title: Effective targeting of Hedgehog signaling in a medulloblastoma model with PF-5274857, a potent and selective Smoothened antagonist that penetrates the blood-brain barrier.

Journal: Molecular cancer therapeutics 20120101

Title: Rohner A, et al. Effective targeting of Hedgehog signaling in a medulloblastoma model with PF-5274857, a potent and selective Smoothened antagonist that penetrates the blood-brain barrier. Mol Cancer Ther. 2012, 11(1), 57-65.

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SDS
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Tags:1373615-35-0 Molecular Formula|1373615-35-0 MDL|1373615-35-0 SMILES|1373615-35-0 PF-5274857