Home Other Building Blocks 142375-60-8
142375-60-8,MFCD00467722
Catalog No.:AA01ENCG

142375-60-8 | FR 139317

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10mg
≥98%
in stock  
$456.00   $319.00
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50mg
≥98%
in stock  
$1,693.00   $1,185.00
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  • Technical Information
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  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA01ENCG
Chemical Name:
FR 139317
CAS Number:
142375-60-8
Molecular Formula:
C33H44N6O5
Molecular Weight:
604.7397
MDL Number:
MFCD00467722
SMILES:
CC(C[C@@H](C(=O)N[C@@H](C(=O)N[C@@H](C(=O)O)Cc1ccccn1)Cc1cn(c2c1cccc2)C)NC(=O)N1CCCCCC1)C
Properties
Computed Properties
 
Complexity:
970  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
3  
Heavy Atom Count:
44  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
12  
XLogP3:
3.8  

Literature

Title: Successful prediction of substrate-binding pocket in SLC17 transporter sialin.

Journal: The Journal of biological chemistry 20120330

Title: Endothelin-mediated in vivo pressor responses following TRPV1 activation.

Journal: American journal of physiology. Heart and circulatory physiology 20110901

Title: Endothelins decrease the expression of aquaporins and plasma membrane water permeability in cultured rat astrocytes.

Journal: Journal of neuroscience research 20110301

Title: Positron emission tomography of [18F]-big endothelin-1 reveals renal excretion but tissue-specific conversion to [18F]-endothelin-1 in lung and liver.

Journal: British journal of pharmacology 20100201

Title: Endothelin and gelatinases in renal changes following blockade of nitric oxide synthase in hypertensive rats.

Journal: The Chinese journal of physiology 20080630

Title: The effects of Delta9-tetrahydrocannabinol in rat mesenteric vasculature, and its interactions with the endocannabinoid anandamide.

Journal: British journal of pharmacology 20050601

Title: Receptor subtypes mediating the inotropic effects and Ca(2+) signaling induced by endothelin-1 through crosstalk with norepinephrine in canine ventricular myocardium.

Journal: Journal of pharmacological sciences 20050301

Title: The distinct alterations produced in cardiovascular functions by prednisolone and nitro-prednisolone (NCX-1015) in the rat highlight a causal role for endothelin-1.

Journal: The Journal of pharmacology and experimental therapeutics 20040901

Title: Analysis of ET-A and ET-B receptors using an isolated perfused rat lung preparation.

Journal: Acta physiologica Scandinavica 20040601

Title: Endothelin-1 receptor antagonists reduce cardiac electrical instability induced by high glucose in rats.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20020901

Title: Local administration of ETA (but not ETB) blockers into the PAG area of the brain decreases blood pressure of DOCA-salt rats.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20020801

Title: Two classes of endothelin receptors mediating contraction in esophageal muscularis mucosae.

Journal: Regulatory peptides 20020530

Title: Use of A-192621 and IRL-2500 to unmask the mesenteric and renal vasodilator role of endothelin ET(B) receptors.

Journal: Journal of cardiovascular pharmacology 20020401

Title: Role of endothelin ET(A)- and ET(B)-receptors in haemodynamic compensation following haemorrhage in anaesthetized rats.

Journal: British journal of pharmacology 20020201

Title: Chelerythrine and genistein inhibit the endothelin-1-induced increase in myofilament Ca(2+) sensitivity in rabbit ventricular myocytes.

Journal: European journal of pharmacology 20010720

Title: Evidence that ET-1, but not ET-3 and S6b, ET(A)-receptor mediated contractions in isolated rat mesenteric arteries are modulated by co-activation of ET(B) receptors.

Journal: British journal of pharmacology 20010701

Title: Potentiation by endothelin-1 of vasoconstrictor response in stroke-prone spontaneously hypertensive rats.

Journal: European journal of pharmacology 20010309

Title: Design, syntheses, and structure-activity relationships of indan derivatives as endothelin antagonists; new lead generation of non-peptidic antagonist from peptidic leads.

Journal: Bioorganic & medicinal chemistry 20010201

Title: Differential effects of endothelin A and B receptor antagonism on fetal growth in normal and nitric oxide-deficient rats.

Journal: Journal of the Society for Gynecologic Investigation 20010101

Title: Endothelin-1 as a protective factor against beta-adrenergic agonist-induced apoptosis in cardiac myocytes.

Journal: Journal of the American College of Cardiology 20001001

Title: Endothelin and blood pressure regulation in the female rat: studies in normal pregnancy and with nitric oxide synthase inhibition-induced hypertension.

Journal: Hypertension in pregnancy 20000101

Title: Endothelin-1 affects capsaicin-evoked release of neuropeptides from rat vas deferens.

Journal: European journal of pharmacology 19990108

Title: Mechanisms of FK 506-induced hypertension in the rat.

Journal: Hypertension (Dallas, Tex. : 1979) 19990101

Title: Effect of a specific endothelin receptor A antagonist and an angiotensin-converting enzyme inhibitor on glomerular mRNA levels for extracellular matrix components, metalloproteinases (MMP) and a tissue inhibitor of MMP in aminonucleoside nephrosis.

Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 19970501

Title: ETA receptor-mediated constrictor responses to endothelin peptides in human blood vessels in vitro.

Journal: British journal of pharmacology 19950501

Title: [3H]BQ-123, a highly specific and reversible radioligand for the endothelin ETA receptor subtype.

Journal: European journal of pharmacology 19950214

Title: [125I]-PD151242: a selective radioligand for human ETA receptors.

Journal: British journal of pharmacology 19940101

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