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151823-14-2,MFCD00919466
Catalog No.:AA00AME4

151823-14-2 | Sapacitabine

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5mg
98%
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$100.00   $70.00
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00AME4
Chemical Name:
Sapacitabine
CAS Number:
151823-14-2
Molecular Formula:
C26H42N4O5
Molecular Weight:
490.6355
MDL Number:
MFCD00919466
SMILES:
CCCCCCCCCCCCCCCC(=O)Nc1ccn(c(=O)n1)[C@@H]1O[C@@H]([C@H]([C@@H]1C#N)O)CO
Properties
Computed Properties
 
Complexity:
775  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Heavy Atom Count:
35  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
17  
XLogP3:
5.2  

Literature

Title: Oral sapacitabine for the treatment of acute myeloid leukaemia in elderly patients: a randomised phase 2 study.

Journal: The Lancet. Oncology 20121101

Title: Sapacitabine, the prodrug of CNDAC, is a nucleoside analog with a unique action mechanism of inducing DNA strand breaks.

Journal: Chinese journal of cancer 20120801

Title: Sapacitabine for cancer.

Journal: Expert opinion on investigational drugs 20120401

Title: Nucleoside and nucleobase analogs in cancer treatment: not only sapacitabine, but also gemcitabine.

Journal: Expert opinion on investigational drugs 20120401

Title: Failure of hypomethylating agent-based therapy in myelodysplastic syndromes.

Journal: Seminars in oncology 20111001

Title: Applicability of a 'Pick a Winner' trial design to acute myeloid leukemia.

Journal: Blood 20110901

Title: Novel agents for the treatment of acute myeloid leukemia in the older patient.

Journal: Journal of the National Comprehensive Cancer Network : JNCCN 20110301

Title: Novel and emerging drugs for acute myeloid leukemia: pharmacology and therapeutic activity.

Journal: Current medicinal chemistry 20110101

Title: Combination of sapacitabine and HDAC inhibitors stimulates cell death in AML and other tumour types.

Journal: British journal of cancer 20101026

Title: Phase I clinical and pharmacokinetic study of oral sapacitabine in patients with acute leukemia and myelodysplastic syndrome.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20100110

Title: Potential role of novel nucleoside analogs in the treatment of acute myeloid leukemia.

Journal: Current opinion in hematology 20080301

Title: Antiproliferative effects of sapacitabine (CYC682), a novel 2'-deoxycytidine-derivative, in human cancer cells.

Journal: British journal of cancer 20070828

Title: A Phase I study of the oral antimetabolite, CS-682, administered once daily 5 days per week in patients with refractory solid tumor malignancies.

Journal: Investigational new drugs 20061101

Title: A phase I clinical and pharmacokinetic study of CS-682 administered orally in advanced malignant solid tumors.

Journal: Investigational new drugs 20060701

Title: Drug evaluation: sapacitabine--an orally available antimetabolite in the treatment of cancer.

Journal: Current opinion in investigational drugs (London, England : 2000) 20060601

Title: Survival efficacy of adjuvant cytosine-analogue CS-682 in a fluorescent orthotopic model of human pancreatic cancer.

Journal: Cancer research 20040301

Title: Selective antimetastatic activity of cytosine analog CS-682 in a red fluorescent protein orthotopic model of pancreatic cancer.

Journal: Cancer research 20030901

Title: High-resolution magnetic resonance imaging of the efficacy of the cytosine analogue 1-[2-C-cyano-2-deoxy-beta-D-arabino-pentofuranosyl]-N(4)-palmitoyl cytosine (CS-682) in a liver-metastasis athymic nude mouse model.

Journal: Cancer research 20030515

Title: Serova M, et al. Antiproliferative effects of sapacitabine (CYC682), a novel 2'-deoxycytidine-derivative, in human cancer cells. Br J Cancer. 2007 Sep 3;97(5):628-36.

Title: Green SR, et al. Combination of sapacitabine and HDAC inhibitors stimulates cell death in AML and other tumour types. Br J Cancer. 2010 Oct 26;103(9):1391-9.

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