Title: Regulation of ozone-induced lung inflammation by the epidermal growth factor receptor in mice.
Journal: Environmental toxicology20161201
Title: Role of EGF receptor ligands in TCDD-induced EGFR down-regulation and cellular proliferation.
Journal: Chemico-biological interactions20160625
Title: Function of DNA methyltransferase 3a in lead (Pb(2+) )-Induced Cyclooxygenase-2 gene.
Journal: Environmental toxicology20150901
Title: Nickel may contribute to EGFR mutation and synergistically promotes tumor invasion in EGFR-mutated lung cancer via nickel-induced microRNA-21 expression.
Journal: Toxicology letters20150819
Title: TG-interacting factor transcriptionally induced by AKT/FOXO3A is a negative regulator that antagonizes arsenic trioxide-induced cancer cell apoptosis.
Journal: Toxicology and applied pharmacology20150515
Title: Pb²⁺ induced IL-8 gene expression by extracellular signal-regulated kinases and the transcription factor, activator protein 1, in human gastric carcinoma cells.
Journal: Environmental toxicology20150301
Title: Pb2+ induces gastrin gene expression by extracellular signal-regulated kinases 1/2 and transcription factor activator protein 1 in human gastric carcinoma cells.
Journal: Environmental toxicology20150201
Title: Expression and regulation of stromal cell-derived factor-1 (SDF1) and chemokine CXC motif receptor 4 (CXCR4) in equine and bovine preovulatory follicles.
Journal: Molecular and cellular endocrinology20140625
Title: Areca nut components affect COX-2, cyclin B1/cdc25C and keratin expression, PGE2 production in keratinocyte is related to reactive oxygen species, CYP1A1, Src, EGFR and Ras signaling.
Journal: PloS one20140101
Title: Sodium arsenite exposure inhibits AKT and Stat3 activation, suppresses self-renewal and induces apoptotic death of embryonic stem cells.
Journal: Apoptosis : an international journal on programmed cell death20130201
Title: Activation of EGFR/MEK/ERK/AP-1 signaling mediated by 1,2-naphthoquinone, an atmospheric electrophile, in human pulmonary A549 cells.
Journal: The Journal of toxicological sciences20130101
Title: Discovery of 6-substituted 4-anilinoquinazolines with dioxygenated rings as novel EGFR tyrosine kinase inhibitors.
Journal: Bioorganic & medicinal chemistry letters20120915
Title: A high-content biosensor-based screen identifies cell-permeable activators and inhibitors of EGFR function: implications in drug discovery.
Journal: Journal of biomolecular screening20120801
Title: Novel tricyclic indeno[2,1-d]pyrimidines with dual antiangiogenic and cytotoxic activities as potent antitumor agents.
Journal: Bioorganic & medicinal chemistry20120715
Title: Mechanism of β-catenin-mediated transcriptional regulation of epidermal growth factor receptor expression in glycogen synthase kinase 3 β-inactivated prostate cancer cells.
Journal: The Journal of biological chemistry20120525
Title: Tyrosine kinase inhibitors influence ABCG2 expression in EGFR-positive MDCK BCRP cells via the PI3K/Akt signaling pathway.
Journal: ChemMedChem20120401
Title: N⁴-(3-Bromophenyl)-7-(substituted benzyl) pyrrolo[2,3-d]pyrimidines as potent multiple receptor tyrosine kinase inhibitors: design, synthesis, and in vivo evaluation.
Journal: Bioorganic & medicinal chemistry20120401
Title: Inhibition of epidermal growth factor receptor tyrosine kinase ameliorates collagen-induced arthritis.
Journal: Journal of immunology (Baltimore, Md. : 1950)20120401
Title: N⁴-Aryl-6-substitutedphenylmethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as receptor tyrosine kinase inhibitors.
Journal: Bioorganic & medicinal chemistry20120115
Title: Therapeutic and preventive effects of an epidermal growth factor receptor inhibitor on oral squamous cell carcinoma.
Journal: The Journal of international medical research20120101
Title: Stroma targeting nuclear imaging and radiopharmaceuticals.
Journal: International journal of molecular imaging20120101
Title: Molecular imaging with 11C-PD153035 PET/CT predicts survival in non-small cell lung cancer treated with EGFR-TKI: a pilot study.
Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine20111001
Title: Suppression of TG-interacting factor sensitizes arsenic trioxide-induced apoptosis in human hepatocellular carcinoma cells.
Journal: The Biochemical journal20110901
Title: EGFR signaling suppresses osteoblast differentiation and inhibits expression of master osteoblastic transcription factors Runx2 and Osterix.
Journal: Journal of cellular biochemistry20110701
Title: Impact of aryloxy-linked quinazolines: a novel series of selective VEGFR-2 receptor tyrosine kinase inhibitors.
Journal: Bioorganic & medicinal chemistry letters20110401
Title: A novel hybrid peptide targeting EGFR-expressing cancers.
Journal: European journal of cancer (Oxford, England : 1990)20110301
Title: Evaluation of radioiodinated quinazoline derivative as a new ligand for EGF receptor tyrosine kinase activity using SPECT.
Journal: Annals of nuclear medicine20110201
Title: Involvement of the epidermal growth factor receptor in Pb²+-induced activation of cPLA₂/COX-2 genes and PGE₂ production in vascular smooth muscle cells.
Journal: Toxicology20110111
Title: Determining the binding mode and binding affinity constant of tyrosine kinase inhibitor PD153035 to DNA using optical tweezers.
Journal: Biochemical and biophysical research communications20110107
Title: Prediction of inhibitory activity of epidermal growth factor receptor inhibitors using grid search-projection pursuit regression method.
Journal: PloS one20110101
Title: Irreversible EGFR inhibitor EKB-569 targets low-LET γ-radiation-triggered rel orchestration and potentiates cell death in squamous cell carcinoma.
Journal: PloS one20110101
Title: Identification of the amyloid β-protein precursor and cystatin C as novel epidermal growth factor receptor regulated secretory proteins in nasopharyngeal carcinoma by proteomics.
Journal: Journal of proteome research20101203
Title: Design, synthesis, and DNA-binding of N-alkyl(anilino)quinazoline derivatives.
Journal: Journal of medicinal chemistry20101125
Title: Synthesis and in vitro study of pseudo-peptide thioureas containing α-aminophosphonate moiety as potential antitumor agents.
Journal: European journal of medicinal chemistry20101101
Title: Discovery of mitogen-activated protein kinase-interacting kinase 1 inhibitors by a comprehensive fragment-oriented virtual screening approach.
Journal: Journal of medicinal chemistry20100923
Title: Synthesis and initial tumor affinity testing of iodine-123 labelled EGFR-affine agents as potential imaging probes for hormone-refractory prostate cancer.
Journal: European journal of medicinal chemistry20100901
Title: Signaling through erbB receptors is a critical functional regulator in the mature cochlea.
Journal: The European journal of neuroscience20100901
Title: Epidermal growth factor receptor tyrosine kinase inhibitors induce CCL2 and CCL5 via reduction in IL-1R2 in keratinocytes.
Journal: Experimental dermatology20100801
Title: Gastrin-releasing peptide promotes the growth of HepG2 cells via EGFR-independent ERK1/2 activation.
Journal: Oncology reports20100801
Title: Design, synthesis and evaluation of 2-amino-4-m-bromoanilino-6-arylmethyl-7H-pyrrolo[2,3-d]pyrimidines as tyrosine kinase inhibitors and antiangiogenic agents.
Journal: Bioorganic & medicinal chemistry20100715
Title: The contribution of a 2-amino group on receptor tyrosine kinase inhibition and antiangiogenic activity in 4-anilinosubstituted pyrrolo[2,3-d]pyrimidines.
Journal: Bioorganic & medicinal chemistry letters20100515
Title: Synthesis and biological activity of N(4)-phenylsubstituted-6-(2,4-dichloro phenylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as vascular endothelial growth factor receptor-2 inhibitors and antiangiogenic and antitumor agents.
Journal: Bioorganic & medicinal chemistry20100515
Title: F84, a quinazoline derivative, exhibits high potent antitumor activity against human gynecologic malignancies.
Journal: Investigational new drugs20100401
Title: Single agents with designed combination chemotherapy potential: synthesis and evaluation of substituted pyrimido[4,5-b]indoles as receptor tyrosine kinase and thymidylate synthase inhibitors and as antitumor agents.
Journal: Journal of medicinal chemistry20100225
Title: Exploring epidermal growth factor receptor (EGFR) inhibitor features: the role of fused dioxygenated rings on the quinazoline scaffold.
Journal: Journal of medicinal chemistry20100225
Title: B5, a novel pyrrole-substituted indolinone, exerts potent antitumor efficacy through G2/M cell cycle arrest.
Journal: Investigational new drugs20100201
Title: Diesel particle-induced transcriptional expression of p21 involves activation of EGFR, Src, and Stat3.
Journal: American journal of respiratory cell and molecular biology20100101
Title: Potent cardioprotective effect of the 4-anilinoquinazoline derivative PD153035: involvement of mitochondrial K(ATP) channel activation.
Journal: PloS one20100101
Title: EGFR tyrosine kinase inhibitor (PD153035) improves glucose tolerance and insulin action in high-fat diet-fed mice.
Journal: Diabetes20091201
Title: EFEMP1 binds the EGF receptor and activates MAPK and Akt pathways in pancreatic carcinoma cells.
Journal: Biological chemistry20091201
Title: NADPH oxidase and lipid raft-associated redox signaling are required for PCB153-induced upregulation of cell adhesion molecules in human brain endothelial cells.
Journal: Toxicology and applied pharmacology20091015
Title: Design, synthesis, and X-ray crystal structures of 2,4-diaminofuro[2,3-d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase inhibitors.
Journal: Bioorganic & medicinal chemistry20091015
Title: The unfolded protein response is activated in differentiating epidermal keratinocytes.
Journal: The Journal of investigative dermatology20090901
Title: Fluoride-induced cyclooxygenase-2 expression and prostaglandin E2 production in A549 human pulmonary epithelial cells.
Journal: Toxicology letters20090810
Title: Molecular imaging of EGFR: it's time to go beyond receptor expression.
Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine20090701
Title: Lead acetate induces EGFR activation upstream of SFK and PKCalpha linkage to the Ras/Raf-1/ERK signaling.
Journal: Toxicology and applied pharmacology20090301
Title: Antitumor activity of a novel EGFR tyrosine kinase inhibitor against human lung carcinoma in vitro and in vivo.
Journal: Investigational new drugs20090201
Title: Growth factors involved in aqueous humour-induced lens cell proliferation.
Journal: Growth factors (Chur, Switzerland)20090201
Title: PET-based biodistribution and radiation dosimetry of epidermal growth factor receptor-selective tracer 11C-PD153035 in humans.
Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine20090201
Title: Curcumin attenuates EGF-induced AQP3 up-regulation and cell migration in human ovarian cancer cells.
Journal: Cancer chemotherapy and pharmacology20081001
Title: Priming with EGFR tyrosine kinase inhibitor and EGF sensitizes ovarian cancer cells to respond to chemotherapeutical drugs.
Journal: Cancer letters20080808
Title: Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity.
Journal: Journal of medicinal chemistry20080724
Title: HTS assays using a disease-relevant cell model for interrogating the MAP kinase pathway initiated by multiple receptors.
Journal: Assay and drug development technologies20080601
Title: Design, synthesis and biological evaluation of substituted pyrrolo[2,3-d]pyrimidines as multiple receptor tyrosine kinase inhibitors and antiangiogenic agents.
Journal: Bioorganic & medicinal chemistry20080515
Title: [Molecular imaging of epidermal growth factor receptor in glioma-bearing rats].
Journal: Zhonghua zhong liu za zhi [Chinese journal of oncology]20080501
Title: Towards predictive inhibitor design for the EGFR autophosphorylation activity.
Journal: European journal of medicinal chemistry20080401
Title: Activation of epidermal growth factor receptor by metal-ligand complexes decreases levels of extracellular amyloid beta peptide.
Journal: The international journal of biochemistry & cell biology20080101
Title: Biochemical assay-based selectivity profiling of clinically relevant kinase inhibitors on mutant forms of EGF receptor.
Journal: Journal of receptor and signal transduction research20080101
Title: Leptin stimulates the proliferation of human oesophageal adenocarcinoma cells via HB-EGF and Tgfalpha mediated transactivation of the epidermal growth factor receptor.
Journal: British journal of biomedical science20080101
Title: A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
Journal: Proceedings of the National Academy of Sciences of the United States of America20071218
Title: The DNA-binding epidermal growth factor-receptor inhibitor PD153035 and other DNA-intercalating cytotoxic drugs reactivate the expression of the retinoic acid receptor-beta tumor-suppressor gene in breast cancer cells.
Journal: Differentiation; research in biological diversity20071101
Title: Synthesis and bioactivities of 6,7,8-trimethoxy-N-aryl-4-aminoquinazoline derivatives.
Journal: Bioorganic & medicinal chemistry20071015
Title: Assessment of 11C-labeled-4-N-(3-bromoanilino)-6,7-dimethoxyquinazoline as a positron emission tomography agent to monitor epidermal growth factor receptor expression.
Journal: Cancer science20070901
Title: Signaling pathway for 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced TNF-alpha production in differentiated THP-1 human macrophages.
Journal: Experimental & molecular medicine20070831
Title: Further characterization of the epidermal growth factor receptor ligand 11C-PD153035.
Journal: Chinese medical journal20070605
Title: Upregulation of retinoic acid receptor-beta by the epidermal growth factor-receptor inhibitor PD153035 is not mediated by blockade of ErbB pathways.
Journal: Journal of cellular physiology20070601
Title: Dual irreversible kinase inhibitors: quinazoline-based inhibitors incorporating two independent reactive centers with each targeting different cysteine residues in the kinase domains of EGFR and VEGFR-2.
Journal: Bioorganic & medicinal chemistry20070601
Title: Protein C is an autocrine growth factor for human skin keratinocytes.
Journal: The Journal of biological chemistry20070504
Title: [Expressions of epidermal growth factor receptor signaling substances in gastric mucosal cells influenced by serum derived from rats treated with electroacupuncture at stomach meridian acupoints].
Journal: Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine20070501
Title: Synthesis and bioactivity of 4-alkyl(aryl)thioquinazoline derivatives.
Journal: Bioorganic & medicinal chemistry letters20070415
Title: Blockage of epidermal growth factor receptor by quinazoline tyrosine kinase inhibitors suppresses growth of human hepatocellular carcinoma.
Journal: Cancer letters20070408
Title: EGF receptor clustering is induced by a 0.4 mT power frequency magnetic field and blocked by the EGF receptor tyrosine kinase inhibitor PD153035.
Journal: Bioelectromagnetics20070401
Title: Immortalization of human urothelial cells by human papillomavirus type 16 E6 and E7 genes in a defined serum-free system.
Journal: Cell proliferation20070401
Title: Diesel exhaust particulate-induced activation of Stat3 requires activities of EGFR and Src in airway epithelial cells.
Journal: American journal of physiology. Lung cellular and molecular physiology20070201
Title: Control of tight junctional sealing: role of epidermal growth factor.
Journal: American journal of physiology. Renal physiology20070201
Title: QSAR analysis of tyrosine kinase inhibitor using modified ant colony optimization and multiple linear regression.
Journal: European journal of medicinal chemistry20070101
Title: Epidermal growth factor receptor inhibition sensitizes renal cell carcinoma cells to the cytotoxic effects of bortezomib.
Journal: Molecular cancer therapeutics20070101
Title: Control of PDGF-induced reactive oxygen species (ROS) generation and signal transduction in human lens epithelial cells.
Journal: Molecular vision20070101
Title: Signal pathways involved in the regulation of prostaglandin E synthase-1 in human gingival fibroblasts.
Journal: Cellular signalling20061201
Title: EGFR-mediated expression of aquaporin-3 is involved in human skin fibroblast migration.
Journal: The Biochemical journal20061201
Title: Multitarget-directed drug design strategy: a novel molecule designed to block epidermal growth factor receptor (EGFR) and to exert proapoptotic effects.
Journal: Journal of medicinal chemistry20061116
Title: The tyrosine kinase inhibitor PD153035: implication of labeling position on radiometabolites formed in vitro.
Journal: Nuclear medicine and biology20061101
Title: UVB radiation induces expression of HIF-1alpha and VEGF through the EGFR/PI3K/DEC1 pathway.
Journal: International journal of molecular medicine20061001
Title: PPARgamma-regulated tight junction development during human urothelial cytodifferentiation.
Journal: Journal of cellular physiology20060801
Title: Inhibition of protein tyrosine phosphatase activity mediates epidermal growth factor receptor signaling in human airway epithelial cells exposed to Zn2+.
Journal: Toxicology and applied pharmacology20060701
Title: Inhibition of EGFR/PI3K/AKT cell survival pathway promotes TSA's effect on cell death and migration in human ovarian cancer cells.
Journal: International journal of oncology20060701
Title: Amphiregulin contributes to the transformed phenotype of human hepatocellular carcinoma cells.
Journal: Cancer research20060615
Title: The epidermal growth factor receptor (EGFR)-S442F mutant displays increased affinity for neuregulin-2beta and agonist-independent coupling with downstream signalling events.
Journal: The Biochemical journal20060515
Title: Indole-3-carbinol-induced death in cancer cells involves EGFR downregulation and is exacerbated in a 3D environment.
Journal: Apoptosis : an international journal on programmed cell death20060501
Title: COX-2-mediated stimulation of the lymphangiogenic factor VEGF-C in human breast cancer.
Journal: British journal of cancer20060424
Title: Transforming growth factor alpha attenuates the functional expression of AMPA receptors in cortical GABAergic neurons.
Journal: Molecular and cellular neurosciences20060401
Title: Opposite effect of ERK1/2 and JNK on p53-independent p21WAF1/CIP1 activation involved in the arsenic trioxide-induced human epidermoid carcinoma A431 cellular cytotoxicity.
Journal: Journal of biomedical science20060101
Title: Suppression of pro-metastasis phenotypes expression in malignant pleural mesothelioma by the PI3K inhibitor LY294002 or the MEK inhibitor UO126.
Journal: Anticancer research20060101
Title: Asbestos-induced activation of cell signaling pathways in human bronchial epithelial cells.
Journal: Experimental lung research20060101
Title: Epidermal growth factor-, transforming growth factor-beta-, retinoic acid- and 1,25-dihydroxyvitamin D3-regulated expression of the novel protein PTPIP51 in keratinocytes.
Journal: Cells, tissues, organs20060101
Title: Anilinodialkoxyquinazolines: screening epidermal growth factor receptor tyrosine kinase inhibitors for potential tumor imaging probes.
Journal: Journal of medicinal chemistry20051117
Title: p38 and EGF receptor kinase-mediated activation of the phosphatidylinositol 3-kinase/Akt pathway is required for Zn2+-induced cyclooxygenase-2 expression.
Journal: American journal of physiology. Lung cellular and molecular physiology20051101
Title: Targeted inhibition of transient activation of the EGFR-mediated cell survival pathway enhances paclitaxel-induced ovarian cancer cell death.
Journal: International journal of oncology20051101
Title: Transient activation of EGFR/AKT cell survival pathway and expression of survivin contribute to reduced sensitivity of human melanoma cells to betulinic acid.
Journal: International journal of oncology20050901
Title: Mechanism of thymus- and activation-regulated chemokine (TARC)/CCL17 production and its modulation by roxithromycin.
Journal: The Journal of investigative dermatology20050901
Title: Heparin-binding epidermal growth factor-like growth factor stimulates cell proliferation in cerebral cortical cultures through phosphatidylinositol 3'-kinase and mitogen-activated protein kinase.
Journal: Journal of neuroscience research20050815
Title: Up-regulation in endothelin-1 by Helicobacter pylori lipopolysaccharide interferes with gastric mucin synthesis via epidermal growth factor receptor transactivation.
Journal: Scandinavian journal of gastroenterology20050801
Title: Antagonistic regulation of swelling-activated Cl- current in rabbit ventricle by Src and EGFR protein tyrosine kinases.
Journal: American journal of physiology. Heart and circulatory physiology20050601
Title: Autocrine regulation of human urothelial cell proliferation and migration during regenerative responses in vitro.
Journal: Experimental cell research20050515
Title: Frontal affinity chromatography with MS detection of EphB2 tyrosine kinase receptor. 2. Identification of small-molecule inhibitors via coupling with virtual screening.
Journal: Journal of medicinal chemistry20050505
Title: The selective epidermal growth factor receptor tyrosine kinase inhibitor PD153035 suppresses expression of prometastasis phenotypes in malignant pleural mesothelioma cells in vitro.
Journal: The Journal of thoracic and cardiovascular surgery20050501
Title: Positive and negative transcriptional regulation of aromatase expression in human breast cancer tissue.
Journal: The Journal of steroid biochemistry and molecular biology20050501
Title: An EGF receptor inhibitor induces RAR-beta expression in breast and ovarian cancer cells.
Journal: Biochemical and biophysical research communications20050422
Title: Inhibition of the epidermal growth factor receptor increases expression of genes that stimulate inflammation, apoptosis, and cell attachment.
Journal: Molecular cancer therapeutics20050401
Title: High performance liquid chromatography analysis of a 4-anilinoquinazoline derivative (PD153035), a specific inhibitor of the epidermal growth factor receptor tyrosine kinase, in rat plasma.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20050325
Title: Epidermal and hepatocyte growth factors, but not keratinocyte growth factor, modulate protein kinase Calpha translocation to the plasma membrane through 15(S)-hydroxyeicosatetraenoic acid synthesis.
Journal: The Journal of biological chemistry20050304
Title: Global kinase screening. Applications of frontal affinity chromatography coupled to mass spectrometry in drug discovery.
Journal: Analytical chemistry20050301
Title: Comparison of ELISA-based tyrosine kinase assays for screening EGFR inhibitors.
Journal: Journal of receptor and signal transduction research20050101
Title: Frontal affinity chromatography with MS detection of EphB2 tyrosine kinase receptor. 1. Comparison with conventional ELISA.
Journal: Journal of medicinal chemistry20041007
Title: [Role of PD153035 in the induction of apoptosis of XG-1 myeloma cell line].
Journal: Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae20041001
Title: Porphyromonas gingivalis lipopolysaccharide-induced up-regulation in endothelin-1 interferes with salivary mucin synthesis via epidermal growth factor receptor transactivation.
Journal: IUBMB life20041001
Title: Co-inhibition of epidermal growth factor receptor and type 1 insulin-like growth factor receptor synergistically sensitizes human malignant glioma cells to CD95L-induced apoptosis.
Journal: Biochemical and biophysical research communications20040827
Title: Involvement of MAP-kinase, PI3-kinase and EGF-receptor in the stimulatory effect of Neurotensin on DNA synthesis in PC3 cells.
Journal: Regulatory peptides20040815
Title: Salivary phospholipid secretion in response to beta-adrenergic stimulation is mediated by Src kinase-dependent epidermal growth factor receptor transactivation.
Journal: Biochemical and biophysical research communications20040521
Title: Prevention of renal vascular and glomerular fibrosis by epidermal growth factor receptor inhibition.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology20040501
Title: Activation of peroxisome proliferator-activated receptor-gamma reverses squamous metaplasia and induces transitional differentiation in normal human urothelial cells.
Journal: The American journal of pathology20040501
Title: Role of PPARgamma and EGFR signalling in the urothelial terminal differentiation programme.
Journal: Journal of cell science20040415
Title: Heparin-binding epidermal growth factor cleavage mediates zinc-induced epidermal growth factor receptor phosphorylation.
Journal: American journal of respiratory cell and molecular biology20040401
Title: Regulation of parathyroid hormone-related protein gene expression by epidermal growth factor-family ligands in primary human keratinocytes.
Journal: The Journal of endocrinology20040401
Title: EphB4 signaling is capable of mediating ephrinB2-induced inhibition of cell migration.
Journal: Biochemical and biophysical research communications20040102
Title: Evaluation of novel epidermal growth factor receptor tyrosine kinase inhibitors.
Journal: Breast cancer research and treatment20040101
Title: Antiangiogenic and antitumor agents. Design, synthesis, and evaluation of novel 2-amino-4-(3-bromoanilino)-6-benzylsubstituted pyrrolo[2,3-d]pyrimidines as inhibitors of receptor tyrosine kinases.
Journal: Bioorganic & medicinal chemistry20031117
Title: Resistance to small molecule inhibitors of epidermal growth factor receptor in malignant gliomas.
Journal: Cancer research20031101
Title: Expression of ErbB receptors in ES cell-derived cardiomyocytes.
Journal: Biochemical and biophysical research communications20030912
Title: Mechanisms of Zn(2+)-induced signal initiation through the epidermal growth factor receptor.
Journal: Toxicology and applied pharmacology20030815
Title: Synergistic antiproliferative and apoptotic effects induced by epidermal growth factor receptor and protein kinase a inhibitors in human prostatic cancer cell lines.
Journal: International journal of cancer20030810
Title: Regulation of TGF-alpha-induced activation of AP-1 in the aging gastric mucosa.
Journal: American journal of physiology. Gastrointestinal and liver physiology20030801
Title: Epidermal growth factor inhibition of c-Myc-mediated apoptosis through Akt and Erk involves Bcl-xL upregulation in mammary epithelial cells.
Journal: Experimental cell research20030715
Title: Induction of aromatase (CYP19) expression in breast cancer cells through a nongenomic action of estrogen receptor alpha.
Journal: Cancer research20030701
Title: Mutation of threonine 766 in the epidermal growth factor receptor reveals a hotspot for resistance formation against selective tyrosine kinase inhibitors.
Journal: The Journal of biological chemistry20030425
Title: Quantitative image analysis of cellular protein translocation induced by magnetic microspheres: application to the EGF receptor.
Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology20030301
Title: Epidermal growth factor receptor trans-activation mediates the tonic and fibrogenic effects of endothelin in the aortic wall of transgenic mice.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology20030201
Title: Synthesis and structure-activity relationships of 6,7-disubstituted 4-anilinoquinoline-3-carbonitriles. The design of an orally active, irreversible inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR) and the human epidermal growth factor receptor-2 (HER-2).
Journal: Journal of medicinal chemistry20030102
Title: PET screening of anticancer drugs. A faster route to drug/target evaluations in vivo.
Journal: Methods in molecular medicine20030101
Title: Enhanced antiangiogenic therapy of squamous cell carcinoma by combined endostatin and epidermal growth factor receptor-antisense therapy.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20021101
Title: Heparin-binding EGF-like growth factor gene transcription regulated by Cdx2 in the intestinal epithelium.
Journal: American journal of physiology. Gastrointestinal and liver physiology20021001
Title: Activation of proteinase-activated receptor 1 stimulates epithelial chloride secretion through a unique MAP kinase- and cyclo-oxygenase-dependent pathway.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology20021001
Title: 4-anilino-3-quinolinecarbonitriles: an emerging class of kinase inhibitors.
Journal: Current topics in medicinal chemistry20020901
Title: Regulation of Akt by EGF-R inhibitors, a possible mechanism of EGF-R inhibitor-enhanced TRAIL-induced apoptosis.
Journal: Biochemical and biophysical research communications20020712
Title: Okadaic acid-induced EGF receptor and MAP kinase activation does not require reactive oxygen species in primary keratinocytes.
Journal: Archives of dermatological research20020701
Title: EBV-expressing AGS gastric carcinoma cell sublines present increased motility and invasiveness.
Journal: International journal of cancer20020610
Title: Establishment and characterization of acquired resistance to the farnesyl protein transferase inhibitor R115777 in a human colon cancer cell line.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20020601
Title: Autocrine-mediated activation of STAT3 correlates with cell proliferation in breast carcinoma lines.
Journal: The Journal of biological chemistry20020517
Title: Role of Ras in metal-induced EGF receptor signaling and NF-kappaB activation in human airway epithelial cells.
Journal: American journal of physiology. Lung cellular and molecular physiology20020501
Title: Regulation of cultured rat hepatocyte proliferation by stellate cells.
Journal: Journal of hepatology20020501
Title: Prostaglandin E2 transactivates EGF receptor: a novel mechanism for promoting colon cancer growth and gastrointestinal hypertrophy.
Journal: Nature medicine20020301
Title: Activation of EGF receptors mediates pulmonary vasoconstriction induced by residual oil fly ash.
Journal: Experimental lung research20020101
Title: Transactivation of the epidermal growth factor receptor is involved in 12-O-tetradecanoylphorbol-13-acetate-induced signal transduction.
Journal: The Journal of biological chemistry20011214
Title: Lymnaea epidermal growth factor promotes axonal regeneration in CNS organ culture.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20011201
Title: Induction of EGFR-dependent and EGFR-independent signaling pathways by ultraviolet A irradiation.
Journal: DNA and cell biology20011201
Title: 1,4-dioxane-fused 4-anilinoquinazoline as inhibitors of epidermal growth factor receptor kinase.
Journal: Archiv der Pharmazie20011101
Title: Epidermal growth factor receptor signaling and the invasive phenotype of ovarian carcinoma cells.
Journal: Journal of the National Cancer Institute20010919
Title: Signaling-inactive epidermal growth factor receptor/ligand complexes in intact carcinoma cells by quinazoline tyrosine kinase inhibitors.
Journal: Cancer research20010801
Title: Differential utilization and localization of ErbB receptor tyrosine kinases in skin compared to normal and malignant keratinocytes.
Journal: Neoplasia (New York, N.Y.)20010701
Title: Epidermal growth factor induction of apolipoprotein A-I is mediated by the Ras-MAP kinase cascade and Sp1.
Journal: The Journal of biological chemistry20010427
Title: DNA interaction of the tyrosine protein kinase inhibitor PD153035 and its N-methyl analogue.
Journal: Biochemistry20010417
Title: Transmodulation of epidermal growth factor receptor mediates IL-1 beta-induced MMP-1 expression in cultured human keratinocytes.
Journal: International journal of molecular medicine20010301
Title: BIBX1382BS, but not AG1478 or PD153035, inhibits the ErbB kinases at different concentrations in intact cells.
Journal: Biochemical and biophysical research communications20010216
Title: Role of transforming growth factor-alpha in von Hippel--Lindau (VHL)(-/-) clear cell renal carcinoma cell proliferation: a possible mechanism coupling VHL tumor suppressor inactivation and tumorigenesis.
Journal: Proceedings of the National Academy of Sciences of the United States of America20010213
Title: A role for endogenous TGFalpha and associated signaling pathways in the differentiation of lens fiber cells.
Journal: Journal of cellular physiology20010201
Title: EGF receptor crosstalks with cytokine receptors leading to the activation of c-Jun kinase in response to UV irradiation in human keratinocytes.
Journal: Cellular signalling20010201
Title: New dermatological agents for the treatment of psoriasis.
Journal: Journal of medicinal chemistry20010201
Title: Allosteric inhibition of fructose-1,6-bisphosphatase by anilinoquinazolines.
Journal: Bioorganic & medicinal chemistry letters20010108
Title: Activation of the EGF receptor signaling pathway in human airway epithelial cells exposed to metals.
Journal: The American journal of physiology19991101
Title: Tyrosine kinase inhibitors. 9. Synthesis and evaluation of fused tricyclic quinazoline analogues as ATP site inhibitors of the tyrosine kinase activity of the epidermal growth factor receptor.
Journal: Journal of medicinal chemistry19960216
Title: Tyrosine kinase inhibitors. 8. An unusually steep structure-activity relationship for analogues of 4-(3-bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a potent inhibitor of the epidermal growth factor receptor.
Journal: Journal of medicinal chemistry19960105
Title: Bridges AJ, et al. Tyrosine kinase inhibitors. 8. An unusually steep structure-activity relationship for analogues of 4-(3-bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a potent inhibitor of the epidermal growth factor receptor. J Med Chem. 1996 Jan 5;39(1):267-76.
Title: Fry DW, et al. A specific inhibitor of the epidermal growth factor receptor tyrosine kinase. Science. 1994 Aug 19;265(5175):1093-5.
Title: Bos M, et al. PD153035, a tyrosine kinase inhibitor, prevents epidermal growth factor receptoractivation and inhibits growth of cancer cells in a receptor number-dependent manner. Clin Cancer Res. 1997 Nov;3(11):2099-106.
Title: Kunkel MW, et al. Inhibition of the epidermal growth factor receptor tyrosine kinase by PD153035 in human A431 tumors in athymic nude mice. Invest New Drugs. 1996;13(4):295-302.
