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Home Amines 202475-60-3
202475-60-3,MFCD01862614
Catalog No.:AA00286R

202475-60-3 | 4-[(6,7-Dimethoxyquinazolin-4-yl)amino]phenol

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$9.00   $7.00
- +
5mg
98%
in stock  
$21.00   $15.00
- +
10mg
98%
in stock  
$29.00   $21.00
- +
25mg
98%
in stock  
$51.00   $36.00
- +
50mg
98%
in stock  
$74.00   $52.00
- +
100mg
98%
in stock  
$111.00   $78.00
- +
250mg
98%
in stock  
$188.00   $132.00
- +
1g
98%
in stock  
$485.00   $340.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00286R
Chemical Name:
4-[(6,7-Dimethoxyquinazolin-4-yl)amino]phenol
CAS Number:
202475-60-3
Molecular Formula:
C16H15N3O3
Molecular Weight:
297.3086
MDL Number:
MFCD01862614
SMILES:
COc1cc2c(ncnc2cc1OC)Nc1ccc(cc1)O
Properties
Computed Properties
 
Complexity:
350  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
4  
XLogP3:
3  

Downstream Synthesis Route

[1]JournalofCardiovascularPharmacology,2000,vol.35,p.179-188

[2]Patent:US6482828,2002,B1

[3]EuropeanJournalofMedicinalChemistry,2016,vol.112,p.20-32

[1]JournalofCardiovascularPharmacology,2000,vol.35,p.179-188

[1]JournalofCardiovascularPharmacology,2000,vol.35,p.179-188

[1]JournalofCardiovascularPharmacology,2000,vol.35,p.179-188

[1]JournalofCardiovascularPharmacology,2000,vol.35,p.179-188

Literature

Title: Sudbeck EA, et al. Structure-based design of specific inhibitors of Janus kinase 3 as apoptosis-inducing antileukemic agents. Clin Cancer Res. 1999 Jun;5(6):1569-82.

Title: Oh YB, et al. Inhibition of Janus activated kinase-3 protects against myocardial ischemia and reperfusion injury in mice. Exp Mol Med. 2013 May 17;45:e23

Title: Uckun FM, et al. In vivo toxicity and pharmacokinetic features of the janus kinase 3 inhibitor WHI-P131 -(4'hydroxyphenyl)-amino-6,7- dimethoxyquinazoline. Clin Cancer Res. 1999 Oct;5(10):2954-62.

Title: Xia F, et al. IL4 (interleukin 4) induces autophagy in B cells leading to exacerbated asthma. Autophagy. 2018;14(3):450-464.

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SDS
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Tags:202475-60-3 Molecular Formula|202475-60-3 MDL|202475-60-3 SMILES|202475-60-3 4-[(6,7-Dimethoxyquinazolin-4-yl)amino]phenol