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161115-59-9,MFCD09027385
Catalog No.:AA001S38

161115-59-9 | Pregna-1,4-diene-3,20-dione, 16,17-[[(R)-cyclohexylmethylene]bis(oxy)]-11,21-dihydroxy-, (11β,16α)-

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1mg
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA001S38
Chemical Name:
Pregna-1,4-diene-3,20-dione, 16,17-[[(R)-cyclohexylmethylene]bis(oxy)]-11,21-dihydroxy-, (11β,16α)-
CAS Number:
161115-59-9
Molecular Formula:
C28H38O6
Molecular Weight:
470.5977
MDL Number:
MFCD09027385
SMILES:
OCC(=O)[C@@]12O[C@@H](O[C@H]1C[C@@H]1[C@]2(C)C[C@H](O)[C@H]2[C@H]1CCC1=CC(=O)C=C[C@]21C)C1CCCCC1
Properties
Properties
 
Form:
Solid  
MP:
223 - 233°C  
Storage:
-20 ℃;  

Computed Properties
 
Complexity:
949  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
9  
Heavy Atom Count:
34  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
3  
XLogP3:
3.7  

Literature

Title: Formoterol synergy with des-ciclesonide inhibits IL-4 expression in IgE/antigen-induced mast cells by inhibiting JNK activation.

Journal: European journal of pharmacology 20150815

Title: Ciclesonide--a novel corticosteroid for the management of asthma.

Journal: Current clinical pharmacology 20120501

Title: Rapid nongenomic actions of inhaled corticosteroids on long-acting β(2)-agonist transport in the airway.

Journal: Pulmonary pharmacology & therapeutics 20111201

Title: Simultaneous determination of ciclesonide and its active metabolite desisobutyryl-ciclesonide in human plasma by LC-APCI-MS/MS: application to pharmacokinetic study in healthy Chinese volunteers.

Journal: Journal of pharmaceutical and biomedical analysis 20110428

Title: Population pharmacokinetics and pharmacodynamics of inhaled ciclesonide and fluticasone propionate in patients with persistent asthma.

Journal: Journal of clinical pharmacology 20101001

Title: Pharmacokinetics of ciclesonide and desisobutyryl ciclesonide after administration via aqueous nasal spray or hydrofluoroalkane nasal aerosol compared with orally inhaled ciclesonide: an open-label, single-dose, three-period crossover study in healthy volunteers.

Journal: Clinical therapeutics 20091201

Title: Clinical pharmacokinetic and pharmacodynamic profile of inhaled ciclesonide.

Journal: Clinical pharmacokinetics 20090101

Title: Effect of coadministered ketoconazole, a strong cytochrome P450 3A4 enzyme inhibitor, on the pharmacokinetics of ciclesonide and its active metabolite desisobutyryl-ciclesonide.

Journal: Clinical pharmacokinetics 20080101

Title: Modulation of human lung fibroblast functions by ciclesonide: evidence for its conversion into the active metabolite desisobutyryl-ciclesonide.

Journal: Immunology letters 20070915

Title: The role of esterases in the metabolism of ciclesonide to desisobutyryl-ciclesonide in human tissue.

Journal: Biochemical pharmacology 20070515

Title: In vitro metabolism of ciclesonide in human nasal epithelial cells.

Journal: Biopharmaceutics & drug disposition 20070101

Title: Uptake and metabolism of ciclesonide and retention of desisobutyryl-ciclesonide for up to 24 hours in rabbit nasal mucosa.

Journal: BMC pharmacology 20070101

Title: In Vitro metabolism of ciclesonide in human lung and liver precision-cut tissue slices.

Journal: Biopharmaceutics & drug disposition 20060501

Title: Safety, tolerability, and exposure of ciclesonide nasal spray in healthy and asymptomatic subjects with seasonal allergic rhinitis.

Journal: Journal of clinical pharmacology 20060401

Title: High lung deposition of 99mTc-labeled ciclesonide administered via HFA-MDI to patients with asthma.

Journal: Respiratory medicine 20060301

Title: Modulation of p-glycoprotein and breast cancer resistance protein by some prescribed corticosteroids.

Journal: European journal of pharmacology 20060215

Title: Pharmacokinetic disposition of inhaled ciclesonide and its metabolite desisobutyryl-ciclesonide in healthy subjects and patients with asthma are similar.

Journal: International journal of clinical pharmacology and therapeutics 20060101

Title: Ciclesonide disposition and metabolism: pharmacokinetics, metabolism, and excretion in the mouse, rat, rabbit, and dog.

Journal: American journal of therapeutics 20060101

Title: Preclinical profile of ciclesonide, a novel corticosteroid for the treatment of asthma.

Journal: The Journal of pharmacology and experimental therapeutics 20050801

Title: Lower oropharyngeal deposition of inhaled ciclesonide via hydrofluoroalkane metered-dose inhaler compared with budesonide via chlorofluorocarbon metered-dose inhaler in healthy subjects.

Journal: European journal of clinical pharmacology 20050501

Title: Comparison of the oropharyngeal deposition of inhaled ciclesonide and fluticasone propionate in patients with asthma.

Journal: Journal of clinical pharmacology 20050201

Title: Protein binding and its potential for eliciting minimal systemic side effects with a novel inhaled corticosteroid, ciclesonide.

Journal: American journal of therapeutics 20050101

Title: Model-based covariate pharmacokinetic analysis and lack of cortisol suppression by the new inhaled corticosteroid ciclesonide using a novel cortisol release model.

Journal: American journal of therapeutics 20050101

Title: Ciclesonide.

Journal: Drugs 20040101

Title: Silvestri M, et al. Ciclesonide modulates in vitro allergen-driven activation of blood mononuclear cells and allergen-specific T-cell blasts. Immunol Lett. 2012 Jan 30;141(2):190-6.

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Tags:161115-59-9 Molecular Formula|161115-59-9 MDL|161115-59-9 SMILES|161115-59-9 Pregna-1,4-diene-3,20-dione, 16,17-[[(R)-cyclohexylmethylene]bis(oxy)]-11,21-dihydroxy-, (11β,16α)-