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Home Other Building Blocks 1611493-60-7
1611493-60-7,MFCD31536971
Catalog No.:AA01EN1S

1611493-60-7 | Bictegravir

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$11.00   $8.00
- +
5mg
98%(HPLC)
in stock  
$43.00   $30.00
- +
250mg
98%
in stock  
$57.00   $40.00
- +
1g
98%
in stock  
$136.00   $96.00
- +
5g
98%
in stock  
$471.00   $330.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA01EN1S
Chemical Name:
Bictegravir
CAS Number:
1611493-60-7
Molecular Formula:
C21H18F3N3O5
Molecular Weight:
449.3799
MDL Number:
MFCD31536971
SMILES:
Fc1cc(F)c(c(c1)F)CNC(=O)c1cn2C[C@H]3O[C@@H]4CC[C@H](N3C(=O)c2c(c1=O)O)C4
Properties
Computed Properties
 
Complexity:
912  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
3  
Heavy Atom Count:
32  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
3  
XLogP3:
2.7  

Downstream Synthesis Route

[1]Patent:WO2018/229798,2018,A1

[2]Patent:WO2019/159199,2019,A1

[3]Patent:WO2020/3151,2020,A1

[1]Patent:WO2019/159199,2019,A1.Locationinpatent:Page/Pagecolumn43;44

[2]Patent:WO2014/100323,2014,A1.Locationinpatent:Page/Pagecolumn100-101

[3]Patent:US2015/366872,2015,A1.Locationinpatent:Paragraph0379;0380

[1]Patent:WO2014/100323,2014,A1

[1]Patent:WO2014/100323,2014,A1

[2]Patent:WO2018/229798,2018,A1

[3]Patent:WO2019/159199,2019,A1

1611493-60-7   
potassium(2R,5S,13aR)-7,9-dioxo-10-((2,4,6-trifluorobenzyl)carbamoyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido1′,2′:4,5pyrazino2,1-b1,3oxazepin-8-olate 

[1]Patent:US2015/366872,2015,A1.Locationinpatent:Paragraph0402;0403

Literature

Title: Antiviral Activity of Bictegravir and Cabotegravir against Integrase Inhibitor-Resistant SIVmac239 and HIV-1.

Journal: Antimicrobial agents and chemotherapy 20171201

Title: Tsiang M, et al. Antiviral Activity of Bictegravir (GS-9883), a Novel Potent HIV-1 Integrase Strand Transfer Inhibitor with an Improved Resistance Profile. Antimicrob Agents Chemother. 2016 Nov 21;60(12):7086-7097.

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SDS
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Tags:1611493-60-7 Molecular Formula|1611493-60-7 MDL|1611493-60-7 SMILES|1611493-60-7 Bictegravir