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Home Amines 1616391-65-1
1616391-65-1,MFCD28411588
Catalog No.:AA001VOC

1616391-65-1 | (S)-N-(3-(3,4-Dihydroisoquinolin-2(1h)-yl)-2-hydroxypropyl)-6-(oxetan-3-ylamino)pyrimidine-4-carboxamide

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Purity
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5mg
98%
in stock  
$22.00   $15.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA001VOC
Chemical Name:
(S)-N-(3-(3,4-Dihydroisoquinolin-2(1h)-yl)-2-hydroxypropyl)-6-(oxetan-3-ylamino)pyrimidine-4-carboxamide
CAS Number:
1616391-65-1
Molecular Formula:
C20H25N5O3
Molecular Weight:
383.4442
MDL Number:
MFCD28411588
SMILES:
O[C@H](CN1CCc2c(C1)cccc2)CNC(=O)c1ncnc(c1)NC1COC1
Properties
Computed Properties
 
Complexity:
518  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
7  
XLogP3:
0.8  

Downstream Synthesis Route

[1]Smith,ChristopherR.;Kulyk,Svitlana;Christensen,JamesG.;Gunn,RobinJ.;Ivetac,Anthony;Ketcham,JohnM.;Kuehler,Jon;Lawson,J.David;Thomas,NicoleC.;Wang,Xiaolun;Marx,MatthewA.;Ahmad,MisbhaUdDin;Arkhipova,Valentina

[2022]

Literature

Title: Proliferative role of TRAF4 in breast cancer by upregulating PRMT5 nuclear expression.

Journal: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 20150801

Title: The PRMT5 arginine methyltransferase: many roles in development, cancer and beyond.

Journal: Cellular and molecular life sciences : CMLS 20150601

Title: Selective inhibition of protein arginine methyltransferase 5 blocks initiation and maintenance of B-cell transformation.

Journal: Blood 20150416

Title: Protein arginine methyltransferase 5 is a key regulator of the MYCN oncoprotein in neuroblastoma cells.

Journal: Molecular oncology 20150301

Title: PRMT5 is required for lymphomagenesis triggered by multiple oncogenic drivers.

Journal: Cancer discovery 20150301

Title: Protein arginine methyltransferase 5 (PRMT5) inhibition induces lymphoma cell death through reactivation of the retinoblastoma tumor suppressor pathway and polycomb repressor complex 2 (PRC2) silencing.

Journal: The Journal of biological chemistry 20131206

Title: Molecular pathways: protein methyltransferases in cancer.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20131201

Title: Low levels of miR-92b/96 induce PRMT5 translation and H3R8/H4R3 methylation in mantle cell lymphoma.

Journal: The EMBO journal 20070808

Title: PRMT5 (Janus kinase-binding protein 1) catalyzes the formation of symmetric dimethylarginine residues in proteins.

Journal: The Journal of biological chemistry 20010831

Title: Chan-Penebre E, et al. A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models. Nat Chem Biol. 2015 Jun;11(6):432-7.

Title: Kryukov GV, et al. MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells. Science. 2016 Mar 11;351(6278):1214-8.

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SDS
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Tags:1616391-65-1 Molecular Formula|1616391-65-1 MDL|1616391-65-1 SMILES|1616391-65-1 (S)-N-(3-(3,4-Dihydroisoquinolin-2(1h)-yl)-2-hydroxypropyl)-6-(oxetan-3-ylamino)pyrimidine-4-carboxamide