[1]CurrentPatentAssignee:M'SSCIENCECORPORATION-US5736546,1998,A
[1]CurrentPatentAssignee:M'SSCIENCECORPORATION-WO2007/21545,2007,A2Locationinpatent:Page/Pagecolumn17-18
Title: Application of [¹¹C]SA4503 to selection of novel σ₁ selective agonists.
Journal: Nuclear medicine and biology 20121101
Title: Re-evaluation of in vivo selectivity of [(11)C]SA4503 to σ(1) receptors in the brain: contributions of emopamil binding protein.
Journal: Nuclear medicine and biology 20121001
Title: Sigma-1 receptor chaperones regulate the secretion of brain-derived neurotrophic factor.
Journal: Synapse (New York, N.Y.) 20120701
Title: Attenuating heat-induced acute lung inflammation and injury by dextromethorphan in rats.
Journal: American journal of respiratory cell and molecular biology 20120301
Title: Effects of the sigma-1 receptor agonist 1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl)-piperazine dihydro-chloride on inflammation after stroke.
Journal: PloS one 20120101
Title: Chloroquine inhibits glutamate-induced death of a neuronal cell line by reducing reactive oxygen species through sigma-1 receptor.
Journal: Journal of neurochemistry 20111101
Title: Synthesis and in vitro biological evaluation of carbonyl group-containing analogues for σ1 receptors.
Journal: Journal of medicinal chemistry 20110811
Title: The sigma receptor agonist SA4503 both attenuates and enhances the effects of methamphetamine.
Journal: Drug and alcohol dependence 20110701
Title: The sigma-1 receptor enhances brain plasticity and functional recovery after experimental stroke.
Journal: Brain : a journal of neurology 20110301
Title: SA 4503 attenuates cocaine-induced hyperactivity and enhances methamphetamine substitution for a cocaine discriminative stimulus.
Journal: Pharmacology, biochemistry, and behavior 20110201
Title: Potentiation of nerve growth factor-induced neurite outgrowth by the ROCK inhibitor Y-27632: a possible role of IP₃ receptors.
Journal: European journal of pharmacology 20101201
Title: SA4503, a sigma-1 receptor agonist, prevents cultured cortical neurons from oxidative stress-induced cell death via suppression of MAPK pathway activation and glutamate receptor expression.
Journal: Neuroscience letters 20100129
Title: High occupancy of sigma1 receptors in the human brain after single oral administration of donepezil: a positron emission tomography study using [11C]SA4503.
Journal: The international journal of neuropsychopharmacology 20090901
Title: Imaging of sigma1 receptors in the human brain using PET and [11C]SA4503.
Journal: Central nervous system agents in medicinal chemistry 20090901
Title: Steroid hormones affect binding of the sigma ligand 11C-SA4503 in tumour cells and tumour-bearing rats.
Journal: European journal of nuclear medicine and molecular imaging 20090701
Title: Further evidence for an antidepressant potential of the selective sigma1 agonist SA 4503: electrophysiological, morphological and behavioural studies.
Journal: The international journal of neuropsychopharmacology 20080601
Title: Shortened protocol in practical [11C]SA4503-PET studies for sigma1 receptor quantification.
Journal: Annals of nuclear medicine 20080201
Title: A change of in vivo characteristics depending on specific activity of radioiodinated (+)-2-[4-(4-iodophenyl)piperidino]cyclohexanol [(+)-pIV] as a ligand for sigma receptor imaging.
Journal: Nuclear medicine and biology 20080101
Title: Potentiation of nerve growth factor-induced neurite outgrowth by fluvoxamine: role of sigma-1 receptors, IP3 receptors and cellular signaling pathways.
Journal: PloS one 20080101
Title: Effects of selective sigma receptor ligands on glucocorticoid receptor-mediated gene transcription in LMCAT cells.
Journal: Pharmacological reports : PR 20080101
Title: High occupancy of sigma-1 receptors in the human brain after single oral administration of fluvoxamine: a positron emission tomography study using [11C]SA4503.
Journal: Biological psychiatry 20071015
Title: Role of N-methyl-D-aspartate receptors in antidepressant-like effects of sigma 1 receptor agonist 1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl)piperazine dihydrochloride (SA-4503) in olfactory bulbectomized rats.
Journal: The Journal of pharmacology and experimental therapeutics 20070901
Title: Rapid reduction of sigma1-receptor binding and 18F-FDG uptake in rat gliomas after in vivo treatment with doxorubicin.
Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20070801
Title: In vivo characterization of radioiodinated (+)-2-[4-(4-iodophenyl) piperidino] cyclohexanol as a potential sigma-1 receptor imaging agent.
Journal: Nuclear medicine and biology 20070801
Title: American Chemical Society--233rd National Meeting. CNS, cancer and cardiovascular targets. 25-29 March 2007, Chicago, IL, USA.
Journal: IDrugs : the investigational drugs journal 20070501
Title: Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of fluvoxamine: role of sigma-1 receptors.
Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20070301
Title: Mapping of human cerebral sigma1 receptors using positron emission tomography and [11C]SA4503.
Journal: NeuroImage 20070301
Title: Antidepressant-like effect of combined treatment with selective sigma receptor agonists and a 5-HT1A receptor agonist in the forced swimming test in rats.
Journal: Pharmacological reports : PR 20070101
Title: A feasibility study of [11C]SA4503-PET for evaluating sigmal receptor occupancy by neuroleptics: the binding of haloperidol to sigma1 and dopamine D2-like receptors.
Journal: Annals of nuclear medicine 20061001
Title: The synergistic effect of selective sigma receptor agonists and uncompetitive NMDA receptor antagonists in the forced swim test in rats.
Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20060601
Title: Sigma1 and sigma2 receptor binding affinity and selectivity of SA4503 and fluoroethyl SA4503.
Journal: Synapse (New York, N.Y.) 20060501
Title: Evaluation of (+)-p-[11C]methylvesamicol for mapping sigma1 receptors: a comparison with [11C]SA4503.
Journal: Nuclear medicine and biology 20060501
Title: Function of sigma1 receptors in Parkinson's disease.
Journal: Acta neurologica Scandinavica 20050801
Title: Tumor imaging with 2 sigma-receptor ligands, 18F-FE-SA5845 and 11C-SA4503: a feasibility study.
Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20041101
Title: Behavioral pharmacology of sigma-ligands.
Journal: Pharmacopsychiatry 20041101
Title: Improved synthesis of [11C]SA4503, [11C]MPDX and [11C]TMSX by use of [11C]methyl triflate.
Journal: Annals of nuclear medicine 20040401
Title: Different brain kinetics of two sigma 1 receptor ligands, [3H](+)-pentazocine and [11C]SA4503, by P-glycoprotein modulation.
Journal: Synapse (New York, N.Y.) 20030501
Title: Sigma1 and dopamine D2 receptor occupancy in the mouse brain after a single administration of haloperidol and two dopamine D2-like receptor ligands.
Journal: Nuclear medicine and biology 20030501
Title: Age-related changes of the binding of [3h]SA4503 to sigma1 receptors in the rat brain.
Journal: Annals of nuclear medicine 20030201
Title: Potential antidepressant activity of sigma ligands.
Journal: Polish journal of pharmacology 20030101
Title: A potential antidepressant activity of SA4503, a selective sigma 1 receptor agonist.
Journal: Behavioural pharmacology 20021101
Title: Effects of sigma(1) receptor ligand MS-377 on D(2) antagonists-induced behaviors.
Journal: Pharmacology, biochemistry, and behavior 20021001
Title: Effect of SA4503 on the electrically evoked release of (3)H-acetylcholine from striatal and hippocampal rat brain slices.
Journal: Synapse (New York, N.Y.) 20021001
Title: Synthesis and evaluation of [18F]fluoroethyl SA4503 as a PET ligand for the sigma receptor.
Journal: Synapse (New York, N.Y.) 20020315
Title: [11C]Raclopride binding was reduced in vivo by sigma(1) receptor ligand SA4503 in the mouse brain, while [11C]SA4503 binding was not by raclopride.
Journal: Nuclear medicine and biology 20011001
Title: The selective sigma(1) receptor agonist, 1-(3,4-dimethoxyphenethyl)-4-(phenylpropyl)piperazine (SA4503), blocks the acquisition of the conditioned place preference response to (-)-nicotine in rats.
Journal: European journal of pharmacology 20010824
Title: The anti-amnesic effects of sigma1 (sigma1) receptor agonists confirmed by in vivo antisense strategy in the mouse.
Journal: Brain research 20010413
Title: Phencyclidine impairs latent learning in mice: interaction between glutamatergic systems and sigma(1) receptors.
Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20010401
Title: Repeated treatment with SA4503, a selective sigma1 receptor agonist, up-regulates alpha-adrenergic system. a behavioral study.
Journal: Polish journal of pharmacology 20010101
Title: SA4503, a novel cognitive enhancer with sigma1 receptor agonist properties, facilitates NMDA receptor-dependent learning in mice.
Journal: European journal of pharmacology 19970605
Title: Lever JR, et al. Sigma1 and sigma2 receptor binding affinity and selectivity of SA4503 and fluoroethyl SA4503. Synapse. 2006 May;59(6):350-8.
Title: Tuerxun T, et al. SA4503, a sigma-1 receptor agonist, prevents cultured cortical neurons from oxidative stress-induced cell death via suppression of MAPK pathway activation and glutamate receptor expression. Neurosci Lett. 2010 Jan 29;469(3):303-8.
