Title: Combined exposure to agriculture pesticides, paraquat and maneb, induces alterations in the N/OFQ-NOPr and PDYN/KOPr systems in rats: Relevance to sporadic Parkinson's disease.

Journal: Environmental toxicology20150101

Title: Cebranopadol: a novel potent analgesic nociceptin/orphanin FQ peptide and opioid receptor agonist.

Journal: The Journal of pharmacology and experimental therapeutics20140601

Title: Discovery of a novel series of orally active nociceptin/orphanin FQ (NOP) receptor antagonists based on a dihydrospiro(piperidine-4,7'-thieno[2,3-c]pyran) scaffold.

Journal: Journal of medicinal chemistry20140424

Title: Synthesis and structure-activity relationship studies in serotonin 5-HT(1A) receptor agonists based on fused pyrrolidone scaffolds.

Journal: European journal of medicinal chemistry20130501

Title: Roles of μ-opioid receptors and nociceptin/orphanin FQ peptide receptors in buprenorphine-induced physiological responses in primates.

Journal: The Journal of pharmacology and experimental therapeutics20121001

Title: Sex differences in the Nociceptin/Orphanin FQ system in rat spinal cord following chronic morphine treatment.

Journal: Neuropharmacology20120901

Title: Effect of stress on hippocampal nociceptin expression in the rat.

Journal: Stress (Amsterdam, Netherlands)20120701

Title: [Orphanin FQ combined with adriamycin reverses multi-drug resistance of K562/ADM and its molecular mechanism].

Journal: Zhongguo shi yan xue ye xue za zhi20120601

Title: Decreased plasma nociceptin/orphanin FQ levels after acute coronary syndromes.

Journal: Acta physiologica Hungarica20120601

Title: Nociceptin/orphanin FQ inhibition with SB612111 ameliorates dextran sodium sulfate-induced colitis.

Journal: European journal of pharmacology20120515

Title: Kainic acid-induced changes in the opioid/nociceptin system and the stress/toxicity pathways in the rat hippocampus.

Journal: Neurochemistry international20120501

Title: Nociceptin/orphanin FQ blockade of corticotropin-releasing factor-induced gamma-aminobutyric acid release in central amygdala is enhanced after chronic ethanol exposure.

Journal: Biological psychiatry20120415

Title: Opioid-related (ORL1) receptors are enriched in a subpopulation of sensory neurons and prolonged activation produces no functional loss of surface N-type calcium channels.

Journal: The Journal of physiology20120401

Title: Brain and whole-body imaging of nociceptin/orphanin FQ peptide receptor in humans using the PET ligand 11C-NOP-1A.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine20120301

Title: Elevated prepronociceptin, nociceptin/orphanin FQ and nocistatin concentrations in rat chronic constriction nerve injury and diabetic neuropathic pain models.

Journal: Neuroscience letters20120106

Title: Biphasic regulation of the acute μ-withdrawal and CCk-8 contracture responses by the ORL-1 system in guinea pig ileum.

Journal: Pharmacological research20120101

Title: Oligodendrocyte responses to buprenorphine uncover novel and opposing roles of μ-opioid- and nociceptin/orphanin FQ receptors in cell development: implications for drug addiction treatment during pregnancy.

Journal: Glia20120101

Title: Nociceptin induces hypophagia in the perifornical and lateral hypothalamic area.

Journal: PloS one20120101

Title: Capturing of the free cysteine residue in the ligand-binding site by affinity labeling of the ORL1 nociceptin receptor.

Journal: Bioorganic & medicinal chemistry20111215

Title: Differential pharmacological actions of methadone and buprenorphine in human embryonic kidney 293 cells coexpressing human μ-opioid and opioid receptor-like 1 receptors.

Journal: Neurochemical research20111101

Title: Orphanin FQ in the mediobasal hypothalamus facilitates sexual receptivity through the deactivation of medial preoptic nucleus mu-opioid receptors.

Journal: Hormones and behavior20111101

Title: Structural determinants of opioid and NOP receptor activity in derivatives of buprenorphine.

Journal: Journal of medicinal chemistry20111013

Title: Synergistic anti-allodynic effects of nociceptin/orphanin FQ and cannabinoid systems in neuropathic mice.

Journal: Pharmacology, biochemistry, and behavior20111001

Title: Synthesis, biological evaluation and structural characterization of novel glycopeptide analogues of nociceptin N/OFQ.

Journal: Organic & biomolecular chemistry20110907

Title: Functional heterogeneity of nociceptin/orphanin FQ receptors revealed by (+)-5a Compound and Ro 64-6198 in rat periaqueductal grey slices.

Journal: The international journal of neuropsychopharmacology20110801

Title: Substance P N-terminal fragment SP(1-7) attenuates chronic morphine tolerance and affects dynorphin B and nociceptin in rats.

Journal: Peptides20110801

Title: Development of nociceptin receptor (NOP) agonists and antagonists.

Journal: Medicinal research reviews20110701

Title: Nociceptin/orphanin FQ suppresses the excitability of neurons in the ventromedial nucleus of the hypothalamus.

Journal: The Journal of physiology20110701

Title: Antinociceptive effects of spinally administered nociceptin/orphanin FQ and its N-terminal fragments on capsaicin-induced nociception.

Journal: Peptides20110701

Title: [Mechanism of general anesthesia and antinociception].

Journal: Masui. The Japanese journal of anesthesiology20110501

Title: Synthesis and evaluation of radioligands for imaging brain nociceptin/orphanin FQ peptide (NOP) receptors with positron emission tomography.

Journal: Journal of medicinal chemistry20110428

Title: Quantitative study of the antagonistic effect of (-)-cis-1-Methyl-7-[[4-(2,6-dichlorophenyl)piperidin-1-yl]methyl]-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol (SB-612111) on nociceptin/orphanin FQ-mediated potassium channel activation in rat periaqueductal gray slices.

Journal: European journal of pharmacology20110425

Title: Pharmacological blockade or genetic knockout of the NOP receptor potentiates the rewarding effect of morphine in rats.

Journal: Drug and alcohol dependence20110401

Title: Effect of perinatal stress on the biogenic amine neurotransmitter level of the adult rat's brain.

Journal: International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience20110401

Title: Pharmacological characterization of a nociceptin receptor from zebrafish (Danio rerio).

Journal: Journal of molecular endocrinology20110401

Title: Antinociception by endogenous ligands at peripheral level.

Journal: Ideggyogyaszati szemle20110330

Title: GIRK channel-mediated inhibition of melanin-concentrating hormone neurons by nociceptin/orphanin FQ.

Journal: Journal of neurophysiology20110301

Title: Dopamine-nociceptin/orphanin FQ interactions in the substantia nigra reticulata of hemiparkinsonian rats: involvement of D2/D3 receptors and impact on nigro-thalamic neurons and motor activity.

Journal: Experimental neurology20110301

Title: Effects of structural analogues of nociceptin(1-13)NH₂ on brain antioxidant status in kainic acid-treated rats.

Journal: Cell biochemistry and function20110301

Title: Regulation of opioid gene expression in the rat brainstem by 3,4-methylenedioxymethamphetamine (MDMA): role of serotonin and involvement of CREB and ERK cascade.

Journal: Naunyn-Schmiedeberg's archives of pharmacology20110201

Title: The nociceptin/orphanin FQ receptor (NOP) as a target for drug abuse medications.

Journal: Current topics in medicinal chemistry20110101

Title: Where are the new cough treatments: a debriefing of recent clinical proof-of-concept trials with the NOP agonist SCH 486757.

Journal: Pharmacology20110101

Title: Nociceptin and its natural and specifically-modified fragments: Structural studies.

Journal: Biopolymers20101201

Title: Further evidence for an involvement of nociceptin/orphanin FQ in the pathophysiology of Parkinson's disease: a behavioral and neurochemical study in reserpinized mice.

Journal: Journal of neurochemistry20101201

Title: Nociceptin/orphanin FQ and the regulation of neuronal excitability in the rat bed nucleus of the stria terminalis: interaction with glucocorticoids.

Journal: Stress (Amsterdam, Netherlands)20101101

Title: Discovery of {1-[4-(2-{hexahydropyrrolo[3,4-c]pyrrol-2(1H)-yl}-1H-benzimidazol-1-yl)piperidin-1-yl]cyclooctyl}methanol, systemically potent novel non-peptide agonist of nociceptin/orphanin FQ receptor as analgesic for the treatment of neuropathic pain: design, synthesis, and structure-activity relationships.

Journal: Bioorganic & medicinal chemistry20101101

Title: Neuropeptide-mediated calcium signaling in the suprachiasmatic nucleus network.

Journal: The European journal of neuroscience20101101

Title: The role of the NOP receptor in regulating food intake, meal pattern, and the excitability of proopiomelanocortin neurons.

Journal: Neuropharmacology20100901

Title: Brain interstitial nociceptin/orphanin FQ levels are elevated in Parkinson's disease.

Journal: Movement disorders : official journal of the Movement Disorder Society20100815

Title: MPTP treatment increases expression of pre-pro-nociceptin/orphanin FQ mRNA in a subset of substantia nigra reticulata neurons.

Journal: Neuroscience20100811

Title: Endogenous nociceptin/orphanin-FQ in the dorsal hippocampus facilitates despair-related behavior.

Journal: Hippocampus20100801

Title: Orphanin FQ/nociceptin not only blocks but also reverses behavioral adaptive changes induced by repeated cocaine in mice.

Journal: Biological psychiatry20100801

Title: Nociceptin inhibits uterine contractions in term-pregnant rats by signaling through multiple pathways.

Journal: Biology of reproduction20100701

Title: Nocistatin excites rostral agranular insular cortex-periaqueductal gray projection neurons by enhancing transient receptor potential cation conductance via G(alphaq/11)-PLC-protein kinase C pathway.

Journal: Neuroscience20100616

Title: Dual motor response to l-dopa and nociceptin/orphanin FQ receptor antagonists in 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) treated mice: Paradoxical inhibition is relieved by D(2)/D(3) receptor blockade.

Journal: Experimental neurology20100601

Title: In vitro studies of the activity of newly sinthesized nociceptin / orphanin FQ receptor ligand analogues.

Journal: Protein and peptide letters20100501

Title: Selective inhibition of the NOP receptor in the ventrolateral periaqueductal gray attenuates the development and the expression of tolerance to morphine-induced antinociception in rats.

Journal: Peptides20100401

Title: Plasma nociceptin/orphanin FQ levels in response to the hyperventilation test in healthy subjects.

Journal: Peptides20100401

Title: Comparative biochemical and pharmacological characterization of a novel, NOP receptor selective hexapeptide, Ac-RYYRIR-ol.

Journal: Brain research bulletin20100316

Title: Endogenous nociceptin/orphanin FQ (N/OFQ) contributes to haloperidol-induced changes of nigral amino acid transmission and parkinsonism: a combined microdialysis and behavioral study in naïve and nociceptin/orphanin FQ receptor knockout mice.

Journal: Neuroscience20100310

Title: Nociceptin/Orphanin FQ in PAG modulates the release of amino acids, serotonin and norepinephrine in the rostral ventromedial medulla and spinal cord in rats.

Journal: Pain20100301

Title: The nociceptin/orphanin FQ system as a target for treating alcoholism.

Journal: CNS & neurological disorders drug targets20100301

Title: Role of innate and drug-induced dysregulation of brain stress and arousal systems in addiction: Focus on corticotropin-releasing factor, nociceptin/orphanin FQ, and orexin/hypocretin.

Journal: Brain research20100216

Title: Nociceptin modulates bronchoconstriction induced by sensory nerve activation in mouse lung.

Journal: American journal of respiratory cell and molecular biology20100201

Title: Swim stress enhances nociceptin/orphanin FQ-induced inhibition of rat dorsal raphe nucleus activity in vivo and in vitro: role of corticotropin releasing factor.

Journal: Neuropharmacology20100201

Title: Nociceptin/orphanin FQ peptide in hypothalamic neurones associated with the control of feeding behaviour.

Journal: Journal of neuroendocrinology20100201

Title: Heterodimerization of ORL1 and opioid receptors and its consequences for N-type calcium channel regulation.

Journal: The Journal of biological chemistry20100108

Title: Long-lasting antinociceptive spinal effects in primates of the novel nociceptin/orphanin FQ receptor agonist UFP-112.

Journal: Pain20100101

Title: The functional antiopioid action of the ventrolateral periaqueductal gray nociceptin/orphanin FQ and nociceptin receptor system underlies DAMGO analgesic tolerance.

Journal: Pharmacology20100101

Title: The nociceptin system and hippocampal cognition in mice: a pharmacological and genetic analysis.

Journal: Brain research20091211

Title: Receptor mediation and nociceptin inhibition of bradykinin-induced plasma extravasation in the knee joint of the rat.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.]20091201

Title: Spare interactions of highly potent [Arg(14),Lys(15)]nociceptin for cooperative induction of ORL1 receptor activation.

Journal: Bioorganic & medicinal chemistry20091201

Title: Endogenous nociceptin / orphanin FQ system involvement in hypothalamic-pituitary-adrenal axis responses: relevance to models of inflammation.

Journal: Journal of neuroendocrinology20091101

Title: Stress-related neuropeptides and alcoholism: CRH, NPY, and beyond.

Journal: Alcohol (Fayetteville, N.Y.)20091101

Title: Cloning and characterization of the rhesus monkey nociceptin/orphanin FQ receptor.

Journal: Genes & genetic systems20091001

Title: Effect of nociceptin/orphanin FQ on feeding behavior and hypothalamic neuropeptide expression in layer-type chicks.

Journal: General and comparative endocrinology20090901

Title: Plasma nociceptin/orphanin FQ levels rise after spontaneous episodes of angina, but not during induced myocardial ischemia.

Journal: Peptides20090901

Title: Temporal lobe epilepsy causes selective changes in mu opioid and nociceptin receptor binding and functional coupling to G-proteins in human temporal neocortex.

Journal: Neurobiology of disease20090901

Title: Spinal nociceptin mediates electroacupuncture-related modulation of visceral sympathoexcitatory reflex responses in rats.

Journal: American journal of physiology. Heart and circulatory physiology20090801

Title: Discriminatory synergistic effect of Trp-substitutions in superagonist [(Arg/Lys)(14), (Arg/Lys)(15)]nociceptin on ORL1 receptor binding and activation.

Journal: Bioorganic & medicinal chemistry20090801

Title: Identification of an additional supraspinal component to the analgesic mechanism of action of buprenorphine.

Journal: British journal of pharmacology20090701

Title: Estrogen-dependent, sex-specific modulation of mustard oil-induced secondary thermal hyperalgesia by orphanin FQ in the rat.

Journal: Neuroscience letters20090605

Title: Chronic intracerebroventricular infusion of nociceptin/orphanin FQ produces body weight gain by affecting both feeding and energy metabolism in mice.

Journal: Endocrinology20090601

Title: Effect of Nociceptin/Orphanin FQ (N/OFQ) and isoflurane on the corticosterone secretory response in mice lacking the N/OFQ prepropeptide (ppN/OFQ-/-).

Journal: Neuropeptides20090601

Title: Expression of the nociceptin receptor during zebrafish development: influence of morphine and nociceptin.

Journal: International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience20090601

Title: Involvement of NMDA receptor in nociceptive effects elicited by intrathecal [Tyr6] gamma2-MSH(6-12), and the interaction with nociceptin/orphanin FQ in pain modulation in mice.

Journal: Brain research20090519

Title: Antinociceptive effects of nociceptin/orphanin FQ administered intrathecally in monkeys.

Journal: The journal of pain : official journal of the American Pain Society20090501

Title: Nociceptin-induced modulation of human T cell function.

Journal: Peptides20090501

Title: Endogenous nociceptin modulates diet preference independent of motivation and reward.

Journal: Physiology & behavior20090420

Title: The hypothalamus-pituitary-adrenal axis does not influence the protective effects of nociceptin/orphanin FQ on the rat gastric mucosa.

Journal: Regulatory peptides20090410

Title: Effect of neonatal nociceptin or nocistatin imprinting on the brain concentration of biogenic amines and their metabolites.

Journal: Brain & development20090401

Title: Nociceptin/orphanin FQ-induced food intake and cocaine amphetamine regulated transcript gene expression in strains derived from rats prone (WOKW) and resistant (Dark Agouti) to metabolic syndrome.

Journal: Peptides20090401

Title: Intrinsic and synaptic long-term depression of NTS relay of nociceptin- and capsaicin-sensitive cardiopulmonary afferents hyperactivity.

Journal: Pflugers Archiv : European journal of physiology20090301

Title: Alterations of N/OFQ and NOP receptor gene expression in the substantia nigra and caudate putamen of MPP+ and 6-OHDA lesioned rats.

Journal: Neuropharmacology20090301

Title: Novel non-peptide nociceptin/orphanin FQ receptor agonist, 1-[1-(1-Methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3-piperidinyl]-1H-benzimidazole: design, synthesis, and structure-activity relationship of oral receptor occupancy in the brain for orally potent antianxiety drug.

Journal: Journal of medicinal chemistry20090212

Title: Chronic high-NaCl intake prolongs the cardiorenal responses to central N/OFQ and produces regional changes in the endogenous brain NOP receptor system.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology20090201

Title: Nociceptin/orphanin FQ peptide receptor agonist Ac-RYYRWKKKKKKK-NH2 (ZP120) induces antinatriuresis in rats by stimulation of amiloride-sensitive sodium reabsorption.

Journal: The Journal of pharmacology and experimental therapeutics20090201

Title: Peripheral anti-nociceptive effect of nociceptin/orphanin FQ in inflammation and stress-induced colonic hyperalgesia in rats.

Journal: Pain20090201

Title: Distinct effects of nociceptin analogs on scopolamine-induced memory impairment in mice.

Journal: European journal of pharmacology20090114

Title: Nociceptin produces antinociception after spinal administration in amphibians.

Journal: Pharmacology, biochemistry, and behavior20090101

Title: Inhibition of serotonin outflow by nociceptin/orphaninFQ in dorsal raphe nucleus slices from normal and stressed rats: Role of corticotropin releasing factor.

Journal: Neurochemistry international20090101

Title: Nocistatin and nociceptin given centrally induce opioid-mediated gastric mucosal protection.

Journal: Peptides20081201

Title: cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.

Journal: Journal of medicinal chemistry20081127

Title: Expression of morphine-conditioned place preference is more vulnerable than naloxone-conditioned place aversion to disruption by nociceptin in mice.

Journal: Neuroscience letters20081003

Title: Activation of nociceptin/orphanin FQ-NOP receptor system inhibits tyrosine hydroxylase phosphorylation, dopamine synthesis, and dopamine D(1) receptor signaling in rat nucleus accumbens and dorsal striatum.

Journal: Journal of neurochemistry20081001

Title: Capsaicin inhibits the in vitro binding of peptides selective for mu- and kappa-opioid, and nociceptin-receptors.

Journal: Brain research bulletin20080930

Title: Coupling specificity of NOP opioid receptors to pertussis-toxin-sensitive Galpha proteins in adult rat stellate ganglion neurons using small interference RNA.

Journal: Journal of neurophysiology20080901

Title: Effect and mechanism of nociceptin/orphanin FQ reversing multi-drug resistance in K562/ADM cell.

Journal: Die Pharmazie20080901

Title: Involvement of the GABA/benzodiazepine receptor in the axiolytic-like effect of nociceptin/orphanin FQ.

Journal: European journal of pharmacology20080820

Title: Dysregulation of nociceptin/orphanin FQ activity in the amygdala is linked to excessive alcohol drinking in the rat.

Journal: Biological psychiatry20080801

Title: GABA(A) signalling is involved in N/OFQ anxiolytic-like effects but not in nocistatin anxiogenic-like action as evaluated in the mouse elevated plus maze.

Journal: Peptides20080801

Title: Central G-alpha subunit protein-mediated control of cardiovascular function, urine output, and vasopressin secretion in conscious Sprague-Dawley rats.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology20080801

Title: Orphanin FQ and glutamate connection in the regulation of gonadotropin-releasing hormone secretion in the preoptic area of conscious male rats.

Journal: Neuroscience letters20080801

Title: Alterations in the level of OFQ/N-IR in rat brain regions by cocaine.

Journal: Neuropharmacology20080801

Title: Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity.

Journal: Journal of medicinal chemistry20080724

Title: Neuropeptide FF receptors antagonist, RF9, attenuates opioid-evoked hypothermia in mice.

Journal: Peptides20080701

Title: Hypocretin/orexin and nociceptin/orphanin FQ coordinately regulate analgesia in a mouse model of stress-induced analgesia.

Journal: The Journal of clinical investigation20080701

Title: Nociceptin and urotensin-II concentrations in critically ill patients with sepsis.

Journal: British journal of anaesthesia20080601

Title: Nociceptin attenuates methamphetamine abstinence-induced withdrawal-like behavior in planarians.

Journal: Neuropeptides20080601

Title: [Analysis of central mechanisms involved in gastric mucosal integrity].

Journal: Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology20080601

Title: A neuropeptide-centric view of psychostimulant addiction.

Journal: British journal of pharmacology20080501

Title: Endogenous nociceptin (orphanin FQ) suppresses basal hedonic state and acute reward responses to methamphetamine and ethanol, but facilitates chronic responses.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology20080301

Title: Designed modification of partial agonist of ORL1 nociceptin receptor for conversion into highly potent antagonist.

Journal: Bioorganic & medicinal chemistry20080301

Title: Nociceptin receptor impairs recognition memory via interaction with NMDA receptor-dependent mitogen-activated protein kinase/extracellular signal-regulated kinase signaling in the hippocampus.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20080227

Title: Role of nociceptin/orphanin FQ and the pseudopeptide [Phe1Psi(CH2NH)Gly2]-nociceptin(1-13)-NH2 and their interaction with classic opioids in the modulation of thermonociception in the land snail Helix aspersa.

Journal: European journal of pharmacology20080226

Title: Nociceptin/orphanin FQ reverses mecamylamine-induced learning and memory impairment as well as decrease in hippocampal acetylcholine release in the rat.

Journal: Brain research20080221

Title: Distinctive role of central histamine H3 receptor in various orexigenic pathways.

Journal: European journal of pharmacology20080128

Title: Estrogen and progesterone modulate [35S]GTPgammaS binding to nociceptin receptors.

Journal: Neuroendocrinology20080101

Title: Role of medullary GABA, opioids, and nociceptin in prolonged inhibition of cardiovascular sympathoexcitatory reflexes during electroacupuncture in cats.

Journal: American journal of physiology. Heart and circulatory physiology20071201

Title: Proinflammatory and vasodilator effects of nociceptin/orphanin FQ in the rat mesenteric microcirculation are mediated by histamine.

Journal: American journal of physiology. Heart and circulatory physiology20071101

Title: Effects of receptor density on Nociceptin/OrphaninFQ peptide receptor desensitisation: studies using the ecdysone inducible expression system.

Journal: Naunyn-Schmiedeberg's archives of pharmacology20071101

Title: Regulation of nociceptin/orphaninFQ secretion by immune cells and functional modulation of interleukin-2.

Journal: Peptides20071101

Title: [Prostaglandin and nociceptin/orphanin FQ].

Journal: Masui. The Japanese journal of anesthesiology20071101

Title: Involvement of cocaine-amphetamine regulated transcript in the differential feeding responses to nociceptin/orphanin FQ in dark agouti and Wistar Ottawa Karlsburg W rats.

Journal: Peptides20071001

Title: Regarding 'Buprenorphine reduces alcohol drinking through activation of the nociceptin/orphanin FQ-NOP receptor system'.

Journal: Biological psychiatry20070915

Title: In vitro pharmacological characterisation of a novel cyclic nociceptin/orphanin FQ analogue c[Cys(7,10)]N/OFQ(1-13)NH (2).

Journal: Naunyn-Schmiedeberg's archives of pharmacology20070801

Title: Nociceptin (1-13)NH2 inhibits stimulated calcitonin-gene-related-peptide release from primary cultures of rat trigeminal ganglia neurones.

Journal: Cephalalgia : an international journal of headache20070801

Title: Role of hypothalamus nociceptin/orphanin FQ in pre-ovulatory luteinizing hormone surge of estrogen and progesterone-primed, ovariectomized rats.

Journal: Acta pharmacologica Sinica20070801

Title: ORL-1 receptor mediates the action of nociceptin on ascending myenteric reflex pathways in rats.

Journal: Gastroenterology20070801

Title: Effect of orphanin FQ/nociceptin (OFQ/N) and isoflurane on the prolactin secretory response in OFQ/N knockout mice.

Journal: Peptides20070801

Title: Synthesis and biological activity of nociceptin/orphanin FQ analogues substituted in position 7 or 11 with Calpha,alpha-dialkylated amino acids.

Journal: Bioorganic & medicinal chemistry20070701

Title: Blockade of the nociceptin/orphanin FQ/NOP receptor system in the rat ventrolateral periaqueductal gray potentiates DAMGO analgesia.

Journal: Peptides20070701

Title: Nociceptin/orphanin FQ decreases serotonin efflux in the rat brain but in contrast to a kappa-opioid has no antagonistic effect on mu-opioid-induced increases in serotonin efflux.

Journal: Neuroscience20070615

Title: Structural modelling and mutation analysis of a nociceptin receptor and its ligand complexes.

Journal: Journal of biochemistry20070601

Title: The neuropeptide nociceptin is a synaptically released endogenous inhibitor of hippocampal long-term potentiation.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20070502

Title: Bradycardia elicited by microinjections of nociceptin/orphanin FQ into the intermediolateral cell column at T1-T2 in the rat.

Journal: Neuroscience letters20070412

Title: Signal pathways coupled to activation of neuronal nitric oxide synthase in the spinal cord by nociceptin/orphanin FQ.

Journal: Neuropharmacology20070401

Title: Possible involvement of endogenous nociceptin/orphanin FQ in the pain-related behavioral responses induced by its own metabolite, nociceptin/orphanin FQ(14-17).

Journal: Peptides20070301

Title: Release of orphanin FQ/nociceptin in the medial preoptic nucleus and ventromedial nucleus of the hypothalamus facilitates lordosis.

Journal: Hormones and behavior20070301

Title: Involvement of local orphanin FQ in the development of analgesic tolerance induced by morphine microinjections into the dorsal raphe nucleus of rats.

Journal: Neuroscience letters20070221

Title: Nociceptin/orphanin FQ blocks the antinociception induced by mu, kappa and delta opioid agonists on the cold water tail-flick test.

Journal: European journal of pharmacology20070214

Title: Buprenorphine reduces alcohol drinking through activation of the nociceptin/orphanin FQ-NOP receptor system.

Journal: Biological psychiatry20070101

Title: Orphanin FQ/nociceptin interacts with the basolateral amygdala noradrenergic system in memory consolidation.

Journal: Learning & memory (Cold Spring Harbor, N.Y.)20070101

Title: Nociceptin/orphanin FQ peptide receptors: pharmacology and clinical implications.

Journal: Current drug targets20070101

Title: Chronic cocaine produces decreases in N/OFQ peptide levels in select rat brain regions.

Journal: Journal of molecular neuroscience : MN20070101

Title: Involvement of local orphanin FQ in the tolerance induced by repeated microinjections of morphine into ventrolateral periaqueductal gray in rats.

Journal: Pharmacology20070101

Title: Regulation of the prepronociceptin gene and its effect on neuronal differentiation.

Journal: Gene20061215

Title: Activation of opioid receptor like-1 receptor in the spinal cord produces sex-specific antinociception in the rat: estrogen attenuates antinociception in the female, whereas testosterone is required for the expression of antinociception in the male.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20061213

Title: Effect of novel nociceptin/orphanin FQ-NOP receptor ligands on ethanol drinking in alcohol-preferring msP rats.

Journal: Peptides20061201

Title: Chronic intracerebroventricular infusion of nociceptin/orphanin FQ increases food and ethanol intake in alcohol-preferring rats.

Journal: Peptides20061101

Title: Interaction between nociceptin/orphanin FQ (N/OFQ) and GABA in response to feeding.

Journal: Physiology & behavior20061030

Title: Nociceptin levels in the cerebrospinal fluid of chronic pain patients with or without intrathecal administration of morphine.

Journal: Journal of pain and symptom management20061001

Title: Coupling of ORL1 (NOP) receptor to G proteins is decreased in the nucleus accumbens of anxious relative to non-anxious mice.

Journal: Brain research20060919

Title: The nociceptin receptor antagonist [Nphe1,Arg14,Lys15]nociceptin/orphanin FQ-NH2 blocks the stimulatory effects of nociceptin/orphanin FQ on the HPA axis in rats.

Journal: Neuroscience20060915

Title: Pharmacological treatment of alcohol dependence: target symptoms and target mechanisms.

Journal: Pharmacology & therapeutics20060901

Title: Anxiolytic-like effects of nociceptin/orphanin FQ in the elevated plus maze and in the conditioned defensive burying test in rats.

Journal: Peptides20060901

Title: Discovery of 4-substituted-8-(2-hydroxy-2-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one as a novel class of highly selective GlyT1 inhibitors with improved metabolic stability.

Journal: Bioorganic & medicinal chemistry letters20060815

Title: Design and synthesis of 4-substituted-8-(2-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one as a novel class of GlyT1 inhibitors: achieving selectivity against the mu opioid and nociceptin/orphanin FQ peptide (NOP) receptors.

Journal: Bioorganic & medicinal chemistry letters20060815

Title: 4-Substituted-8-(1-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one as a novel class of highly selective GlyT1 inhibitors with superior pharmacological and pharmacokinetic parameters.

Journal: Bioorganic & medicinal chemistry letters20060815

Title: Stimulation of sensory neuropeptide release by nociceptin/orphanin FQ leads to hyperaemia in acutely inflamed rat knees.

Journal: British journal of pharmacology20060801

Title: Endogenous orphanin FQ/nociceptin is involved in the development of morphine tolerance.

Journal: The Journal of pharmacology and experimental therapeutics20060701

Title: [Endogenous nociceptin level in ischemic stroke: connection to serotonin system].

Journal: Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology20060601

Title: Site-specific estrogen and progestin regulation of orphanin FQ/nociceptin and nociceptin opioid receptor mRNA expression in the female rat limbic hypothalamic system.

Journal: The Journal of comparative neurology20060510

Title: Two C-terminal amino acids, Ser(334) and Ser(335), are required for homologous desensitization and agonist-induced phosphorylation of opioid receptor-like 1 receptors.

Journal: Cellular signalling20060501

Title: Nociceptin/orphanin FQ evokes knee joint pain in rats via a mast cell independent mechanism.

Journal: Neuroscience letters20060501

Title: Effects of melatonin on orphanin FQ/nociceptin-induced hyperalgesia in mice.

Journal: Brain research20060426

Title: ORL1 and opioid receptor preferences of nociceptin and dynorphin A analogues with Dmp substituted for N-terminal aromatic residues.

Journal: Bioorganic & medicinal chemistry20060401

Title: Distribution of nociceptin and Ro64-6198 activated [35S]-GTPgammaS binding in the rat brain.

Journal: Neuropeptides20060401

Title: Nociceptin-induced histamine release in the brain: comparison with compound 48/80- and substance P-induced amine secretions.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.]20060401

Title: Increased opioid receptor binding and G protein coupling in the accumbens and ventral tegmental area of postnatal day 2 rats.

Journal: Neuroscience letters20060313

Title: Transcriptional profiling of brain-derived-neurotrophic factor-induced neuronal plasticity: a novel role for nociceptin in hippocampal neurite outgrowth.

Journal: Journal of neurobiology20060301

Title: Effect of nociceptin in acid-evoked cough and airway sensory nerve activation in guinea pigs.

Journal: American journal of respiratory and critical care medicine20060201

Title: Pharmacological characterization of inhibitory effects of postsynaptic opioid and cannabinoid receptors on calcium currents in neonatal rat nucleus tractus solitarius.

Journal: British journal of pharmacology20060201

Title: The opioid peptide nociceptin/orphanin FQ mediates prostaglandin E2-induced allodynia, tactile pain associated with nerve injury.

Journal: The European journal of neuroscience20060201

Title: Identification of mature nocistatin and nociceptin in human brain and cerebrospinal fluid by mass spectrometry combined with affinity chromatography and HPLC.

Journal: Peptides20060101

Title: Role of nociceptin and opioid receptor like 1 on entrainment function in the rat suprachiasmatic nucleus.

Journal: Neuroscience20060101

Title: Effects of [Nphe1]nociceptin(1-13)NH2, [Phe1(CH2-NH)Gly2]nociceptin(1- 13)NH2, and nocistatin on nociceptin inhibited constrictions of guinea pig isolated bronchus.

Journal: Protein and peptide letters20060101

Title: Opioid receptor-like (ORL1) receptor utilizes both G(oA) and G(oB) for signal transduction.

Journal: Protein and peptide letters20060101

Title: In vitro binding and functional studies of Ac-RYYRIK-ol and its derivatives, novel partial agonists of the nociceptin/orphanin F/Q receptor.

Journal: Neuro-Signals20060101

Title: Morphine-induced overexpression of prepro-nociceptin/orphanin FQ in cultured astrocytes.

Journal: Peptides20051201

Title: Effects of intraplantar injections of nociceptin and its N-terminal fragments on nociceptive and desensitized responses induced by capsaicin in mice.

Journal: Peptides20051201

Title: Nociceptin/orphanin FQ-induced delay in gastric emptying: role of central corticotropin-releasing factor and glucocorticoid receptors.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society20051201

Title: Effect of supraspinal Nocistatin on Nociceptin/Orphanin FQ antagonism of selective opioid analgesia.

Journal: Neuroscience letters20051028

Title: Blockade of nociceptin/orphanin FQ transmission attenuates symptoms and neurodegeneration associated with Parkinson's disease.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20051019

Title: [A role of nociceptin in the entrainment mechanism of the biological clock].

Journal: Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology20051001

Title: Peripheral mechanisms involved in gastric mucosal protection by intracerebroventricular and intraperitoneal nociceptin in rats.

Journal: Endocrinology20050901

Title: Regulation of vascular reactivity by established and emerging GPCRs.

Journal: Trends in pharmacological sciences20050901

Title: The effects of [Arg14, Lys15] nociceptin/orphanin FQ, a highly potent agonist of the NOP receptor, on in vitro and in vivo gastrointestinal functions.

Journal: Peptides20050901

Title: NOC/oFQ activates ERK and JNK but not p38 MAPK to impair prostaglandin cerebrovasodilation after brain injury.

Journal: Brain research20050823

Title: Opioid receptor-like 1 (NOP) receptors in the rat dorsal raphe nucleus: evidence for localization on serotoninergic neurons and functional adaptation after 5,7-dihydroxytryptamine lesion.

Journal: Journal of neuroscience research20050815

Title: Lack of involvement of dopamine and serotonin during the orphanin FQ/Nociceptin (OFQ/N)-induced prolactin secretory response.

Journal: Life sciences20050812

Title: Hypothalamic cocaine- and amphetamine-regulated transcript (CART) and agouti-related protein (AgRP) neurons coexpress the NOP1 receptor and nociceptin alters CART and AgRP release.

Journal: Endocrinology20050801

Title: Orphanin FQ/nociceptin potentiates [D-Ala2,N-Me-Phe4,Gly5-ol]-enkephalin-Induced mu-opioid receptor phosphorylation.

Journal: Molecular pharmacology20050801

Title: Nociceptin/orphanin FQ stimulates human monocyte chemotaxis via NOP receptor activation.

Journal: Peptides20050801

Title: Nociceptin/orphanin FQ inhibits electrically induced contractions of the human bronchus via NOP receptor activation.

Journal: Peptides20050801

Title: Effects of maternal separation on voluntary ethanol intake and brain peptide systems in female Wistar rats.

Journal: Pharmacology, biochemistry, and behavior20050701

Title: Tryptophan replacement in the nociceptin/orphanin FQ receptor ligand Ac-RYYRWK-NH2.

Journal: The journal of peptide research : official journal of the American Peptide Society20050701

Title: Synthesis and biological studies of nociceptin derivatives containing the DTPA chelating group for further labeling with therapeutic radionuclides.

Journal: Peptides20050701

Title: Nociceptin system does not affect MAC of volatile anaesthetics.

Journal: Acta anaesthesiologica Scandinavica20050701

Title: Modeling of overloaded gradient elution of nociceptin/orphanin FQ in reversed-phase liquid chromatography.

Journal: Journal of chromatography. A20050624

Title: Nociceptin in rVLM mediates electroacupuncture inhibition of cardiovascular reflex excitatory response in rats.

Journal: Journal of applied physiology (Bethesda, Md. : 1985)20050601

Title: Mechanism of cardiovascular effects of nociceptin microinjected into the nucleus tractus solitarius of the rat.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology20050601

Title: Molecular insight into the electrostatic membrane surface potential by 14n/31p MAS NMR spectroscopy: nociceptin-lipid association.

Journal: Journal of the American Chemical Society20050511

Title: Enhanced antinociception by intracerebroventricularly and intrathecally-administered orexin A and B (hypocretin-1 and -2) in mice.

Journal: Peptides20050501

Title: Spinal opioid receptor like1 receptor agonist, but not N-methyl-D-aspartic acid antagonist, reverses the secondary mechanical allodynia induced by intradermal injection of capsaicin in rats.

Journal: Anesthesia and analgesia20050401

Title: Stimulating effect of nociceptin on histamine release in the rat brain?

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.]20050401

Title: The interaction of highly helical structural mutants with the NOP receptor discloses the role of the address domain of nociceptin/orphanin FQ.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany)20050318

Title: The nociceptin pharmacophore site for opioid receptor binding derived from the NMR structure and bioactivity relationships.

Journal: The Journal of biological chemistry20050304

Title: Activation of the nociceptin/orphanin FQ receptor reduces bronchoconstriction and microvascular leakage in a rabbit model of gastroesophageal reflux.

Journal: British journal of pharmacology20050301

Title: Substance P and opioid peptidergic innervation of the anterior eye segment of the rat: an immunohistochemical study.

Journal: Journal of anatomy20050301

Title: An investigation of binding sites for paracetamol in the mouse brain and spinal cord.

Journal: European journal of pharmacology20050131

Title: Melatonin exerts its analgesic actions not by binding to opioid receptor subtypes but by increasing the release of beta-endorphin an endogenous opioid.

Journal: Brain research bulletin20050130

Title: Nociceptin/orphanin FQ prevents ethanol-induced gastric lesions in the rat.

Journal: Regulatory peptides20050115

Title: Nociceptin/orphanin FQ prevents the antinociceptive action of paracetamol on the rat hot plate test.

Journal: European journal of pharmacology20050110

Title: Orphanin FQ antagonizes the inhibition of Ca(2+) currents induced by mu-opioid receptors.

Journal: Journal of molecular neuroscience : MN20050101

Title: Opioid-modulating peptides: mechanisms of action.

Journal: Current topics in medicinal chemistry20050101

Title: Nociceptin/orphanin FQ (N/OFQ) inhibits excitatory and inhibitory synaptic signaling in the suprachiasmatic nucleus (SCN).

Journal: Neuroscience20050101

Title: A new synthetic approach of N-(4-amino-2-methylquinolin-6-yl)-2-(4-ethylphenoxymethyl)benzamide (JTC-801) and its analogues and their pharmacological evaluation as nociceptin receptor (NOP) antagonists.

Journal: European journal of medicinal chemistry20041201

Title: Blockade of nociceptin/orphanin FQ transmission in rat substantia nigra reverses haloperidol-induced akinesia and normalizes nigral glutamate release.

Journal: Journal of neurochemistry20041201

Title: Ro 64-6198 [(1S,3aS)-8-(2,3,3a,4,5,6-Hexahydro-1H-phenalen-1-yl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one] acts differently from nociceptin/orphanin FQ in rat periaqueductal gray slices.

Journal: The Journal of pharmacology and experimental therapeutics20041101

Title: Involvement of the histaminergic system in the nociceptin-induced pain-related behaviors in the mouse spinal cord.

Journal: Pain20041101

Title: Effects of nociceptin/orphanin FQ and endomorphin-1 on glutamate and GABA release, intracellular [Ca2+] and cell excitability in primary cultures of rat cortical neurons.

Journal: Neuropharmacology20041101

Title: The relaxant effect of nociceptin on porcine coronary arterial ring segments.

Journal: Canadian journal of physiology and pharmacology20041101

Title: Role of nociceptin in the modulation of nociception in the arcuate nucleus of rats.

Journal: Brain research20041029

Title: Molecular mechanisms underlying calcium current modulation by nociceptin.

Journal: Neuroreport20041005

Title: Post-triptan era for the treatment of acute migraine.

Journal: Current pain and headache reports20041001

Title: Kainate seizures increase nociceptin/orphanin FQ release in the rat hippocampus and thalamus: a microdialysis study.

Journal: Journal of neurochemistry20041001

Title: Influence of nociceptin(1-17) fragments and its tyrosine-substituted derivative on morphine-withdrawal signs in rats.

Journal: Neuropeptides20041001

Title: Pharmacological characterization of nociceptin/orphanin FQ receptors, a novel opioid receptor family, in the midbrain periaqueductal gray.

Journal: Annals of the New York Academy of Sciences20041001

Title: Nociceptin/orphanin FQ, hedonic state and the response to abused drugs.

Journal: Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology20041001

Title: Structure-activity studies on high affinity NOP-active hexapeptides.

Journal: The journal of peptide research : official journal of the American Peptide Society20040901

Title: Nociceptin inhibits vanilloid TRPV-1-mediated neurosensitization induced by fenoterol in human isolated bronchi.

Journal: Naunyn-Schmiedeberg's archives of pharmacology20040901

Title: Study in vitro and in vivo of nociceptin/orphanin FQ(1-13)NH2 analogues substituting N-Me-Gly for Gly2 or Gly3.

Journal: Peptides20040801

Title: Blockade of nociceptin/orphanin FQ receptor signaling in rat substantia nigra pars reticulata stimulates nigrostriatal dopaminergic transmission and motor behavior.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20040728

Title: Opioid receptor-like 1 stimulation in the collecting duct induces aquaresis through vasopressin-independent aquaporin-2 downregulation.

Journal: American journal of physiology. Renal physiology20040701

Title: Intradermal nociceptin elicits itch-associated responses through leukotriene B(4) in mice.

Journal: The Journal of investigative dermatology20040701

Title: Evidence for an exclusive antinociceptive effect of nociceptin/orphanin FQ, an endogenous ligand for the ORL1 receptor, in two animal models of neuropathic pain.

Journal: Pain20040701

Title: Non-opioid actions of opioid peptides.

Journal: Life sciences20040604

Title: Ligand-regulated internalization of the opioid receptor-like 1: a confocal study.

Journal: Endocrinology20040601

Title: Nonpeptide/peptide chimeric ligands for the nociceptin/orphanin FQ receptor: design, synthesis and in vitro pharmacological activity.

Journal: The journal of peptide research : official journal of the American Peptide Society20040601

Title: Antidepressant-like effects of the nociceptin/orphanin FQ receptor antagonist UFP-101: new evidence from rats and mice.

Journal: Naunyn-Schmiedeberg's archives of pharmacology20040601

Title: Gastrointestinal effects of intracerebroventricularly injected nociceptin/orphaninFQ in rats.

Journal: Peptides20040601

Title: The receptor-Galpha fusion protein as a tool for ligand screening: a model study using a nociceptin receptor-Galphai2 fusion protein.

Journal: Journal of biochemistry20040501

Title: Effects of nociceptin on the exploratory behavior of mice in the hole-board test.

Journal: European journal of pharmacology20040405

Title: Functional coupling of the nociceptin/orphanin FQ receptor in dog brain membranes.

Journal: Brain research20040402

Title: Nociceptin/orphanin FQ modulates human T cell function in vitro.

Journal: Journal of neuroimmunology20040401

Title: Exogenous, but not endogenous nociceptin modulates mesolimbic dopamine release in mice.

Journal: Journal of neurochemistry20040401

Title: Central administration of nociceptin/orphanin FQ blocks the acquisition of conditioned place preference to morphine and cocaine, but not conditioned place aversion to naloxone in mice.

Journal: Psychopharmacology20040301

Title: Attenuation of ethanol self-administration and of conditioned reinstatement of alcohol-seeking behaviour by the antiopioid peptide nociceptin/orphanin FQ in alcohol-preferring rats.

Journal: Psychopharmacology20040301

Title: Nociceptin inhibits airway microvascular leakage induced by HCl intra-oesophageal instillation.

Journal: British journal of pharmacology20040301

Title: Pharmacological profile of nociceptin/orphanin FQ receptors regulating 5-hydroxytryptamine release in the mouse neocortex.

Journal: The European journal of neuroscience20040301

Title: Orphanin FQ/nociceptin suppresses motor activity through an action along the mesoaccumbens axis in rats.

Journal: Journal of psychiatry & neuroscience : JPN20040301

Title: Tonic inhibition by orphanin FQ/nociceptin of noradrenaline neurotransmission in the amygdala.

Journal: European journal of pharmacology20040206

Title: Nociceptin/orphanin FQ alters prostaglandin cerebrovascular action following brain injury.

Journal: Journal of neurotrauma20040201

Title: Dissociated histaminergic neuron cultures from the tuberomammillary nucleus of rats: culture methods and ghrelin effects.

Journal: Journal of neuroscience methods20040130

Title: Cholecystokinin fails to block the spinal inhibitory effects of nociceptin in sham operated and neuropathic rats.

Journal: European journal of pharmacology20040126

Title: The design and synthesis of a novel quinolizidine template for potent opioid and opioid receptor-like (ORL1, NOP) receptor ligands.

Journal: Bioorganic & medicinal chemistry letters20040105

Title: Nociceptin/orphanin FQ increases anxiety-related behavior and circulating levels of corticosterone during neophobic tests of anxiety.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology20040101

Title: Evidence in locomotion test for the functional heterogeneity of ORL-1 receptors.

Journal: British journal of pharmacology20040101

Title: Nociceptin/orphanin FQ modulation of rat midbrain dopamine neurons in primary culture.

Journal: Neuroscience20040101

Title: Anti-opioid systems in morphine tolerance and addiction--locus-specific involvement of nociceptin and the NMDA receptor.

Journal: Novartis Foundation symposium20040101

Title: Cerebrospinal fluid levels of opioid peptides in fibromyalgia and chronic low back pain.

Journal: BMC musculoskeletal disorders20040101

Title: [The mechanism of antiarrhythmic action of the endogenous ORL1 receptor agonist nociceptin].

Journal: Eksperimental'naia i klinicheskaia farmakologiia20040101

Title: Orphanin FQ/nociceptin blocks methamphetamine place preference in rats.

Journal: Neuroreport20031219

Title: Nociceptin inhibition of acetylcholine efflux from different brain areas.

Journal: Neuroreport20031202

Title: Pharmacological profile of the cyclic nociceptin/orphanin FQ analogues c[Cys10,14]N/OFQ(1-14)NH2 and c[Nphe1,Cys10,14]N/OFQ(1-14)NH2.

Journal: Naunyn-Schmiedeberg's archives of pharmacology20031201

Title: [Changes and significance of orphanin and serotonin in patients with postpartum depression].

Journal: Zhonghua fu chan ke za zhi20031201

Title: Lack of mu-opioid receptor-mediated G-protein activation in the spinal cord of mice lacking Exon 1 or Exons 2 and 3 of the MOR-1 gene.

Journal: Journal of pharmacological sciences20031201

Title: Synthetic peptides in the form of dendrimers become resistant to protease activity.

Journal: The Journal of biological chemistry20031121

Title: Effect of JTC-801 (nociceptin antagonist) on neuropathic pain in a rat model.

Journal: Neuroscience letters20031120

Title: Buprenorphine-induced antinociception is mediated by mu-opioid receptors and compromised by concomitant activation of opioid receptor-like receptors.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20031112

Title: N-terminal modifications leading to peptide ORL1 partial agonists and antagonists.

Journal: The journal of peptide research : official journal of the American Peptide Society20031101

Title: Human neutrophils as a source of nociceptin: a novel link between pain and inflammation.

Journal: Biochemistry20030909

Title: Glycinergic inputs to cardiac vagal neurons in the nucleus ambiguus are inhibited by nociceptin and mu-selective opioids.

Journal: Journal of neurophysiology20030901

Title: Nociceptin inhibits acquisition of amphetamine-induced place preference and sensitization to stereotypy in rats.

Journal: European journal of pharmacology20030808

Title: Effects of orexin (hypocretin) on GIRK channels.

Journal: Journal of neurophysiology20030801

Title: Reciprocal interactions between the amygdala and ventrolateral periaqueductal gray in mediating of Q/N(1-17)-induced analgesia in the rat.

Journal: Brain research20030801

Title: Neuronal mechanism of nociceptin-induced modulation of learning and memory: involvement of N-methyl-D-aspartate receptors.

Journal: Molecular psychiatry20030801

Title: Long-term effects on brain opioid and opioid receptor like-1 receptors after short periods of maternal separation in rats.

Journal: Neuroscience letters20030724

Title: Nocistatin and prepro-nociceptin/orphanin FQ 160-187 cause nociception through activation of Gi/o in capsaicin-sensitive and of Gs in capsaicin-insensitive nociceptors, respectively.

Journal: The Journal of pharmacology and experimental therapeutics20030701

Title: Binding and GTPgammaS autoradiographic analysis of preproorphanin precursor peptide products at the ORL1 and opioid receptors.

Journal: Journal of chemical neuroanatomy20030701

Title: Involvement of sympathetic efferents but not capsaicin-sensitive afferents in nociceptin-mediated dual control of rat synovial blood flow.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology20030601

Title: Effect of neonatal beta-endorphin imprinting on sexual behavior and brain serotonin level in adult rats.

Journal: Life sciences20030523

Title: In vivo pain-inhibitory role of nociceptin/orphanin FQ in spinal cord.

Journal: The Journal of pharmacology and experimental therapeutics20030501

Title: Lack of an interaction between orexinergic and opioid/nociceptinergic systems in rat cerebrocortical slices.

Journal: Neuroscience letters20030417

Title: Nociceptin/orphanin FQ: actions within the brain.

Journal: The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry20030401

Title: Attenuation of neuropathic pain by the nociceptin/orphanin FQ antagonist JTC-801 is mediated by inhibition of nitric oxide production.

Journal: The European journal of neuroscience20030401

Title: [Role of ORL1 receptors in the regulation of cardiac resistance to arrhythmogenic effects ].

Journal: Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova20030401

Title: Non-peptidergic OP4 receptor agonist inhibits morphine antinociception but does not influence morphine dependence.

Journal: Neuroreport20030324

Title: Nociceptin immunoreactivity and receptor mRNA in the human trigeminal ganglion.

Journal: Brain research20030227

Title: Nociceptin/Orphanin FQ(1-13)NH2 analogues modified in the Phe1-Gly2 peptide bond.

Journal: Bioorganic & medicinal chemistry letters20030210

Title: Newborn pig nociceptin/orphanin FQ activates protein tyrosine kinase and mitogen activated protein kinase to impair NMDA cerebrovasodilation after ischemia.

Journal: Neuroreport20030210

Title: Spinal nociceptin inhibits AMPA-induced nociceptive behavior and Fos expression in rat spinal cord.

Journal: Pharmacology, biochemistry, and behavior20030201

Title: PTK, MAPK, and NOC/oFQ impair hypercapnic cerebrovasodilation after hypoxia/ischemia.

Journal: American journal of physiology. Heart and circulatory physiology20030101

Title: Acquisition, expression, and reinstatement of ethanol-induced conditioned place preference in mice: effects of opioid receptor-like 1 receptor agonists and naloxone.

Journal: The Journal of pharmacology and experimental therapeutics20030101

Title: Pharmacological profiles of presynaptic nociceptin/orphanin FQ receptors modulating 5-hydroxytryptamine and noradrenaline release in the rat neocortex.

Journal: British journal of pharmacology20030101

Title: Nociceptin/orphanin FQ content is decreased in forebrain neurones during acute stress.

Journal: Journal of neuroendocrinology20030101

Title: Possible mechanism underlying the antiarrhythmic effect of peptides nociceptin and DALDA on the heart.

Journal: Bulletin of experimental biology and medicine20030101

Title: Inhibition of striatal and retinal dopamine release via nociceptin/orphanin FQ receptors.

Journal: British journal of pharmacology20021201

Title: Constitutive activation of the opioid receptor-like (ORL1) receptor by mutation of Asn133 to tryptophan in the third transmembrane region.

Journal: Journal of neurochemistry20021201

Title: Agonist-induced internalization and desensitization of the human nociceptin receptor expressed in CHO cells.

Journal: Cellular and molecular life sciences : CMLS20021201

Title: Nociceptin/orphanin FQ and related peptides reduce the increase in plasma corticosterone elicited in mice by an intracerebroventricular injection.

Journal: Life sciences20021129

Title: Effect of nociceptin/orphanin FQ on venous tone in conscious rats.

Journal: European journal of pharmacology20021129

Title: Novel, potent ORL-1 receptor agonist peptides containing alpha-Helix-promoting conformational constraints.

Journal: Journal of medicinal chemistry20021121

Title: Probing opioid receptor interactions with azacycloalkane amino acids. Synthesis of a potent and selective ORL1 antagonist.

Journal: Journal of medicinal chemistry20021121

Title: Involvement of the neuropeptide nociceptin/orphanin FQ in kainate seizures.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20021115

Title: Synthesis and structure-activity relationships of aminoalkylazetidines as ORL1 receptor ligands.

Journal: Bioorganic & medicinal chemistry letters20021104

Title: Orphanin FQ/nociceptin blocks cocaine-induced behavioral sensitization in rats.

Journal: Psychopharmacology20021101

Title: Antagonistic effects of CompB on orphanin FQ-induced colonic contractions in rats.

Journal: European journal of pharmacology20021101

Title: Induction of G protein-coupled receptor kinases 2 and 3 contributes to the cross-talk between mu and ORL1 receptors following prolonged agonist exposure.

Journal: Neuropharmacology20021101

Title: Autoradiography of opioid and ORL1 ligands in opioid receptor triple knockout mice.

Journal: The European journal of neuroscience20021101

Title: Heroin-induced locomotion and mesolimbic dopamine release is unchanged in mice lacking the ORL.1 receptor gene.

Journal: Brain research20021025

Title: Degradation of nociceptin (orphanin FQ) by mouse spinal cord synaptic membranes is triggered by endopeptidase-24.11: an in vitro and in vivo study.

Journal: Biochemical pharmacology20021015

Title: Effects of nociceptin (13-17) in pain modulation at supraspinal level in mice.

Journal: Neuroscience letters20021011

Title: Influence of a deletion of protein kinase C gamma isoform in the G-protein activation mediated through opioid receptor-like-1 and mu-opioid receptors in the mouse pons/medulla.

Journal: Neuroscience letters20021004

Title: Effect of nociceptin/orphanin FQ on food intake in rats that differ in diet preference.

Journal: Pharmacology, biochemistry, and behavior20021001

Title: Nociceptin/orphanin FQ modulation of ionic conductances in rat basal forebrain neurons.

Journal: The Journal of pharmacology and experimental therapeutics20021001

Title: Characterization of nociceptin/orphanin FQ-induced pain responses by the novel receptor antagonist N-(4-amino-2-methylquinolin-6-yl)-2-(4-ethylphenoxymethyl) benzamide monohydrochloride.

Journal: The Journal of pharmacology and experimental therapeutics20021001

Title: Orphanin FQ/nociceptin blocks chronic morphine-induced tyrosine hydroxylase upregulation.

Journal: Brain research. Molecular brain research20020930

Title: Lack of the nociceptin receptor does not affect acute or chronic nociception in mice.

Journal: Peptides20020901

Title: Comparison of the binding of [(3)H]nociceptin/orphaninFQ(1-13)NH(2), [(3)H]nociceptin/orphaninFQ(1-17)OH and [(125)I]Tyr(14)nociceptin/orphaninFQ(1-17)OH to recombinant human and native rat cerebrocortical nociceptin/orphanin FQ receptors.

Journal: Neuroscience letters20020802

Title: Effects of chronic nociceptin/orphanin FQ exposure on cAMP accumulation and receptor density in Chinese hamster ovary cells expressing human nociceptin/orphanin FQ receptors.

Journal: European journal of pharmacology20020802

Title: Conditioned opioid withdrawal decreases nociceptin/orphanin FQ levels in the frontal cortex and olfactory tubercle.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology20020801

Title: Orphanin FQ/nociceptin-mediated desensitization of opioid receptor-like 1 receptor and mu opioid receptors involves protein kinase C: a molecular mechanism for heterologous cross-talk.

Journal: The Journal of pharmacology and experimental therapeutics20020801

Title: Morphine-3beta-D-glucuronide suppresses inhibitory synaptic transmission in rat substantia gelatinosa.

Journal: The Journal of pharmacology and experimental therapeutics20020801

Title: Actions of orphanin FQ/nociceptin on rat ventral tegmental area neurons in vitro.

Journal: British journal of pharmacology20020801

Title: Direct and indirect inhibition by nociceptin/orphanin FQ on noradrenaline release from rodent cerebral cortex in vitro.

Journal: British journal of pharmacology20020801

Title: Relationship between NOC/oFQ, dynorphin, and COX-2 activation in impaired NMDA cerebrovasodilation after brain injury.

Journal: Journal of neurotrauma20020801

Title: Involvement of endogenous opioid systems in nociceptin-induced spinal antinociception in rats.

Journal: Brain research20020726

Title: Orphanin FQ inhibits GnRH secretion from rat hypothalamic fragments but not GT1-7 neurons.

Journal: Neuroreport20020719

Title: Rat ventral midbrain dopamine neurons express the orphanin FQ/nociceptin receptor ORL-1.

Journal: Neuroreport20020702

Title: Cough: potential pharmacological developments.

Journal: Expert opinion on investigational drugs20020701

Title: Nociceptin/orphanin FQ inhibits glutamate release from rat cerebellar and brain stem slices.

Journal: Neuroscience letters20020628

Title: Up-regulation of ORL-1 receptors in spinal tissue of allodynic rats after sciatic nerve injury.

Journal: European journal of pharmacology20020628

Title: Spinal nociceptin inhibits septide but not N-methyl-D-aspartate-induced nociceptive behavior in rats.

Journal: European journal of pharmacology20020607

Title: Pharmacological characterisation of [(pX)Phe4]nociceptin(1-13)amide analogues. 1. In vitro studies.

Journal: Naunyn-Schmiedeberg's archives of pharmacology20020601

Title: Endocrine effects of centrally injected nociceptin in the rat.

Journal: Brain research20020531

Title: Effects of [(pF)Phe(4)]nociceptin/orphanin FQ-(1-13)NH(2) on GTPgamma(35)S binding and cAMP formation in Chinese hamster ovary cells expressing the human nociceptin/orphanin FQ receptor.

Journal: European journal of pharmacology20020517

Title: Effect of opioid and cannabinoid receptor antagonism on orphanin FQ-induced hyperphagia in rats.

Journal: European journal of pharmacology20020510

Title: NOC/oFQ and NMDA contribute to piglet hypoxic ischemic hypotensive cerebrovasodilation impairment.

Journal: Pediatric research20020501

Title: Orphanin FQ/nociceptin but not Ro 65-6570 inhibits the expression of cocaine-induced conditioned place preference.

Journal: Behavioural pharmacology20020501

Title: Gastric acid secretion stimulated by centrally injected nociceptin in urethane-anesthetized rats.

Journal: European journal of pharmacology20020419

Title: Sensitization to cocaine after a single intra-cerebral injection of orphanin FQ/nociceptin.

Journal: Behavioural brain research20020401

Title: Activation of spinal ORL-1 receptors prevents acute cutaneous neurogenic inflammation: role of nociceptin-induced suppression of primary afferent depolarization.

Journal: Pain20020401

Title: Nociceptin/orphanin FQ and opioid receptor-like receptor mRNA expression in dopamine systems.

Journal: The Journal of comparative neurology20020318

Title: Nociceptin, OP4 receptor ligand in different models of experimental epilepsy.

Journal: Peptides20020301

Title: Regulation of cyclic AMP-dependent response element-binding protein (CREB) by the nociceptin/orphanin FQ in human dopaminergic SH-SY5Y cells.

Journal: Biochemical and biophysical research communications20020301

Title: Responses to microinjections of endomorphin and nociceptin into the medullary cardiovascular areas.

Journal: Clinical and experimental pharmacology & physiology20020301

Title: Nociceptin/orphanin FQ tissue concentration in the rat brain. Effects of repeated ethanol administration at various post-treatment intervals.

Journal: Progress in neuro-psychopharmacology & biological psychiatry20020201

Title: Nociceptin/orphanin FQ inhibits capsaicin-induced guinea-pig airway contraction through an inward-rectifier potassium channel.

Journal: British journal of pharmacology20020201

Title: Comparison of the ORL1 receptor-mediated inhibition of noradrenaline release in human and rat neocortical slices.

Journal: British journal of pharmacology20020201

Title: Orphanin FQ inhibits capsaicin-induced thermal nociception in monkeys by activation of peripheral ORL1 receptors.

Journal: British journal of pharmacology20020201

Title: Chronic paroxetine increases [3H]nociceptin binding in rat dorsal raphe nucleus.

Journal: Neuroreport20020121

Title: Does ethanol activate G-protein coupled inwardly rectifying K+ channels?

Journal: Neuroreport20020121

Title: Nociceptin/orphanin FQ increases ANP secretion in neonatal cardiac myocytes.

Journal: Life sciences20020118

Title: Nociceptin and dynorphin A(1-17) produce antianalgesia through independent systems in mice.

Journal: Life sciences20020118

Title: Nociceptin inhibits gamma-aminobutyric acidergic inputs to cardiac parasympathetic neurons in the nucleus ambiguus.

Journal: The Journal of pharmacology and experimental therapeutics20020101

Title: NOC/oFQ activates PKC and generates superoxide to impair hypotensive cerebrovasodilation after hypoxia/ischemia.

Journal: Medical science monitor : international medical journal of experimental and clinical research20020101

Title: Pharmacological properties of nociceptin/orphanin FQ-induced stimulation and inhibition of cyclic AMP formation in distinct layers of rat olfactory bulb.

Journal: British journal of pharmacology20020101

Title: Nociceptin inhibits excitatory but not inhibitory transmission to substantia gelatinosa neurones of adult rat spinal cord.

Journal: Neuroscience20020101

Title: Pharmacological characterization of the nociceptin receptor which mediates reduction of alcohol drinking in rats.

Journal: Peptides20020101

Title: Pharmacological profiles of a novel opioid receptor-like1 (ORL(1)) receptor antagonist, JTC-801.

Journal: British journal of pharmacology20020101

Title: [Nphe1]nociceptin(1-13)-NH2 antagonizes nociceptin-induced hypotension, bradycardia, and hindquarters vasodilation in the anesthetized rat.

Journal: Canadian journal of physiology and pharmacology20020101

Title: Nociceptin/orphanin FQ receptors modulate glutamate extracellular levels in the substantia nigra pars reticulata. A microdialysis study in the awake freely moving rat.

Journal: Neuroscience20020101

Title: Co-expressions of different opioid receptor types differentially modulate their signaling via G(16).

Journal: Neuro-Signals20020101

Title: Antitussive effect of nociceptin/orphanin FQ in experimental cough models.

Journal: Pulmonary pharmacology & therapeutics20020101

Title: Involvement of the neuropeptide orphanin FQ/nociceptin in kainate and kindling seizures and epileptogenesis.

Journal: Epilepsia20020101

Title: Orphanin FQ-induced hyperphagia is mediated by corticosterone and central glucocorticoid receptors.

Journal: Neuroscience20020101

Title: Central and peripheral roles of prostaglandins in pain and their interactions with novel neuropeptides nociceptin and nocistatin.

Journal: Neuroscience research20011201

Title: Structure-activity studies on nociceptin analogues: ORL1 receptor binding and biological activity of cyclic disulfide-containing analogues of nociceptin peptides.

Journal: Journal of medicinal chemistry20011108

Title: Spontaneous transient outward currents: modulation by nociceptin in murine dentate gyrus granule cells.

Journal: Brain research20011102

Title: Antitussive action of nociceptin in the cat.

Journal: European journal of pharmacology20011026

Title: Nociceptin-induced internalization of the ORL1 receptor in human neuroblastoma cells.

Journal: Neuroreport20011008

Title: Dynorphin A inhibits nociceptin-converting enzyme from the rat spinal cord.

Journal: Biochemical and biophysical research communications20011005

Title: The dopamine transporter in mesencephalic cultures is refractory to physiological changes in membrane voltage.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20011001

Title: Potentiation of opioid analgesia in dopamine2 receptor knock-out mice: evidence for a tonically active anti-opioid system.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20011001

Title: Nociceptin inhibits calcium channel currents in a subpopulation of small nociceptive trigeminal ganglion neurons in mouse.

Journal: The Journal of physiology20011001

Title: Orphanin FQ/nociceptin attenuates the development of morphine tolerance in rats.

Journal: British journal of pharmacology20011001

Title: Changes in brain content of nociceptin/orphanin FQ and endomorphin 2 in a rat model of neuropathic pain.

Journal: Neuroscience letters20010921

Title: Leukemia inhibitory factor induces nociceptin mRNA in cultured rat cortical neurons.

Journal: Neuroscience letters20010921

Title: Ovarian sex steroid-dependent plasticity of nociceptin/orphanin FQ and opioid modulation of spinal dynorphin release.

Journal: The Journal of pharmacology and experimental therapeutics20010901

Title: Structure-activity relationships of neuropeptide FF: role of C-terminal regions.

Journal: Peptides20010901

Title: Nociceptin reduces epileptiform events in CA3 hippocampus via presynaptic and postsynaptic mechanisms.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20010901

Title: Modulation of the cardiac autonomic transmission of pithed rats by presynaptic opioid OP4 and cannabinoid CB1 receptors.

Journal: Naunyn-Schmiedeberg's archives of pharmacology20010901

Title: Inhibitory action of nociceptin/orphanin FQ on functionally different thalamic neurons in urethane-anaesthetized rats.

Journal: British journal of pharmacology20010901

Title: Pharmacological characterization of the novel nonpeptide orphanin FQ/nociceptin receptor agonist Ro 64-6198: rapid and reversible desensitization of the ORL1 receptor in vitro and lack of tolerance in vivo.

Journal: The Journal of pharmacology and experimental therapeutics20010801

Title: Effects of loperamide and other opioid-related substances on the transcriptional regulation of the rat pro-opiomelanocortin gene in AtT20 cells.

Journal: Neuroendocrinology20010801

Title: Actions of nociceptin/orphanin FQ and other prepronociceptin products on rat rostral ventromedial medulla neurons in vitro.

Journal: The Journal of physiology20010801

Title: Characterization of specific [3H]nociceptin binding in rat brain and spinal cord.

Journal: Biological & pharmaceutical bulletin20010801

Title: Inhibitory activity of nociceptin/orphanin FQ on capsaicin-induced bronchoconstriction in the guinea-pig.

Journal: Life sciences20010727

Title: Analgesia elicited by OFQ/nociceptin and its fragments from the amygdala in rats.

Journal: Brain research20010713

Title: Quantitative autoradiographic mapping of the ORL1, mu-, delta- and kappa-receptors in the brains of knockout mice lacking the ORL1 receptor gene.

Journal: Brain research20010706

Title: Pre- and postsynaptic inhibition by nociceptin in guinea pig small intestinal myenteric plexus in vitro.

Journal: American journal of physiology. Gastrointestinal and liver physiology20010701

Title: The putative OP(4) antagonist, [Nphe(1)]nociceptin(1-13)NH(2), prevents the effects of nociceptin in neuropathic rats.

Journal: Brain research20010629

Title: Possible mechanism of hypothermia induced by intracerebroventricular injection of orphanin FQ/nociceptin.

Journal: Brain research20010622

Title: Effects of nociceptin on cardiac norepinephrine and acetylcholine release evoked by ouabain.

Journal: Brain research20010615

Title: In vitro inhibitory effects of J-113397 on nociceptin/orphanin FQ-stimulated.

Journal: Neuroreport20010613

Title: Nocistatin, a peptide reversing acute and chronic morphine tolerance.

Journal: Neuroreport20010613

Title: Dual coupling of opioid receptor-like (ORL1) receptors to adenylyl cyclase in the different layers of the rat main olfactory bulb.

Journal: Journal of neurochemistry20010601

Title: Differential antagonism by naloxone benzoylhydrazone of the activation of inward rectifying K+ channels by nociceptin and a mu-opioid in rat periaqueductal grey slices.

Journal: Naunyn-Schmiedeberg's archives of pharmacology20010601

Title: Age-Dependent vasopressinergic modulation of Noc/oFQ-induced impairment of NMDA cerebrovasodilation after brain injury.

Journal: Journal of neurotrauma20010601

Title: Inhibition by nociceptin on excitatory non-adrenergic non-cholinergic response in guinea pig airways.

Journal: Acta pharmacologica Sinica20010601

Title: Effects of nociceptinNH2 and [Nphe1]nociceptin(1-13)NH2 on rat brain noradrenaline release in vivo and in vitro.

Journal: Neuroscience letters20010511

Title: C-Terminal glycine is crucial for hyperalgesic activity of nociceptin/orphanin FQ-(1-6).

Journal: European journal of pharmacology20010504

Title: Control of glutamate and GABA release by nociceptin/orphanin FQ in the rat lateral amygdala.

Journal: The Journal of physiology20010501

Title: Differential splicing of transcripts encoding the orphanin FQ/nociceptin precursor.

Journal: Journal of neurochemistry20010501

Title: Orphanin FQ/nociceptin binds to functionally coupled ORL1 receptors on human immune cell lines and alters peripheral blood mononuclear cell proliferation.

Journal: Brain research bulletin20010401

Title: Orphanin FQ: an endogenous antagonist of rat brain dopamine transporter.

Journal: Neuroreport20010326

Title: Cutting edge: nociceptin stimulates neutrophil chemotaxis and recruitment: inhibition by aspirin-triggered-15-epi-lipoxin A4.

Journal: Journal of immunology (Baltimore, Md. : 1950)20010315

Title: Effects of orphanin FQ on central dopaminergic neuronal activities and prolactin secretion.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology20010301

Title: Modulation of synaptic transmission by nociceptin/orphanin FQ and nocistatin in the spinal cord dorsal horn of mutant mice lacking the nociceptin/orphanin FQ receptor.

Journal: Molecular pharmacology20010301

Title: Nociceptin inhibits cough in the guinea-pig by activation of ORL(1) receptors.

Journal: British journal of pharmacology20010301

Title: Orphanin FQ/nociceptin and naloxone benzoylhydrazone activate distinct receptors in BE(2)-C human neuroblastoma cells.

Journal: Neuroscience letters20010223

Title: Nociceptin/orphanin FQ exacerbates excitotoxic white-matter lesions in the murine neonatal brain.

Journal: The Journal of clinical investigation20010215

Title: Characterization of the locomotor activity-inhibiting effect of nociceptin/orphanin FQ in mice.

Journal: Naunyn-Schmiedeberg's archives of pharmacology20010201

Title: Orphanin FQ/nociceptin attenuates motor stimulation and changes in nucleus accumbens extracellular dopamine induced by cocaine in rats.

Journal: Psychopharmacology20010201

Title: Distribution and chemical coding of orphanin FQ/nociceptin-immunoreactive neurons in the myenteric plexus of guinea pig intestines and sphincter of Oddi.

Journal: The Journal of comparative neurology20010129

Title: The role of the ORL1 receptor in the modulation of spinal neurotransmission by nociceptin/orphanin FQ and nocistatin.

Journal: European journal of pharmacology20010119

Title: Antianalgesic action of nociceptin originating in the brain is mediated by spinal prostaglandin E(2) in mice.

Journal: The Journal of pharmacology and experimental therapeutics20010101

Title: Chemical coding of intrinsic and extrinsic nerves in the guinea pig gallbladder: distributions of PACAP and orphanin FQ.

Journal: The Anatomical record20010101

Title: Age dependent endothelin contribution to NOC/oFQ induced impairment of NMDA cerebrovasodilation after brain injury.

Journal: Peptides20010101

Title: Characterisation and comparison of novel ligands for the nociceptin/orphanin FQ receptor.

Journal: Naunyn-Schmiedeberg's archives of pharmacology20010101

Title: Nociceptin/orphanin FQ regulates neuroendocrine function of the limbic-hypothalamic-pituitary-adrenal axis.

Journal: Neuroscience20010101

Title: Bi-directional modulation of 5-hydroxytryptamine-induced plasma extravasation in the rat knee joint by nociceptin.

Journal: Neuroscience20010101

Title: Morphine tolerance and dependence in nociceptin/orphanin FQ transgenic knock-out mice.

Journal: Neuroscience20010101

Title: Alteration of orphanin FQ immunoreactivity and ppOFQ mRNA by combination of melatonin with electroacupuncture.

Journal: Acupuncture & electro-therapeutics research20010101

Title: Effects of neonatal handling on nociceptin/orphanin FQ and opioid peptide levels in female rats.

Journal: Pharmacology, biochemistry, and behavior20010101

Title: Orphanin FQ produces gender-specific modulation of trigeminal nociception: behavioral and electrophysiological observations.

Journal: Neuroscience20010101

Title: Bidirectional actions of nociceptin/orphanin FQ on A delta-fibre-evoked responses in rat superficial spinal dorsal horn in vitro.

Journal: Neuroscience20010101

Title: Nociceptin-induced outward current in substantia gelatinosa neurones of the adult rat spinal cord.

Journal: Neuroscience20010101

Title: Novel nociceptin analogues.

Journal: Acta biochimica Polonica20010101

Title: 4-Aminoquinolines: novel nociceptin antagonists with analgesic activity.

Journal: Journal of medicinal chemistry20001130

Title: Enhanced spinal nociceptin receptor expression develops morphine tolerance and dependence.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20001015

Title: Characterization of the ORL(1) receptor on adrenergic nerves in the rat anococcygeus muscle.

Journal: British journal of pharmacology20000901

Title: Nocistatin: a novel neuropeptide encoded by the gene for the nociceptin/orphanin FQ precursor.

Journal: Peptides20000701

Title: Orphanin FQ/nociceptin inhibits morphine withdrawal.

Journal: Life sciences20000114

Title: Nociceptin receptor activation produces nitric oxide-mediated systemic hypotension.

Journal: Life sciences20000101

Title: Dose-related opposite modulation by nociceptin/orphanin FQ of substance P nociception in the nociceptors and spinal cord.

Journal: The Journal of pharmacology and experimental therapeutics19991001

Title: Nociceptin/orphanin FQ and nocistatin on learning and memory impairment induced by scopolamine in mice.

Journal: British journal of pharmacology19990601

Title: Comparison of the effects of [Phe1psi(CH2-NH)Gly2]nociceptin(1-13)NH2 in rat brain, rat vas deferens and CHO cells expressing recombinant human nociceptin receptors.

Journal: British journal of pharmacology19990501

Title: Binding and in vitro activities of peptides with high affinity for the nociceptin/orphanin FQ receptor, ORL1.

Journal: The Journal of pharmacology and experimental therapeutics19971101

Title: Relationship between binding affinity and functional activity of nociceptin/orphanin FQ.

Journal: Neuropeptides19971001

Title: Address and message sequences for the nociceptin receptor: a structure-activity study of nociceptin-(1-13)-peptide amide.

Journal: Journal of medicinal chemistry19970606

Title: Nociceptin (orphanin FQ), an endogenous ligand for the QRL1 (opioid-receptor-like1) receptor; modulates responses of trigeminal neurons evoked by excitatory amino acids and somatosensory stimuli.

Journal: Journal of neurophysiology19961101

Title: The mu-opioid receptor antagonist D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (CTOP) [but not D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 (CTAP)] produces a nonopioid receptor-mediated increase in K+ conductance of rat locus ceruleus neurons.

Journal: Molecular pharmacology19960901

Title: Pronociceptive effects of the neuropeptide, nociceptin, in the land snail, Cepaea nemoralis.

Journal: Peptides19960101

Title: Bedini A, et al. Nociceptin/orphanin FQ antagonizes lipopolysaccharide-stimulated proliferation, migration and inflammatory signaling in human glioblastoma U87 cells. Biochem Pharmacol. 2017 Sep 15;140:89-104.

170713-75-4 | Nociceptin trifluoroacetate salt