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Home Other Building Blocks 1707289-21-1
1707289-21-1,MFCD30496704
Catalog No.:AA00AMEC

1707289-21-1 | BLU-554

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
97%
in stock  
$15.00   $11.00
- +
5mg
97%
in stock  
$35.00   $25.00
- +
50mg
95%
in stock  
$176.00   $123.00
- +
250mg
95%
in stock  
$446.00   $312.00
- +
1g
95%
in stock  
$1,128.00   $790.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00AMEC
Chemical Name:
BLU-554
CAS Number:
1707289-21-1
Molecular Formula:
C24H24Cl2N4O4
Molecular Weight:
503.3778
MDL Number:
MFCD30496704
SMILES:
C=CC(=O)N[C@H]1CCOC[C@H]1Nc1ncc2c(n1)ccc(c2)c1c(Cl)c(OC)cc(c1Cl)OC
Properties
Computed Properties
 
Complexity:
688  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
34  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
7  
XLogP3:
4.7  

Downstream Synthesis Route

[1]CurrentPatentAssignee:BLUEPRINTMEDICINESCORP-US2015/119405,2015,A1

[1]CurrentPatentAssignee:BLUEPRINTMEDICINESCORP-US2015/119405,2015,A1Locationinpatent:Paragraph0178;0183;0184

[1]CurrentPatentAssignee:BLUEPRINTMEDICINESCORP-US2015/119405,2015,A1

[1]CurrentPatentAssignee:BLUEPRINTMEDICINESCORP-US2015/119405,2015,A1

[1]CurrentPatentAssignee:BLUEPRINTMEDICINESCORP-US2015/119405,2015,A1

Literature

Title: Dogan-Topal B, et al. Quantification of FGFR4 inhibitor BLU-554 in mouse plasma and tissue homogenates using liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2019 Mar 15;1110-1111:116-123.

Title: Richard Kim, et al. First-in-human study of BLU-554, a potent, highly selective FGFR4 inhibitor designed for hepatocellular carcinoma (HCC) with FGFR4 pathway activation. EJC. December 2016, Volume 69, Supplement 1, Page S41.

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SDS
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