Home Other Building Blocks 172889-26-8
172889-26-8,MFCD01076570
Catalog No.:AA007C8A

172889-26-8 | Pp1

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1mg
≥98%
in stock  
$70.00   $49.00
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5mg
≥98%
in stock  
$172.00   $120.00
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10mg
≥98%
in stock  
$246.00   $172.00
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25mg
95%
in stock  
$284.00   $199.00
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100mg
95%
in stock  
$506.00   $354.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA007C8A
Chemical Name:
Pp1
CAS Number:
172889-26-8
Molecular Formula:
C16H19N5
Molecular Weight:
281.3556
MDL Number:
MFCD01076570
SMILES:
Cc1ccc(cc1)c1nn(c2c1c(N)ncn2)C(C)(C)C
Properties
Computed Properties
 
Complexity:
358  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
21  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
2  
XLogP3:
2.8  

Downstream Synthesis Route

[1]Todorovic,Nick;Awuah,Emelia;Shakya,Tushar;Wright,GerardD.;Capretta,Alfredo[TetrahedronLetters,2011,vol.52,#44,p.5761-5763]

[2]CurrentPatentAssignee:UNIVERSITYOFCALIFORNIA-US2007/293516,2007,A1Locationinpatent:Page/Pagecolumn25

CASUnavailable 
 
CASUnavailable 
  172889-26-8 

[1]CurrentPatentAssignee:COMMONWEALTHSYSTEMOFHIGHEREDUCATION-WO2005/44181,2005,A2Locationinpatent:Page/Pagecolumn71-72

[1]Todorovic,Nick;Awuah,Emelia;Shakya,Tushar;Wright,GerardD.;Capretta,Alfredo[TetrahedronLetters,2011,vol.52,#44,p.5761-5763]

[1]Todorovic,Nick;Awuah,Emelia;Shakya,Tushar;Wright,GerardD.;Capretta,Alfredo[TetrahedronLetters,2011,vol.52,#44,p.5761-5763]

Literature

Title: Rapid Discovery and Structure-Activity Relationships of Pyrazolopyrimidines That Potently Suppress Breast Cancer Cell Growth via SRC Kinase Inhibition with Exceptional Selectivity over ABL Kinase.

Journal: Journal of medicinal chemistry 20160526

Title: A fluorescent reporter of ATP binding-competent receptor kinases.

Journal: Bioorganic & medicinal chemistry letters 20120901

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Displacement assay for the detection of stabilizers of inactive kinase conformations.

Journal: Journal of medicinal chemistry 20100114

Title: Kinetic mechanism and inhibitor characterization of WNK1 kinase.

Journal: Biochemistry 20091103

Title: Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases.

Journal: Nature chemical biology 20081101

Title: The selectivity of protein kinase inhibitors: a further update.

Journal: The Biochemical journal 20071215

Title: Characterization of the intracellular mechanisms involved in the antiaggregant properties of cinnamtannin B-1 from bay wood in human platelets.

Journal: Journal of medicinal chemistry 20070809

Title: Synthesis and c-Src inhibitory activity of imidazo[1,5-a]pyrazine derivatives as an agent for treatment of acute ischemic stroke.

Journal: Bioorganic & medicinal chemistry 20070115

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Requirement of Gbetagamma and c-Src in D2 dopamine receptor-mediated nuclear factor-kappaB activation.

Journal: Molecular pharmacology 20030801

Title: The specificities of protein kinase inhibitors: an update.

Journal: The Biochemical journal 20030401

Title: The Src-selective kinase inhibitor PP1 also inhibits Kit and Bcr-Abl tyrosine kinases.

Journal: The Journal of biological chemistry 20030214

Title: Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation.

Journal: The Journal of biological chemistry 19960112

Title: Hanke JH, et al. Discovery of a novel, potent, and Src family-selective tyrosine kinase inhibitor. Study of Lck- and FynT-dependent T cell activation. J Biol Chem. 1996 Jan 12;271(2):695-701.

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SDS
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