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Title: Cisplatin inhibits testosterone synthesis by a mechanism that includes the action of reactive oxygen species (ROS) at the level of P450scc.
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Title: LXR agonists and ABCG1-dependent cholesterol efflux in MCF-7 breast cancer cells: relation to proliferation and apoptosis.
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Title: Dietary supplementation with 22-S-hydroxycholesterol to rats reduces body weight gain and the accumulation of liver triacylglycerol.
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Title: Liver X receptor activation downregulates organic anion transporter 1 (OAT1) in the renal proximal tubule.
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Title: The liver X receptor modulator 22(S)-hydroxycholesterol exerts cell-type specific effects on lipid and glucose metabolism.
Journal: The Journal of steroid biochemistry and molecular biology 20120201
Title: A steroid isolated from the water mold Achlya heterosexualis induces neurogenesis in vitro and in vivo.
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Title: Caprospinol: discovery of a steroid drug candidate to treat Alzheimer's disease based on 22R-hydroxycholesterol structure and properties.
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Title: Simvastatin reduces steroidogenesis by inhibiting Cyp17a1 gene expression in rat ovarian theca-interstitial cells.
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Title: Regulation of LXR by fatty acids, insulin, growth hormone and tumor necrosis factor-α in rainbow trout myocytes.
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Title: Dysregulation of SREBP2 induces BACE1 expression.
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Title: The human placenta expresses CYP17 and generates androgens de novo.
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Title: Structural basis for three-step sequential catalysis by the cholesterol side chain cleavage enzyme CYP11A1.
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Title: Oxysterols inhibit differentiation and fusion of term primary trophoblasts by activating liver X receptors.
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Title: Antiproliferative effect of LXR agonists T0901317 and 22(R)-hydroxycholesterol on multiple human cancer cell lines.
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Title: Identification of a naturally occurring rexinoid, honokiol, that activates the retinoid X receptor.
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Title: Testosterone synthesized in cultured human SZ95 sebocytes derives mainly from dehydroepiandrosterone.
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Title: Mesenchymal stem cells differentiate into renin-producing juxtaglomerular (JG)-like cells under the control of liver X receptor-alpha.
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Title: LXR-activating oxysterols induce the expression of inflammatory markers in endothelial cells through LXR-independent mechanisms.
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Title: Effects of cholesterol and cAMP on progesterone production in cultured luteal cells isolated from pseudopregnant cat ovaries.
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Title: Mechanism underlying apolipoprotein E (ApoE) isoform-dependent lipid efflux from neural cells in culture.
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Title: OSBP-related protein 2 is a sterol receptor on lipid droplets that regulates the metabolism of neutral lipids.
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Title: Activators of PPARs and LXR decrease the adverse effects of exogenous glucocorticoids on the epidermis.
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Title: Highly sensitive quantification of key regulatory oxysterols in biological samples by LC-ESI-MS/MS.
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Title: Transport-metabolism interplay: LXRalpha-mediated induction of human ABC transporter ABCC2 (cMOAT/MRP2) in HepG2 cells.
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Title: Epoxycholesterol impairs cholesteryl ester hydrolysis in macrophage foam cells, resulting in decreased cholesterol efflux.
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Title: Co-existence of alpha-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development.
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Title: Fenvalerate inhibits progesterone production through cAMP-dependent signal pathway.
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Title: 22R-Hydroxycholesterol induces differentiation of human NT2 precursor (Ntera2/D1 teratocarcinoma) cells.
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Title: Monobutyl phthalate inhibits steroidogenesis by downregulating steroidogenic acute regulatory protein expression in mouse Leydig tumor cells (MLTC-1).
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Title: 22-Hydroxycholesterols regulate lipid metabolism differently than T0901317 in human myotubes.
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Title: Sesquiterpene lactone helenalin suppresses Leydig and adrenocortical cell steroidogenesis by inhibiting expression of the steroidogenic acute regulatory protein.
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Title: Energized, polarized, and actively respiring mitochondria are required for acute Leydig cell steroidogenesis.
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Title: Synergistic effect of peroxisome proliferator activated receptor-gamma and liver X receptor-alpha in the regulation of inflammation in macrophages.
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Title: HPLC method for quantification and characterization of cholesterol and its oxidation products in eggs.
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Title: Oxysterol 22(R)-hydroxycholesterol induces the expression of the bile salt export pump through nuclear receptor farsenoid X receptor but not liver X receptor.
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Title: Carbaryl inhibits basal and FSH-induced progesterone biosynthesis of primary human granulosa-lutein cells.
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Title: Liver X receptors mediate inhibition of hCG secretion in a human placental trophoblast cell line.
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Title: Liver X receptor and retinoic X receptor agonists modulate the expression of genes involved in lipid metabolism in human endothelial cells.
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Title: Osteogenic oxysterols inhibit the adverse effects of oxidative stress on osteogenic differentiation of marrow stromal cells.
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Title: Diterpenoid, steroid, and triterpenoid agonists of liver X receptors from diversified terrestrial plants and marine sources.
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Title: Discovery and development of dimeric podocarpic acid leads as potent agonists of liver X receptor with HDL cholesterol raising activity in mice and hamsters.
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Title: Regulatory mechanism of Toona sinensis on mouse leydig cell steroidogenesis.
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Title: Rosiglitazone upregulates caveolin-1 expression in THP-1 cells through a PPAR-dependent mechanism.
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Title: Evaluation of the role of FSH in regulation of Leydig cell function during different stages of its differentiation.
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Title: Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia.
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Title: The effect of LXR activators on AP-1 proteins in keratinocytes.
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Title: Oxidized LDL upregulated ATP binding cassette transporter-1 in THP-1 macrophages.
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Title: Role of p160 coactivator complex in the activation of liver X receptor.
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Title: Apolipoprotein A-I activates cellular cAMP signaling through the ABCA1 transporter.
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Title: Verapamil increases the apolipoprotein-mediated release of cellular cholesterol by induction of ABCA1 expression via Liver X receptor-independent mechanism.
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Title: Oxysterols induce cyclooxygenase-2 expression in cholangiocytes: implications for biliary tract carcinogenesis.
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Title: Identification of naturally occurring spirostenols preventing beta-amyloid-induced neurotoxicity.
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Title: Oxysterol and 9-cis-retinoic acid stimulate the group IIA secretory phospholipase A2 gene in rat smooth-muscle cells.
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Title: Identification and characterization of rodent ABCA1 in isolated type II pneumocytes.
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Title: Induction of intestinal ATP-binding cassette transporters by a phytosterol-derived liver X receptor agonist.
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Title: Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. II. LXRs suppress lipid degradation gene promoters through inhibition of PPAR signaling.
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Title: Oxysterols suppress constitutive fibrinogen expression.
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Title: Human skin is a steroidogenic tissue: steroidogenic enzymes and cofactors are expressed in epidermis, normal sebocytes, and an immortalized sebocyte cell line (SEB-1).
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Title: Regulatory mechanism of Cordyceps sinensis mycelium on mouse Leydig cell steroidogenesis.
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Title: Liver X receptor activators display anti-inflammatory activity in irritant and allergic contact dermatitis models: liver-X-receptor-specific inhibition of inflammation and primary cytokine production.
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Title: Truncation mutations in ABCA1 suppress normal upregulation of full-length ABCA1 by 9-cis-retinoic acid and 22-R-hydroxycholesterol.
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Title: Stimulation of progesterone production in human granulosa-lutein cells by lipoproteins: evidence for cholesterol-independent actions of high-density lipoproteins.
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Title: Creation and activity of COS-1 cells stably expressing the F2 fusion of the human cholesterol side-chain cleavage enzyme system.
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Title: Regulation of cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription by the liver orphan receptor (LXRalpha).
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Title: Melatonin inhibits the expression of steroidogenic acute regulatory protein and steroidogenesis in MA-10 cells.
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