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Title: 27-Hydroxycholesterol regulates cholesterol synthesis and transport in C6 glioma cells.
Journal: Neurotoxicology 20170301
Title: The ROS-mediated activation of STAT-3/VEGF signaling is involved in the 27-hydroxycholesterol-induced angiogenesis in human breast cancer cells.
Journal: Toxicology letters 20161215
Title: 27-Hydroxycholesterol and 7alpha-hydroxycholesterol trigger a sequence of events leading to migration of CCR5-expressing Th1 lymphocytes.
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Title: Loading into nanoparticles improves quercetin's efficacy in preventing neuroinflammation induced by oxysterols.
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Title: Neonatal cholestasis with increased 3β-monohydroxy-Δ⁵ bile acids in serum and urine: not necessarily primary oxysterol 7α hydroxylase deficiency.
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Title: Increased appearance rate of 27-hydroxycholesterol in vivo in hypercholesterolemia: a possible compensatory mechanism.
Journal: Nutrition, metabolism, and cardiovascular diseases : NMCD 20121001
Title: Cholesterol metabolism is associated with soluble amyloid precursor protein production in Alzheimer's disease.
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Title: Relationships of coronary heart disease with 27-hydroxycholesterol, low-density lipoprotein cholesterol, and menopausal hormone therapy.
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Journal: Neuroscience letters 20120906
Title: 27-hydroxycholesterol and the expression of three estrogen-sensitive proteins in MCF7 cells.
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Title: Increase of 27-hydroxycholesterol in the airways of patients with COPD: possible role of 27-hydroxycholesterol in tissue fibrosis.
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Title: 27-Hydroxycholesterol, does it exist? On the nomenclature and stereochemistry of 26-hydroxylated sterols.
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Title: Liver x receptor modulation of gene expression leading to proluteolytic effects in primate luteal cells.
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Title: Endoplasmic reticulum stress-induced CHOP activation mediates the down-regulation of leptin in human neuroblastoma SH-SY5Y cells treated with the oxysterol 27-hydroxycholesterol.
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Title: side-chain-oxidized oxysterols upregulate ACE2 and Mas receptor in rat primary neurons.
Journal: Neuro-degenerative diseases 20120101
Title: Markers of cholesterol metabolism in the brain show stronger associations with cerebrovascular disease than Alzheimer's disease.
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Title: The oxysterol, 27-hydroxycholesterol, links cholesterol metabolism to bone homeostasis through its actions on the estrogen and liver X receptors.
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Title: The oxysterol 27-hydroxycholesterol regulates α-synuclein and tyrosine hydroxylase expression levels in human neuroblastoma cells through modulation of liver X receptors and estrogen receptors--relevance to Parkinson's disease.
Journal: Journal of neurochemistry 20111201
Title: 27-hydroxycholesterol induces the transition of MCF7 cells into a mesenchymal phenotype.
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Title: Oxysterols direct B-cell migration through EBI2.
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Title: Side chain-oxidized oxysterols regulate the brain renin-angiotensin system through a liver X receptor-dependent mechanism.
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Title: Biomarkers of oxidative damage in cigarette smokers: which biomarkers might reflect acute versus chronic oxidative stress?
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Title: Interaction between 24-hydroxycholesterol, oxidative stress, and amyloid-β in amplifying neuronal damage in Alzheimer's disease: three partners in crime.
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Title: Marked accumulation of 27-hydroxycholesterol in the brains of Alzheimer's patients with the Swedish APP 670/671 mutation.
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Title: 27-Hydroxycholesterol: the first identified endogenous SERM.
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Title: Plasma levels of 27-hydroxycholesterol in humans and mice with monogenic disturbances of high density lipoprotein metabolism.
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Title: Quantification of cholesterol-metabolizing P450s CYP27A1 and CYP46A1 in neural tissues reveals a lack of enzyme-product correlations in human retina but not human brain.
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Title: Upregulation of brain renin angiotensin system by 27-hydroxycholesterol in Alzheimer's disease.
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Title: Oxysterol derivatives of cholesterol in neurodegenerative disorders.
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Title: Silencing GADD153/CHOP gene expression protects against Alzheimer's disease-like pathology induced by 27-hydroxycholesterol in rabbit hippocampus.
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Title: The endogenous selective estrogen receptor modulator 27-hydroxycholesterol is a negative regulator of bone homeostasis.
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Title: Overexpression of steroidogenic acute regulatory protein increases macrophage cholesterol efflux to apolipoprotein AI.
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Title: Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis.
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Title: FTY720 stimulates 27-hydroxycholesterol production and confers atheroprotective effects in human primary macrophages.
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Title: An alternative pathway of reverse cholesterol transport: the oxysterol 27-hydroxycholesterol.
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Title: Inhibition of carboxylesterase activity of THP1 monocytes/macrophages and recombinant human carboxylesterase 1 by oxysterols and fatty acids.
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Title: Leptin reduces the accumulation of Abeta and phosphorylated tau induced by 27-hydroxycholesterol in rabbit organotypic slices.
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Title: The oxysterol 27-hydroxycholesterol increases β-amyloid and oxidative stress in retinal pigment epithelial cells.
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Title: Vitamin E and enzymatic/oxidative stress-driven oxysterols in amnestic mild cognitive impairment subtypes and Alzheimer's disease.
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Title: Expression of sterol 27-hydroxylase in glial cells and its regulation by liver X receptor signaling.
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Title: LXR-activating oxysterols induce the expression of inflammatory markers in endothelial cells through LXR-independent mechanisms.
Journal: Atherosclerosis 20091101
Title: Plasma levels of 24S-hydroxycholesterol reflect brain volumes in patients without objective cognitive impairment but not in those with Alzheimer's disease.
Journal: Neuroscience letters 20091002
Title: Role of CYP27A1 in progesterone metabolism in vitro and in vivo.
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Title: Effect of 27-hydroxycholesterol on survival and death of human macrophages and vascular smooth muscle cells.
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Title: Regulation of fibroblast mitochondrial 27-hydroxycholesterol production by active plasma membrane cholesterol.
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Title: Serum 24S-hydroxycholesterol and hippocampal size in middle-aged normal individuals.
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Title: Interactions of oxysterols with membranes and proteins.
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Title: Highly sensitive quantification of key regulatory oxysterols in biological samples by LC-ESI-MS/MS.
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Title: Dopant assisted-atmospheric pressure photoionization (DA-APPI) liquid chromatography-mass spectrometry for the quantification of 27-hydroxycholesterol in plasma.
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Title: Activity-regulated cytoskeleton-associated protein in rodent brain is down-regulated by high fat diet in vivo and by 27-hydroxycholesterol in vitro.
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Title: Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on beta-amyloid precursor protein levels and processing in human neuroblastoma SH-SY5Y cells.
Journal: Molecular neurodegeneration 20090101
Title: Impact of 27-hydroxycholesterol on amyloid-beta peptide production and ATP-binding cassette transporter expression in primary human neurons.
Journal: Journal of Alzheimer's disease : JAD 20090101
Title: Hypercholesterolemia-induced Abeta accumulation in rabbit brain is associated with alteration in IGF-1 signaling.
Journal: Neurobiology of disease 20081201
Title: Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on tyrosine hydroxylase and alpha-synuclein in human neuroblastoma SH-SY5Y cells.
Journal: Journal of neurochemistry 20081201
Title: Potential mechanisms linking cholesterol to Alzheimer's disease-like pathology in rabbit brain, hippocampal organotypic slices, and skeletal muscle.
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Title: Regulation of alpha-synuclein expression by liver X receptor ligands in vitro.
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Title: 27-Hydroxycholesterol: a potential endogenous regulator of estrogen receptor signaling.
Journal: Trends in pharmacological sciences 20081001
Title: Plasma oxysterols in normal and cholestatic children as indicators of the two pathways of bile acid synthesis.
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Title: Plasma 24S-hydroxycholesterol and other oxysterols in acute closed head injury.
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Title: Niemann-Pick C1 protects against atherosclerosis in mice via regulation of macrophage intracellular cholesterol trafficking.
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Title: A cholesterol-free, high-fat diet suppresses gene expression of cholesterol transporters in murine small intestine.
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Title: Effectors of rapid homeostatic responses of endoplasmic reticulum cholesterol and 3-hydroxy-3-methylglutaryl-CoA reductase.
Journal: The Journal of biological chemistry 20080118
Title: 27-hydroxycholesterol is an endogenous selective estrogen receptor modulator.
Journal: Molecular endocrinology (Baltimore, Md.) 20080101
Title: Glucocorticoid receptor-mediated upregulation of human CYP27A1, a potential anti-atherogenic enzyme.
Journal: Biochimica et biophysica acta 20080101
Title: Biosynthesis of the regulatory oxysterol, 5-cholesten-3beta,25-diol 3-sulfate, in hepatocytes.
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Title: 27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen.
Journal: Nature medicine 20071001
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Journal: Atherosclerosis 20070901
Title: Changes in classic and alternative pathways of bile acid synthesis in chronic liver disease.
Journal: Clinica chimica acta; international journal of clinical chemistry 20070701
Title: 24S-hydroxycholesterol in relation to disease manifestations of acute experimental autoimmune encephalomyelitis.
Journal: Journal of neuroscience research 20070515
Title: Unique patient with cerebrotendinous xanthomatosis. Evidence for presence of a defect in a gene that is not identical to sterol 27-hydroxylase.
Journal: Journal of internal medicine 20070501
Title: Novel route for elimination of brain oxysterols across the blood-brain barrier: conversion into 7alpha-hydroxy-3-oxo-4-cholestenoic acid.
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Title: Osteopontin levels are associated with cholesterol synthesis markers in mildly hypercholesterolaemic patients.
Journal: Acta cardiologica 20070401
Title: PXR induces CYP27A1 and regulates cholesterol metabolism in the intestine.
Journal: Journal of lipid research 20070201
Title: Enzymatic reduction of oxysterols impairs LXR signaling in cultured cells and the livers of mice.
Journal: Cell metabolism 20070101
Title: Crossing the barrier: oxysterols as cholesterol transporters and metabolic modulators in the brain.
Journal: Journal of internal medicine 20061201
Title: High-dose statin treatment does not alter plasma marker for brain cholesterol metabolism in patients with moderately elevated plasma cholesterol levels.
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Title: Synthesis of the aglycone of the shark repellent pavoninin-4 using remote functionalization.
Journal: Organic letters 20060525
Title: Short-term hepatic effects of depleted uranium on xenobiotic and bile acid metabolizing cytochrome P450 enzymes in the rat.
Journal: Archives of toxicology 20060401
Title: Biliary lipids, cholesterol and bile synthesis: different adaptive mechanisms to dietary cholesterol in lean and obese subjects.
Journal: Alimentary pharmacology & therapeutics 20060401
Title: 27-Hydroxycholesterol causes remodeling in endothelial cell membrane lipid composition comparable to remodeling in the failed vein grafts of CABG patients.
Journal: Life sciences 20060125
Title: Effect of pravastatin on plasma sterols and oxysterols in men.
Journal: European journal of clinical pharmacology 20060101
Title: Oxysterols and Alzheimer's disease.
Journal: Acta neurologica Scandinavica. Supplementum 20060101
Title: Mitochondrial cholesterol transport: a possible target in the management of hyperlipidemia.
Journal: Lipids 20051201
Title: Crossing the barrier: net flux of 27-hydroxycholesterol into the human brain.
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Title: A minimally invasive technique for the evaluation of the regulatory steps of the two major pathways of bile acid synthesis.
Journal: Clinica chimica acta; international journal of clinical chemistry 20050501
Title: Detection of the steroidogenic acute regulatory protein, StAR, in human liver cells.
Journal: Biochimica et biophysica acta 20050415
Title: Regulation of sterol 27-hydroxylase in human monocyte-derived macrophages: up-regulation by transforming growth factor beta1.
Journal: Biochimica et biophysica acta 20050221
Title: Adipocytic differentiation and liver x receptor pathways regulate the accumulation of triacylglycerols in human vascular smooth muscle cells.
Journal: The Journal of biological chemistry 20050204
Title: Patients with atherosclerosis may have increased circulating levels of 27-hydroxycholesterol and cholestenoic acid.
Journal: Scandinavian journal of clinical and laboratory investigation 20050101
Title: Serum cholestenoic acid as a potential marker of pulmonary cholesterol homeostasis: increased levels in patients with pulmonary alveolar proteinosis.
Journal: Journal of lipid research 20041201
Title: Altered levels of plasma 24S- and 27-hydroxycholesterol in demented patients.
Journal: Neuroscience letters 20040930
Title: Differential expression of cholesterol hydroxylases in Alzheimer's disease.
Journal: The Journal of biological chemistry 20040813
Title: 27-Hydroxycholesterol inhibits neutral sphingomyelinase in cultured human endothelial cells.
Journal: Life sciences 20040813
Title: Determination of 24S- and 27-hydroxycholesterol in plasma by high-performance liquid chromatography-mass spectrometry.
Journal: Journal of lipid research 20040401
Title: Diagnostic use of cerebral and extracerebral oxysterols.
Journal: Clinical chemistry and laboratory medicine 20040201
Title: Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's disease.
Journal: Journal of lipid research 20040101
Title: Significance of plasma 7alpha-hydroxy-4-cholesten-3-one and 27-hydroxycholesterol concentrations as markers for hepatic bile acid synthesis in cholesterol-fed rabbits.
Journal: Metabolism: clinical and experimental 20040101
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Journal: Archives of biochemistry and biophysics 20031201
Title: Clofibrate, a peroxisome-proliferator, enhances reverse cholesterol transport through cytochrome P450 activation and oxysterol generation.
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Title: Serum ferritin concentration is associated with plasma levels of cholesterol oxidation products in man.
Journal: Free radical biology & medicine 20031015
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Title: Effects of dietary 27-hydroxycholesterol on cholesterol metabolism and bile acid biosynthesis in the hamster.
Journal: Canadian journal of physiology and pharmacology 20030901
Title: 27-Hydroxylation of 7- and 8-dehydrocholesterol in Smith-Lemli-Opitz syndrome: a novel metabolic pathway.
Journal: Steroids 20030801
Title: NPC1 and NPC2 regulate cellular cholesterol homeostasis through generation of low density lipoprotein cholesterol-derived oxysterols.
Journal: The Journal of biological chemistry 20030711
Title: Side chain oxidized oxysterols in cerebrospinal fluid and the integrity of blood-brain and blood-cerebrospinal fluid barriers.
Journal: Journal of lipid research 20030401
Title: Expression of sterol 27-hydroxylase (CYP27A1) enhances cholesterol efflux.
Journal: The Journal of biological chemistry 20030328
Title: Marked induction of sterol 27-hydroxylase activity and mRNA levels during differentiation of human cultured monocytes into macrophages.
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Journal: Neurobiology of aging 20030101
Title: Transport of cholesterol into mitochondria is rate-limiting for bile acid synthesis via the alternative pathway in primary rat hepatocytes.
Journal: The Journal of biological chemistry 20021213
Title: Human sterol 27-hydroxylase (CYP27) overexpressor transgenic mouse model. Evidence against 27-hydroxycholesterol as a critical regulator of cholesterol homeostasis.
Journal: The Journal of biological chemistry 20020913
Title: Mechanism of accumulation of cholesterol and cholestanol in tendons and the role of sterol 27-hydroxylase (CYP27A1).
Journal: Arteriosclerosis, thrombosis, and vascular biology 20020701
Title: Regulation of oxysterol 7alpha-hydroxylase (CYP7B1) in primary cultures of rat hepatocytes.
Journal: Hepatology (Baltimore, Md.) 20020601
Title: Conversion of 7 alpha-hydroxycholesterol to bile acid in human subjects: is there an alternate pathway favoring cholic acid synthesis?
Journal: The Journal of laboratory and clinical medicine 20020201
Title: Oxysterols induce interleukin-1beta production in human macrophages.
Journal: European journal of clinical investigation 20020101
Title: Effect of deposited lipids in atheromatous lesions on the migration of vascular smooth muscle cells.
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Title: Immune complexes and IFN-gamma decrease cholesterol 27-hydroxylase in human arterial endothelium and macrophages.
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Title: Antiepileptic drugs increase plasma levels of 4beta-hydroxycholesterol in humans: evidence for involvement of cytochrome p450 3A4.
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Title: Overexpression of CYP27 in hepatic and extrahepatic cells: role in the regulation of cholesterol homeostasis.
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Title: Cholesterol dynamics in the foetal and neonatal brain as reflected by circulatory levels of 24S-hydroxycholesterol.
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