[1]JournalofOrganicChemistry,2001,vol.66,#12,p.4369-4378
[2]Patent:US2014/256952,2014,A1,.Locationinpatent:Paragraph0288-0289;sheet10;20
[3]Patent:WO2015/87351,2015,A2,.Locationinpatent:Page/Pagecolumn60
[1]JournaloftheAmericanChemicalSociety,2000,vol.122,#37,p.8890-8897
[2]Patent:WO2015/87351,2015,A2,.Locationinpatent:Page/Pagecolumn62
[1]Patent:WO2013/164102,2013,A1,.Locationinpatent:Page/Pagecolumn11
[1]JournaloftheAmericanChemicalSociety,2000,vol.122,#37,p.8890-8897
[2]Patent:WO2015/87351,2015,A2,
[1]Patent:WO2011/153221,2011,A1,
[2]Patent:WO2015/87351,2015,A2,
[1]Borzilleri;Zheng;Schmidt;Johnson;Kim;DiMarco;Fairchild;Gougoutas;Lee;Long;Vite[JournaloftheAmericanChemicalSociety,2000,vol.122,#37,p.8890-8897]
[1]Stachel;ChulBomLee;Spassova;Chappell;Bornmann;Danishefsky;Chou;Guan[JournalofOrganicChemistry,2001,vol.66,#12,p.4369-4378]
[2]CurrentPatentAssignee:SCINOPHARMTAIWAN,LTD.-US2014/256952,2014,A1Locationinpatent:Paragraph0288-0289;sheet10;20
[3]CurrentPatentAssignee:MSNLABORATORIESPRIVATELIMITED-WO2015/87351,2015,A2Locationinpatent:Page/Pagecolumn60
[1]Borzilleri;Zheng;Schmidt;Johnson;Kim;DiMarco;Fairchild;Gougoutas;Lee;Long;Vite[JournaloftheAmericanChemicalSociety,2000,vol.122,#37,p.8890-8897]
[2]CurrentPatentAssignee:MSNLABORATORIESPRIVATELIMITED-WO2015/87351,2015,A2Locationinpatent:Page/Pagecolumn62
[1]Borzilleri;Zheng;Schmidt;Johnson;Kim;DiMarco;Fairchild;Gougoutas;Lee;Long;Vite[JournaloftheAmericanChemicalSociety,2000,vol.122,#37,p.8890-8897]
[2]Aujay,Monette;Dherange,BaluD.;Gavrilyuk,Julia;Gu,Christine;Hammond,Mikhail;Kempema,Aaron;Lin,Baiwei;Nicolaou,K.C.;Sandoval,Joseph;Shelke,YogeshG.[JournalofOrganicChemistry,2020]
[1]Stachel;ChulBomLee;Spassova;Chappell;Bornmann;Danishefsky;Chou;Guan[JournalofOrganicChemistry,2001,vol.66,#12,p.4369-4378]
Title: Nerve growth factor alters microtubule targeting agent-induced neurotransmitter release but not MTA-induced neurite retraction in sensory neurons.
Journal: Experimental neurology 20160501
Title: Phase I trial of ixabepilone administered as three oral doses each separated by 6 hours every 3 weeks in patients with advanced solid tumors.
Journal: Investigational new drugs 20121201
Title: Ixabepilone-associated peripheral neuropathy: data from across the phase II and III clinical trials.
Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20121101
Title: A phase II trial of ixabepilone in Asian patients with advanced gastric cancer previously treated with fluoropyrimidine-based chemotherapy.
Journal: Cancer chemotherapy and pharmacology 20121001
Title: Phase II trial of ixabepilone and carboplatin with or without bevacizumab in patients with previously untreated advanced non-small-cell lung cancer.
Journal: Lung cancer (Amsterdam, Netherlands) 20121001
Title: Maintenance of clinical efficacy after dose reduction of ixabepilone plus capecitabine in patients with anthracycline- and taxane-resistant metastatic breast cancer: a retrospective analysis of pooled data from 2 phase III randomized clinical trials.
Journal: Clinical breast cancer 20120801
Title: Patupilone and ixabepilone: the effect of a point structural change on the exo-endo conformational profile.
Journal: The journal of physical chemistry. B 20120705
Title: Dasatinib synergizes with both cytotoxic and signal transduction inhibitors in heterogeneous breast cancer cell lines--lessons for design of combination targeted therapy.
Journal: Cancer letters 20120701
Title: Beyond taxanes: the next generation of microtubule-targeting agents.
Journal: Breast cancer research and treatment 20120601
Title: Phase II trial of weekly ixabepilone in men with metastatic castrate-resistant prostate cancer (E3803): a trial of the Eastern Cooperative Oncology Group.
Journal: Clinical genitourinary cancer 20120601
Title: A phase I study of ixabepilone in combination with epirubicin in patients with metastatic breast cancer.
Journal: Clinical breast cancer 20120601
Title: Gene expression profiling of breast tumor cell lines to predict for therapeutic response to microtubule-stabilizing agents.
Journal: Breast cancer research and treatment 20120401
Title: RhoB mediates antitumor synergy of combined ixabepilone and sunitinib in human ovarian serous cancer.
Journal: Gynecologic oncology 20120301
Title: Ixabepilone plus capecitabine in advanced breast cancer patients with early relapse after adjuvant anthracyclines and taxanes: a pooled subset analysis of two phase III studies.
Journal: Breast (Edinburgh, Scotland) 20120201
Title: Q-TWiST analysis of ixabepilone in combination with capecitabine on quality of life in patients with metastatic breast cancer.
Journal: Cancer 20120115
Title: The paradox of triple negative breast cancer: novel approaches to treatment.
Journal: The breast journal 20120101
Title: Weekly ixabepilone administration in heavily pretreated metastatic breast cancer patients.
Journal: Medical oncology (Northwood, London, England) 20111201
Title: Epothilone-induced peripheral neuropathy: a review of current knowledge.
Journal: Journal of pain and symptom management 20111201
Title: Phase I clinical and pharmacokinetic study of UTD1, a genetically engineered epothilone analog in patients with advanced solid tumors.
Journal: Cancer chemotherapy and pharmacology 20111001
Title: Alternative dosing schedules and administration updates for ixabepilone.
Journal: Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners 20110901
Title: Bending the cost curve in cancer care.
Journal: The New England journal of medicine 20110818
Title: Comparison of neuropathy-inducing effects of eribulin mesylate, paclitaxel, and ixabepilone in mice.
Journal: Cancer research 20110601
Title: Ixabepilone: clinical role in metastatic breast cancer.
Journal: Clinical breast cancer 20110601
Title: Ixabepilone, a novel microtubule-targeting agent for breast cancer, is a substrate for P-glycoprotein (P-gp/MDR1/ABCB1) but not breast cancer resistance protein (BCRP/ABCG2).
Journal: The Journal of pharmacology and experimental therapeutics 20110501
Title: Global experience with ixabepilone in breast cancer.
Journal: Expert review of anticancer therapy 20110501
Title: Few positives for triple-negative breast cancer.
Journal: Journal of the National Cancer Institute 20110406
Title: Hallmarks of molecular action of microtubule stabilizing agents: effects of epothilone B, ixabepilone, peloruside A, and laulimalide on microtubule conformation.
Journal: The Journal of biological chemistry 20110401
Title: Ixabepilone plus capecitabine in metastatic breast cancer patients with reduced performance status previously treated with anthracyclines and taxanes: a pooled analysis by performance status of efficacy and safety data from 2 phase III studies.
Journal: Breast cancer research and treatment 20110201
Title: Epothilones in prostate cancer.
Journal: Urologic oncology 20110101
Title: Ixabepilone for the treatment of breast cancer.
Journal: Annals of medicine 20110101
Title: The epothilone B analogue ixabepilone in patients with advanced hepatobiliary cancers: a trial of the University of Chicago Phase II Consortium.
Journal: Investigational new drugs 20101201
Title: Identifying subsets of metastatic breast cancer patients likely to benefit from treatment with the epothilone B analog ixabepilone.
Journal: American journal of clinical oncology 20101201
Title: A phase I/II trial and pharmacokinetic study of ixabepilone in adult patients with recurrent high-grade gliomas.
Journal: Journal of neuro-oncology 20101101
Title: Optimizing ixabepilone treatment schedules in patients with advanced or metastatic breast cancer.
Journal: Cancer chemotherapy and pharmacology 20101101
Title: Recall those thrilling days of yesteryear ..
Journal: The oncologist 20101101
Title: Ixabepilone, a new treatment option for metastatic breast cancer.
Journal: American journal of clinical oncology 20101001
Title: Phase I trial of ixabepilone plus pegylated liposomal doxorubicin in patients with adenocarcinoma of breast or ovary.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20101001
Title: Management of triple negative breast cancer.
Journal: Breast (Edinburgh, Scotland) 20101001
Title: Ixabepilone plus capecitabine for breast cancer patients with an early metastatic relapse after adjuvant chemotherapy: two clinical trials.
Journal: Clinical breast cancer 20101001
Title: Ixabepilone plus capecitabine for Chinese patients with metastatic breast cancer progressing after anthracycline and taxane treatment.
Journal: Cancer chemotherapy and pharmacology 20100801
Title: Randomized phase III trial of ixabepilone plus capecitabine versus capecitabine in patients with metastatic breast cancer previously treated with an anthracycline and a taxane.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20100710
Title: Analysis of overall survival from a phase III study of ixabepilone plus capecitabine versus capecitabine in patients with MBC resistant to anthracyclines and taxanes.
Journal: Breast cancer research and treatment 20100701
Title: [Current impact of natural products in the discovery of anticancer drugs].
Journal: Annales pharmaceutiques francaises 20100701
Title: Efficacy of ixabepilone in ER/PR/HER2-negative (triple-negative) breast cancer.
Journal: Breast cancer research and treatment 20100601
Title: Supporting Asian patients with metastatic breast cancer during ixabepilone therapy.
Journal: Expert opinion on drug safety 20100501
Title: A phase II clinical trial of ixabepilone (Ixempra; BMS-247550; NSC 710428), an epothilone B analog, in patients with metastatic renal cell carcinoma.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20100301
Title: [Treatment possibilities in breast cancer progressing after anthracyclines and/or taxanes].
Journal: Magyar onkologia 20100301
Title: Liquid chromatography and tandem mass spectrometry for the quantitative determination of ixabepilone (BMS-247550, Ixempra) in human plasma: method validation, overcoming curve splitting issues and eliminating chromatographic interferences from degradants.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100215
Title: A phase II trial of trastuzumab plus weekly ixabepilone and carboplatin in patients with HER2-positive metastatic breast cancer: an Eastern Cooperative Oncology Group Trial.
Journal: Breast cancer research and treatment 20100201
Title: Ixabepilone.
Journal: Clinical journal of oncology nursing 20100201
Title: Visceral disease in patients with metastatic breast cancer: efficacy and safety of treatment with ixabepilone and other chemotherapeutic agents.
Journal: Clinical breast cancer 20100201
Title: Ixabepilone plus capecitabine with capecitabine alone for metastatic breast cancer.
Journal: Future oncology (London, England) 20100201
Title: Phase II trial of ixabepilone administered daily for five days in children and young adults with refractory solid tumors: a report from the children's oncology group.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20100115
Title: Phase II clinical trial of ixabepilone in patients with recurrent or persistent platinum- and taxane-resistant ovarian or primary peritoneal cancer: a gynecologic oncology group study.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20100101
Title: Advances in breast cancer treatment: the emerging role of ixabepilone.
Journal: Expert review of anticancer therapy 20100101
Title: A phase II trial of the epothilone B analog ixabepilone (BMS-247550) in patients with metastatic melanoma.
Journal: PloS one 20100101
Title: Long-lasting control of triple-negative metastatic breast cancer with the novel drug combination ixabepilone and capecitabine--case report.
Journal: Onkologie 20100101
Title: Chemotherapy resistance in metastatic breast cancer: the evolving role of ixabepilone.
Journal: Breast cancer research : BCR 20100101
Title: Current combination chemotherapy regimens for metastatic breast cancer.
Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20091201
Title: Activity of ixabepilone in oestrogen receptor-negative and oestrogen receptor-progesterone receptor-human epidermal growth factor receptor 2-negative metastatic breast cancer.
Journal: European journal of cancer (Oxford, England : 1990) 20091101
Title: Sensory-motor axonal peripheral neuropathy in an advanced breast cancer patient treated with ixabepilone.
Journal: Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 20091101
Title: Prolonged disease control in a patient with anthracycline- and taxane-resistant breast cancer.
Journal: Clinical breast cancer 20091101
Title: Neurological adverse effects caused by cytotoxic and targeted therapies.
Journal: Nature reviews. Clinical oncology 20091001
Title: Ixabepilone: new drug. Similar to taxanes, but no better.
Journal: Prescrire international 20090801
Title: Ixabepilone: in locally advanced or metastatic breast cancer.
Journal: Drugs 20090730
Title: Phase II trial of ixabepilone as second-line treatment in advanced endometrial cancer: gynecologic oncology group trial 129-P.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20090701
Title: Phase I study of ixabepilone, mitoxantrone, and prednisone in patients with metastatic castration-resistant prostate cancer previously treated with docetaxel-based therapy: a study of the department of defense prostate cancer clinical trials consortium.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20090610
Title: The optimal therapeutic use of ixabepilone in patients with locally advanced or metastatic breast cancer.
Journal: Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners 20090601
Title: Ready for a comeback of natural products in oncology.
Journal: Biochemical pharmacology 20090501
Title: Efficacy does not necessarily translate to cost effectiveness: a case study in the challenges associated with 21st-century cancer drug pricing.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20090501
Title: Cost effectiveness of ixabepilone plus capecitabine for metastatic breast cancer progressing after anthracycline and taxane treatment.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20090501
Title: Proactive management of adverse events maintains the clinical benefit of ixabepilone.
Journal: The oncologist 20090501
Title: Impact, mechanisms, and novel chemotherapy strategies for overcoming resistance to anthracyclines and taxanes in metastatic breast cancer.
Journal: Breast cancer research and treatment 20090301
Title: Ixabepilone: a new active chemotherapy in the treatment of breast cancer.
Journal: Women's health (London, England) 20090301
Title: Phase I dose escalation study of weekly ixabepilone, an epothilone analog, in patients with advanced solid tumors who have failed standard therapy.
Journal: Cancer chemotherapy and pharmacology 20090201
Title: Phase I trial and pharmacokinetic study of ixabepilone administered daily for 5 days in children and adolescents with refractory solid tumors.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20090201
Title: Phase II genomics study of ixabepilone as neoadjuvant treatment for breast cancer.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20090201
Title: Discovery of ixabepilone.
Journal: Molecular cancer therapeutics 20090201
Title: Ixabepilone and other epothilones: microtubule-targeting agents for metastatic breast cancer.
Journal: Clinical advances in hematology & oncology : H&O 20090201
Title: Preclinical efficacy spectrum and pharmacokinetics of ixabepilone.
Journal: Cancer chemotherapy and pharmacology 20090101
Title: Ixabepilone: targeting betaIII-tubulin expression in taxane-resistant malignancies.
Journal: Molecular cancer therapeutics 20090101
Title: The efficacy and safety of ixabepilone monotherapy in the treatment of breast and gynecologic malignancies.
Journal: Expert opinion on drug safety 20090101
Title: Budget impact analysis of ixabepilone used according to FDA approved labeling in treatment-resistant metastatic breast cancer.
Journal: Journal of managed care pharmacy : JMCP 20090101
Title: Other paradigms: growth rate constants and tumor burden determined using computed tomography data correlate strongly with the overall survival of patients with renal cell carcinoma.
Journal: Cancer journal (Sudbury, Mass.) 20090101
Title: Biotransformation profiling of [(14)C]ixabepilone in human plasma, urine and feces samples using accelerator mass spectrometry (AMS).
Journal: Drug metabolism and pharmacokinetics 20090101
Title: Synergistic antitumor activity of ixabepilone (BMS-247550) plus bevacizumab in multiple in vivo tumor models.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20081215
Title: A phase I and pharmacokinetic study of ixabepilone in combination with Carboplatin in patients with advanced solid malignancies.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20081215
Title: Preclinical discovery of ixabepilone, a highly active antineoplastic agent.
Journal: Cancer chemotherapy and pharmacology 20081201
Title: Novel neurosensory testing in cancer patients treated with the epothilone B analog, ixabepilone.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20081201
Title: Activity of ixabepilone in patients with metastatic breast cancer with primary resistance to taxanes.
Journal: Clinical breast cancer 20081201
Title: Clinical development of ixabepilone and other epothilones in patients with advanced solid tumors.
Journal: The oncologist 20081201
Title: Pharmacokinetic profile of the microtubule stabilizer patupilone in tumor-bearing rodents and comparison of anti-cancer activity with other MTS in vitro and in vivo.
Journal: Cancer chemotherapy and pharmacology 20081101
Title: Application of epothilones in breast cancer therapy.
Journal: Current opinion in oncology 20081101
Title: Ixabepilone: a novel microtubule-stabilizing agent for the treatment of metastatic breast cancer.
Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20081101
Title: Ixabepilone in metastatic breast cancer: complement or alternative to taxanes?
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20081101
Title: A multicentre phase II clinical experience with the novel aza-epothilone Ixabepilone (BMS247550) in patients with relapsed or refractory indolent non-Hodgkin lymphoma and mantle cell lymphoma.
Journal: British journal of haematology 20081001
Title: Lapatinib and ixabepilone for the treatment of metastatic breast cancer.
Journal: Pharmacotherapy 20081001
Title: Ixabepilone: a new antimitotic for the treatment of metastatic breast cancer.
Journal: The Annals of pharmacotherapy 20080901
Title: Ixabepilone: a novel microtubule inhibitor for the treatment of locally advanced or metastatic breast cancer.
Journal: Clinical therapeutics 20080901
Title: Epothilones: a novel class of microtubule-stabilizing drugs for the treatment of cancer.
Journal: Future oncology (London, England) 20080801
Title: Ixabepilone in combination with capecitabine and as monotherapy for treatment of advanced breast cancer refractory to previous chemotherapies.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20080715
Title: New drugs08, part 2.
Journal: Nursing 20080701
Title: Ixabepilone for the treatment of taxane-refractory breast cancer.
Journal: Future oncology (London, England) 20080601
Title: [Oncology 2008].
Journal: Deutsche medizinische Wochenschrift (1946) 20080601
Title: Phase I/II study of ixabepilone plus capecitabine in anthracycline-pretreated/resistant and taxane-resistant metastatic breast cancer.
Journal: Clinical breast cancer 20080601
Title: A randomized phase II study of ixabepilone (BMS-247550) given daily x 5 days every 3 weeks or weekly in patients with metastatic or recurrent squamous cell cancer of the head and neck: an Eastern Cooperative Oncology Group study.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20080501
Title: Ixabepilone plus capecitabine for metastatic breast cancer progressing after anthracycline and taxane treatment.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20080501
Title: The effect of ketoconazole on the pharmacokinetics and pharmacodynamics of ixabepilone: a first in class epothilone B analogue in late-phase clinical development.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20080501
Title: Ixabepilone: a new microtubule-targeting agent for breast cancer.
Journal: Expert review of anticancer therapy 20080501
Title: Epothilones: clinical update and future directions.
Journal: Oncology (Williston Park, N.Y.) 20080415
Title: Phase I clinical and pharmacokinetic study of 3-weekly, 3-h infusion of ixabepilone (BMS-247550), an epothilone B analog, in Japanese patients with refractory solid tumors.
Journal: Cancer chemotherapy and pharmacology 20080401
Title: Epothilones and new analogues of the microtubule modulators in taxane-resistant disease.
Journal: Expert opinion on investigational drugs 20080401
Title: Ixabepilone, a novel epothilone analog in the treatment of breast cancer.
Journal: Expert opinion on investigational drugs 20080401
Title: Preclinical investigations with epothilones in breast cancer models.
Journal: Seminars in oncology 20080401
Title: Clinical studies with epothilones for the treatment of metastatic breast cancer.
Journal: Seminars in oncology 20080401
Title: Safety of repeated administrations of ixabepilone given as a 3-hour infusion every other week in combination with irinotecan in patients with advanced malignancies.
Journal: European journal of cancer (Oxford, England : 1990) 20080301
Title: Ixabepilone for the treatment of solid tumors: a review of clinical data.
Journal: Expert opinion on investigational drugs 20080301
Title: Ixabepilone: a novel antineoplastic agent with low susceptibility to multiple tumor resistance mechanisms.
Journal: The oncologist 20080301
Title: Clinical experience with epothilones in patients with breast cancer.
Journal: Clinical breast cancer 20080301
Title: Current perspectives of epothilones in breast cancer.
Journal: European journal of cancer (Oxford, England : 1990) 20080201
Title: [Efficacy and safety of ixabepilone (BMS-247550), a novel epothilone B analogue].
Journal: Bulletin du cancer 20080201
Title: Epothilones.
Journal: Oncology (Williston Park, N.Y.) 20080201
Title: Ixabepilone (Ixempra) for breast cancer.
Journal: The Medical letter on drugs and therapeutics 20080128
Title: San Antonio Breast Cancer Symposium.
Journal: The Lancet. Oncology 20080101
Title: New drugs: doripenem, raltegravir, and ixabepilone.
Journal: Journal of the American Pharmacists Association : JAPhA 20080101
Title: New therapeutic options for chemotherapy-resistant metastatic breast cancer: the epothilones.
Journal: Drugs 20080101
Title: Evidence for microtubule target engagement in tumors of patients receiving ixabepilone.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20071215
Title: FDA approves new breast cancer treatment.
Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20071201
Title: Ixabepilone plus capecitabine for metastatic breast cancer progressing after anthracycline and taxane treatment.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20071120
Title: Phase II trial of ixabepilone in patients with cisplatin-refractory germ cell tumors.
Journal: Investigational new drugs 20071001
Title: Ixabepilone, first in a new class of antineoplastic agents: the natural epothilones and their analogues.
Journal: Clinical breast cancer 20071001
Title: Phase 2 trial of epothilone B analog BMS-247550 (ixabepilone) in advanced carcinoma of the urothelium (E3800): a trial of the Eastern Cooperative Oncology Group.
Journal: Cancer 20070815
Title: Ixabepilone and the narrow path to developing new cytotoxic drugs.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20070810
Title: Phase II trial of ixabepilone, an epothilone B analog, in patients with metastatic breast cancer previously untreated with taxanes.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20070810
Title: Phase II clinical trial of ixabepilone (BMS-247550), an epothilone B analog, as first-line therapy in patients with metastatic breast cancer previously treated with anthracycline chemotherapy.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20070810
Title: Phase II clinical trial of the epothilone B analog, ixabepilone, in patients with non small-cell lung cancer whose tumors have failed first-line platinum-based chemotherapy.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20070810
Title: Efficacy and safety of ixabepilone (BMS-247550) in a phase II study of patients with advanced breast cancer resistant to an anthracycline, a taxane, and capecitabine.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20070810
Title: Phase II clinical trial of ixabepilone (BMS-247550), an epothilone B analog, in patients with taxane-resistant metastatic breast cancer.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20070810
Title: Human mass balance study of the novel anticancer agent ixabepilone using accelerator mass spectrometry.
Journal: Investigational new drugs 20070801
Title: A phase I trial of BMS-247550 (NSC# 710428) and gemcitabine in patients with advanced solid tumors.
Journal: Investigational new drugs 20070801
Title: Activity of second-line chemotherapy in docetaxel-refractory hormone-refractory prostate cancer patients : randomized phase 2 study of ixabepilone or mitoxantrone and prednisone.
Journal: Cancer 20070801
Title: Epothilones in breast cancer: review of clinical experience.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20070701
Title: Epothilones in prostate cancer: review of clinical experience.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20070701
Title: Potential clinical applications of epothilones: a review of phase II studies.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20070701
Title: Novel tubulin-targeting agents: anticancer activity and pharmacologic profile of epothilones and related analogues.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20070701
Title: [Promising new treatment options for metastatic androgen-independent prostate cancer].
Journal: Actas urologicas espanolas 20070601
Title: A phase II study of ixabepilone (BMS-247550) in metastatic renal-cell carcinoma.
Journal: Cancer biology & therapy 20070401
Title: Efficacy and safety of ixabepilone, a novel epothilone analogue.
Journal: Clinical breast cancer 20070401
Title: Phase I study of the novel epothilone analog ixabepilone (BMS-247550) in patients with advanced solid tumors and lymphomas.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20070320
Title: Phase II trial of ixabepilone, an epothilone B analog, given daily for three days every three weeks, in metastatic breast cancer.
Journal: Investigational new drugs 20070201
Title: Peripheral blood mononuclear and tumor cell pharmacodynamics of the novel epothilone B analogue, ixabepilone.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20070101
Title: Advances in chemotherapy options for metastatic breast cancer: introduction of epothilones.
Journal: ONS connect 20070101
Title: Total synthesis and antitumor activity of ZK-EPO: the first fully synthetic epothilone in clinical development.
Journal: Angewandte Chemie (International ed. in English) 20061204
Title: A Phase II trial of epothilone B analogue BMS-247550 (NSC #710428) ixabepilone, in patients with advanced pancreas cancer: a Southwest Oncology Group study.
Journal: Investigational new drugs 20061101
Title: A multi-center phase II study of BMS-247550 (Ixabepilone) by two schedules in patients with metastatic gastric adenocarcinoma previously treated with a taxane.
Journal: Investigational new drugs 20060901
Title: Epothilones in the treatment of cancer.
Journal: Expert opinion on investigational drugs 20060601
Title: Changes in neurologic function tests may predict neurotoxicity caused by ixabepilone.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20060501
Title: Peripheral neuropathy induced by microtubule-stabilizing agents.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20060401
Title: A retrospective evaluation of second-line chemotherapy response in hormone-refractory prostate carcinoma: second line taxane-based therapy after first-line epothilone-B analog ixabepilone (BMS-247550) therapy.
Journal: Cancer 20060101
Title: Dermatological toxicity of ixabepilone.
Journal: Anticancer research 20060101
Title: Current state of the art of new tubulin inhibitors in the clinic.
Journal: Current clinical pharmacology 20060101
Title: Ixabepilone (epothilone B analogue BMS-247550) is active in chemotherapy-naive patients with hormone-refractory prostate cancer: a Southwest Oncology Group trial S0111.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20051201
Title: Development of novel chemotherapeutic agents to evade the mechanisms of multidrug resistance (MDR).
Journal: Seminars in oncology 20051201
Title: In vivo evaluation of ixabepilone (BMS247550), a novel epothilone B derivative, against pediatric cancer models.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20051001
Title: Promising systemic therapy for renal cell carcinoma.
Journal: Current treatment options in oncology 20050901
Title: Phase I clinical trial of BMS-247550, a derivative of epothilone B, using accelerated titration 2B design.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20050901
Title: Activation of the steroid and xenobiotic receptor (human pregnane X receptor) by nontaxane microtubule-stabilizing agents.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20050901
Title: Epothilones and the next generation of phase III trials for prostate cancer.
Journal: BJU international 20050801
Title: A Phase I clinical trial of ixabepilone (BMS-247550), an epothilone B analog, administered intravenously on a daily schedule for 3 days.
Journal: Cancer 20050501
Title: Update in the management of patients with hormone-refractory prostate cancer.
Journal: Current opinion in urology 20050501
Title: Phase II clinical trial of ixabepilone (BMS-247550), an epothilone B analog, in metastatic and locally advanced breast cancer.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20050420
Title: Multi-institutional randomized phase II trial of the epothilone B analog ixabepilone (BMS-247550) with or without estramustine phosphate in patients with progressive castrate metastatic prostate cancer.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20050301
Title: Much anticipated--the bioactive conformation of epothilone and its binding to tubulin.
Journal: Angewandte Chemie (International ed. in English) 20050218
Title: Nail disorders in a woman treated with ixabepilone for metastatic breast cancer.
Journal: Anticancer research 20050101
Title: Novel agents for the treatment of advanced kidney cancer.
Journal: Clinical advances in hematology & oncology : H&O 20041001
Title: Regulation of Bax activation and apoptotic response to microtubule-damaging agents by p53 transcription-dependent and -independent pathways.
Journal: The Journal of biological chemistry 20040917
Title: Activity of epothilone B analogues ixabepilone and patupilone in hormone-refractory prostate cancer.
Journal: Clinical prostate cancer 20040901
Title: A phase II trial of the epothilone B analog, BMS-247550, in patients with previously treated advanced colorectal cancer.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20040601
Title: Phase I clinical and pharmacokinetic study of BMS-247550, a novel derivative of epothilone B, in solid tumors.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20040215
Title: Pilot study of epothilone B analog (BMS-247550) and estramustine phosphate in patients with progressive metastatic prostate cancer following castration.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20031001
Title: Potential radiation-sensitizing effect of semisynthetic epothilone B in human lung cancer cells.
Journal: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20030901
Title: Treatment of recurrent cervical adenocarcinoma with BMS-247550, an epothilone B analog.
Journal: Gynecologic oncology 20030701
Title: BMS-247550 Bristol-Myers Squibb/GBF.
Journal: Current opinion in investigational drugs (London, England : 2000) 20030601
Title: Phase I trial and pharmacokinetic study of BMS-247550, an epothilone B analog, administered intravenously on a daily schedule for five days.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20030501
Title: Molecular determinants of epothilone B derivative (BMS 247550) and Apo-2L/TRAIL-induced apoptosis of human ovarian cancer cells.
Journal: Gynecologic oncology 20030401
Title: Epothilone B and its analogs - a new family of anticancer agents.
Journal: Mini reviews in medicinal chemistry 20030301
Title: Validation of the pharmacodynamics of BMS-247550, an analogue of epothilone B, during a phase I clinical study.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20020701
Title: Ectopic overexpression of second mitochondria-derived activator of caspases (Smac/DIABLO) or cotreatment with N-terminus of Smac/DIABLO peptide potentiates epothilone B derivative-(BMS 247550) and Apo-2L/TRAIL-induced apoptosis.
Journal: Blood 20020501
Title: Epothilone B analogue (BMS-247550)-mediated cytotoxicity through induction of Bax conformational change in human breast cancer cells.
Journal: Cancer research 20020115
Title: Epothilones: a novel class of non-taxane microtubule-stabilizing agents.
Journal: Current pharmaceutical design 20020101
Title: New anti-tubulin agents.
Journal: I supplementi di Tumori : official journal of Societa italiana di cancerologia ... [et al.] 20020101
Title: Clinical trials referral resource. Current clinical trials of epothilone B analog (BMS-247550).
Journal: Oncology (Williston Park, N.Y.) 20010901
Title: BMS-247550: a novel epothilone analog with a mode of action similar to paclitaxel but possessing superior antitumor efficacy.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20010501
Title: John T. Hunt Discovery of Ixabepilone. Mol Cancer Ther February 2009 8; 275