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236395-14-5,MFCD06798333
Catalog No.:AA002NWY

236395-14-5 | Eslicarbazepine acetate

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25mg
98%(HPLC)
in stock  
$43.00   $30.00
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100mg
98%(HPLC)
in stock  
$80.00   $56.00
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250mg
98%(HPLC)
in stock  
$167.00   $117.00
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1g
98%(HPLC)
in stock  
$421.00   $295.00
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5g
98%(HPLC)
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$1,548.00   $1,084.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA002NWY
Chemical Name:
Eslicarbazepine acetate
CAS Number:
236395-14-5
Molecular Formula:
C17H16N2O3
Molecular Weight:
296.3205
MDL Number:
MFCD06798333
SMILES:
CC(=O)O[C@H]1Cc2ccccc2N(c2c1cccc2)C(=O)N
Properties
Properties
 
BP:
427.4°C at 760 mmHg  
Form:
Solid  
MP:
176 - 178°C  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
440  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
2  
XLogP3:
2  

Literature

Title: The Efficacy of Eslicarbazepine Acetate in Models of Trigeminal, Neuropathic, and Visceral Pain: The Involvement of 5-HT1B/1D Serotonergic and CB1/CB2 Cannabinoid Receptors.

Journal: Anesthesia and analgesia 20151201

Title: A review of the efficacy and safety of eslicarbazepine acetate in the management of partial-onset seizures.

Journal: Therapeutic advances in neurological disorders 20150701

Title: Pharmacokinetic/pharmacodynamic evaluation of eslicarbazepine for the treatment of epilepsy.

Journal: Expert opinion on drug metabolism & toxicology 20150401

Title: Eslicarbazepine acetate for the treatment of focal epilepsy: an update on its proposed mechanisms of action.

Journal: Pharmacology research & perspectives 20150301

Title: Eslicarbazepine acetate as adjunctive therapy in patients with uncontrolled partial-onset seizures: Results of a phase III, double-blind, randomized, placebo-controlled trial.

Journal: Epilepsia 20150201

Title: Clinical utility of eslicarbazepine: current evidence.

Journal: Drug design, development and therapy 20150101

Title: Efficacy and safety of conversion to monotherapy with eslicarbazepine acetate in adults with uncontrolled partial-onset seizures: a historical-control phase III study.

Journal: BMC neurology 20150101

Title: Long-term safety and efficacy of eslicarbazepine acetate in patients with focal seizures: results of the 1-year ESLIBASE retrospective study.

Journal: Epilepsy research 20140901

Title: The effects of eslicarbazepine on persistent Na⁺ current and the role of the Na⁺ channel β subunits.

Journal: Epilepsy research 20140201

Title: Aptiom (eslicarbazepine acetate) as a dual inhibitor of β-secretase and voltage-gated sodium channel: advancement in Alzheimer's disease-epilepsy linkage via an enzoinformatics study.

Journal: CNS & neurological disorders drug targets 20140101

Title: Pharmacokinetics and drug interactions of eslicarbazepine acetate.

Journal: Epilepsia 20120601

Title: [Eslicarbazepine acetate: a novel therapeutic alternative in the treatment of focal seizures].

Journal: Revista de neurologia 20120501

Title: Pharmacotherapy of the third-generation AEDs: lacosamide, retigabine and eslicarbazepine acetate.

Journal: Expert opinion on pharmacotherapy 20120401

Title: Highly efficient, selective, sensitive and stability indicating RP-HPLC-UV method for the quantitative determination of potential impurities and characterization of four novel impurities in eslicarbazepine acetate active pharmaceutical ingredient by LC/ESI-IT/MS/MS.

Journal: Journal of pharmaceutical and biomedical analysis 20120305

Title: Pharmacokinetics, drug interactions and exposure-response relationship of eslicarbazepine acetate in adult patients with partial-onset seizures: population pharmacokinetic and pharmacokinetic/pharmacodynamic analyses.

Journal: CNS drugs 20120101

Title: Eslicarbazepine acetate add-on for drug-resistant partial epilepsy.

Journal: The Cochrane database of systematic reviews 20111207

Title: Eslicarbazepine acetate for partial-onset seizures.

Journal: Expert review of neurotherapeutics 20111201

Title: In vitro transport profile of carbamazepine, oxcarbazepine, eslicarbazepine acetate, and their active metabolites by human P-glycoprotein.

Journal: Epilepsia 20111001

Title: [New antiepileptic drugs, and therapeutic considerations].

Journal: Ideggyogyaszati szemle 20110930

Title: Hepatic UDP-glucuronosyltransferase is responsible for eslicarbazepine glucuronidation.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20110901

Title: Pharmacokinetics of eslicarbazepine acetate at steady-state in adults with partial-onset seizures.

Journal: Epilepsy research 20110901

Title: Development and validation of an enantioselective liquid-chromatography/tandem mass spectrometry method for the separation and quantification of eslicarbazepine acetate, eslicarbazepine, R-licarbazepine and oxcarbazepine in human plasma.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110901

Title: [Abrupt switch from extended-release oxcarbazepine to eslicarbazepine acetate].

Journal: Der Nervenarzt 20110601

Title: A chiral HPLC-UV method for the quantification of dibenz[b,f]azepine-5-carboxamide derivatives in mouse plasma and brain tissue: eslicarbazepine acetate, carbamazepine and main metabolites.

Journal: Journal of separation science 20110601

Title: Development of liquid chromatographic enantiomer separation methods and validation for the estimation of (R)-enantiomer in eslicarbazepine acetate.

Journal: Journal of pharmaceutical and biomedical analysis 20110105

Title: Long-term efficacy and safety of eslicarbazepine acetate: results of a 1-year open-label extension study in partial-onset seizures in adults with epilepsy.

Journal: Epilepsia 20101001

Title: Enantioselective assay for therapeutic drug monitoring of eslicarbazepine acetate: no interference with carbamazepine and its metabolites.

Journal: Therapeutic drug monitoring 20100801

Title: Effect of eslicarbazepine acetate and oxcarbazepine on cognition and psychomotor function in healthy volunteers.

Journal: Epilepsy & behavior : E&B 20100801

Title: Pharmacokinetic interaction study between eslicarbazepine acetate and topiramate in healthy subjects.

Journal: Current medical research and opinion 20100601

Title: Development and validation of an HPLC-UV method for the simultaneous quantification of carbamazepine, oxcarbazepine, eslicarbazepine acetate and their main metabolites in human plasma.

Journal: Analytical and bioanalytical chemistry 20100601

Title: Eslicarbazepine acetate as adjunctive therapy in adult patients with partial epilepsy.

Journal: Epilepsy research 20100501

Title: Pharmacokinetic interaction study between eslicarbazepine acetate and lamotrigine in healthy subjects.

Journal: Acta neurologica Scandinavica 20100401

Title: Key factors in the discovery and development of new antiepileptic drugs.

Journal: Nature reviews. Drug discovery 20100101

Title: Effect of eslicarbazepine acetate on the steady-state pharmacokinetics and pharmacodynamics of warfarin in healthy subjects during a three-stage, open-label, multiple-dose, single-period study.

Journal: Clinical therapeutics 20100101

Title: Eslicarbazepine acetate: A novel agent for the adjunctive treatment of epilepsy.

Journal: Drugs of today (Barcelona, Spain : 1998) 20100101

Title: Efficacy and safety of 800 and 1200 mg eslicarbazepine acetate as adjunctive treatment in adults with refractory partial-onset seizures.

Journal: Acta neurologica Scandinavica 20091101

Title: Effect of eslicarbazepine acetate on the pharmacokinetics of digoxin in healthy subjects.

Journal: Fundamental & clinical pharmacology 20090801

Title: Effect of eslicarbazepine acetate on the pharmacokinetics of metformin in healthy subjects.

Journal: International journal of clinical pharmacology and therapeutics 20090401

Title: Efficacy and safety of eslicarbazepine acetate as adjunctive treatment in adults with refractory partial-onset seizures: a randomized, double-blind, placebo-controlled, parallel-group phase III study.

Journal: Epilepsia 20090301

Title: Eslicarbazepine acetate: a new option for the treatment of focal epilepsy.

Journal: Expert opinion on investigational drugs 20090201

Title: Eslicarbazepine acetate.

Journal: CNS drugs 20090101

Title: Disposition of eslicarbazepine acetate in the mouse after oral administration.

Journal: Fundamental & clinical pharmacology 20081001

Title: Pharmacokinetics, efficacy, and tolerability of eslicarbazepine acetate in children and adolescents with epilepsy.

Journal: Journal of clinical pharmacology 20080801

Title: Pharmacokinetics of eslicarbazepine acetate in patients with moderate hepatic impairment.

Journal: European journal of clinical pharmacology 20080301

Title: Effect of renal impairment on the pharmacokinetics of eslicarbazepine acetate.

Journal: International journal of clinical pharmacology and therapeutics 20080301

Title: Dosage form proportionality and food effect of the final tablet formulation of eslicarbazepine acetate: randomized, open-label, crossover, single-centre study in healthy volunteers.

Journal: Drugs in R&D 20080101

Title: Enantioselective HPLC-UV method for determination of eslicarbazepine acetate (BIA 2-093) and its metabolites in human plasma.

Journal: Biomedical chromatography : BMC 20071101

Title: Effect of eslicarbazepine acetate (BIA 2-093) on latrunculin A-induced seizures and extracellular amino acid concentrations in the rat hippocampus.

Journal: Epilepsy research 20071001

Title: Simultaneous and enantioselective liquid chromatographic determination of eslicarbazepine acetate, S-licarbazepine, R-licarbazepine and oxcarbazepine in mouse tissue samples using ultraviolet detection.

Journal: Analytica chimica acta 20070716

Title: Effect of gender on the pharmacokinetics of eslicarbazepine acetate (BIA 2-093), a new voltage-gated sodium channel blocker.

Journal: Biopharmaceutics & drug disposition 20070701

Title: Eslicarbazepine acetate: a double-blind, add-on, placebo-controlled exploratory trial in adult patients with partial-onset seizures.

Journal: Epilepsia 20070301

Title: Eslicarbazepine acetate (BIA 2-093).

Journal: Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 20070101

Title: Anticonvulsant effect of eslicarbazepine acetate (BIA 2-093) on seizures induced by microperfusion of picrotoxin in the hippocampus of freely moving rats.

Journal: Epilepsy research 20061201

Title: Single-dose and steady-state pharmacokinetics of eslicarbazepine acetate (BIA 2-093) in healthy elderly and young subjects.

Journal: Journal of clinical pharmacology 20050901

Title: Effect of food on the pharmacokinetic profile of eslicarbazepine acetate (BIA 2-093).

Journal: Drugs in R&D 20050101

Title: Eslicarbazepine acetate (BIA 2-093) : relative bioavailability and bioequivalence of 50 mg/mL oral suspension and 200mg and 800mg tablet formulations.

Journal: Drugs in R&D 20050101

Title: Neurotoxicity induced by antiepileptic drugs in cultured hippocampal neurons: a comparative study between carbamazepine, oxcarbazepine, and two new putative antiepileptic drugs, BIA 2-024 and BIA 2-093.

Journal: Epilepsia 20041201

Title: Safety, tolerability, and pharmacokinetic profile of BIA 2-093, a novel putative antiepileptic, in a rising multiple-dose study in young healthy humans.

Journal: Journal of clinical pharmacology 20040801

Title: Safety, tolerability and pharmacokinetic profile of BIA 2-093, a novel putative antiepileptic agent, during first administration to humans.

Journal: Drugs in R&D 20030101

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: The novel anticonvulsant BIA 2-093 inhibits transmitter release during opening of voltage-gated sodium channels: a comparison with carbamazepine and oxcarbazepine.

Journal: Neurochemistry international 20020401

Title: Effects of carbamazepine and novel 10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide derivatives on synaptic transmission in rat hippocampal slices.

Journal: Pharmacology & toxicology 20020401

Title: Mechanisms of action of carbamazepine and its derivatives, oxcarbazepine, BIA 2-093, and BIA 2-024.

Journal: Neurochemical research 20020201

Title: Inhibition of glutamate release by BIA 2-093 and BIA 2-024, two novel derivatives of carbamazepine, due to blockade of sodium but not calcium channels.

Journal: Biochemical pharmacology 20010515

Title: Metabolism of two new antiepileptic drugs and their principal metabolites S(+)- and R(-)-10,11-dihydro-10-hydroxy carbamazepine.

Journal: Epilepsy research 20010501

Title: Interaction of the novel anticonvulsant, BIA 2-093, with voltage-gated sodium channels: comparison with carbamazepine.

Journal: Epilepsia 20010501

Title: Sibhghatulla Shaikh, et al. Aptiom (Eslicarbazepine Acetate) as a Dual Inhibitor of β-Secretase and Voltage-Gated Sodium Channel: Advancement in Alzheimer's Disease-Epilepsy Linkage via an Enzoinformatics Study. CNS & Neurological Disorders Drug Targets Volume 13 , Issue 7 , 2014.

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Tags:236395-14-5 Molecular Formula|236395-14-5 MDL|236395-14-5 SMILES|236395-14-5 Eslicarbazepine acetate