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36507-30-9,MFCD00467137
Catalog No.:AA00BZC6

36507-30-9 | Carbamazepine 10,11-epoxide

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5mg
≥98%
in stock  
$82.00   $57.00
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10mg
≥98%
in stock  
$143.00   $100.00
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25mg
97%
in stock  
$157.00   $110.00
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1g
97%
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$231.00   $162.00
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  • Technical Information
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA00BZC6
Chemical Name:
Carbamazepine 10,11-epoxide
CAS Number:
36507-30-9
Molecular Formula:
C15H12N2O2
Molecular Weight:
252.2680
MDL Number:
MFCD00467137
SMILES:
NC(=O)N1c2ccccc2C2C(c3c1cccc3)O2
Properties
Properties
 
BP:
390.2°C at 760 mmHg  
Form:
Solid  
MP:
204-206°C  
Storage:
Keep in dry area;-20 ℃;  

Computed Properties
 
Complexity:
358  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
19  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Undefined Atom Stereocenter Count:
2  
XLogP3:
1.3  

Literature

Title: Mass Spectrometric Characterization of Circulating Covalent Protein Adducts Derived from Epoxide Metabolites of Carbamazepine in Patients.

Journal: Chemical research in toxicology 20170717

Title: A new herb-drug interaction of Polygonum cuspidatum, a resveratrol-rich nutraceutical, with carbamazepine in rats.

Journal: Toxicology and applied pharmacology 20120915

Title: Carbamazepine, carbamazepine epoxide and dihydroxycarbamazepine sorption to soil and occurrence in a wastewater reuse site in Tunisia.

Journal: Chemosphere 20120601

Title: Identification of phthalates in medications and dietary supplement formulations in the United States and Canada.

Journal: Environmental health perspectives 20120301

Title: Assessment of the health risks related to the presence of drug residues in water for human consumption: application to carbamazepine.

Journal: Regulatory toxicology and pharmacology : RTP 20120201

Title: Successful treatment of carbamazepine poisoning with hemodialysis: a case report and review of the literature.

Journal: Hemodialysis international. International Symposium on Home Hemodialysis 20110701

Title: Carbamazepine and the active epoxide metabolite are effectively cleared by hemodialysis followed by continuous venovenous hemodialysis in an acute overdose.

Journal: Hemodialysis international. International Symposium on Home Hemodialysis 20110701

Title: In vivo solid-phase microextraction for single rodent pharmacokinetics studies of carbamazepine and carbamazepine-10,11-epoxide in mice.

Journal: Journal of chromatography. A 20110527

Title: Occurrence and removal of pharmaceuticals and hormones through drinking water treatment.

Journal: Water research 20110101

Title: Effects of carbamazepine and metabolites on IL-2, IL-5, IL-6, IL-10 and IFN-γ secretion in epileptic patients: the influence of co-medication.

Journal: Pharmacological reports : PR 20110101

Title: Discordant carbamazepine values between two immunoassays: carbamazepine values determined by ADVIA Centaur correlate better with those determined by LC-MS/MS than PETINIA assay.

Journal: Journal of clinical laboratory analysis 20110101

Title: Development and validation of an HPLC-UV method for the simultaneous quantification of carbamazepine, oxcarbazepine, eslicarbazepine acetate and their main metabolites in human plasma.

Journal: Analytical and bioanalytical chemistry 20100601

Title: Estimation of carbamazepine and carbamazepine-10,11-epoxide concentrations in plasma using mathematical equations generated with two carbamazepine immunoassays.

Journal: American journal of clinical pathology 20100501

Title: Analytical performance evaluation of ADVIA Chemistry Carbamazepine_2 assay: minimal cross-reactivity with carbamazepine 10, 11-epoxide and none with hydroxyzine or cetirizine.

Journal: Journal of clinical laboratory analysis 20100101

Title: Effect of berberine on the pharmacokinetics of substrates of CYP3A and P-gp.

Journal: Phytotherapy research : PTR 20091101

Title: Transitional polytherapy: tricks of the trade for monotherapy to monotherapy AED conversions.

Journal: Current neuropharmacology 20090601

Title: Instrumental planar chromatographic method for determination of carbamazepine in human serum.

Journal: Journal of separation science 20090501

Title: Inhibition of aquaporin 4 by antiepileptic drugs.

Journal: Bioorganic & medicinal chemistry 20090101

Title: Chemometric resolution of fully overlapped CE peaks: quantitation of carbamazepine in human serum in the presence of several interferences.

Journal: Electrophoresis 20081101

Title: Quantification of carbamazepine, carbamazepine-10,11-epoxide, phenytoin and phenobarbital in plasma samples by stir bar-sorptive extraction and liquid chromatography.

Journal: Journal of pharmaceutical and biomedical analysis 20080929

Title: Pharmacokinetic interaction between efavirenz and carbamazepine after multiple-dose administration in healthy subjects.

Journal: Journal of clinical pharmacology 20080801

Title: Approaches to treatment of type 2 diabetes.

Journal: Diabetes care 20080801

Title: A PLS-based extractive spectrophotometric method for simultaneous determination of carbamazepine and carbamazepine-10,11-epoxide in plasma and comparison with HPLC.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20071101

Title: [Carbamazepine-associated pseudolymphoma].

Journal: Revista de neurologia 20061201

Title: Transcriptional profiling of genes induced in the livers of patients treated with carbamazepine.

Journal: Clinical pharmacology and therapeutics 20061101

Title: Simultaneous determination of zonisamide, carbamazepine and carbamazepine-10,11-epoxide in infant serum by high-performance liquid chromatography.

Journal: Journal of pharmaceutical and biomedical analysis 20060616

Title: A reverse phase high performance liquid chromatography method for simultaneous estimation of melatonin, carbamazepine epoxide and carbamazepine simultaneously in serum.

Journal: Indian journal of physiology and pharmacology 20060101

Title: Human in vitro glutathionyl and protein adducts of carbamazepine-10,11-epoxide, a stable and pharmacologically active metabolite of carbamazepine.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20051201

Title: Patterns of care, outcomes, and direct health plan costs of antiepileptic therapy: a pharmacoeconomic analysis of the available carbamazepine formulations.

Journal: Clinical therapeutics 20050701

Title: Effect of probenecid on the pharmacokinetics of carbamazepine in healthy subjects.

Journal: European journal of clinical pharmacology 20050601

Title: Carbamazepine is an inhibitor of histone deacetylases.

Journal: Life sciences 20050513

Title: Haplotype structures of EPHX1 and their effects on the metabolism of carbamazepine-10,11-epoxide in Japanese epileptic patients.

Journal: European journal of clinical pharmacology 20050301

Title: Analytic performance evaluation of a new turbidimetric immunoassay for carbamazepine on the ADVIA 1650 analyzer: effect of carbamazepine 10,11-epoxide.

Journal: Therapeutic drug monitoring 20050201

Title: Population pharmacokinetics of delavirdine and N-delavirdine in HIV-infected individuals.

Journal: Clinical pharmacokinetics 20050101

Title: Effects of add-on melatonin administration on antioxidant enzymes in children with epilepsy taking carbamazepine monotherapy: a randomized, double-blind, placebo-controlled trial.

Journal: Epilepsia 20041201

Title: Population pharmacokinetic modeling of steady state clearance of carbamazepine and its epoxide metabolite from sparse routine clinical data.

Journal: Journal of clinical pharmacy and therapeutics 20040601

Title: Interference of carbamazepine and carbamazepine 10,11-epoxide in the fluorescence polarization immunoassay for tricyclic antidepressants: estimation of the true tricyclic antidepressant concentration in the presence of carbamazepine using a mathematical model.

Journal: American journal of clinical pathology 20040301

Title: Pharmacokinetic study of carbamazepine and its carbamazepine 10,11-epoxide metabolite in a group of female epileptic patients under chronic treatment.

Journal: Archives of medical research 20040101

Title: [Chemical diagnosis of carbamazepine intoxication and its usefulness in toxicological jurisprudence].

Journal: Archiwum medycyny sadowej i kryminologii 20040101

Title: Direct interaction between substrates and endogenous steroids in the active site may change the activity of cytochrome P450 3A4.

Journal: Biochemistry 20031230

Title: Inhibitory effect of stiripentol on carbamazepine and saquinavir metabolism in human.

Journal: British journal of clinical pharmacology 20031101

Title: The psychomotor effects of carbamazepine in epileptic patients and healthy volunteers.

Journal: Journal of psychopharmacology (Oxford, England) 20030901

Title: In vivo CYP3A4 heteroactivation is a possible mechanism for the drug interaction between felbamate and carbamazepine.

Journal: The Journal of pharmacology and experimental therapeutics 20030601

Title: How suitable are currently used carbamazepine immunoassays for quantifying carbamazepine-10,11-epoxide in serum samples?

Journal: Therapeutic drug monitoring 20030601

Title: CYP3A4 and CYP3A7-mediated carbamazepine 10,11-epoxidation are activated by differential endogenous steroids.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20030401

Title: Patch testing with carbamazepine and its main metabolite carbamazepine epoxide in cutaneous adverse drug reactions to carbamazepine.

Journal: Contact dermatitis 20030301

Title: Cross-reactivity assessment of carbamazepine-10,11-epoxide, oxcarbazepine, and 10-hydroxy-carbazepine in two automated carbamazepine immunoassays: PETINIA and EMIT 2000.

Journal: Therapeutic drug monitoring 20030201

Title: Postmortem toxicology of carbamazepine.

Journal: Journal of analytical toxicology 20030101

Title: Simultaneous plasma lamotrigine analysis with carbamazepine, carbamazepine 10,11 epoxide, primidone, phenytoin, phenobarbital, and PEMA by micellar electrokinetic capillary chromatography (MECC).

Journal: Journal of analytical toxicology 20030101

Title: Comment on antiepileptics and antipsychotics.

Journal: Teratology 20021201

Title: Elevation of carbamazepine-10,11-epoxide by quetiapine.

Journal: Pharmacotherapy 20021101

Title: Administration of Carbatrol to children with feeding tubes.

Journal: Pediatric neurology 20020901

Title: Decreased bioavailability of carbamazepine suppository after its intrarectal and intracolostomal administration to rectal-resected or colostoma-constructed rabbits.

Journal: International journal of pharmaceutics 20020725

Title: Determination of carbamazepine and carbamazepine 10,11-epoxide in human plasma by tandem liquid chromatography-mass spectrometry with electrospray ionisation.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20020325

Title: Reanalysis of carbamazepine and carbamazepine-epoxide pharmacokinetics after multiple dosing of extended release formulation.

Journal: Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20020101

Title: Carbamazepine poisoning: elimination kinetics and quantitative relationship with carbamazepine 10,11-epoxide.

Journal: Journal of toxicology. Clinical toxicology 20020101

Title: Determination of carbamazepine and its metabolite carbamazepine-10,11-epoxide in serum with gas-chromatography mass spectrometry.

Journal: Methods and findings in experimental and clinical pharmacology 20011101

Title: Determination of carbamazepine and carbamazepine-10,11-epoxide in human serum and plasma by micellar electrokinetic capillary chromatography in the absence of electroosmosis.

Journal: Electrophoresis 20010401

Title: Characterization of cross reactivity by carbamazepine 10,11-epoxide with carbamazepine assays.

Journal: Clinical biochemistry 20010301

Title: The influence of food on the bioavailability of a twice-daily controlled release carbamazepine formulation.

Journal: Journal of clinical pharmacology 20010201

Title: Effect of lamotrigine on the pharmacokinetics of carbamazepine and its active metabolite in dogs.

Journal: European journal of drug metabolism and pharmacokinetics 20010101

Title: Carbamazepine toxicity with lamotrigine: pharmacokinetic or pharmacodynamic interaction?

Journal: Epilepsia 19980201

Title: Carbamazepine-induced thrombocytopenia and carbamazepine-10,11-epoxide: a case report.

Journal: Psychiatry and clinical neurosciences 19950301

Title: In vivo and in vitro correlation of microsomal epoxide hydrolase inhibition by progabide.

Journal: Clinical pharmacology and therapeutics 19931101

Title: Genetic differences in the time course for the development and persistence of the anticonvulsant effects of carbamazepine against cocaine seizures.

Journal: Brain research 19930115

Title: Exacerbation of partial seizures and onset of nonepileptic myoclonus with carbamazepine.

Journal: Epilepsia 19910101

Title: Lateral gaze nystagmus in carbamazepine-treated epileptic patients: correlation with total and free plasma concentrations of parent drug and its 10,11-epoxide metabolite.

Journal: Therapeutic drug monitoring 19850101

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