Home Other Building Blocks 260415-63-2
260415-63-2,MFCD16038305
Catalog No.:AA002RE5

260415-63-2 | Pd173955

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$46.00   $32.00
- +
5mg
≥98%
in stock  
$166.00   $116.00
- +
10mg
≥98%
in stock  
$306.00   $214.00
- +
25mg
≥98%
in stock  
$545.00   $381.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA002RE5
Chemical Name:
Pd173955
CAS Number:
260415-63-2
Molecular Formula:
C21H16Cl2N4OS
Molecular Weight:
443.3489
MDL Number:
MFCD16038305
SMILES:
CSc1cccc(c1)Nc1ncc2c(n1)n(C)c(=O)c(c2)c1c(Cl)cccc1Cl
Properties
Computed Properties
 
Complexity:
626  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
4  
XLogP3:
5.4  

Downstream Synthesis Route
CASUnavailable 
  185039-48-9    260415-63-2 

[1]Locationinpatent:experimentalpartKraus,GeorgeA.;Gupta,Vinayak;Mokhtarian,Marjan;Mehanovic,Samir;Nilsen-Hamilton,Marit[BioorganicandMedicinalChemistry,2010,vol.18,#17,p.6316-6321]

[2]Zhang,Jing;Lu,Dai;Wei,Han-Xun;Gu,Yongli;Selkoe,DennisJ.;Wolfe,MichaelS.;Augelli-Szafran,CorinneE.[BioorganicandMedicinalChemistryLetters,2016,vol.26,#9,p.2138-2141]

[1]Zhang,Jing;Lu,Dai;Wei,Han-Xun;Gu,Yongli;Selkoe,DennisJ.;Wolfe,MichaelS.;Augelli-Szafran,CorinneE.[BioorganicandMedicinalChemistryLetters,2016,vol.26,#9,p.2138-2141]

[2]Zhang,Jing;Lu,Dai;Wei,Han-Xun;Gu,Yongli;Selkoe,DennisJ.;Wolfe,MichaelS.;Augelli-Szafran,CorinneE.[BioorganicandMedicinalChemistryLetters,2016,vol.26,#9,p.2138-2141]

17759-30-7   
6-(2,6-dichlorophenyl)-8-methyl-2-(3-methylsulfanylanilino)pyrido2,3-dpyrimidin-7-one 

[1]BioorganicandMedicinalChemistryLetters,2016,vol.26,p.2138-2141

[2]BioorganicandMedicinalChemistryLetters,2016,vol.26,p.2138-2141

[1]Zhang,Jing;Lu,Dai;Wei,Han-Xun;Gu,Yongli;Selkoe,DennisJ.;Wolfe,MichaelS.;Augelli-Szafran,CorinneE.[BioorganicandMedicinalChemistryLetters,2016,vol.26,#9,p.2138-2141]

[2]Zhang,Jing;Lu,Dai;Wei,Han-Xun;Gu,Yongli;Selkoe,DennisJ.;Wolfe,MichaelS.;Augelli-Szafran,CorinneE.[BioorganicandMedicinalChemistryLetters,2016,vol.26,#9,p.2138-2141]

[1]Zhang,Jing;Lu,Dai;Wei,Han-Xun;Gu,Yongli;Selkoe,DennisJ.;Wolfe,MichaelS.;Augelli-Szafran,CorinneE.[BioorganicandMedicinalChemistryLetters,2016,vol.26,#9,p.2138-2141]

Literature

Title: Discovery, synthesis, and characterization of an orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3.

Journal: Journal of medicinal chemistry 20131024

Title: Comprehensive analysis of kinase inhibitor selectivity.

Journal: Nature biotechnology 20111030

Title: Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry.

Journal: Chemistry & biology 20101124

Title: New effective inhibitors of the Abelson kinase.

Journal: Bioorganic & medicinal chemistry 20100901

Title: A bead-based activity screen for small-molecule inhibitors of signal transduction in chronic myelogenous leukemia cells.

Journal: Molecular cancer therapeutics 20100501

Title: Induced disorder in protein-ligand complexes as a drug-design strategy.

Journal: Molecular pharmaceutics 20080101

Title: Structural insights into the ATP binding pocket of the anaplastic lymphoma kinase by site-directed mutagenesis, inhibitor binding analysis, and homology modeling.

Journal: Journal of medicinal chemistry 20060921

Title: Phosphorylation of IkappaB-beta is necessary for neuronal survival.

Journal: The Journal of biological chemistry 20060120

Title: Inhibition of wild-type and mutant Bcr-Abl by AP23464, a potent ATP-based oncogenic protein kinase inhibitor: implications for CML.

Journal: Blood 20041015

Title: Direct evidence that Bcr-Abl tyrosine kinase activity disrupts normal synergistic interactions between Kit ligand and cytokines in primary primitive progenitor cells.

Journal: Molecular cancer research : MCR 20030101

Title: Src activation regulates anoikis in human colon tumor cell lines.

Journal: Oncogene 20021107

Title: Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571).

Journal: Cancer research 20020801

Title: Characterization of potent inhibitors of the Bcr-Abl and the c-kit receptor tyrosine kinases.

Journal: Cancer research 20020801

Title: Moasser MM, et al. Inhibition of Src kinases by a selective tyrosine kinase inhibitor causes mitotic arrest. Cancer Res. 1999 Dec 15;59(24):6145-52.

Title: Kraus GA, et al. New effective inhibitors of the Abelson kinase. Bioorg Med Chem. 2010 Sep 1;18(17):6316-21.

Title: Windham TC, et al. Src activation regulates anoikis in human colon tumor cell lines. Oncogene. 2002 Nov 7;21(51):7797-807.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:260415-63-2 Molecular Formula|260415-63-2 MDL|260415-63-2 SMILES|260415-63-2 Pd173955