Home Fluorides 286456-42-6
286456-42-6,MFCD08690609
Catalog No.:AA002VWD

286456-42-6 | 5-({[7-tert-butyl-3-(2,5-difluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]oxy}methyl)-1-methyl-1,2,4-triazole

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5mg
98%
in stock  
$339.00   $237.00
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25mg
98%
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$902.00   $632.00
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA002VWD
Chemical Name:
5-({[7-tert-butyl-3-(2,5-difluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]oxy}methyl)-1-methyl-1,2,4-triazole
CAS Number:
286456-42-6
Molecular Formula:
C19H19F2N7O
Molecular Weight:
399.3973
MDL Number:
MFCD08690609
SMILES:
Fc1ccc(c(c1)c1nnc2n1nc(OCc1ncnn1C)c(c2)C(C)(C)C)F
Properties
Properties
 
Form:
Solid  
MP:
196-203˚C  
Storage:
-20 ℃;  

Computed Properties
 
Complexity:
565  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
8  
Rotatable Bond Count:
5  
XLogP3:
3.2  

Literature

Title: GABAB-mediated rescue of altered excitatory-inhibitory balance, gamma synchrony and behavioral deficits following constitutive NMDAR-hypofunction.

Journal: Translational psychiatry 20120701

Title: GABAA receptor subtype-selective modulators. II. α5-selective inverse agonists for cognition enhancement.

Journal: Current topics in medicinal chemistry 20110101

Title: GABAA receptor subtype-selective modulators. I. α2/α3-selective agonists as non-sedating anxiolytics.

Journal: Current topics in medicinal chemistry 20110101

Title: Enhanced fear expression in a psychopathological mouse model of trait anxiety: pharmacological interventions.

Journal: PloS one 20110101

Title: Discriminative stimulus effects of L-838,417 (7-tert-butyl-3-(2,5-difluoro-phenyl)-6-(2-methyl-2H-[1,2,4]triazol-3-ylmethoxy)-[1,2,4]triazolo[4,3-b]pyridazine): role of GABA(A) receptor subtypes.

Journal: Neuropharmacology 20100201

Title: Alpha1- and alpha2-containing GABAA receptor modulation is not necessary for benzodiazepine-induced hyperphagia.

Journal: Appetite 20090601

Title: In vivo saturation binding of GABA-A receptor ligands to estimate receptor occupancy using liquid chromatography/tandem mass spectrometry.

Journal: Biopharmaceutics & drug disposition 20090101

Title: A high-throughput functional assay for characterization of gamma-aminobutyric acid(A) channel modulators using cryopreserved transiently transfected cells.

Journal: Assay and drug development technologies 20081201

Title: GABA regulates the rat hypothalamic-pituitary-adrenocortical axis via different GABA-A receptor alpha-subtypes.

Journal: Annals of the New York Academy of Sciences 20081201

Title: Strain- and model-dependent effects of chlordiazepoxide, L-838,417 and zolpidem on anxiety-like behaviours in laboratory mice.

Journal: Pharmacology, biochemistry, and behavior 20080701

Title: Reversal of pathological pain through specific spinal GABAA receptor subtypes.

Journal: Nature 20080117

Title: Comparative effects of nonselective and subtype-selective gamma-aminobutyric acidA receptor positive modulators in the rat-conditioned emotional response test.

Journal: Behavioural pharmacology 20070501

Title: Pharmacological and computational analysis of alpha-subunit preferential GABA(A) positive allosteric modulators on the rat septo-hippocampal activity.

Journal: Neuropharmacology 20070301

Title: Effects of genetic background and null mutation of 5-HT1A receptors on basal and stress-induced body temperature: modulation by serotonergic and GABAA-ergic drugs.

Journal: European journal of pharmacology 20061121

Title: Comparative cue generalization profiles of L-838, 417, SL651498, zolpidem, CL218,872, ocinaplon, bretazenil, zopiclone, and various benzodiazepines in chlordiazepoxide and zolpidem drug discrimination.

Journal: The Journal of pharmacology and experimental therapeutics 20060301

Title: Do subtype-selective gamma-aminobutyric acid A receptor modulators have a reduced propensity to induce physical dependence in mice?

Journal: The Journal of pharmacology and experimental therapeutics 20060301

Title: Differential behavioral effects of low efficacy positive GABAA modulators in combination with benzodiazepines and a neuroactive steroid in rhesus monkeys.

Journal: British journal of pharmacology 20060201

Title: A comparison of chlordiazepoxide, bretazenil, L838,417 and zolpidem in a validated mouse Vogel conflict test.

Journal: Psychopharmacology 20051101

Title: Effects of benzodiazepines receptor agonists on the hypothalamic-pituitary-adrenocortical axis.

Journal: European journal of pharmacology 20050920

Title: Rodent pharmacokinetics and receptor occupancy of the GABAA receptor subtype selective benzodiazepine site ligand L-838417.

Journal: Biopharmaceutics & drug disposition 20050101

Title: Anxioselective anxiolytics: can less be more?

Journal: European journal of pharmacology 20041001

Title: Subtype-selective GABAergic drugs facilitate extinction of mouse operant behaviour.

Journal: Neuropharmacology 20040201

Title: Anxiolytic-like action of diazepam: which GABA(A) receptor subtype is involved?

Journal: Trends in pharmacological sciences 20010801

Title: Ciara McCabe, et al. Subtype-selective GABAergic drugs facilitate extinction of mouse operant behavior. Neuropharmacology. 2004 Feb;46(2):171-8.

Title: Melissa Morales, et al. Anxiolytic effects of the GABAA receptor partial agonist, L-838,417: Impact of age, test context familiarity, and stress. Pharmacol Biochem Behav. 2013 Aug;109:31-7.

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Tags:286456-42-6 Molecular Formula|286456-42-6 MDL|286456-42-6 SMILES|286456-42-6 5-({[7-tert-butyl-3-(2,5-difluorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]oxy}methyl)-1-methyl-1,2,4-triazole