Home Other Building Blocks 289483-69-8
289483-69-8,MFCD09833234
Catalog No.:AA002X2V

289483-69-8 | E7820

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$51.00   $36.00
- +
5mg
≥98%
in stock  
$53.00   $37.00
- +
10mg
≥98%
in stock  
$98.00   $68.00
- +
50mg
≥98%
in stock  
$405.00   $283.00
- +
100mg
≥98%(HPLC)
in stock  
$557.00   $390.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA002X2V
Chemical Name:
E7820
CAS Number:
289483-69-8
Molecular Formula:
C17H12N4O2S
Molecular Weight:
336.3678
MDL Number:
MFCD09833234
SMILES:
N#Cc1cccc(c1)S(=O)(=O)Nc1ccc(c2c1[nH]cc2C#N)C
NSC Number:
719239
Properties
Computed Properties
 
Complexity:
668  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
3  
XLogP3:
2.4  

Downstream Synthesis Route
289483-87-0    56542-67-7   
N-(3-cyano-4-methyl-1H-indole-7-yl)-3-cyanobenzenesulfonamide 

[1]Patent:EP1666463,2006,A1.Locationinpatent:Page/Pagecolumn13-15

[2]Patent:EP1666463,2006,A1.Locationinpatent:Page/Pagecolumn12-13

[3]Patent:EP1666463,2006,A1.Locationinpatent:Page/Pagecolumn10-12

[4]Patent:US2002/128480,2002,A1

[5]Patent:US2007/37854,2007,A1.Locationinpatent:Page/Pagecolumn4-5

[6]Patent:US2007/37854,2007,A1.Locationinpatent:Page/Pagecolumn6

289483-87-0   
N-(3-cyano-4-methyl-1H-indole-7-yl)-3-cyanobenzenesulfonamide 

[1]Patent:US2004/18192,2004,A1

Literature

Title: Evaluation of α2-integrin expression as a biomarker for tumor growth inhibition for the investigational integrin inhibitor E7820 in preclinical and clinical studies.

Journal: The AAPS journal 20110601

Title: Phase I study of E7820, an oral inhibitor of integrin alpha-2 expression with antiangiogenic properties, in patients with advanced malignancies.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20110101

Title: Small molecule integrin antagonists in cancer therapy.

Journal: Mini reviews in medicinal chemistry 20091001

Title: Application of population pharmacokinetic modeling in early clinical development of the anticancer agent E7820.

Journal: Investigational new drugs 20090401

Title: Integrins: molecular targets in cancer therapy.

Journal: Current oncology reports 20060301

Title: An angiogenesis inhibitor E7820 shows broad-spectrum tumor growth inhibition in a xenograft model: possible value of integrin alpha2 on platelets as a biological marker.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20040215

Title: Sulfonamide derivative, E7820, is a unique angiogenesis inhibitor suppressing an expression of integrin alpha2 subunit on endothelium.

Journal: Cancer research 20021101

Title: Funahashi Y, et al. Sulfonamide derivative, E7820, is a unique angiogenesis inhibitor suppressing an expression of integrin alpha2 subunit on endothelium. Cancer Res. 2002;62(21):6116-6123.

Title: Ito K, et al. Enhanced anti-angiogenic effect of E7820 in combination with erlotinib in epidermal growth factor receptor-tyrosine kinase inhibitor-resistant non-small-cell lung cancer xenograft models. Cancer Sci. 2014;105(8):1023-1031.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Related Products of 289483-69-8
Tags:289483-69-8 Molecular Formula|289483-69-8 MDL|289483-69-8 SMILES|289483-69-8 E7820