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313-04-2,MFCD00056432
Catalog No.:AA00BZH5

313-04-2 | DESMOSTEROL

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1mg
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5mg
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$100.00   $70.00
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10mg
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00BZH5
Chemical Name:
DESMOSTEROL
CAS Number:
313-04-2
Molecular Formula:
C27H44O
Molecular Weight:
384.6377
MDL Number:
MFCD00056432
SMILES:
O[C@H]1CC[C@]2(C(=CC[C@@H]3[C@@H]2CC[C@]2([C@H]3CC[C@@H]2[C@@H](CCC=C(C)C)C)C)C1)C
Properties
Computed Properties
 
Complexity:
641  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
8  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
1  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
4  
XLogP3:
8.3  

Literature

Title: Benzyl butyl phthalate promotes adipogenesis in 3T3-L1 preadipocytes: A High Content Cellomics and metabolomic analysis.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20160401

Title: Human Mincle Binds to Cholesterol Crystals and Triggers Innate Immune Responses.

Journal: The Journal of biological chemistry 20151016

Title: E2012-induced cataract and its predictive biomarkers.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20140101

Title: Alzheimer's disease: brain desmosterol levels.

Journal: Journal of Alzheimer's disease : JAD 20130101

Title: Analysis of bioactive oxysterols in newborn mouse brain by LC/MS.

Journal: Journal of lipid research 20121101

Title: Gas chromatography-tandem mass spectrometry method for the simultaneous determination of oxysterols, plant sterols, and cholesterol precursors.

Journal: Clinical chemistry 20121101

Title: Bi-lateral changes to hippocampal cholesterol levels during epileptogenesis and in chronic epilepsy following focal-onset status epilepticus in mice.

Journal: Brain research 20121022

Title: Differences in synthesis and absorption of cholesterol of two effective lipid-lowering therapies.

Journal: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20121001

Title: Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses.

Journal: Cell 20120928

Title: The endogenous regulator 24(S),25-epoxycholesterol inhibits cholesterol synthesis at DHCR24 (Seladin-1).

Journal: Biochimica et biophysica acta 20120901

Title: Brain isoprenoids farnesyl pyrophosphate and geranylgeranyl pyrophosphate are increased in aged mice.

Journal: Molecular neurobiology 20120801

Title: A comprehensive method for extraction and quantitative analysis of sterols and secosteroids from human plasma.

Journal: Journal of lipid research 20120701

Title: Substrate analog studies of the ω-regiospecificity of Mycobacterium tuberculosis cholesterol metabolizing cytochrome P450 enzymes CYP124A1, CYP125A1 and CYP142A1.

Journal: Bioorganic & medicinal chemistry 20120701

Title: Increased hepatic synthesis and dysregulation of cholesterol metabolism is associated with the severity of nonalcoholic fatty liver disease.

Journal: Cell metabolism 20120502

Title: Lipid metabolite profiling identifies desmosterol metabolism as a new antiviral target for hepatitis C virus.

Journal: Journal of the American Chemical Society 20120425

Title: Differential effect of cholesterol and its biosynthetic precursors on membrane dipole potential.

Journal: Biophysical journal 20120404

Title: Inorganic nitrogen, sterols and bacterial source tracking as tools to characterize water quality and possible contamination sources in surface water.

Journal: Water research 20120315

Title: Lanosterol induces mitochondrial uncoupling and protects dopaminergic neurons from cell death in a model for Parkinson's disease.

Journal: Cell death and differentiation 20120301

Title: Amyloid pathway-based candidate gene analysis of [(11)C]PiB-PET in the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort.

Journal: Brain imaging and behavior 20120301

Title: Liver x receptor modulation of gene expression leading to proluteolytic effects in primate luteal cells.

Journal: Biology of reproduction 20120301

Title: Identification of a new plasma biomarker of Alzheimer's disease using metabolomics technology.

Journal: Journal of lipid research 20120301

Title: The membrane topological analysis of 3β-hydroxysteroid-Delta24 reductase (DHCR24) on endoplasmic reticulum.

Journal: Journal of molecular endocrinology 20120201

Title: Identification and potency of cyclodextrin-lipid inhibitors of Staphylococcus aureus α-toxin.

Journal: Current eye research 20120201

Title: Euterpe oleracea (açai) modifies sterol metabolism and attenuates experimentally-induced atherosclerosis.

Journal: Journal of atherosclerosis and thrombosis 20120101

Title: Cholesterol synthesis is associated with hepatic lipid content and dependent on fructose/glucose intake in healthy humans.

Journal: Experimental diabetes research 20120101

Title: Cytotoxicity of fucosterol containing fraction of marine algae against breast and colon carcinoma cell line.

Journal: Pharmacognosy magazine 20120101

Title: Internalization of modified lipids by CD36 and SR-A leads to hepatic inflammation and lysosomal cholesterol storage in Kupffer cells.

Journal: PloS one 20120101

Title: Genomics of Dementia: APOE- and CYP2D6-Related Pharmacogenetics.

Journal: International journal of Alzheimer's disease 20120101

Title: Sterol lipid metabolism in down syndrome revisited: down syndrome is associated with a selective reduction in serum brassicasterol levels.

Journal: Current gerontology and geriatrics research 20120101

Title: A highly specific and sensitive quantification analysis of the sterols in silkworm larvae by high performance liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry.

Journal: Analytical biochemistry 20111215

Title: Selection of the derivatization reagent--the case of human blood cholesterol, its precursors and phytosterols GC-MS analyses.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20111215

Title: Severe dysfunction of respiratory chain and cholesterol metabolism in Atp7b(-/-) mice as a model for Wilson disease.

Journal: Biochimica et biophysica acta 20111201

Title: Effect of dalcetrapib, a CETP modulator, on non-cholesterol sterol markers of cholesterol homeostasis in healthy subjects.

Journal: Atherosclerosis 20111201

Title: Feeding of grey squirrels (Sciurus carolinensis) with the contraceptive agent DiazaCon™: effect on cholesterol, hematology, and blood chemistry.

Journal: Integrative zoology 20111201

Title: Chance and serendipity in science: two examples from my own career.

Journal: The Journal of biological chemistry 20111104

Title: Biosynthesis of cholesterol and other sterols.

Journal: Chemical reviews 20111012

Title: Desmosterol replaces cholesterol for ligand binding function of the serotonin(1A) receptor in solubilized hippocampal membranes: support for nonannular binding sites for cholesterol?

Journal: Biochimica et biophysica acta 20111001

Title: Membrane cholesterol as a mediator of the neuroprotective effects of estrogens.

Journal: Neuroscience 20110915

Title: The desmosterolosis phenotype: spasticity, microcephaly and micrognathia with agenesis of corpus callosum and loss of white matter.

Journal: European journal of human genetics : EJHG 20110901

Title: Cholesterol metabolism is required for intracellular hedgehog signal transduction in vivo.

Journal: PLoS genetics 20110901

Title: Desmosterolosis-phenotypic and molecular characterization of a third case and review of the literature.

Journal: American journal of medical genetics. Part A 20110701

Title: Cerebral accumulation of dietary derivable plant sterols does not interfere with memory and anxiety related behavior in Abcg5-/- mice.

Journal: Plant foods for human nutrition (Dordrecht, Netherlands) 20110601

Title: Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target.

Journal: Journal of lipid research 20110301

Title: Synthetic LXR agonist suppresses endogenous cholesterol biosynthesis and efficiently lowers plasma cholesterol.

Journal: Current pharmaceutical biotechnology 20110201

Title: Cholesterol absorption status and fasting plasma cholesterol are modulated by the microsomal triacylglycerol transfer protein -493 G/T polymorphism and the usual diet in women.

Journal: Genes & nutrition 20110201

Title: HDL-C concentration is related to markers of absorption and of cholesterol synthesis: Study in subjects with low vs. high HDL-C.

Journal: Clinica chimica acta; international journal of clinical chemistry 20110114

Title: Cholesterol synthesis is increased and absorption decreased in non-alcoholic fatty liver disease independent of obesity.

Journal: Journal of hepatology 20110101

Title: Low density lipoprotein cholesterol is inversely correlated with abdominal visceral fat area: a magnetic resonance imaging study.

Journal: Lipids in health and disease 20110101

Title: Animal products, diseases and drugs: a plea for better integration between agricultural sciences, human nutrition and human pharmacology.

Journal: Lipids in health and disease 20110101

Title: Lipid pathway alterations in Parkinson's disease primary visual cortex.

Journal: PloS one 20110101

Title: The C3435T polymorphism in ABCB1 influences atorvastatin efficacy and muscle symptoms in a high-risk vascular cohort.

Journal: Journal of clinical lipidology 20110101

Title: Hepatic gene expression profiles are altered by dietary unsalted korean fermented soybean (chongkukjang) consumption in mice with diet-induced obesity.

Journal: Journal of nutrition and metabolism 20110101

Title: Sterol composition in larvae of the silkworm, Bombyx mori.

Journal: Bioscience, biotechnology, and biochemistry 20110101

Title: Pathogenesis of the cutaneous phenotype in inherited disorders of cholesterol metabolism: Therapeutic implications for topical treatment of these disorders.

Journal: Dermato-endocrinology 20110101

Title: Sterols from the red algae, Gracilaria salicornia and Hypnea flagelliformis, from Persian Gulf.

Journal: Pharmacognosy magazine 20110101

Title: Characterisation of a desmosterol reductase involved in phytosterol dealkylation in the silkworm, Bombyx mori.

Journal: PloS one 20110101

Title: The role of soluble fiber intake in patients under highly effective lipid-lowering therapy.

Journal: Nutrition journal 20110101

Title: Bioactivities from marine algae of the genus Gracilaria.

Journal: International journal of molecular sciences 20110101

Title: Molecular basis for certain neuroprotective effects of thyroid hormone.

Journal: Frontiers in molecular neuroscience 20110101

Title: Enteric microbiome metabolites correlate with response to simvastatin treatment.

Journal: PloS one 20110101

Title: Genome characterization of the oleaginous fungus Mortierella alpina.

Journal: PloS one 20110101

Title: The ELBA force field for coarse-grain modeling of lipid membranes.

Journal: PloS one 20110101

Title: Statins: past and present.

Journal: Heart views : the official journal of the Gulf Heart Association 20110101

Title: Desmosterol, the main sterol in rabbit semen: distribution among semen subfractions and its role in the in vitro spermatozoa acrosome reaction and motility.

Journal: Asian journal of andrology 20101101

Title: Hair and skin sterols in normal mice and those with deficient dehydrosterol reductase (DHCR7), the enzyme associated with Smith-Lemli-Opitz syndrome.

Journal: The Journal of steroid biochemistry and molecular biology 20101101

Title: The reduced form of coenzyme Q10 mediates distinct effects on cholesterol metabolism at the transcriptional and metabolite level in SAMP1 mice.

Journal: IUBMB life 20101101

Title: Markers of cholesterol absorption and synthesis predict the low-density lipoprotein cholesterol response to atorvastatin.

Journal: Journal of cardiovascular pharmacology 20101001

Title: Subcellular organelle lipidomics in TLR-4-activated macrophages.

Journal: Journal of lipid research 20100901

Title: New insights into the molecular mechanisms of general anaesthetics.

Journal: British journal of pharmacology 20100901

Title: Adaptation of cholesterol synthesis to fasting and TNF-alpha: profiling cholesterol intermediates in the liver, brain, and testis.

Journal: The Journal of steroid biochemistry and molecular biology 20100801

Title: Alterations of cholesterol precursor levels in Alzheimer's disease.

Journal: Biochimica et biophysica acta 20100801

Title: Cholesterol metabolism in pediatric short bowel syndrome after weaning off parenteral nutrition.

Journal: Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20100801

Title: Quantitative analysis of five sterols in amniotic fluid by GC-MS: application to the diagnosis of cholesterol biosynthesis defects.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100801

Title: Insulin resistance is associated with increased cholesterol synthesis, decreased cholesterol absorption and enhanced lipid response to statin therapy.

Journal: Atherosclerosis 20100701

Title: Cholesterol and desmosterol in two sperm populations separated on Sil-Select gradient.

Journal: International journal of andrology 20100601

Title: Applicability of non-cholesterol sterols in predicting response in cholesterol metabolism to simvastatin and fluvastatin treatment among hypercholesterolemic men.

Journal: Nutrition, metabolism, and cardiovascular diseases : NMCD 20100601

Title: Cholesterol absorption decreases after Roux-en-Y gastric bypass but not after gastric banding.

Journal: Metabolism: clinical and experimental 20100601

Title: A historical perspective on the discovery of statins.

Journal: Proceedings of the Japan Academy. Series B, Physical and biological sciences 20100511

Title: Serum plant and other noncholesterol sterols, cholesterol metabolism and 22-year mortality among middle-aged men.

Journal: Atherosclerosis 20100501

Title: Delivering cholesterol or cholestanol to bull sperm membranes improves cryosurvival.

Journal: Animal reproduction science 20100401

Title: Cellular production of n-3 PUFAs and reduction of n-6-to-n-3 ratios in the pancreatic beta-cells and islets enhance insulin secretion and confer protection against cytokine-induced cell death.

Journal: Diabetes 20100201

Title: Cholesterol absorption and synthesis markers in individuals with and without a CHD event during pravastatin therapy: insights from the PROSPER trial.

Journal: Journal of lipid research 20100101

Title: Familial combined hyperlipidemia is associated with alterations in the cholesterol synthesis pathway.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20100101

Title: Changes in cholesterol biosynthetic and transport pathways after excitotoxicity.

Journal: Journal of neurochemistry 20100101

Title: Alterations in brain cholesterol metabolism in the APPSLxPS1mut mouse, a model for Alzheimer's disease.

Journal: Journal of Alzheimer's disease : JAD 20100101

Title: Alterations in the homeostasis of phospholipids and cholesterol by antitumor alkylphospholipids.

Journal: Lipids in health and disease 20100101

Title: Cholesterol induces specific spatial and orientational order in cholesterol/phospholipid membranes.

Journal: PloS one 20100101

Title: Effect of methylene blue on the genomic response to reperfusion injury induced by cardiac arrest and cardiopulmonary resuscitation in porcine brain.

Journal: BMC medical genomics 20100101

Title: A combined transcriptomics and lipidomics analysis of subcutaneous, epididymal and mesenteric adipose tissue reveals marked functional differences.

Journal: PloS one 20100101

Title: A systematic screen for protein-lipid interactions in Saccharomyces cerevisiae.

Journal: Molecular systems biology 20100101

Title: The reverse cholesterol transport pathway improves understanding of genetic networks for fat deposition and muscle growth in beef cattle.

Journal: PloS one 20100101

Title: Perspective on plasma membrane cholesterol efflux and spermatozoal function.

Journal: Journal of human reproductive sciences 20100101

Title: Sterols from the Madagascar sponge Fascaplysinopsis sp.

Journal: Marine drugs 20100101

Title: Twenty-one year tracking of serum non-cholesterol sterols. The Cardiovascular Risk in Young Finns study.

Journal: Nutrition, metabolism, and cardiovascular diseases : NMCD 20091001

Title: Differential effects of cholesterol and desmosterol on the ligand binding function of the hippocampal serotonin(1A) receptor: implications in desmosterolosis.

Journal: Biochimica et biophysica acta 20091001

Title: Alterations in cholesterol absorption/synthesis markers characterize Framingham offspring study participants with CHD.

Journal: Journal of lipid research 20090901

Title: Combined gas chromatographic/mass spectrometric analysis of cholesterol precursors and plant sterols in cultured cells.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090715

Title: [Seladin-1/DHCR24: a key protein of cell homeostasis and cholesterol biosynthesis].

Journal: Postepy higieny i medycyny doswiadczalnej (Online) 20090713

Title: New insights on the neuroprotective role of sterols and sex steroids: the seladin-1/DHCR24 paradigm.

Journal: Frontiers in neuroendocrinology 20090701

Title: Requirement of DHCR24 for postnatal development of epidermis and hair follicles in mice.

Journal: The American Journal of dermatopathology 20090701

Title: Plant stanol ester spreads as components of a balanced diet for pregnant and breast-feeding women: evaluation of clinical safety.

Journal: The British journal of nutrition 20090601

Title: Age-dependent increase in desmosterol restores DRM formation and membrane-related functions in cholesterol-free DHCR24-/- mice.

Journal: Neurochemical research 20090601

Title: Do plant sterol concentrations correlate with coronary artery disease in type 1 diabetes? A report from the Pittsburgh Epidemiology of Diabetes Complications Study.

Journal: Journal of diabetes 20090601

Title: Desmosterol can replace cholesterol in sustaining cell proliferation and regulating the SREBP pathway in a sterol-Delta24-reductase-deficient cell line.

Journal: The Biochemical journal 20090513

Title: How essential is cholesterol?

Journal: The Biochemical journal 20090513

Title: High cholesterol content and decreased membrane fluidity in human spermatozoa are associated with protein tyrosine phosphorylation and functional deficiencies.

Journal: Journal of andrology 20090101

Title: Age-dependent increase in desmosterol restores DRM formation and membrane-related functions in cholesterol-free DHCR24(-/-) mice. Neurochemical Research (34, 1167-82).

Journal: Neurochemical research 20090101

Title: Papular xanthomas and erosive arthritis in a 3 year old girl, is this a new MRH variant?

Journal: Pediatric rheumatology online journal 20090101

Title: Dose-dependent dual effects of cholesterol and desmosterol on J774 macrophage proliferation.

Journal: Biochemical and biophysical research communications 20081212

Title: Elevated cholesterol precursors other than cholestanol can also be a hallmark for CTX.

Journal: Journal of inherited metabolic disease 20081201

Title: Neuroprotective effects of the Alzheimer's disease-related gene seladin-1.

Journal: Journal of molecular endocrinology 20081101

Title: Comparison of cholesterol and its direct precursors along the biosynthetic pathway: effects of cholesterol, desmosterol and 7-dehydrocholesterol on saturated and unsaturated lipid bilayers.

Journal: The Journal of chemical physics 20081021

Title: Overexpression of human ABCG1 does not affect atherosclerosis in fat-fed ApoE-deficient mice.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20081001

Title: Polymorphism of the hepatic influx transporter organic anion transporting polypeptide 1B1 is associated with increased cholesterol synthesis rate.

Journal: Pharmacogenetics and genomics 20081001

Title: Seladin-1 is a fundamental mediator of the neuroprotective effects of estrogen in human neuroblast long-term cell cultures.

Journal: Endocrinology 20080901

Title: Homology modelling of human DHCR24 (seladin-1) and analysis of its binding properties through molecular docking and dynamics simulations.

Journal: Steroids 20080801

Title: Discovering oxysterols in plasma: a window on the metabolome.

Journal: Journal of proteome research 20080801

Title: Estrogen receptor-mediated neuroprotection: The role of the Alzheimer's disease-related gene seladin-1.

Journal: Neuropsychiatric disease and treatment 20080801

Title: Cholesterol substitution increases the structural heterogeneity of caveolae.

Journal: The Journal of biological chemistry 20080523

Title: Differential effects of cholesterol and its immediate biosynthetic precursors on membrane organization.

Journal: Biochemistry 20080520

Title: SREBP-1c gene polymorphism is associated with increased inhibition of cholesterol-absorption in response to ezetimibe treatment.

Journal: Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20080501

Title: ATP-binding cassette transporters G1 and G4 mediate cholesterol and desmosterol efflux to HDL and regulate sterol accumulation in the brain.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20080401

Title: Increased expression of aquaporin-3 in the epidermis of DHCR24 knockout mice.

Journal: The British journal of dermatology 20080401

Title: Mutational screening analysis of DHCR24/seladin-1 gene in Italian familial Alzheimer's disease.

Journal: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 20080105

Title: Moderately elevated plant sterol levels are associated with reduced cardiovascular risk--the LASA study.

Journal: Atherosclerosis 20080101

Title: Effects of ezetimibe, simvastatin, atorvastatin, and ezetimibe-statin therapies on non-cholesterol sterols in patients with primary hypercholesterolemia.

Journal: Current medical research and opinion 20080101

Title: Dynamical modeling of the cholesterol regulatory pathway with Boolean networks.

Journal: BMC systems biology 20080101

Title: Diets high in selenium and isoflavones decrease androgen-regulated gene expression in healthy rat dorsolateral prostate.

Journal: Reproductive biology and endocrinology : RB&E 20080101

Title: Annexin A6-induced alterations in cholesterol transport and caveolin export from the Golgi complex.

Journal: Traffic (Copenhagen, Denmark) 20071101

Title: Studies on the cholesterol-free mouse: strong activation of LXR-regulated hepatic genes when replacing cholesterol with desmosterol.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20071001

Title: The distribution of squalene and non-cholesterol sterols in lipoproteins in type 2 diabetes.

Journal: Atherosclerosis 20070901

Title: Atorvastatin in patients with primary biliary cirrhosis and incomplete biochemical response to ursodeoxycholic acid.

Journal: Hepatology (Baltimore, Md.) 20070901

Title: Role of sterol type on lateral pressure profiles of lipid membranes affecting membrane protein functionality: Comparison between cholesterol, desmosterol, 7-dehydrocholesterol and ketosterol.

Journal: Journal of structural biology 20070801

Title: Serum adipokines are associated with cholesterol metabolism in the metabolic syndrome.

Journal: Clinica chimica acta; international journal of clinical chemistry 20070801

Title: Seasonal and geographical variations of sterol composition in snow crab hepatopancreas and pelagic fish viscera from Eastern Quebec.

Journal: Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20070701

Title: Loss of apolipoprotein E exacerbates the neonatal lethality of the Smith-Lemli-Opitz syndrome mouse.

Journal: Molecular genetics and metabolism 20070501

Title: Separation and determination of diversiform phytosterols in food materials using supercritical carbon dioxide extraction and ultraperformance liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry.

Journal: Analytica chimica acta 20070404

Title: Assessing the nature of lipid raft membranes.

Journal: PLoS computational biology 20070201

Title: [Factors modulating parameters of cholesterol homeostasis in the metabolic syndrome].

Journal: Casopis lekaru ceskych 20070101

Title: Quantifying raft proteins in neonatal mouse brain by 'tube-gel' protein digestion label-free shotgun proteomics.

Journal: Proteome science 20070101

Title: Postprandial behavior of plasma squalene and non-cholesterol sterols in men with varying cholesterol absorption.

Journal: Clinica chimica acta; international journal of clinical chemistry 20061201

Title: Endothelial function in hypercholesterolemic subjects: Effects of plant stanol and sterol esters.

Journal: Atherosclerosis 20061001

Title: Sterol intermediates from cholesterol biosynthetic pathway as liver X receptor ligands.

Journal: The Journal of biological chemistry 20060922

Title: Simultaneous determination of plasmatic phytosterols and cholesterol precursors using gas chromatography-mass spectrometry (GC-MS) with selective ion monitoring (SIM).

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060914

Title: Cholesterol precursors stabilize ordinary and ceramide-rich ordered lipid domains (lipid rafts) to different degrees. Implications for the Bloch hypothesis and sterol biosynthesis disorders.

Journal: The Journal of biological chemistry 20060804

Title: Neuronal differentiation of human mesenchymal stem cells: changes in the expression of the Alzheimer's disease-related gene seladin-1.

Journal: Experimental cell research 20060801

Title: Regulation of cholesterol 25-hydroxylase expression by vitamin D3 metabolites in human prostate stromal cells.

Journal: Biochemical and biophysical research communications 20060630

Title: DHCR24-knockout embryonic fibroblasts are susceptible to serum withdrawal-induced apoptosis because of dysfunction of caveolae and insulin-Akt-Bad signaling.

Journal: Endocrinology 20060601

Title: HPLC method for quantification and characterization of cholesterol and its oxidation products in eggs.

Journal: Lipids 20060601

Title: Phase behavior of lipid monolayers containing DPPC and cholesterol analogs.

Journal: Biophysical journal 20060501

Title: DHCR24 gene knockout mice demonstrate lethal dermopathy with differentiation and maturation defects in the epidermis.

Journal: The Journal of investigative dermatology 20060301

Title: Studies on the transcriptional regulation of cholesterol 24-hydroxylase (CYP46A1): marked insensitivity toward different regulatory axes.

Journal: The Journal of biological chemistry 20060217

Title: Cholesterol absorption and synthesis in pediatric kidney, liver, and heart transplant recipients.

Journal: Transplantation 20060215

Title: Oxysterols suppress inducible nitric oxide synthase expression in lipopolysaccharide-stimulated astrocytes through liver X receptor.

Journal: Neuroreport 20060206

Title: Serum noncholesterol sterols in children with heterozygous familial hypercholesterolemia undergoing pravastatin therapy.

Journal: The Journal of pediatrics 20060201

Title: Significance of sterol structural specificity. Desmosterol cannot replace cholesterol in lipid rafts.

Journal: The Journal of biological chemistry 20060106

Title: Changes in serum level and metabolism of cholesterol with plant stanol esters in postmenopausal women with and without coronary artery disease.

Journal: Menopause (New York, N.Y.) 20060101

Title: Analysis of sterols by high-performance liquid chromatography/mass spectrometry combined with chemometrics.

Journal: Rapid communications in mass spectrometry : RCM 20060101

Title: Regulation of hippocampal cholesterol metabolism by apoE and environmental stimulation.

Journal: Journal of neurochemistry 20051101

Title: Recent insights into the Smith-Lemli-Opitz syndrome.

Journal: Clinical genetics 20051101

Title: Sterol profiling of amniotic fluid: a routine method for the detection of distal cholesterol synthesis deficit.

Journal: Prenatal diagnosis 20051101

Title: Diffusion of cholesterol and its precursors in lipid membranes studied by 1H pulsed field gradient magic angle spinning NMR.

Journal: Biophysical journal 20051001

Title: Reductions in cholesterol and synaptic markers in association cortex in mood disorders.

Journal: Bipolar disorders 20051001

Title: Comparative aspects of sperm membrane fatty acid composition in silver (Vulpes vulpes) and blue (Alopex lagopus) foxes, and their relationship to cell cryopreservation.

Journal: Cryobiology 20050801

Title: Cytochrome P450 17alpha hydroxylase/17,20 lyase (CYP17) function in cholesterol biosynthesis: identification of squalene monooxygenase (epoxidase) activity associated with CYP17 in Leydig cells.

Journal: Molecular endocrinology (Baltimore, Md.) 20050701

Title: A comparison of the behavior of cholesterol and selected derivatives in mixed sterol-phospholipid Langmuir monolayers: a fluorescence microscopy study.

Journal: Chemistry and physics of lipids 20050701

Title: Lipid composition of deep-sea hydrothermal vent tubeworm Riftia pachyptila, crabs Munidopsis subsquamosa and Bythograea thermydron, mussels Bathymodiolus sp. and limpets Lepetodrilus spp.

Journal: Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20050601

Title: Determination of sterols in biological samples by SPME with on-fiber derivatization and GC/FID.

Journal: Analytical and bioanalytical chemistry 20050401

Title: Desmosterol may replace cholesterol in lipid membranes.

Journal: Biophysical journal 20050301

Title: [Oxysterol (3,5-cholestadien-7-one, 5 beta-cholestan-3-one, 5,24-cholestadien-3 beta-OL) induced cytotoxicity and apoptosis in gallbladder epithelial cells].

Journal: The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi 20041201

Title: Secretion of sterols and the NPC2 protein from primary astrocytes.

Journal: The Journal of biological chemistry 20041119

Title: Sperm membrane fatty acid composition in the Eastern grey kangaroo (Macropus giganteus), koala (Phascolarctos cinereus), and common wombat (Vombatus ursinus) and its relationship to cold shock injury and cryopreservation success.

Journal: Cryobiology 20041001

Title: Oxysteroids: a new class of steroids with autocrine and paracrine functions.

Journal: Trends in endocrinology and metabolism: TEM 20041001

Title: Polymorphisms in the ABCG5 and ABCG8 genes associate with cholesterol absorption and insulin sensitivity.

Journal: Journal of lipid research 20040901

Title: An HPLC method for the quantification of sterols in edible seaweeds.

Journal: Biomedical chromatography : BMC 20040401

Title: Insulin resistance is associated with increased cholesterol synthesis and decreased cholesterol absorption in normoglycemic men.

Journal: Journal of lipid research 20040301

Title: Expression of the novel adrenocorticotropin-responsive gene selective Alzheimer's disease indicator-1 in the normal adrenal cortex and in adrenocortical adenomas and carcinomas.

Journal: The Journal of clinical endocrinology and metabolism 20040301

Title: Impact of 10 dietary sterols on growth and reproduction of Daphnia galeata.

Journal: Journal of chemical ecology 20040301

Title: Effectiveness of twenty, twenty-five diazacholesterol, avian gonadotropin-releasing hormone, and chicken riboflavin carrier protein for inhibiting reproduction in Coturnix quail.

Journal: Poultry science 20040201

Title: Late gestational lung hypoplasia in a mouse model of the Smith-Lemli-Opitz syndrome.

Journal: BMC developmental biology 20040101

Title: Reactive oxygen species and sperm cells.

Journal: Reproductive biology and endocrinology : RB&E 20040101

Title: Generation of viable cholesterol-free mice.

Journal: Science (New York, N.Y.) 20031219

Title: Novel sterols synthesized via the CYP27A1 metabolic pathway.

Journal: Archives of biochemistry and biophysics 20031201

Title: Synthesis and absorption markers of cholesterol in serum and lipoproteins during a large dose of statin treatment.

Journal: European journal of clinical investigation 20031101

Title: Formal synthesis of squalamine from desmosterol.

Journal: Chemical & pharmaceutical bulletin 20031001

Title: Decrease in order of human sperm lipids during capacitation.

Journal: Biology of reproduction 20030801

Title: Differential mobilization of newly synthesized cholesterol and biosynthetic sterol precursors from cells.

Journal: The Journal of biological chemistry 20030530

Title: Impact of simvastatin, niacin, and/or antioxidants on cholesterol metabolism in CAD patients with low HDL.

Journal: Journal of lipid research 20030401

Title: Structural features of sterols required to inhibit human sperm capacitation.

Journal: Biology of reproduction 20030401

Title: Identification of farnesoid X receptor beta as a novel mammalian nuclear receptor sensing lanosterol.

Journal: Molecular and cellular biology 20030201

Title: On the role of liver X receptors in lipid accumulation in adipocytes.

Journal: Molecular endocrinology (Baltimore, Md.) 20030201

Title: First synthesis of ent-desmosterol and its conversion to ent-deuterocholesterol.

Journal: Steroids 20030201

Title: Serum cholesterol, precursors and metabolites and cognitive performance in an aging population.

Journal: Neurobiology of aging 20030101

Title: Desmosterol: a biomarker for the efficient development of 20,25-diazacholesterol as a contraceptive for pest wildlife.

Journal: Journal of agricultural and food chemistry 20030101

Title: Desmosterolosis presenting with multiple congenital anomalies and profound developmental delay.

Journal: American journal of medical genetics 20021215

Title: Serum plant sterols as a potential risk factor for coronary heart disease.

Journal: Metabolism: clinical and experimental 20021201

Title: Specificity of the commonly used enzymatic assay for plasma cholesterol determination.

Journal: Journal of clinical pathology 20021101

Title: Ineffective decrease of serum cholesterol by simvastatin in a subgroup of hypercholesterolemic coronary patients.

Journal: Atherosclerosis 20020901

Title: Inhibition of cholesterol biosynthesis by Delta22-unsaturated phytosterols via competitive inhibition of sterol Delta24-reductase in mammalian cells.

Journal: The Biochemical journal 20020815

Title: Limb malformations of rat fetuses exposed to a distal inhibitor of cholesterol biosynthesis.

Journal: Journal of lipid research 20020801

Title: Profile of cholesterol-related sterols in aged amyloid precursor protein transgenic mouse brain.

Journal: Journal of lipid research 20020701

Title: Lipid, FA, and sterol composition of New Zealand green lipped mussel (Perna canaliculus) and Tasmanian blue mussel (Mytilus edulis).

Journal: Lipids 20020601

Title: Influence of simvastatin, pravastatin, and BM 15.766 on neutral sterols in liver and testis of guinea pigs.

Journal: Metabolism: clinical and experimental 20020401

Title: Interannual and between species comparison of the lipids, fatty acids and sterols of Antarctic krill from the US AMLR Elephant Island survey area.

Journal: Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20020401

Title: Heritability of plasma noncholesterol sterols and relationship to DNA sequence polymorphism in ABCG5 and ABCG8.

Journal: Journal of lipid research 20020301

Title: Effects of calcium and plant sterols on serum lipids in obese Zucker rats on a low-fat diet.

Journal: The British journal of nutrition 20020301

Title: Acute effects of weight reduction on cholesterol metabolism in obese type 2 diabetes.

Journal: Clinica chimica acta; international journal of clinical chemistry 20020201

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Journal: Bioorganicheskaia khimiia 20020101

Title: Short-term LDL cholesterol-lowering efficacy of plant stanol esters.

Journal: BMC cardiovascular disorders 20020101

Title: Apolipoprotein E phenotype regulates cholesterol absorption in healthy 13-month-old children--The STRIP Study.

Journal: Pediatric research 20011201

Title: Quantitative analysis of desmosterol, cholesterol and cholesterol sulfate in semen by high-performance liquid chromatography.

Journal: Journal of chromatography. A 20011123

Title: Mutations in the 3beta-hydroxysterol Delta24-reductase gene cause desmosterolosis, an autosomal recessive disorder of cholesterol biosynthesis.

Journal: American journal of human genetics 20011001

Title: Blocking protein geranylgeranylation is essential for lovastatin-induced apoptosis of human acute myeloid leukemia cells.

Journal: Leukemia 20010901

Title: Neutral sterols of rat epididymis. High concentrations of dehydrocholesterols in rat caput epididymidis.

Journal: Journal of lipid research 20010701

Title: Mammalian exocrine secretions XVI. Constitutents of secretion of supplementary sacculi of dwarf hamster, Phodopus sungorus sungorus.

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Title: Interannual variations in the lipids of the Antarctic pteropods Clione limacina and Clio pyramidata.

Journal: Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20010301

Title: Progestins block cholesterol synthesis to produce meiosis-activating sterols.

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Title: Clofibrate-induced myotonia in the rat.

Journal: Experientia 19781215

Title: [Steroid alkaloids. 138(12). Chemical composition of the fruits and grains of Holarrhena mitis R. Br. (Apocynacea): alkaloids and unsaponifiable material].

Journal: Annales pharmaceutiques francaises 19721201

Title: Clark RM, et al. Desmosterol in human milk. Lipids. 1983;18(3):264-266.

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Tags:313-04-2 Molecular Formula|313-04-2 MDL|313-04-2 SMILES|313-04-2 DESMOSTEROL