31329-57-4,MFCD00868290
Catalog No.:AA00C67V

31329-57-4 | NAFRONYL

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1g
2 weeks  
$5,143.00   $3,600.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00C67V
Chemical Name:
NAFRONYL
CAS Number:
31329-57-4
Molecular Formula:
C24H33NO3
Molecular Weight:
383.5237
MDL Number:
MFCD00868290
SMILES:
CCN(CCOC(=O)C(Cc1cccc2c1cccc2)CC1CCCO1)CC
Properties
Computed Properties
 
Complexity:
465  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
0  
Isotope Atom Count:
0  
Rotatable Bond Count:
11  
Undefined Atom Stereocenter Count:
2  
Undefined Bond Stereocenter Count:
0  
XLogP3:
4.8  

Downstream Synthesis Route

[1]Valenta,Vladimir;Holubek,Jiri;Svatek,Emil;Miller,Vladimir;Vlkova,Marie;Protiva,Miroslav[CollectionofCzechoslovakChemicalCommunications,1987,vol.52,#10,p.2534-2544]

[1]HelveticaChimicaActa,1991,vol.74,p.1757-1763

[2]BioorganicandMedicinalChemistryLetters,2012,vol.22,p.3441-3444

[1]HelveticaChimicaActa,1991,vol.74,p.1757-1763

[2]BioorganicandMedicinalChemistryLetters,2012,vol.22,p.3441-3444

[1]Valenta,Vladimir;Holubek,Jiri;Svatek,Emil;Miller,Vladimir;Vlkova,Marie;Protiva,Miroslav[CollectionofCzechoslovakChemicalCommunications,1987,vol.52,#10,p.2534-2544]

Literature

Title: Screening of a chemical library reveals novel PXR-activating pharmacologic compounds.

Journal: Toxicology letters 20150105

Title: Intravenous naftidrofuryl for critical limb ischaemia.

Journal: The Cochrane database of systematic reviews 20120711

Title: Practical access to four stereoisomers of naftidrofuryl and their binding affinity towards 5-hydroxytryptamine 2A receptor.

Journal: Bioorganic & medicinal chemistry letters 20120515

Title: Peripheral arterial disease of the lower extremities.

Journal: Archives of medical science : AMS 20120509

Title: Preventive aspects in peripheral artery disease.

Journal: Therapeutic advances in cardiovascular disease 20120401

Title: Naftidrofuryl for dementia.

Journal: The Cochrane database of systematic reviews 20111207

Title: A systematic review and economic evaluation of cilostazol, naftidrofuryl oxalate, pentoxifylline and inositol nicotinate for the treatment of intermittent claudication in people with peripheral arterial disease.

Journal: Health technology assessment (Winchester, England) 20111201

Title: [Vagal stimulation - a new possibility for conservative treatment of peripheral arterial occlusion disease].

Journal: Zentralblatt fur Chirurgie 20111001

Title: Optimal management of peripheral arterial disease for the non-specialist.

Journal: The Ulster medical journal 20110101

Title: Muscle cramps: quinine derivatives likely to be effective but not recommended for routine use due to toxicity; vitamin B complex, naftidrofuryl and calcium channel blockers possibly effective.

Journal: Evidence-based medicine 20100801

Title: I suffer from frequent leg cramps and I've heard that quinine can help. Should I consider taking it?

Journal: The Johns Hopkins medical letter health after 50 20100601

Title: Silence of the limbs pharmacological symptomatic treatment of intermittent claudication.

Journal: Current vascular pharmacology 20100501

Title: Assessment: symptomatic treatment for muscle cramps (an evidence-based review): report of the therapeutics and technology assessment subcommittee of the American academy of neurology.

Journal: Neurology 20100223

Title: Current approach to the diagnosis and treatment of femoral-popliteal arterial disease. A systematic review.

Journal: Current cardiology reviews 20091101

Title: Vasodilators and vasoactive substances for idiopathic sudden sensorineural hearing loss.

Journal: The Cochrane database of systematic reviews 20091007

Title: Fatal intoxication with naftidrofuryl.

Journal: Legal medicine (Tokyo, Japan) 20090901

Title: Assessment of binding affinity to 5-hydroxytryptamine 2A (5-HT2A) receptor and inverse agonist activity of naftidrofuryl: comparison with those of sarpogrelate.

Journal: Journal of pharmacological sciences 20090801

Title: Current management of intermittent claudication: the role of pharmacological and nonpharmacological symptom-directed therapies.

Journal: Current vascular pharmacology 20090701

Title: Pharmacologic therapy for intermittent claudication.

Journal: Pharmacotherapy 20090501

Title: Naftidrofuryl for intermittent claudication: meta-analysis based on individual patient data.

Journal: BMJ (Clinical research ed.) 20090101

Title: Naftidrofuryl for intermittent claudication.

Journal: The Cochrane database of systematic reviews 20080416

Title: Management of peripheral arterial disease in the elderly: focus on cilostazol.

Journal: Clinical interventions in aging 20080301

Title: Peripheral arterial disease in the elderly.

Journal: Clinical interventions in aging 20071201

Title: [Idiopathic sudden sensorineural hearing loss. What's the appropriate management?].

Journal: La Tunisie medicale 20071001

Title: Naftidrofuryl for acute stroke.

Journal: The Cochrane database of systematic reviews 20070418

Title: A novel inhibitor of Mycobacterium tuberculosis pantothenate synthetase.

Journal: Journal of biomolecular screening 20070201

Title: Prognostic indicators of management of sudden sensorineural hearing loss in an Asian hospital.

Journal: Singapore medical journal 20070101

Title: [Inpatient infusion treatment for acute tinnitus with and without adjuvant psychotherapeutic intervention. A comparison of psychological effectiveness].

Journal: HNO 20061001

Title: [Vasoactive agents and prostanoids in the therapy of PAD: facts, questions, disproven assumptions].

Journal: Hamostaseologie 20060801

Title: Cost effectiveness of cilostazol compared with naftidrofuryl and pentoxifylline in the treatment of intermittent claudication in the UK.

Journal: Current medical research and opinion 20050601

Title: Acral necrosis after inadequate excessive administration of bleomycin in a testicular cancer patient.

Journal: Onkologie 20050101

Title: Pharmacokinetics of naftidrofuryl in patients with renal impairment.

Journal: Arzneimittel-Forschung 20050101

Title: Naftidrofuryl: a review of its use in the treatment of intermittent claudication.

Journal: Drugs & aging 20050101

Title: Therapy of hearing disorders - conservative procedures.

Journal: GMS current topics in otorhinolaryngology, head and neck surgery 20050101

Title: Calcium oxalate deposition in renal allografts: morphologic spectrum and clinical implications.

Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20040801

Title: [Secondary prevention and conservative therapy of obliterative arteriosclerosis].

Journal: Orvosi hetilap 20040516

Title: Drug treatment of intermittent claudication.

Journal: Drugs 20040101

Title: [Evidence-based therapy of intermittent claudication].

Journal: Krankenpflege Journal 20040101

Title: Naftidrofuryl-induced liver injury.

Journal: The American journal of gastroenterology 20030601

Title: Raynaud's phenomenon (primary).

Journal: Clinical evidence 20030601

Title: Naftidrofuryl-driven regulation of endothelial ICAM-1 involves nitric oxide.

Journal: Free radical biology & medicine 20030301

Title: Characterization of the CNS effects of naftidrofuryl (Praxilène) by quantitative EEG and functional MRI: a study in healthy elderly subjects.

Journal: Neuropsychobiology 20030101

Title: Can claudication be improved with medication?

Journal: Seminars in vascular surgery 20021201

Title: Nocturnal leg cramps in older people.

Journal: Postgraduate medical journal 20021001

Title: Reduction of endothelin-1 binding and inhibition of endothelin-1-mediated detrusor contraction by naftidrofuryl.

Journal: Clinical science (London, England : 1979) 20020801

Title: Vitamin A metabolism is altered in brown Norway and long-Evans rats infused with naftidrofuryl or erythromycin intravenously.

Journal: International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition 20020701

Title: Findings of the Naftidrofuryl in Quality of Life (NIQOL) European study program.

Journal: International angiology : a journal of the International Union of Angiology 20020301

Title: Naftidrofuryl exerts antiserotonergic but no endothelin-receptor blocking effects in AS4.1 cells, juxtaglomerular cells and isolated perfused rat kidneys.

Journal: Journal of cardiovascular pharmacology 20020101

Title: Effect of naftidrofuryl on intramuscular partial oxygen pressure (pO2) prior to, during and after physical load on the treadmill in apparently healthy subjects.

Journal: Clinical hemorheology and microcirculation 20020101

Title: [Current EMNID survey on peripheral arterial occlusive disease].

Journal: Krankenpflege Journal 20020101

Title: [Application of prostaglandin E1 and Naftidrofuryl in combined treatment of purulent-necrotic complications of the diabetic foot syndrome].

Journal: Klinichna khirurhiia 20020101

Title: Naftidrofuryl in quality of life (NIQOL). A Belgian study.

Journal: International angiology : a journal of the International Union of Angiology 20011201

Title: Naftidrofuryl in the treatment of vascular dementia.

Journal: European archives of psychiatry and clinical neuroscience 20011201

Title: Pharmacotherapy of intermittent claudication.

Journal: Expert opinion on pharmacotherapy 20011101

Title: [Intermittent claudication. Walking plus vasoactive drug treatment].

Journal: MMW Fortschritte der Medizin 20010705

Title: [Deleterious cardiac effects of serotonin in myocardial ischemia: role of naftidrofuryl].

Journal: Annales de cardiologie et d'angeiologie 20010601

Title: Treatment alternatives for nocturnal leg cramps.

Journal: The Medical journal of Australia 20010521

Title: Inhibition of purified pig and human liver retinyl ester hydrolase by pharmacologic agents.

Journal: Lipids 20010501

Title: New treatment options in intermittent claudication: the US experience.

Journal: International journal of clinical practice. Supplement 20010401

Title: [Effect of naftidrofuryl on physiological walking distance in patients with intermittent claudication].

Journal: Annales de cardiologie et d'angeiologie 20010401

Title: A new study demonstrates the efficacy of naftidrofuryl in the treatment of intermittent claudication. Findings of the Naftidrofuryl Clinical Ischemia Study (NCIS).

Journal: International angiology : a journal of the International Union of Angiology 20010301

Title: Behavioral studies of the effects of moderate oligemic hypoxia caused by bilateral clamping of carotid arteries in mice. Impairment of spatial working memory.

Journal: Polish journal of pharmacology 19980101

Title: Naftidrofuryl oxalate, nootropic effects on the scopolamine- and the basal forebrain lesion-induced amnesia in rats.

Journal: Pharmacology, biochemistry, and behavior 19910801

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Tags:31329-57-4 Molecular Formula|31329-57-4 MDL|31329-57-4 SMILES|31329-57-4 NAFRONYL
Catalog No.: AA00C67V
31329-57-4,MFCD00868290
31329-57-4 | NAFRONYL
Pack Size: 1g
Purity:
2 weeks
$5,143.00 $3,600.00
Quantity
- +
Add to Card
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Technical Information
Catalog Number: AA00C67V
Chemical Name: NAFRONYL
CAS Number: 31329-57-4
Molecular Formula: C24H33NO3
Molecular Weight: 383.5237
MDL Number: MFCD00868290
SMILES: CCN(CCOC(=O)C(Cc1cccc2c1cccc2)CC1CCCO1)CC
Properties
Complexity: 465  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 28  
Hydrogen Bond Acceptor Count: 4  
Hydrogen Bond Donor Count: 0  
Isotope Atom Count: 0  
Rotatable Bond Count: 11  
Undefined Atom Stereocenter Count: 2  
Undefined Bond Stereocenter Count: 0  
XLogP3: 4.8  
Downstream Synthesis Route
113527-39-2    77-78-1    100-37-8    31329-57-4 

[1]Valenta,Vladimir;Holubek,Jiri;Svatek,Emil;Miller,Vladimir;Vlkova,Marie;Protiva,Miroslav[CollectionofCzechoslovakChemicalCommunications,1987,vol.52,#10,p.2534-2544]

97-99-4    31329-57-4 

[1]HelveticaChimicaActa,1991,vol.74,p.1757-1763

[2]BioorganicandMedicinalChemistryLetters,2012,vol.22,p.3441-3444

97-99-4    31329-57-4 

[1]HelveticaChimicaActa,1991,vol.74,p.1757-1763

[2]BioorganicandMedicinalChemistryLetters,2012,vol.22,p.3441-3444

1192-30-9    31329-57-4 

[1]Valenta,Vladimir;Holubek,Jiri;Svatek,Emil;Miller,Vladimir;Vlkova,Marie;Protiva,Miroslav[CollectionofCzechoslovakChemicalCommunications,1987,vol.52,#10,p.2534-2544]

Literature fold

Title: Screening of a chemical library reveals novel PXR-activating pharmacologic compounds.

Journal: Toxicology letters20150105

Title: Intravenous naftidrofuryl for critical limb ischaemia.

Journal: The Cochrane database of systematic reviews20120711

Title: Practical access to four stereoisomers of naftidrofuryl and their binding affinity towards 5-hydroxytryptamine 2A receptor.

Journal: Bioorganic & medicinal chemistry letters20120515

Title: Peripheral arterial disease of the lower extremities.

Journal: Archives of medical science : AMS20120509

Title: Preventive aspects in peripheral artery disease.

Journal: Therapeutic advances in cardiovascular disease20120401

Title: Naftidrofuryl for dementia.

Journal: The Cochrane database of systematic reviews20111207

Title: A systematic review and economic evaluation of cilostazol, naftidrofuryl oxalate, pentoxifylline and inositol nicotinate for the treatment of intermittent claudication in people with peripheral arterial disease.

Journal: Health technology assessment (Winchester, England)20111201

Title: [Vagal stimulation - a new possibility for conservative treatment of peripheral arterial occlusion disease].

Journal: Zentralblatt fur Chirurgie20111001

Title: Optimal management of peripheral arterial disease for the non-specialist.

Journal: The Ulster medical journal20110101

Title: Muscle cramps: quinine derivatives likely to be effective but not recommended for routine use due to toxicity; vitamin B complex, naftidrofuryl and calcium channel blockers possibly effective.

Journal: Evidence-based medicine20100801

Title: I suffer from frequent leg cramps and I've heard that quinine can help. Should I consider taking it?

Journal: The Johns Hopkins medical letter health after 5020100601

Title: Silence of the limbs pharmacological symptomatic treatment of intermittent claudication.

Journal: Current vascular pharmacology20100501

Title: Assessment: symptomatic treatment for muscle cramps (an evidence-based review): report of the therapeutics and technology assessment subcommittee of the American academy of neurology.

Journal: Neurology20100223

Title: Current approach to the diagnosis and treatment of femoral-popliteal arterial disease. A systematic review.

Journal: Current cardiology reviews20091101

Title: Vasodilators and vasoactive substances for idiopathic sudden sensorineural hearing loss.

Journal: The Cochrane database of systematic reviews20091007

Title: Fatal intoxication with naftidrofuryl.

Journal: Legal medicine (Tokyo, Japan)20090901

Title: Assessment of binding affinity to 5-hydroxytryptamine 2A (5-HT2A) receptor and inverse agonist activity of naftidrofuryl: comparison with those of sarpogrelate.

Journal: Journal of pharmacological sciences20090801

Title: Current management of intermittent claudication: the role of pharmacological and nonpharmacological symptom-directed therapies.

Journal: Current vascular pharmacology20090701

Title: Pharmacologic therapy for intermittent claudication.

Journal: Pharmacotherapy20090501

Title: Naftidrofuryl for intermittent claudication: meta-analysis based on individual patient data.

Journal: BMJ (Clinical research ed.)20090101

Title: Naftidrofuryl for intermittent claudication.

Journal: The Cochrane database of systematic reviews20080416

Title: Management of peripheral arterial disease in the elderly: focus on cilostazol.

Journal: Clinical interventions in aging20080301

Title: Peripheral arterial disease in the elderly.

Journal: Clinical interventions in aging20071201

Title: [Idiopathic sudden sensorineural hearing loss. What's the appropriate management?].

Journal: La Tunisie medicale20071001

Title: Naftidrofuryl for acute stroke.

Journal: The Cochrane database of systematic reviews20070418

Title: A novel inhibitor of Mycobacterium tuberculosis pantothenate synthetase.

Journal: Journal of biomolecular screening20070201

Title: Prognostic indicators of management of sudden sensorineural hearing loss in an Asian hospital.

Journal: Singapore medical journal20070101

Title: [Inpatient infusion treatment for acute tinnitus with and without adjuvant psychotherapeutic intervention. A comparison of psychological effectiveness].

Journal: HNO20061001

Title: [Vasoactive agents and prostanoids in the therapy of PAD: facts, questions, disproven assumptions].

Journal: Hamostaseologie20060801

Title: Cost effectiveness of cilostazol compared with naftidrofuryl and pentoxifylline in the treatment of intermittent claudication in the UK.

Journal: Current medical research and opinion20050601

Title: Acral necrosis after inadequate excessive administration of bleomycin in a testicular cancer patient.

Journal: Onkologie20050101

Title: Pharmacokinetics of naftidrofuryl in patients with renal impairment.

Journal: Arzneimittel-Forschung20050101

Title: Naftidrofuryl: a review of its use in the treatment of intermittent claudication.

Journal: Drugs & aging20050101

Title: Therapy of hearing disorders - conservative procedures.

Journal: GMS current topics in otorhinolaryngology, head and neck surgery20050101

Title: Calcium oxalate deposition in renal allografts: morphologic spectrum and clinical implications.

Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons20040801

Title: [Secondary prevention and conservative therapy of obliterative arteriosclerosis].

Journal: Orvosi hetilap20040516

Title: Drug treatment of intermittent claudication.

Journal: Drugs20040101

Title: [Evidence-based therapy of intermittent claudication].

Journal: Krankenpflege Journal20040101

Title: Naftidrofuryl-induced liver injury.

Journal: The American journal of gastroenterology20030601

Title: Raynaud's phenomenon (primary).

Journal: Clinical evidence20030601

Title: Naftidrofuryl-driven regulation of endothelial ICAM-1 involves nitric oxide.

Journal: Free radical biology & medicine20030301

Title: Characterization of the CNS effects of naftidrofuryl (Praxilène) by quantitative EEG and functional MRI: a study in healthy elderly subjects.

Journal: Neuropsychobiology20030101

Title: Can claudication be improved with medication?

Journal: Seminars in vascular surgery20021201

Title: Nocturnal leg cramps in older people.

Journal: Postgraduate medical journal20021001

Title: Reduction of endothelin-1 binding and inhibition of endothelin-1-mediated detrusor contraction by naftidrofuryl.

Journal: Clinical science (London, England : 1979)20020801

Title: Vitamin A metabolism is altered in brown Norway and long-Evans rats infused with naftidrofuryl or erythromycin intravenously.

Journal: International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition20020701

Title: Findings of the Naftidrofuryl in Quality of Life (NIQOL) European study program.

Journal: International angiology : a journal of the International Union of Angiology20020301

Title: Naftidrofuryl exerts antiserotonergic but no endothelin-receptor blocking effects in AS4.1 cells, juxtaglomerular cells and isolated perfused rat kidneys.

Journal: Journal of cardiovascular pharmacology20020101

Title: Effect of naftidrofuryl on intramuscular partial oxygen pressure (pO2) prior to, during and after physical load on the treadmill in apparently healthy subjects.

Journal: Clinical hemorheology and microcirculation20020101

Title: [Current EMNID survey on peripheral arterial occlusive disease].

Journal: Krankenpflege Journal20020101

Title: [Application of prostaglandin E1 and Naftidrofuryl in combined treatment of purulent-necrotic complications of the diabetic foot syndrome].

Journal: Klinichna khirurhiia20020101

Title: Naftidrofuryl in quality of life (NIQOL). A Belgian study.

Journal: International angiology : a journal of the International Union of Angiology20011201

Title: Naftidrofuryl in the treatment of vascular dementia.

Journal: European archives of psychiatry and clinical neuroscience20011201

Title: Pharmacotherapy of intermittent claudication.

Journal: Expert opinion on pharmacotherapy20011101

Title: [Intermittent claudication. Walking plus vasoactive drug treatment].

Journal: MMW Fortschritte der Medizin20010705

Title: [Deleterious cardiac effects of serotonin in myocardial ischemia: role of naftidrofuryl].

Journal: Annales de cardiologie et d'angeiologie20010601

Title: Treatment alternatives for nocturnal leg cramps.

Journal: The Medical journal of Australia20010521

Title: Inhibition of purified pig and human liver retinyl ester hydrolase by pharmacologic agents.

Journal: Lipids20010501

Title: New treatment options in intermittent claudication: the US experience.

Journal: International journal of clinical practice. Supplement20010401

Title: [Effect of naftidrofuryl on physiological walking distance in patients with intermittent claudication].

Journal: Annales de cardiologie et d'angeiologie20010401

Title: A new study demonstrates the efficacy of naftidrofuryl in the treatment of intermittent claudication. Findings of the Naftidrofuryl Clinical Ischemia Study (NCIS).

Journal: International angiology : a journal of the International Union of Angiology20010301

Title: Behavioral studies of the effects of moderate oligemic hypoxia caused by bilateral clamping of carotid arteries in mice. Impairment of spatial working memory.

Journal: Polish journal of pharmacology19980101

Title: Naftidrofuryl oxalate, nootropic effects on the scopolamine- and the basal forebrain lesion-induced amnesia in rats.

Journal: Pharmacology, biochemistry, and behavior19910801

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