33570-04-6,MFCD00238547
Catalog No.:AA0037J3

33570-04-6 | Bilobalide

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
98%(HPLC)powder
in stock  
$56.00   $39.00
- +
10mg
≥95%
in stock  
$85.00   $59.00
- +
25mg
in stock  
$147.00   $103.00
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50mg
in stock  
$218.00   $153.00
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100mg
in stock  
$343.00   $240.00
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  • Technical Information
  • Properties
  • Literature
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Technical Information
Catalog Number:
AA0037J3
Chemical Name:
Bilobalide
CAS Number:
33570-04-6
Molecular Formula:
C15H18O8
Molecular Weight:
326.2986
MDL Number:
MFCD00238547
SMILES:
O=C1O[C@@H]2[C@@]3(C1)C(=O)O[C@H]1[C@]3([C@](C2)(O)C(C)(C)C)[C@@H](O)C(=O)O1
Properties
Properties
 
BP:
651.7°C at 760 mmHg  
Form:
Solid  
MP:
>275°C (dec.)  
Storage:
Keep in dry area;-20 ℃;  

Computed Properties
 
Complexity:
650  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
6  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0  
Rotatable Bond Count:
1  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
-0.3  

Literature

Title: Complete 1H NMR spectral analysis of ten chemical markers of Ginkgo biloba.

Journal: Magnetic resonance in chemistry : MRC 20120801

Title: Mitochondrial effects of Ginkgo biloba extract.

Journal: International psychogeriatrics 20120801

Title: Effects of the standardized Ginkgo biloba extract EGb 761® on neuroplasticity.

Journal: International psychogeriatrics 20120801

Title: Design of countercurrent separation of Ginkgo biloba terpene lactones by nuclear magnetic resonance.

Journal: Journal of chromatography. A 20120615

Title: Co-encapsulation and sustained-release of four components in ginkgo terpenes from injectable PELGE nanoparticles.

Journal: Fitoterapia 20120601

Title: Ginkgo biloba extract (GbE) enhances the anti-atherogenic effect of cilostazol by inhibiting ROS generation.

Journal: Experimental & molecular medicine 20120531

Title: Effect of Ginkgo biloba special extract EGb 761® on human cytochrome P450 activity: a cocktail interaction study in healthy volunteers.

Journal: European journal of clinical pharmacology 20120501

Title: A single amino acid determines the toxicity of Ginkgo biloba extracts.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20120501

Title: Preconditioning with Ginkgo biloba (EGb 761®) provides neuroprotection through HO1 and CRMP2.

Journal: Neurobiology of disease 20120401

Title: Different neuroprotective responses of Ginkgolide B and bilobalide, the two Ginkgo components, in ischemic rats with hyperglycemia.

Journal: European journal of pharmacology 20120227

Title: The phosphatidyl inositol 3 kinase-glycogen synthase kinase 3β pathway mediates bilobalide-induced reduction in amyloid β-peptide.

Journal: Neurochemical research 20120201

Title: Ginkgo biloba extract attenuates warfarin-mediated anticoagulation through induction of hepatic cytochrome P450 enzymes by bilobalide in mice.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20120115

Title: Species-dependent and receptor-selective action of bilobalide on the function of constitutive androstane receptor and pregnane X receptor.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20120101

Title: Ginkgo biloba responds to herbivory by activating early signaling and direct defenses.

Journal: PloS one 20120101

Title: An overview of the evidence and mechanisms of herb-drug interactions.

Journal: Frontiers in pharmacology 20120101

Title: The bad, the good, and the ugly about oxidative stress.

Journal: Oxidative medicine and cellular longevity 20120101

Title: Mouse models of Down syndrome as a tool to unravel the causes of mental disabilities.

Journal: Neural plasticity 20120101

Title: Ginkgo biloba extract EGB761 protects against aging-associated diastolic dysfunction in cardiomyocytes of D-galactose-induced aging rat.

Journal: Oxidative medicine and cellular longevity 20120101

Title: Neuroprotective effects of bilobalide are accompanied by a reduction of ischemia-induced glutamate release in vivo.

Journal: Brain research 20111124

Title: Isoform-selective activation of human constitutive androstane receptor by Ginkgo biloba extract: functional analysis of the SV23, SV24, and SV25 splice variants.

Journal: The Journal of pharmacology and experimental therapeutics 20111101

Title: Effects of Ginkgo biloba constituents on fruit-infesting behavior of codling moth (Cydia pomonella) in apples.

Journal: Journal of agricultural and food chemistry 20111026

Title: Bilobalide protects mitochondrial function in ovariectomized rats by up-regulation of mRNA and protein expression of cytochrome c oxidase subunit I.

Journal: Journal of molecular neuroscience : MN 20111001

Title: EGb 761 (Ginkgo biloba) protects cochlear hair cells against ototoxicity induced by gentamicin via reducing reactive oxygen species and nitric oxide-related apoptosis.

Journal: The Journal of nutritional biochemistry 20110901

Title: The facilitative effects of bilobalide, a unique constituent of Ginkgo biloba, on synaptic transmission and plasticity in hippocampal subfields.

Journal: The journal of physiological sciences : JPS 20110901

Title: MicroRNA expression is differentially altered by xenobiotic drugs in different human cell lines.

Journal: Biopharmaceutics & drug disposition 20110901

Title: Pancreatic lipase inhibition activity of trilactone terpenes of Ginkgo biloba.

Journal: Journal of enzyme inhibition and medicinal chemistry 20110801

Title: Bilobalide regulates soluble amyloid precursor protein release via phosphatidyl inositol 3 kinase-dependent pathway.

Journal: Neurochemistry international 20110801

Title: Binding sites for bilobalide, diltiazem, ginkgolide, and picrotoxinin at the 5-HT3 receptor.

Journal: Molecular pharmacology 20110701

Title: Modulation of CYP1A1 activity by a Ginkgo biloba extract in the human intestinal Caco-2 cells.

Journal: Toxicology letters 20110510

Title: Ginkgolide B and bilobalide block the pore of the 5-HT₃receptor at a location that overlaps the picrotoxin binding site.

Journal: Neuropharmacology 20110201

Title: Paeoniae alba Radix Promotes Peripheral Nerve Regeneration.

Journal: Evidence-based complementary and alternative medicine : eCAM 20110101

Title: Neuron Regeneration and Proliferation Effects of Danshen and Tanshinone IIA.

Journal: Evidence-based complementary and alternative medicine : eCAM 20110101

Title: Ginkgo biloba extract (EGb761) inhibits mitochondria-dependent caspase pathway and prevents apoptosis in hypoxia-reoxygenated cardiomyocytes.

Journal: Chinese medicine 20110101

Title: Drug discovery from Chinese medicine against neurodegeneration in Alzheimer's and vascular dementia.

Journal: Chinese medicine 20110101

Title: Alleviating neuropsychiatric symptoms in dementia: the effects of Ginkgo biloba extract EGb 761. Findings from a randomized controlled trial.

Journal: Neuropsychiatric disease and treatment 20110101

Title: EGb761, a Ginkgo biloba extract, is effective against atherosclerosis in vitro, and in a rat model of type 2 diabetes.

Journal: PloS one 20110101

Title: Flavonoids lower Alzheimer's Aβ production via an NFκB dependent mechanism.

Journal: Bioinformation 20110101

Title: Evaluation of Antioxidant and Cerebroprotective Effect of Medicago sativa Linn. against Ischemia and Reperfusion Insult.

Journal: Evidence-based complementary and alternative medicine : eCAM 20110101

Title: Ginkgo biloba extract in the treatment of tinnitus: a systematic review.

Journal: Neuropsychiatric disease and treatment 20110101

Title: Examining brain-cognition effects of ginkgo biloba extract: brain activation in the left temporal and left prefrontal cortex in an object working memory task.

Journal: Evidence-based complementary and alternative medicine : eCAM 20110101

Title: The alteration of components in the fermented Hwangryunhaedok-tang and its neuroprotective activity.

Journal: Pharmacognosy magazine 20110101

Title: The chemopreventive effect of Ginkgo biloba and Silybum marianum extracts on hepatocarcinogenesis in rats.

Journal: Cancer cell international 20110101

Title: Antibacterial activities of Ginkgo biloba L. leaf extracts.

Journal: TheScientificWorldJournal 20110101

Title: Environmental enrichment decreases GABAergic inhibition and improves cognitive abilities, synaptic plasticity, and visual functions in a mouse model of Down syndrome.

Journal: Frontiers in cellular neuroscience 20110101

Title: Human pregnane X receptor agonism by Ginkgo biloba extract: assessment of the role of individual ginkgolides.

Journal: The Journal of pharmacology and experimental therapeutics 20101201

Title: Neuroprotective effect of honokiol and magnolol, compounds from Magnolia officinalis, on beta-amyloid-induced toxicity in PC12 cells.

Journal: Phytotherapy research : PTR 20101001

Title: Bilobalide prevents apoptosis through activation of the PI3K/Akt pathway in SH-SY5Y cells.

Journal: Apoptosis : an international journal on programmed cell death 20100601

Title: Intestinal and blood-brain barrier permeability of ginkgolides and bilobalide: in vitro and in vivo approaches.

Journal: Planta medica 20100401

Title: Pharmacokinetics of bilobalide, ginkgolide A and B after administration of three different Ginkgo biloba L. preparations in humans.

Journal: Phytotherapy research : PTR 20100301

Title: Inhibition of intestinal and hepatic glucuronidation of mycophenolic acid by Ginkgo biloba extract and flavonoids.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20100201

Title: The Ginkgo biloba extract EGb 761(R) and its main constituent flavonoids and ginkgolides increase extracellular dopamine levels in the rat prefrontal cortex.

Journal: British journal of pharmacology 20100201

Title: Effects of poly-gamma-glutamic acid on serum and brain concentrations of glutamate and GABA in diet-induced obese rats.

Journal: Nutrition research and practice 20100201

Title: Ginkgo biloba extract in Alzheimer's disease: from action mechanisms to medical practice.

Journal: International journal of molecular sciences 20100101

Title: Cinnamomum cassia bark in two herbal formulas increases life span in Caenorhabditis elegans via insulin signaling and stress response pathways.

Journal: PloS one 20100101

Title: EGb761 protects motoneurons against avulsion-induced oxidative stress in rats.

Journal: Journal of brachial plexus and peripheral nerve injury 20100101

Title: Neuroprotective properties of chitosan and its derivatives.

Journal: Marine drugs 20100101

Title: Ginkgo biloba extract ameliorates oxidative phosphorylation performance and rescues abeta-induced failure.

Journal: PloS one 20100101

Title: Improved mitochondrial function in brain aging and Alzheimer disease - the new mechanism of action of the old metabolic enhancer piracetam.

Journal: Frontiers in neuroscience 20100101

Title: Assessment of health claims, content, and safety of herbal supplements containing Ginkgo biloba.

Journal: Food & nutrition research 20100101

Title: Brain permeability of bilobalide as probed by microdialysis before and after middle cerebral artery occlusion in mice.

Journal: Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20100101

Title: Optimization of extraction technique and validation of developed RP-HPLC-ELSD method for determination of terpene trilactones in Ginkgo biloba leaves.

Journal: Journal of pharmaceutical and biomedical analysis 20091205

Title: Gene Regulatory Effects of Ginkgo biloba Extract and Its Flavonol and Terpenelactone Fractions in Mouse Brain.

Journal: Journal of clinical biochemistry and nutrition 20091101

Title: Validation of an LC-MS/MS assay of terpene trilactones in Ginkgo biloba extracts and pharmaceutical formulations through standard addition method.

Journal: Journal of pharmaceutical and biomedical analysis 20091015

Title: Development of an alternative method for determination of terpene lactones in ginkgo dry extract.

Journal: Pharmeuropa bio & scientific notes 20091001

Title: Liquid chromatography/atmospheric pressure chemical ionization ion trap mass spectrometry of bilobalide in plasma and brain of rats after oral administration of its phospholipidic complex.

Journal: Journal of pharmaceutical and biomedical analysis 20090908

Title: Inhibition of human CYP2B6-catalyzed bupropion hydroxylation by Ginkgo biloba extract: effect of terpene trilactones and flavonols.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20090901

Title: Modulation of CYP1B1 and CYP1A1 gene expression and activation of aryl hydrocarbon receptor by Ginkgo biloba extract in MCF-10A human mammary epithelial cells.

Journal: Canadian journal of physiology and pharmacology 20090901

Title: The mixture of procyanidins extracted from the lotus seed pod and bilobalide ameliorates scopolamine-induced memory impairment in mice.

Journal: Neuroscience bulletin 20090801

Title: Adult reversal of cognitive phenotypes in neurodevelopmental disorders.

Journal: Journal of neurodevelopmental disorders 20090601

Title: Influence of antivitamins ginkgotoxin 5'-phosphate and deoxypyridoxine 5'-phosphate on human pyridoxine 5'-phosphate oxidase.

Journal: Planta medica 20090501

Title: Bioactive terpenoids and flavonoids from Ginkgo biloba extract induce the expression of hepatic drug-metabolizing enzymes through pregnane X receptor, constitutive androstane receptor, and aryl hydrocarbon receptor-mediated pathways.

Journal: Pharmaceutical research 20090401

Title: Chemical analysis and quality control of Ginkgo biloba leaves, extracts, and phytopharmaceuticals.

Journal: Journal of chromatography. A 20090313

Title: Time-dependent induction of hepatic cytochrome P450 enzyme activity and mRNA expression by bilobalide in rats.

Journal: Journal of pharmacological sciences 20090301

Title: Effect of biotic elicitors on the accumulation of bilobalide and ginkgolides in Ginkgo biloba cell cultures.

Journal: Journal of biotechnology 20090101

Title: Column liquid chromatography/electrospray ionization-time of flight-mass spectrometry and ultraperformance column liquid chromatography/mass spectrometry methods for the determination of ginkgolides and bilobalide in the leaves of Ginkgo biloba and dietary supplements.

Journal: Journal of AOAC International 20090101

Title: Bilobalide modulates serotonin-controlled behaviors in the nematode Caenorhabditis elegans.

Journal: BMC neuroscience 20090101

Title: Stimulation of neurogenesis and synaptogenesis by bilobalide and quercetin via common final pathway in hippocampal neurons.

Journal: Journal of Alzheimer's disease : JAD 20090101

Title: Ginkgo biloba extract neuroprotective action is dependent on heme oxygenase 1 in ischemic reperfusion brain injury.

Journal: Stroke 20081201

Title: Influence of elevated carbon dioxide and ozone on the foliar nonvolatile terpenoids in ginkgo biloba.

Journal: Bulletin of environmental contamination and toxicology 20081101

Title: Induction of cytochrome P450s by terpene trilactones and flavonoids of the Ginkgo biloba extract EGb 761 in rats.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20080501

Title: Bilobalide inhibits 6-OHDA-induced activation of NF-kappaB and loss of dopaminergic neurons in rat substantia nigra.

Journal: Acta pharmacologica Sinica 20080501

Title: Subunit-specific potentiation of recombinant glycine receptors by NV-31, a bilobalide-derived compound.

Journal: Neuroscience letters 20080418

Title: Spectroscopic investigation of Ginkgo biloba terpene trilactones and their interaction with amyloid peptide Abeta(25-35).

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20080401

Title: Role of glycine receptors and glycine release for the neuroprotective activity of bilobalide.

Journal: Brain research 20080327

Title: Simultaneous determination of ginkgolides A, B, C and bilobalide in plasma by LC-MS/MS and its application to the pharmacokinetic study of Ginkgo biloba extract in rats.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080315

Title: Simultaneous determination of ginkgo flavonoids and terpenoids in plasma: ammonium formate in LC mobile phase enhancing electrospray ionization efficiency and capacity.

Journal: Journal of the American Society for Mass Spectrometry 20080301

Title: Chemical markers for the quality control of herbal medicines: an overview.

Journal: Chinese medicine 20080101

Title: Recent advances in the compound-oriented and pattern-oriented approaches to the quality control of herbal medicines.

Journal: Chinese medicine 20080101

Title: Induction of cytochrome P450 3A by the Ginkgo biloba extract and bilobalides in human and rat primary hepatocytes.

Journal: Drug metabolism letters 20080101

Title: Restoration of impaired phosphorylation of cyclic AMP response element-binding protein (CREB) by EGb 761 and its constituents in Abeta-expressing neuroblastoma cells.

Journal: The European journal of neuroscience 20071101

Title: Characterization of a suite of ginkgo-containing standard reference materials.

Journal: Analytical and bioanalytical chemistry 20070901

Title: Effect of Ginkgo biloba extract on oxidative metabolism of valproic acid in hepatic microsomes from donors with the CYP2C9*1/*1 genotype.

Journal: Canadian journal of physiology and pharmacology 20070901

Title: Drug treatment improves memory in mice.

Journal: Down's syndrome, research and practice : the journal of the Sarah Duffen Centre 20070701

Title: Acute cognitive effects of standardised Ginkgo biloba extract complexed with phosphatidylserine.

Journal: Human psychopharmacology 20070601

Title: Bilobalide in Ginkgo biloba extract is a major substance inducing hepatic CYPs.

Journal: The Journal of pharmacy and pharmacology 20070601

Title: Treating senile dementia with traditional Chinese medicine.

Journal: Clinical interventions in aging 20070601

Title: Role of GABAergic antagonism in the neuroprotective effects of bilobalide.

Journal: Brain research 20070112

Title: Bilobalide prevents ischemia-induced edema formation in vitro and in vivo.

Journal: Neuroscience 20070105

Title: Single-laboratory validation for the determination of terpene lactones in Ginkgo biloba dietary supplement crude materials and finished products by high-performance liquid chromatography with evaporative light-scattering detection.

Journal: Journal of AOAC International 20070101

Title: Analysis of flavonol aglycones and terpenelactones in Ginkgo biloba extract: A comparison of high-performance thin-layer chromatography and column high-performance liquid chromatography.

Journal: Journal of AOAC International 20070101

Title: Validation of capillary gas chromatographic method for determination of bilobalide and ginkgolides A, B, C in Ginkgo biloba dry and liquid extracts.

Journal: Acta poloniae pharmaceutica 20070101

Title: Cardiovascular pharmacology of sinomenine: the mechanical and electropharmacological actions.

Journal: Drug target insights 20070101

Title: A screening platform for compounds with potential immuno-regulatory activities using human cord blood mononuclear cells.

Journal: Combinatorial chemistry & high throughput screening 20061201

Title: In vitro peroxynitrite scavenging activity of 6-hydroxykynurenic acid and other flavonoids from Gingko biloba yellow leaves.

Journal: Archives of pharmacal research 20061201

Title: Analysis of ginkgolides and bilobalide in food products using LC-APCI-MS.

Journal: Journal of pharmaceutical and biomedical analysis 20060828

Title: Application of reverse-flow micellar electrokinetic chromatography for the simultaneous determination of flavonols and terpene trilactones in Ginkgo biloba dosage forms.

Journal: Journal of chromatography. A 20060728

Title: Molecular determinants of ginkgolide binding in the glycine receptor pore.

Journal: Journal of neurochemistry 20060701

Title: Effect of Ginkgo biloba extract on procarcinogen-bioactivating human CYP1 enzymes: identification of isorhamnetin, kaempferol, and quercetin as potent inhibitors of CYP1B1.

Journal: Toxicology and applied pharmacology 20060515

Title: Effect of supplementing terpenoid biosynthetic precursors on the accumulation of bilobalide and ginkgolides in Ginkgo biloba cell cultures.

Journal: Journal of biotechnology 20060503

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Determination of terpene trilactones in Ginkgo biloba solid oral dosage forms using HPLC with evaporative light scattering detection.

Journal: Journal of pharmaceutical and biomedical analysis 20060411

Title: Distinct role of bilobalide and ginkgolide A in the modulation of rat CYP2B1 and CYP3A23 gene expression by Ginkgo biloba extract in cultured hepatocytes.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20060201

Title: Identification of class 2 1-deoxy-D-xylulose 5-phosphate synthase and 1-deoxy-D-xylulose 5-phosphate reductoisomerase genes from Ginkgo biloba and their transcription in embryo culture with respect to ginkgolide biosynthesis.

Journal: Planta medica 20060201

Title: Mixed antagonistic effects of bilobalide at rho1 GABAC receptor.

Journal: Neuroscience 20060101

Title: Quantitative determination of major active components in Ginkgo biloba dietary supplements by liquid chromatography/mass spectrometry.

Journal: Rapid communications in mass spectrometry : RCM 20060101

Title: [Quantitative determination of ginkgolides by liquid chromatography-electrospray mass spectrometry].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20051201

Title: Suppression of pacemaker activity by Ginkgo biloba extract and its main constituent, bilobalide in rat sino-atrial nodal cells.

Journal: Life sciences 20051119

Title: A picrotoxin-specific conformational change in the glycine receptor M2-M3 loop.

Journal: The Journal of biological chemistry 20051028

Title: Preparative isolation of terpene trilactones from Ginkgo biloba leaves.

Journal: Journal of chromatography. A 20051021

Title: Development of a ginkgo biloba fingerprint chromatogram with UV and evaporative light scattering detection and optimization of the evaporative light scattering detector operating conditions.

Journal: Journal of chromatography. A 20050902

Title: Terpene trilactones from Gingko biloba: from ancient times to the 21st century.

Journal: Bioorganic & medicinal chemistry 20050901

Title: Ginkgolides and bilobalide: their physical, chromatographic and spectroscopic properties.

Journal: Bioorganic & medicinal chemistry 20050901

Title: Age-related changes in the vasodilating actions of Ginkgo biloba extract and its main constituent, bilobalide, in rat aorta.

Journal: Clinica chimica acta; international journal of clinical chemistry 20050401

Title: Biological activities of Ginkgo extracts.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20050401

Title: Liquid chromatography/electrospray tandem mass spectrometry of terpenoid lactones in Ginkgo biloba.

Journal: Journal of mass spectrometry : JMS 20050301

Title: Effects of ginkgo biloba extract on cation currents in rat ventricular myocytes.

Journal: Life sciences 20050121

Title: [Applications of two-dimensional liquid chromatography coupled to mass spectrometry for the separation and identification of compounds in ginkgo biloba extracts].

Journal: Se pu = Chinese journal of chromatography 20050101

Title: HPLC determination of certain flavonoids and terpene lactones in selected Ginkgo biloba L. phytopharmaceuticals.

Journal: Farmaco (Societa chimica italiana : 1989) 20050101

Title: Isolation of ginkgolides A, B, C, J and bilobalide from G. biloba extracts.

Journal: Phytochemistry 20041101

Title: A method for extraction and quantification of Ginkgo terpene trilactones.

Journal: Analytical chemistry 20040801

Title: Inhibition of human cytochromes P450 by components of Ginkgo biloba.

Journal: The Journal of pharmacy and pharmacology 20040801

Title: Preventive effects of extract of leaves of ginkgo (Ginkgo biloba) and its component bilobalide on azoxymethane-induced colonic aberrant crypt foci in rats.

Journal: Cancer letters 20040716

Title: Determination of ginkgolide A, B, and bilobalide in biloba L. extracts by microdialysis-HPLC.

Journal: Analytical and bioanalytical chemistry 20040601

Title: [Studies on the cell growth, differentiation and terpene lactone accumulation in Ginkgo biloba cell suspension cultures].

Journal: Sheng wu gong cheng xue bao = Chinese journal of biotechnology 20040501

Title: Electropharmacological actions of Ginkgo biloba extract on vascular smooth and heart muscles.

Journal: Clinica chimica acta; international journal of clinical chemistry 20040401

Title: Chemistry and biology of terpene trilactones from Ginkgo biloba.

Journal: Angewandte Chemie (International ed. in English) 20040319

Title: Effect of bilobalide on peripheral nerve regeneration.

Journal: Biomaterials 20040201

Title: Comparative vasodilating actions among terpenoids and flavonoids contained in Ginkgo biloba extract.

Journal: Clinica chimica acta; international journal of clinical chemistry 20040101

Title: Effect of Ginkgo biloba extract on rat hepatic microsomal CYP1A activity: role of ginkgolides, bilobalide, and flavonols.

Journal: Canadian journal of physiology and pharmacology 20040101

Title: Sample preparation and determination of ginkgo terpene trilactones in selected beverage, snack, and dietary supplement products by liquid chromatography with evaporative light-scattering detection.

Journal: Journal of AOAC International 20040101

Title: Ginkgo biloba--an appraisal.

Journal: Kathmandu University medical journal (KUMJ) 20040101

Title: Terpene trilactones from Ginkgo biloba are antagonists of cortical glycine and GABA(A) receptors.

Journal: The Journal of biological chemistry 20031205

Title: Analysis of ginkgolides and bilobalide in Ginkgo biloba L. extract injections by high-performance liquid chromatography with evaporative light scattering detection.

Journal: Journal of pharmaceutical and biomedical analysis 20031124

Title: An anxiolytic-like effect of Ginkgo biloba extract and its constituent, ginkgolide-A, in mice.

Journal: Journal of natural products 20031001

Title: Liquid chromatography/atmospheric pressure chemical ionization ion trap mass spectrometry of terpene lactones in plasma of animals.

Journal: Journal of pharmaceutical and biomedical analysis 20030808

Title: Pharmacological studies supporting the therapeutic use of Ginkgo biloba extract for Alzheimer's disease.

Journal: Pharmacopsychiatry 20030601

Title: Cognitive and other behavioral effects of EGb 761 in animal models.

Journal: Pharmacopsychiatry 20030601

Title: Pharmacokinetics of Ginkgo biloba extracts.

Journal: Pharmacopsychiatry 20030601

Title: Structure-activity studies with Ginkgo biloba extract constituents as receptor-gated chloride channel blockers and modulators.

Journal: Pharmacopsychiatry 20030601

Title: Excitotoxic hippocampal membrane breakdown and its inhibition by bilobalide: role of chloride fluxes.

Journal: Pharmacopsychiatry 20030601

Title: Effects of bilobalide on cerebral amino acid neurotransmission.

Journal: Pharmacopsychiatry 20030601

Title: Neuroprotective effects of bilobalide, a component of Ginkgo biloba extract (EGb 761) in global brain ischemia and in excitotoxicity-induced neuronal death.

Journal: Pharmacopsychiatry 20030601

Title: Mechanisms for the vasodilations induced by Ginkgo biloba extract and its main constituent, bilobalide, in rat aorta.

Journal: Life sciences 20030425

Title: Bilobalide, a sesquiterpene trilactone from Ginkgo biloba, is an antagonist at recombinant alpha1beta2gamma2L GABA(A) receptors.

Journal: European journal of pharmacology 20030307

Title: Quantitative analysis of bilobalide and ginkgolides from Ginkgo biloba leaves and Ginkgo products using (1)H-NMR.

Journal: Chemical & pharmaceutical bulletin 20030201

Title: Development and validation of a gas chromatographic-mass spectrometric method for simultaneous identification and quantification of marker compounds including bilobalide, ginkgolides and flavonoids in Ginkgo biloba L. extract and pharmaceutical preparations.

Journal: Journal of chromatography. A 20030131

Title: Homocysteine stimulates inducible nitric oxide synthase expression in macrophages: antagonizing effect of ginkgolides and bilobalide.

Journal: Molecular and cellular biochemistry 20030101

Title: EGb 761: ginkgo biloba extract, Ginkor.

Journal: Drugs in R&D 20030101

Title: Effects of ginkgo biloba extract and bilobalide, a main constituent, on the ionic currents in guinea pig ventricular cardiomyocytes.

Journal: Arzneimittel-Forschung 20030101

Title: Bilobalide and neuroprotection.

Journal: Pharmacological research 20021201

Title: Influence of pharmaceutical quality on the bioavailability of active components from Ginkgo biloba preparations.

Journal: The Journal of pharmacy and pharmacology 20021101

Title: Efficient extraction of ginkgolides and bilobalide from Ginkgo biloba leaves.

Journal: Journal of natural products 20021001

Title: Identification and the retention index of bilobalide and ginkgolides using capillary gas chromatography.

Journal: Journal of chromatographic science 20021001

Title: What is Ginkgo biloba extract EGb 761? An overview--from molecular biology to clinical medicine.

Journal: Cellular and molecular biology (Noisy-le-Grand, France) 20020901

Title: Bilobalide, a component of the Ginkgo biloba extract (EGb 761), protects against neuronal death in global brain ischemia and in glutamate-induced excitotoxicity.

Journal: Cellular and molecular biology (Noisy-le-Grand, France) 20020901

Title: Effects of chronic administration of bilobalide on amino acid levels in mouse brain.

Journal: Cellular and molecular biology (Noisy-le-Grand, France) 20020901

Title: EGb 761 is a neuroprotective agent against beta-amyloid toxicity.

Journal: Cellular and molecular biology (Noisy-le-Grand, France) 20020901

Title: Anti-apoptotic properties of Ginkgo biloba extract EGb 761 in differentiated PC12 cells.

Journal: Cellular and molecular biology (Noisy-le-Grand, France) 20020901

Title: Ginkgolide derivatives for photolabeling studies: preparation and pharmacological evaluation.

Journal: Journal of medicinal chemistry 20020829

Title: Simultaneous determination of terpene lactones and flavonoid aglycones in Ginkgo biloba by high-performance liquid chromatography with evaporative light scattering detection.

Journal: Journal of pharmaceutical and biomedical analysis 20020822

Title: Chemical analysis of Ginkgo biloba leaves and extracts.

Journal: Journal of chromatography. A 20020816

Title: Effects of bilobalide on amino acid release and electrophysiology of cortical slices.

Journal: Amino acids 20020601

Title: Pharmaceutical quality of different Ginkgo biloba brands.

Journal: The Journal of pharmacy and pharmacology 20020501

Title: Effects of bilobalide on hypoxia/hypoglycemia-stimulated glutamate efflux from rat cortical brain slices.

Journal: Neurochemical research 20020501

Title: Liquid chromatography-electrospray mass spectrometric studies of ginkgolides and bilobalide using simultaneous monitoring of proton, ammonium and sodium adducts.

Journal: The Analyst 20020501

Title: Mitochondrial respiratory chain as a new target for anti-ischemic molecules.

Journal: European journal of pharmacology 20020419

Title: Ginkgo biloba extracts EGb 761 and bilobalide increase NADH dehydrogenase mRNA level and mitochondrial respiratory control ratio in PC12 cells.

Journal: Neurochemical research 20020401

Title: Selective responses of three Ginkgo biloba leaf-derived constituents on human intestinal bacteria.

Journal: Journal of agricultural and food chemistry 20020327

Title: Effects of extract of Ginkgo biloba leaves and its constituents on carcinogen-metabolizing enzyme activities and glutathione levels in mouse liver.

Journal: Life sciences 20020222

Title: Liquid chromatography-atmospheric pressure chemical ionisation/mass spectrometry: a rapid and selective method for the quantitative determination of ginkgolides and bilobalide in ginkgo leaf extracts and phytopharmaceuticals.

Journal: Phytochemical analysis : PCA 20020101

Title: [Plant biotechnology: an avant-garde research for an ancestral tree, the Ginkgo biloba].

Journal: Annales pharmaceutiques francaises 20020101

Title: [Value of Ginkgo biloba in treatment of Alzheimer dementia].

Journal: Wiener medizinische Wochenschrift (1946) 20020101

Title: Neuroprotective effects of bilobalide, a component of the Ginkgo biloba extract (EGb 761), in gerbil global brain ischemia.

Journal: Brain research 20011220

Title: [Analysis and structure identification of trace constituent in the total ginkgolide by using LC/DAD/ESI/MS].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20010801

Title: Selective dissolution and one step separation of terpene trilactones in ginkgo leaf extracts for GC-FID determination.

Journal: Talanta 20010530

Title: Inhibition by ginkgolides and bilobalide of the production of nitric oxide in macrophages (THP-1) but not in endothelial cells (HUVEC).

Journal: Biochemical pharmacology 20010215

Title: Neuroprotective effects of NV-31, a bilobalide-derived compound: evidence for an antioxidative mechanism.

Journal: Brain research 20010202

Title: Induction of heme oxygenase-1 by Ginkgo biloba extract but not its terpenoids partially mediated its protective effect against lysophosphatidylcholine-induced damage.

Journal: Pharmacological research 20010101

Title: Liquid chromatography/atmospheric pressure chemical ionization mass spectrometry of terpene lactones in plasma of volunteers dosed with Ginkgo biloba L. extracts.

Journal: Rapid communications in mass spectrometry : RCM 20010101

Title: Induction of glutathione synthesis in human keratinocytes by Ginkgo biloba extract (EGb761).

Journal: BioFactors (Oxford, England) 20010101

Title: Protective effect of bilobalide against nitric oxide-induced neurotoxicity in PC12 cells.

Journal: Acta pharmacologica Sinica 20000501

Title: New drug developments for opportunistic infections in immunosuppressed patients: Pneumocystis carinii.

Journal: Journal of medicinal chemistry 19951124

Title: Activity of bilobalide, a sesquiterpene from Ginkgo biloba, on Pneumocystis carinii.

Journal: Antimicrobial agents and chemotherapy 19930701

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Tags:33570-04-6 Molecular Formula|33570-04-6 MDL|33570-04-6 SMILES|33570-04-6 Bilobalide
Catalog No.: AA0037J3
33570-04-6,MFCD00238547
33570-04-6 | Bilobalide
Pack Size: 5mg
Purity: 98%(HPLC)powder
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Technical Information
Catalog Number: AA0037J3
Chemical Name: Bilobalide
CAS Number: 33570-04-6
Molecular Formula: C15H18O8
Molecular Weight: 326.2986
MDL Number: MFCD00238547
SMILES: O=C1O[C@@H]2[C@@]3(C1)C(=O)O[C@H]1[C@]3([C@](C2)(O)C(C)(C)C)[C@@H](O)C(=O)O1
Properties
BP: 651.7°C at 760 mmHg  
Form: Solid  
MP: >275°C (dec.)  
Storage: Keep in dry area;-20 ℃;  
Complexity: 650  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 6  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 23  
Hydrogen Bond Acceptor Count: 8  
Hydrogen Bond Donor Count: 2  
Isotope Atom Count: 0  
Rotatable Bond Count: 1  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: -0.3  
Literature fold

Title: Complete 1H NMR spectral analysis of ten chemical markers of Ginkgo biloba.

Journal: Magnetic resonance in chemistry : MRC20120801

Title: Mitochondrial effects of Ginkgo biloba extract.

Journal: International psychogeriatrics20120801

Title: Effects of the standardized Ginkgo biloba extract EGb 761® on neuroplasticity.

Journal: International psychogeriatrics20120801

Title: Design of countercurrent separation of Ginkgo biloba terpene lactones by nuclear magnetic resonance.

Journal: Journal of chromatography. A20120615

Title: Co-encapsulation and sustained-release of four components in ginkgo terpenes from injectable PELGE nanoparticles.

Journal: Fitoterapia20120601

Title: Ginkgo biloba extract (GbE) enhances the anti-atherogenic effect of cilostazol by inhibiting ROS generation.

Journal: Experimental & molecular medicine20120531

Title: Effect of Ginkgo biloba special extract EGb 761® on human cytochrome P450 activity: a cocktail interaction study in healthy volunteers.

Journal: European journal of clinical pharmacology20120501

Title: A single amino acid determines the toxicity of Ginkgo biloba extracts.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology20120501

Title: Preconditioning with Ginkgo biloba (EGb 761®) provides neuroprotection through HO1 and CRMP2.

Journal: Neurobiology of disease20120401

Title: Different neuroprotective responses of Ginkgolide B and bilobalide, the two Ginkgo components, in ischemic rats with hyperglycemia.

Journal: European journal of pharmacology20120227

Title: The phosphatidyl inositol 3 kinase-glycogen synthase kinase 3β pathway mediates bilobalide-induced reduction in amyloid β-peptide.

Journal: Neurochemical research20120201

Title: Ginkgo biloba extract attenuates warfarin-mediated anticoagulation through induction of hepatic cytochrome P450 enzymes by bilobalide in mice.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology20120115

Title: Species-dependent and receptor-selective action of bilobalide on the function of constitutive androstane receptor and pregnane X receptor.

Journal: Drug metabolism and disposition: the biological fate of chemicals20120101

Title: Ginkgo biloba responds to herbivory by activating early signaling and direct defenses.

Journal: PloS one20120101

Title: An overview of the evidence and mechanisms of herb-drug interactions.

Journal: Frontiers in pharmacology20120101

Title: The bad, the good, and the ugly about oxidative stress.

Journal: Oxidative medicine and cellular longevity20120101

Title: Mouse models of Down syndrome as a tool to unravel the causes of mental disabilities.

Journal: Neural plasticity20120101

Title: Ginkgo biloba extract EGB761 protects against aging-associated diastolic dysfunction in cardiomyocytes of D-galactose-induced aging rat.

Journal: Oxidative medicine and cellular longevity20120101

Title: Neuroprotective effects of bilobalide are accompanied by a reduction of ischemia-induced glutamate release in vivo.

Journal: Brain research20111124

Title: Isoform-selective activation of human constitutive androstane receptor by Ginkgo biloba extract: functional analysis of the SV23, SV24, and SV25 splice variants.

Journal: The Journal of pharmacology and experimental therapeutics20111101

Title: Effects of Ginkgo biloba constituents on fruit-infesting behavior of codling moth (Cydia pomonella) in apples.

Journal: Journal of agricultural and food chemistry20111026

Title: Bilobalide protects mitochondrial function in ovariectomized rats by up-regulation of mRNA and protein expression of cytochrome c oxidase subunit I.

Journal: Journal of molecular neuroscience : MN20111001

Title: EGb 761 (Ginkgo biloba) protects cochlear hair cells against ototoxicity induced by gentamicin via reducing reactive oxygen species and nitric oxide-related apoptosis.

Journal: The Journal of nutritional biochemistry20110901

Title: The facilitative effects of bilobalide, a unique constituent of Ginkgo biloba, on synaptic transmission and plasticity in hippocampal subfields.

Journal: The journal of physiological sciences : JPS20110901

Title: MicroRNA expression is differentially altered by xenobiotic drugs in different human cell lines.

Journal: Biopharmaceutics & drug disposition20110901

Title: Pancreatic lipase inhibition activity of trilactone terpenes of Ginkgo biloba.

Journal: Journal of enzyme inhibition and medicinal chemistry20110801

Title: Bilobalide regulates soluble amyloid precursor protein release via phosphatidyl inositol 3 kinase-dependent pathway.

Journal: Neurochemistry international20110801

Title: Binding sites for bilobalide, diltiazem, ginkgolide, and picrotoxinin at the 5-HT3 receptor.

Journal: Molecular pharmacology20110701

Title: Modulation of CYP1A1 activity by a Ginkgo biloba extract in the human intestinal Caco-2 cells.

Journal: Toxicology letters20110510

Title: Ginkgolide B and bilobalide block the pore of the 5-HT₃receptor at a location that overlaps the picrotoxin binding site.

Journal: Neuropharmacology20110201

Title: Paeoniae alba Radix Promotes Peripheral Nerve Regeneration.

Journal: Evidence-based complementary and alternative medicine : eCAM20110101

Title: Neuron Regeneration and Proliferation Effects of Danshen and Tanshinone IIA.

Journal: Evidence-based complementary and alternative medicine : eCAM20110101

Title: Ginkgo biloba extract (EGb761) inhibits mitochondria-dependent caspase pathway and prevents apoptosis in hypoxia-reoxygenated cardiomyocytes.

Journal: Chinese medicine20110101

Title: Drug discovery from Chinese medicine against neurodegeneration in Alzheimer's and vascular dementia.

Journal: Chinese medicine20110101

Title: Alleviating neuropsychiatric symptoms in dementia: the effects of Ginkgo biloba extract EGb 761. Findings from a randomized controlled trial.

Journal: Neuropsychiatric disease and treatment20110101

Title: EGb761, a Ginkgo biloba extract, is effective against atherosclerosis in vitro, and in a rat model of type 2 diabetes.

Journal: PloS one20110101

Title: Flavonoids lower Alzheimer's Aβ production via an NFκB dependent mechanism.

Journal: Bioinformation20110101

Title: Evaluation of Antioxidant and Cerebroprotective Effect of Medicago sativa Linn. against Ischemia and Reperfusion Insult.

Journal: Evidence-based complementary and alternative medicine : eCAM20110101

Title: Ginkgo biloba extract in the treatment of tinnitus: a systematic review.

Journal: Neuropsychiatric disease and treatment20110101

Title: Examining brain-cognition effects of ginkgo biloba extract: brain activation in the left temporal and left prefrontal cortex in an object working memory task.

Journal: Evidence-based complementary and alternative medicine : eCAM20110101

Title: The alteration of components in the fermented Hwangryunhaedok-tang and its neuroprotective activity.

Journal: Pharmacognosy magazine20110101

Title: The chemopreventive effect of Ginkgo biloba and Silybum marianum extracts on hepatocarcinogenesis in rats.

Journal: Cancer cell international20110101

Title: Antibacterial activities of Ginkgo biloba L. leaf extracts.

Journal: TheScientificWorldJournal20110101

Title: Environmental enrichment decreases GABAergic inhibition and improves cognitive abilities, synaptic plasticity, and visual functions in a mouse model of Down syndrome.

Journal: Frontiers in cellular neuroscience20110101

Title: Human pregnane X receptor agonism by Ginkgo biloba extract: assessment of the role of individual ginkgolides.

Journal: The Journal of pharmacology and experimental therapeutics20101201

Title: Neuroprotective effect of honokiol and magnolol, compounds from Magnolia officinalis, on beta-amyloid-induced toxicity in PC12 cells.

Journal: Phytotherapy research : PTR20101001

Title: Bilobalide prevents apoptosis through activation of the PI3K/Akt pathway in SH-SY5Y cells.

Journal: Apoptosis : an international journal on programmed cell death20100601

Title: Intestinal and blood-brain barrier permeability of ginkgolides and bilobalide: in vitro and in vivo approaches.

Journal: Planta medica20100401

Title: Pharmacokinetics of bilobalide, ginkgolide A and B after administration of three different Ginkgo biloba L. preparations in humans.

Journal: Phytotherapy research : PTR20100301

Title: Inhibition of intestinal and hepatic glucuronidation of mycophenolic acid by Ginkgo biloba extract and flavonoids.

Journal: Drug metabolism and disposition: the biological fate of chemicals20100201

Title: The Ginkgo biloba extract EGb 761(R) and its main constituent flavonoids and ginkgolides increase extracellular dopamine levels in the rat prefrontal cortex.

Journal: British journal of pharmacology20100201

Title: Effects of poly-gamma-glutamic acid on serum and brain concentrations of glutamate and GABA in diet-induced obese rats.

Journal: Nutrition research and practice20100201

Title: Ginkgo biloba extract in Alzheimer's disease: from action mechanisms to medical practice.

Journal: International journal of molecular sciences20100101

Title: Cinnamomum cassia bark in two herbal formulas increases life span in Caenorhabditis elegans via insulin signaling and stress response pathways.

Journal: PloS one20100101

Title: EGb761 protects motoneurons against avulsion-induced oxidative stress in rats.

Journal: Journal of brachial plexus and peripheral nerve injury20100101

Title: Neuroprotective properties of chitosan and its derivatives.

Journal: Marine drugs20100101

Title: Ginkgo biloba extract ameliorates oxidative phosphorylation performance and rescues abeta-induced failure.

Journal: PloS one20100101

Title: Improved mitochondrial function in brain aging and Alzheimer disease - the new mechanism of action of the old metabolic enhancer piracetam.

Journal: Frontiers in neuroscience20100101

Title: Assessment of health claims, content, and safety of herbal supplements containing Ginkgo biloba.

Journal: Food & nutrition research20100101

Title: Brain permeability of bilobalide as probed by microdialysis before and after middle cerebral artery occlusion in mice.

Journal: Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques20100101

Title: Optimization of extraction technique and validation of developed RP-HPLC-ELSD method for determination of terpene trilactones in Ginkgo biloba leaves.

Journal: Journal of pharmaceutical and biomedical analysis20091205

Title: Gene Regulatory Effects of Ginkgo biloba Extract and Its Flavonol and Terpenelactone Fractions in Mouse Brain.

Journal: Journal of clinical biochemistry and nutrition20091101

Title: Validation of an LC-MS/MS assay of terpene trilactones in Ginkgo biloba extracts and pharmaceutical formulations through standard addition method.

Journal: Journal of pharmaceutical and biomedical analysis20091015

Title: Development of an alternative method for determination of terpene lactones in ginkgo dry extract.

Journal: Pharmeuropa bio & scientific notes20091001

Title: Liquid chromatography/atmospheric pressure chemical ionization ion trap mass spectrometry of bilobalide in plasma and brain of rats after oral administration of its phospholipidic complex.

Journal: Journal of pharmaceutical and biomedical analysis20090908

Title: Inhibition of human CYP2B6-catalyzed bupropion hydroxylation by Ginkgo biloba extract: effect of terpene trilactones and flavonols.

Journal: Drug metabolism and disposition: the biological fate of chemicals20090901

Title: Modulation of CYP1B1 and CYP1A1 gene expression and activation of aryl hydrocarbon receptor by Ginkgo biloba extract in MCF-10A human mammary epithelial cells.

Journal: Canadian journal of physiology and pharmacology20090901

Title: The mixture of procyanidins extracted from the lotus seed pod and bilobalide ameliorates scopolamine-induced memory impairment in mice.

Journal: Neuroscience bulletin20090801

Title: Adult reversal of cognitive phenotypes in neurodevelopmental disorders.

Journal: Journal of neurodevelopmental disorders20090601

Title: Influence of antivitamins ginkgotoxin 5'-phosphate and deoxypyridoxine 5'-phosphate on human pyridoxine 5'-phosphate oxidase.

Journal: Planta medica20090501

Title: Bioactive terpenoids and flavonoids from Ginkgo biloba extract induce the expression of hepatic drug-metabolizing enzymes through pregnane X receptor, constitutive androstane receptor, and aryl hydrocarbon receptor-mediated pathways.

Journal: Pharmaceutical research20090401

Title: Chemical analysis and quality control of Ginkgo biloba leaves, extracts, and phytopharmaceuticals.

Journal: Journal of chromatography. A20090313

Title: Time-dependent induction of hepatic cytochrome P450 enzyme activity and mRNA expression by bilobalide in rats.

Journal: Journal of pharmacological sciences20090301

Title: Effect of biotic elicitors on the accumulation of bilobalide and ginkgolides in Ginkgo biloba cell cultures.

Journal: Journal of biotechnology20090101

Title: Column liquid chromatography/electrospray ionization-time of flight-mass spectrometry and ultraperformance column liquid chromatography/mass spectrometry methods for the determination of ginkgolides and bilobalide in the leaves of Ginkgo biloba and dietary supplements.

Journal: Journal of AOAC International20090101

Title: Bilobalide modulates serotonin-controlled behaviors in the nematode Caenorhabditis elegans.

Journal: BMC neuroscience20090101

Title: Stimulation of neurogenesis and synaptogenesis by bilobalide and quercetin via common final pathway in hippocampal neurons.

Journal: Journal of Alzheimer's disease : JAD20090101

Title: Ginkgo biloba extract neuroprotective action is dependent on heme oxygenase 1 in ischemic reperfusion brain injury.

Journal: Stroke20081201

Title: Influence of elevated carbon dioxide and ozone on the foliar nonvolatile terpenoids in ginkgo biloba.

Journal: Bulletin of environmental contamination and toxicology20081101

Title: Induction of cytochrome P450s by terpene trilactones and flavonoids of the Ginkgo biloba extract EGb 761 in rats.

Journal: Xenobiotica; the fate of foreign compounds in biological systems20080501

Title: Bilobalide inhibits 6-OHDA-induced activation of NF-kappaB and loss of dopaminergic neurons in rat substantia nigra.

Journal: Acta pharmacologica Sinica20080501

Title: Subunit-specific potentiation of recombinant glycine receptors by NV-31, a bilobalide-derived compound.

Journal: Neuroscience letters20080418

Title: Spectroscopic investigation of Ginkgo biloba terpene trilactones and their interaction with amyloid peptide Abeta(25-35).

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy20080401

Title: Role of glycine receptors and glycine release for the neuroprotective activity of bilobalide.

Journal: Brain research20080327

Title: Simultaneous determination of ginkgolides A, B, C and bilobalide in plasma by LC-MS/MS and its application to the pharmacokinetic study of Ginkgo biloba extract in rats.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20080315

Title: Simultaneous determination of ginkgo flavonoids and terpenoids in plasma: ammonium formate in LC mobile phase enhancing electrospray ionization efficiency and capacity.

Journal: Journal of the American Society for Mass Spectrometry20080301

Title: Chemical markers for the quality control of herbal medicines: an overview.

Journal: Chinese medicine20080101

Title: Recent advances in the compound-oriented and pattern-oriented approaches to the quality control of herbal medicines.

Journal: Chinese medicine20080101

Title: Induction of cytochrome P450 3A by the Ginkgo biloba extract and bilobalides in human and rat primary hepatocytes.

Journal: Drug metabolism letters20080101

Title: Restoration of impaired phosphorylation of cyclic AMP response element-binding protein (CREB) by EGb 761 and its constituents in Abeta-expressing neuroblastoma cells.

Journal: The European journal of neuroscience20071101

Title: Characterization of a suite of ginkgo-containing standard reference materials.

Journal: Analytical and bioanalytical chemistry20070901

Title: Effect of Ginkgo biloba extract on oxidative metabolism of valproic acid in hepatic microsomes from donors with the CYP2C9*1/*1 genotype.

Journal: Canadian journal of physiology and pharmacology20070901

Title: Drug treatment improves memory in mice.

Journal: Down's syndrome, research and practice : the journal of the Sarah Duffen Centre20070701

Title: Acute cognitive effects of standardised Ginkgo biloba extract complexed with phosphatidylserine.

Journal: Human psychopharmacology20070601

Title: Bilobalide in Ginkgo biloba extract is a major substance inducing hepatic CYPs.

Journal: The Journal of pharmacy and pharmacology20070601

Title: Treating senile dementia with traditional Chinese medicine.

Journal: Clinical interventions in aging20070601

Title: Role of GABAergic antagonism in the neuroprotective effects of bilobalide.

Journal: Brain research20070112

Title: Bilobalide prevents ischemia-induced edema formation in vitro and in vivo.

Journal: Neuroscience20070105

Title: Single-laboratory validation for the determination of terpene lactones in Ginkgo biloba dietary supplement crude materials and finished products by high-performance liquid chromatography with evaporative light-scattering detection.

Journal: Journal of AOAC International20070101

Title: Analysis of flavonol aglycones and terpenelactones in Ginkgo biloba extract: A comparison of high-performance thin-layer chromatography and column high-performance liquid chromatography.

Journal: Journal of AOAC International20070101

Title: Validation of capillary gas chromatographic method for determination of bilobalide and ginkgolides A, B, C in Ginkgo biloba dry and liquid extracts.

Journal: Acta poloniae pharmaceutica20070101

Title: Cardiovascular pharmacology of sinomenine: the mechanical and electropharmacological actions.

Journal: Drug target insights20070101

Title: A screening platform for compounds with potential immuno-regulatory activities using human cord blood mononuclear cells.

Journal: Combinatorial chemistry & high throughput screening20061201

Title: In vitro peroxynitrite scavenging activity of 6-hydroxykynurenic acid and other flavonoids from Gingko biloba yellow leaves.

Journal: Archives of pharmacal research20061201

Title: Analysis of ginkgolides and bilobalide in food products using LC-APCI-MS.

Journal: Journal of pharmaceutical and biomedical analysis20060828

Title: Application of reverse-flow micellar electrokinetic chromatography for the simultaneous determination of flavonols and terpene trilactones in Ginkgo biloba dosage forms.

Journal: Journal of chromatography. A20060728

Title: Molecular determinants of ginkgolide binding in the glycine receptor pore.

Journal: Journal of neurochemistry20060701

Title: Effect of Ginkgo biloba extract on procarcinogen-bioactivating human CYP1 enzymes: identification of isorhamnetin, kaempferol, and quercetin as potent inhibitors of CYP1B1.

Journal: Toxicology and applied pharmacology20060515

Title: Effect of supplementing terpenoid biosynthetic precursors on the accumulation of bilobalide and ginkgolides in Ginkgo biloba cell cultures.

Journal: Journal of biotechnology20060503

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology20060501

Title: Determination of terpene trilactones in Ginkgo biloba solid oral dosage forms using HPLC with evaporative light scattering detection.

Journal: Journal of pharmaceutical and biomedical analysis20060411

Title: Distinct role of bilobalide and ginkgolide A in the modulation of rat CYP2B1 and CYP3A23 gene expression by Ginkgo biloba extract in cultured hepatocytes.

Journal: Drug metabolism and disposition: the biological fate of chemicals20060201

Title: Identification of class 2 1-deoxy-D-xylulose 5-phosphate synthase and 1-deoxy-D-xylulose 5-phosphate reductoisomerase genes from Ginkgo biloba and their transcription in embryo culture with respect to ginkgolide biosynthesis.

Journal: Planta medica20060201

Title: Mixed antagonistic effects of bilobalide at rho1 GABAC receptor.

Journal: Neuroscience20060101

Title: Quantitative determination of major active components in Ginkgo biloba dietary supplements by liquid chromatography/mass spectrometry.

Journal: Rapid communications in mass spectrometry : RCM20060101

Title: [Quantitative determination of ginkgolides by liquid chromatography-electrospray mass spectrometry].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica20051201

Title: Suppression of pacemaker activity by Ginkgo biloba extract and its main constituent, bilobalide in rat sino-atrial nodal cells.

Journal: Life sciences20051119

Title: A picrotoxin-specific conformational change in the glycine receptor M2-M3 loop.

Journal: The Journal of biological chemistry20051028

Title: Preparative isolation of terpene trilactones from Ginkgo biloba leaves.

Journal: Journal of chromatography. A20051021

Title: Development of a ginkgo biloba fingerprint chromatogram with UV and evaporative light scattering detection and optimization of the evaporative light scattering detector operating conditions.

Journal: Journal of chromatography. A20050902

Title: Terpene trilactones from Gingko biloba: from ancient times to the 21st century.

Journal: Bioorganic & medicinal chemistry20050901

Title: Ginkgolides and bilobalide: their physical, chromatographic and spectroscopic properties.

Journal: Bioorganic & medicinal chemistry20050901

Title: Age-related changes in the vasodilating actions of Ginkgo biloba extract and its main constituent, bilobalide, in rat aorta.

Journal: Clinica chimica acta; international journal of clinical chemistry20050401

Title: Biological activities of Ginkgo extracts.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology20050401

Title: Liquid chromatography/electrospray tandem mass spectrometry of terpenoid lactones in Ginkgo biloba.

Journal: Journal of mass spectrometry : JMS20050301

Title: Effects of ginkgo biloba extract on cation currents in rat ventricular myocytes.

Journal: Life sciences20050121

Title: [Applications of two-dimensional liquid chromatography coupled to mass spectrometry for the separation and identification of compounds in ginkgo biloba extracts].

Journal: Se pu = Chinese journal of chromatography20050101

Title: HPLC determination of certain flavonoids and terpene lactones in selected Ginkgo biloba L. phytopharmaceuticals.

Journal: Farmaco (Societa chimica italiana : 1989)20050101

Title: Isolation of ginkgolides A, B, C, J and bilobalide from G. biloba extracts.

Journal: Phytochemistry20041101

Title: A method for extraction and quantification of Ginkgo terpene trilactones.

Journal: Analytical chemistry20040801

Title: Inhibition of human cytochromes P450 by components of Ginkgo biloba.

Journal: The Journal of pharmacy and pharmacology20040801

Title: Preventive effects of extract of leaves of ginkgo (Ginkgo biloba) and its component bilobalide on azoxymethane-induced colonic aberrant crypt foci in rats.

Journal: Cancer letters20040716

Title: Determination of ginkgolide A, B, and bilobalide in biloba L. extracts by microdialysis-HPLC.

Journal: Analytical and bioanalytical chemistry20040601

Title: [Studies on the cell growth, differentiation and terpene lactone accumulation in Ginkgo biloba cell suspension cultures].

Journal: Sheng wu gong cheng xue bao = Chinese journal of biotechnology20040501

Title: Electropharmacological actions of Ginkgo biloba extract on vascular smooth and heart muscles.

Journal: Clinica chimica acta; international journal of clinical chemistry20040401

Title: Chemistry and biology of terpene trilactones from Ginkgo biloba.

Journal: Angewandte Chemie (International ed. in English)20040319

Title: Effect of bilobalide on peripheral nerve regeneration.

Journal: Biomaterials20040201

Title: Comparative vasodilating actions among terpenoids and flavonoids contained in Ginkgo biloba extract.

Journal: Clinica chimica acta; international journal of clinical chemistry20040101

Title: Effect of Ginkgo biloba extract on rat hepatic microsomal CYP1A activity: role of ginkgolides, bilobalide, and flavonols.

Journal: Canadian journal of physiology and pharmacology20040101

Title: Sample preparation and determination of ginkgo terpene trilactones in selected beverage, snack, and dietary supplement products by liquid chromatography with evaporative light-scattering detection.

Journal: Journal of AOAC International20040101

Title: Ginkgo biloba--an appraisal.

Journal: Kathmandu University medical journal (KUMJ)20040101

Title: Terpene trilactones from Ginkgo biloba are antagonists of cortical glycine and GABA(A) receptors.

Journal: The Journal of biological chemistry20031205

Title: Analysis of ginkgolides and bilobalide in Ginkgo biloba L. extract injections by high-performance liquid chromatography with evaporative light scattering detection.

Journal: Journal of pharmaceutical and biomedical analysis20031124

Title: An anxiolytic-like effect of Ginkgo biloba extract and its constituent, ginkgolide-A, in mice.

Journal: Journal of natural products20031001

Title: Liquid chromatography/atmospheric pressure chemical ionization ion trap mass spectrometry of terpene lactones in plasma of animals.

Journal: Journal of pharmaceutical and biomedical analysis20030808

Title: Pharmacological studies supporting the therapeutic use of Ginkgo biloba extract for Alzheimer's disease.

Journal: Pharmacopsychiatry20030601

Title: Cognitive and other behavioral effects of EGb 761 in animal models.

Journal: Pharmacopsychiatry20030601

Title: Pharmacokinetics of Ginkgo biloba extracts.

Journal: Pharmacopsychiatry20030601

Title: Structure-activity studies with Ginkgo biloba extract constituents as receptor-gated chloride channel blockers and modulators.

Journal: Pharmacopsychiatry20030601

Title: Excitotoxic hippocampal membrane breakdown and its inhibition by bilobalide: role of chloride fluxes.

Journal: Pharmacopsychiatry20030601

Title: Effects of bilobalide on cerebral amino acid neurotransmission.

Journal: Pharmacopsychiatry20030601

Title: Neuroprotective effects of bilobalide, a component of Ginkgo biloba extract (EGb 761) in global brain ischemia and in excitotoxicity-induced neuronal death.

Journal: Pharmacopsychiatry20030601

Title: Mechanisms for the vasodilations induced by Ginkgo biloba extract and its main constituent, bilobalide, in rat aorta.

Journal: Life sciences20030425

Title: Bilobalide, a sesquiterpene trilactone from Ginkgo biloba, is an antagonist at recombinant alpha1beta2gamma2L GABA(A) receptors.

Journal: European journal of pharmacology20030307

Title: Quantitative analysis of bilobalide and ginkgolides from Ginkgo biloba leaves and Ginkgo products using (1)H-NMR.

Journal: Chemical & pharmaceutical bulletin20030201

Title: Development and validation of a gas chromatographic-mass spectrometric method for simultaneous identification and quantification of marker compounds including bilobalide, ginkgolides and flavonoids in Ginkgo biloba L. extract and pharmaceutical preparations.

Journal: Journal of chromatography. A20030131

Title: Homocysteine stimulates inducible nitric oxide synthase expression in macrophages: antagonizing effect of ginkgolides and bilobalide.

Journal: Molecular and cellular biochemistry20030101

Title: EGb 761: ginkgo biloba extract, Ginkor.

Journal: Drugs in R&D20030101

Title: Effects of ginkgo biloba extract and bilobalide, a main constituent, on the ionic currents in guinea pig ventricular cardiomyocytes.

Journal: Arzneimittel-Forschung20030101

Title: Bilobalide and neuroprotection.

Journal: Pharmacological research20021201

Title: Influence of pharmaceutical quality on the bioavailability of active components from Ginkgo biloba preparations.

Journal: The Journal of pharmacy and pharmacology20021101

Title: Efficient extraction of ginkgolides and bilobalide from Ginkgo biloba leaves.

Journal: Journal of natural products20021001

Title: Identification and the retention index of bilobalide and ginkgolides using capillary gas chromatography.

Journal: Journal of chromatographic science20021001

Title: What is Ginkgo biloba extract EGb 761? An overview--from molecular biology to clinical medicine.

Journal: Cellular and molecular biology (Noisy-le-Grand, France)20020901

Title: Bilobalide, a component of the Ginkgo biloba extract (EGb 761), protects against neuronal death in global brain ischemia and in glutamate-induced excitotoxicity.

Journal: Cellular and molecular biology (Noisy-le-Grand, France)20020901

Title: Effects of chronic administration of bilobalide on amino acid levels in mouse brain.

Journal: Cellular and molecular biology (Noisy-le-Grand, France)20020901

Title: EGb 761 is a neuroprotective agent against beta-amyloid toxicity.

Journal: Cellular and molecular biology (Noisy-le-Grand, France)20020901

Title: Anti-apoptotic properties of Ginkgo biloba extract EGb 761 in differentiated PC12 cells.

Journal: Cellular and molecular biology (Noisy-le-Grand, France)20020901

Title: Ginkgolide derivatives for photolabeling studies: preparation and pharmacological evaluation.

Journal: Journal of medicinal chemistry20020829

Title: Simultaneous determination of terpene lactones and flavonoid aglycones in Ginkgo biloba by high-performance liquid chromatography with evaporative light scattering detection.

Journal: Journal of pharmaceutical and biomedical analysis20020822

Title: Chemical analysis of Ginkgo biloba leaves and extracts.

Journal: Journal of chromatography. A20020816

Title: Effects of bilobalide on amino acid release and electrophysiology of cortical slices.

Journal: Amino acids20020601

Title: Pharmaceutical quality of different Ginkgo biloba brands.

Journal: The Journal of pharmacy and pharmacology20020501

Title: Effects of bilobalide on hypoxia/hypoglycemia-stimulated glutamate efflux from rat cortical brain slices.

Journal: Neurochemical research20020501

Title: Liquid chromatography-electrospray mass spectrometric studies of ginkgolides and bilobalide using simultaneous monitoring of proton, ammonium and sodium adducts.

Journal: The Analyst20020501

Title: Mitochondrial respiratory chain as a new target for anti-ischemic molecules.

Journal: European journal of pharmacology20020419

Title: Ginkgo biloba extracts EGb 761 and bilobalide increase NADH dehydrogenase mRNA level and mitochondrial respiratory control ratio in PC12 cells.

Journal: Neurochemical research20020401

Title: Selective responses of three Ginkgo biloba leaf-derived constituents on human intestinal bacteria.

Journal: Journal of agricultural and food chemistry20020327

Title: Effects of extract of Ginkgo biloba leaves and its constituents on carcinogen-metabolizing enzyme activities and glutathione levels in mouse liver.

Journal: Life sciences20020222

Title: Liquid chromatography-atmospheric pressure chemical ionisation/mass spectrometry: a rapid and selective method for the quantitative determination of ginkgolides and bilobalide in ginkgo leaf extracts and phytopharmaceuticals.

Journal: Phytochemical analysis : PCA20020101

Title: [Plant biotechnology: an avant-garde research for an ancestral tree, the Ginkgo biloba].

Journal: Annales pharmaceutiques francaises20020101

Title: [Value of Ginkgo biloba in treatment of Alzheimer dementia].

Journal: Wiener medizinische Wochenschrift (1946)20020101

Title: Neuroprotective effects of bilobalide, a component of the Ginkgo biloba extract (EGb 761), in gerbil global brain ischemia.

Journal: Brain research20011220

Title: [Analysis and structure identification of trace constituent in the total ginkgolide by using LC/DAD/ESI/MS].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica20010801

Title: Selective dissolution and one step separation of terpene trilactones in ginkgo leaf extracts for GC-FID determination.

Journal: Talanta20010530

Title: Inhibition by ginkgolides and bilobalide of the production of nitric oxide in macrophages (THP-1) but not in endothelial cells (HUVEC).

Journal: Biochemical pharmacology20010215

Title: Neuroprotective effects of NV-31, a bilobalide-derived compound: evidence for an antioxidative mechanism.

Journal: Brain research20010202

Title: Induction of heme oxygenase-1 by Ginkgo biloba extract but not its terpenoids partially mediated its protective effect against lysophosphatidylcholine-induced damage.

Journal: Pharmacological research20010101

Title: Liquid chromatography/atmospheric pressure chemical ionization mass spectrometry of terpene lactones in plasma of volunteers dosed with Ginkgo biloba L. extracts.

Journal: Rapid communications in mass spectrometry : RCM20010101

Title: Induction of glutathione synthesis in human keratinocytes by Ginkgo biloba extract (EGb761).

Journal: BioFactors (Oxford, England)20010101

Title: Protective effect of bilobalide against nitric oxide-induced neurotoxicity in PC12 cells.

Journal: Acta pharmacologica Sinica20000501

Title: New drug developments for opportunistic infections in immunosuppressed patients: Pneumocystis carinii.

Journal: Journal of medicinal chemistry19951124

Title: Activity of bilobalide, a sesquiterpene from Ginkgo biloba, on Pneumocystis carinii.

Journal: Antimicrobial agents and chemotherapy19930701

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