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342-10-9,MFCD00076275
Catalog No.:AA00BYQ6

342-10-9 | KALLIDIN

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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA00BYQ6
Chemical Name:
KALLIDIN
CAS Number:
342-10-9
Molecular Formula:
C56H85N17O12
Molecular Weight:
1188.3808
MDL Number:
MFCD00076275
SMILES:
NCCCCC(C(=O)NC(C(=O)N1CCCC1C(=O)N1CCCC1C(=O)NCC(=O)NC(C(=O)NC(C(=O)N1CCCC1C(=O)NC(C(=O)NC(C(=O)O)CCCN=C(N)N)Cc1ccccc1)CO)Cc1ccccc1)CCCN=C(N)N)N
Properties
Computed Properties
 
Complexity:
2330  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
9  
Heavy Atom Count:
85  
Hydrogen Bond Acceptor Count:
16  
Hydrogen Bond Donor Count:
14  
Rotatable Bond Count:
33  
XLogP3:
-5.3  

Literature

Title: Differential regulation of collagen secretion by kinin receptors in cardiac fibroblast and myofibroblast.

Journal: Toxicology and applied pharmacology 20120615

Title: Induction of selective blood-tumor barrier permeability and macromolecular transport by a biostable kinin B1 receptor agonist in a glioma rat model.

Journal: PloS one 20120101

Title: Cross-talk between carboxypeptidase M and the kinin B1 receptor mediates a new mode of G protein-coupled receptor signaling.

Journal: The Journal of biological chemistry 20110527

Title: Bradykinin acutely inhibits activity of the epithelial Na+ channel in mammalian aldosterone-sensitive distal nephron.

Journal: American journal of physiology. Renal physiology 20110501

Title: Involvement of the kallikrein-kinin system in a model of hyperalgesia in low kallikrein rats.

Journal: Veterinary research communications 20090901

Title: Bradykinin-related peptides up-regulate the expression of kinin B1 and B2 receptor genes in human promonocytic cell line U937.

Journal: Acta biochimica Polonica 20090101

Title: Molecular bases for the recognition of short peptide substrates and cysteine-directed modifications of human insulin-degrading enzyme.

Journal: Biochemistry 20081202

Title: Vascular B1 kinin receptors in patients with congestive heart failure.

Journal: Journal of cardiovascular pharmacology 20081101

Title: Enhancement of human sperm motility.

Journal: The Journal of urology 20080801

Title: The relevance of kinin B1 receptor upregulation in a mouse model of colitis.

Journal: British journal of pharmacology 20080701

Title: Carboxypeptidase M and kinin B1 receptors interact to facilitate efficient b1 signaling from B2 agonists.

Journal: The Journal of biological chemistry 20080321

Title: Inflammatory pain in the rabbit: a new, efficient method for measuring mechanical hyperalgesia in the hind paw.

Journal: Journal of neuroscience methods 20080215

Title: Essential role of TM V and VI for binding the C-terminal sequences of Des-Arg-kinins.

Journal: International immunopharmacology 20080201

Title: Asparatic acid 221 is critical in the calcium-induced modulation of the enzymatic activity of human aminopeptidase A.

Journal: The Journal of biological chemistry 20071221

Title: Pharmacological, pharmacokinetic, and primate analgesic efficacy profile of the novel bradykinin B1 Receptor antagonist ELN441958.

Journal: The Journal of pharmacology and experimental therapeutics 20070801

Title: Pharmacological and biochemical characterization of bradykinin B2 receptors in the mouse colon: influence of the TNBS-induced colitis.

Journal: Regulatory peptides 20070607

Title: Functional evidence of des-Arg10-kallidin enzymatic inactivating pathway in isolated human umbilical vein.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20070501

Title: Antihyperalgesic effects of vanilloid-1 and bradykinin-1 receptor antagonists following spinal cord injury in rats.

Journal: Journal of neurosurgery. Spine 20070501

Title: Characterization of kinin receptors in human cultured detrusor smooth muscle cells.

Journal: British journal of pharmacology 20070101

Title: The bradykinin B2 receptor antagonist icatibant (Hoe 140) blocks aminopeptidase N at micromolar concentrations: off-target alterations of signaling mediated by the bradykinin B1 and angiotensin receptors.

Journal: European journal of pharmacology 20061203

Title: Kinins and neuroinflammation: dual effect on prostaglandin synthesis.

Journal: European journal of pharmacology 20060928

Title: Enzymatic properties of human aminopeptidase A. Regulation of its enzymatic activity by calcium and angiotensin IV.

Journal: The Journal of biological chemistry 20060818

Title: Kallidin-like peptide mediates the cardioprotective effect of the ACE inhibitor captopril against ischaemic reperfusion injury of rat heart.

Journal: British journal of pharmacology 20060701

Title: Role of bradykinin B2 receptors in the modulation of the peristaltic reflex of the guinea pig isolated ileum.

Journal: European journal of pharmacology 20060606

Title: Angiotensin I-converting enzyme inhibitors block protein kinase C epsilon by activating bradykinin B1 receptors in human endothelial cells.

Journal: The Journal of pharmacology and experimental therapeutics 20060301

Title: Protein kinase C (PKC)-delta/-epsilon mediate the PKC/Akt-dependent phosphorylation of extracellular signal-regulated kinases 1 and 2 in MCF-7 cells stimulated by bradykinin.

Journal: The Journal of endocrinology 20060101

Title: A prostacyclin receptor antagonist inhibits the sensitized release of substance P from rat sensory neurons.

Journal: The Journal of pharmacology and experimental therapeutics 20051201

Title: Rat tissue kallikrein releases a kallidin-like peptide from rat low-molecular-weight kininogen.

Journal: British journal of pharmacology 20051201

Title: A kallidin-like peptide is a protective cardiac kinin, released by ischaemic preconditioning of rat heart.

Journal: British journal of pharmacology 20051201

Title: Ca2+-dependent K+ channels are targets for bradykinin B1 receptor ligands and for lipopolysaccharide in the rat aorta.

Journal: European journal of pharmacology 20051121

Title: Functional role of prostacyclin receptor in rat dorsal root ganglion neurons.

Journal: Neuroscience letters 20051118

Title: Na+/Ca2+ exchanger activity modulates connective tissue growth factor mRNA expression in transforming growth factor beta1- and Des-Arg10-kallidin-stimulated myofibroblasts.

Journal: The Journal of biological chemistry 20050415

Title: B1 kinin receptor does not contribute to vascular tone or tissue plasminogen activator release in the peripheral circulation of patients with heart failure.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20050401

Title: Bradykinin upregulates IL-8 production in human gingival fibroblasts stimulated by interleukin-1beta and tumor necrosis factor alpha.

Journal: Regulatory peptides 20050330

Title: Kinin peptides in human trapezius muscle during sustained isometric contraction and their relation to pain.

Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20050201

Title: Losartan increases bradykinin levels in hypertensive humans.

Journal: Circulation 20050125

Title: Structural characterization of cyclic kallidin analogues in DMSO by nuclear magnetic resonance and molecular dynamics.

Journal: Journal of peptide science : an official publication of the European Peptide Society 20050101

Title: The plasma and tissue kininogen-kallikrein-kinin system: role in the cardiovascular system.

Journal: Current medicinal chemistry. Cardiovascular and hematological agents 20050101

Title: Kinin B2 receptor-coupled signal transduction in human cultured keratinocytes.

Journal: The Journal of investigative dermatology 20050101

Title: Induction of B1 bradykinin receptors in the kindled hippocampus increases extracellular glutamate levels: a microdialysis study.

Journal: Neuroscience 20050101

Title: Structural and functional analyses of phosphoglucose isomerase from Vibrio vulnificus and its lysyl aminopeptidase activity.

Journal: Biochimica et biophysica acta 20041001

Title: Pharmacological characterization and radioligand binding properties of a high-affinity, nonpeptide, bradykinin B1 receptor antagonist.

Journal: European journal of pharmacology 20040919

Title: Lys-[Leu8,des-Arg9]-bradykinin blocks lipopolysaccharide-induced SHR aorta hyperpolarization by inhibition of Ca(++)- and ATP-dependent K+ channels.

Journal: European journal of pharmacology 20040913

Title: A novel encoded particle technology that enables simultaneous interrogation of multiple cell types.

Journal: Journal of biomolecular screening 20040401

Title: Kinins are involved in the development of allergic nasal hyperresponsiveness in guinea pigs.

Journal: European journal of pharmacology 20030829

Title: Do angiotensin-converting enzyme inhibitors directly stimulate the kinin B1 receptor?

Journal: American journal of physiology. Heart and circulatory physiology 20030701

Title: Kininase I-type carboxypeptidases enhance nitric oxide production in endothelial cells by generating bradykinin B1 receptor agonists.

Journal: American journal of physiology. Heart and circulatory physiology 20030601

Title: High agonist-independent clearance of rabbit kinin B1 receptors in cultured cells.

Journal: American journal of physiology. Heart and circulatory physiology 20030501

Title: Kinin-induced anion-dependent secretion in porcine ileum: characterization and involvement of opioid- and cannabinoid-sensitive enteric neural circuits.

Journal: The Journal of pharmacology and experimental therapeutics 20030501

Title: Study of the mechanisms involved in the bradykinin-induced contraction of the pig iris sphincter muscle in vitro.

Journal: European journal of pharmacology 20030101

Title: Prediction of band profiles of mixtures of bradykinin and kallidin from data acquired by competitive frontal analysis.

Journal: Biotechnology progress 20030101

Title: Contraction-related factors affect the concentration of a kallidin-like peptide in rat muscle tissue.

Journal: The Journal of physiology 20021001

Title: COX-dependent and -independent pathways in bradykinin-induced anion secretion in rat epididymis.

Journal: Journal of cellular physiology 20020501

Title: Effect of cationic peptides on rat ileum muscle contraction and histamine release from rat peritoneal mast cells.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20020401

Title: Agonist-induced translocation of the kinin B(1) receptor to caveolae-related rafts.

Journal: Molecular pharmacology 20020301

Title: Characterization of bradykinin receptors in canine cultured corneal epithelial cells: pharmacological and functional studies.

Journal: Journal of biomedical science 20020101

Title: No evidence for bradykinin B1 receptors in rat dorsal root ganglion neurons.

Journal: Neuroreport 20011008

Title: Bradykinin B1 receptor up-regulation by interleukin-1beta and B1 agonist occurs through independent and synergistic intracellular signaling mechanisms in human lung fibroblasts.

Journal: The Journal of pharmacology and experimental therapeutics 20010701

Title: Plasma extravasation mediated by lipopolysaccharide-induction of kinin B1 receptors in rat tissues.

Journal: Mediators of inflammation 20010601

Title: Electrophoresis separation in open microchannels. A method for coupling electrophoresis with MALDI-MS.

Journal: Analytical chemistry 20010501

Title: Functional studies of bradykinin receptors in Chinese hamster ovary cells stably expressing the human B2 bradykinin receptor.

Journal: International immunopharmacology 20010501

Title: Detection of bradykinin B1 receptors in rat aortic smooth muscle cells.

Journal: Biochemical pharmacology 20010201

Title: Portal hypertensive response to bradykinin in inflamed or cirrhotic rat livers is mediated by B2-type receptors.

Journal: Journal of gastroenterology and hepatology 20010101

Title: Molecular characterisation of cloned bradykinin B1 receptors from rat and human.

Journal: European journal of pharmacology 19990625

Title: Effect of dexamethasone on cyclophosphamide-induced cystitis in rats: lack of relation with bradykinin B1 receptor-mediated motor responses.

Journal: European journal of pharmacology 19990312

Title: Stable expression of human kinin B1 receptor in 293 cells: pharmacological and functional characterization.

Journal: British journal of pharmacology 19970901

Title: Stable expression of the human kinin B1 receptor in Chinese hamster ovary cells. Characterization of ligand binding and effector pathways.

Journal: The Journal of biological chemistry 19970425

Title: Identification of metabolic pathways of brain angiotensin II and III using specific aminopeptidase inhibitors: predominant role of angiotensin III in the control of vasopressin release.

Journal: Proceedings of the National Academy of Sciences of the United States of America 19961015

Title: The agonist selectivity of a mouse B1 bradykinin receptor differs from human and rabbit B1 receptors.

Journal: Immunopharmacology 19960601

Title: The in vivo metabolism of cholecystokinin (CCK-8) is essentially ensured by aminopeptidase A.

Journal: Peptides 19960101

Title: Expression cloning of a human B1 bradykinin receptor.

Journal: The Journal of biological chemistry 19940826

Title: Synthesis and biological activity of some linear and cyclic kinin analogues.

Journal: International journal of peptide and protein research 19940701

Title: Differential pharmacology of cloned human and mouse B2 bradykinin receptors.

Journal: Molecular pharmacology 19940101

Title: Purification of a vasoactive peptide related to lysyl-bradykinin from trout plasma.

Journal: FEBS letters 19931108

Title: Mechanism of digestion of bradykinin and lysylbradykinin (kallidin) in human serum. Role of carboxypeptidase, angiotensin-converting enzyme and determination of final degradation products.

Journal: Biochemical pharmacology 19890315

Title: Isolation of [hydroxyproline3]Lysyl-bradykinin formed by kallikrein from human plasma protein.

Journal: Advances in experimental medicine and biology 19890101

Title: Identification of [hydroxyproline3]-lysyl-bradykinin released from human plasma protein by kallikrein.

Journal: Biochemical and biophysical research communications 19880115

Title: Studies of the digestion of bradykinin, Lys-bradykinin, and des-Arg9-bradykinin by angiotensin converting enzyme.

Journal: Biochemical pharmacology 19860615

Title: Studies of the digestion of bradykinin, lysyl bradykinin, and kinin-degradation products by carboxypeptidases A, B, and N.

Journal: Biochemical pharmacology 19860615

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Tags:342-10-9 Molecular Formula|342-10-9 MDL|342-10-9 SMILES|342-10-9 KALLIDIN