Home Other Building Blocks 42079-78-7
42079-78-7,MFCD00016942
Catalog No.:AA003MRI

42079-78-7 | 5-Methoxyflavone

Pack Size
Purity
Availability
Price(USD)
Quantity
  
250mg
>98%(GC)
in stock  
$64.00   $45.00
- +
1g
>98.0%(GC)
in stock  
$104.00   $73.00
- +
5g
>98.0%(GC)
in stock  
$310.00   $217.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003MRI
Chemical Name:
5-Methoxyflavone
CAS Number:
42079-78-7
Molecular Formula:
C16H12O3
Molecular Weight:
252.2647
MDL Number:
MFCD00016942
SMILES:
COc1cccc2c1c(=O)cc(o2)c1ccccc1
Properties
Properties
 
BP:
422.5°C at 760 mmHg  

Computed Properties
 
Complexity:
368  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
19  
Hydrogen Bond Acceptor Count:
3  
Rotatable Bond Count:
2  
XLogP3:
3.5  

Literature

Title: Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.

Journal: Bioorganic & medicinal chemistry 20121115

Title: Relationship between the structures of flavonoids and their NF-κB-dependent transcriptional activities.

Journal: Bioorganic & medicinal chemistry letters 20111015

Title: Methoxyflavone derivatives modulate the effect of TRAIL-induced apoptosis in human leukemic cell lines.

Journal: Journal of hematology & oncology 20110101

Title: [Chemical constituents of rhizoma imperatae and their anti-complementary activity].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20101201

Title: Antagonism of aryl hydrocarbon receptor signaling by 6,2',4'-trimethoxyflavone.

Journal: The Journal of pharmacology and experimental therapeutics 20100101

Title: Methylation of dietary flavones increases their metabolic stability and chemopreventive effects.

Journal: International journal of molecular sciences 20091101

Title: Effect of flavonoids on androgen and glucocorticoid receptors based on in vitro reporter gene assay.

Journal: Bioorganic & medicinal chemistry letters 20090815

Title: Microbial metabolism. Part 10: Metabolites of 7,8-dimethoxyflavone and 5-methoxyflavone.

Journal: Natural product research 20090101

Title: Bioavailable flavonoids: cytochrome P450-mediated metabolism of methoxyflavones.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20071101

Title: Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods.

Journal: Journal of molecular graphics & modelling 20061101

Title: Phytoestrogens as inhibitors of fungal 17beta-hydroxysteroid dehydrogenase.

Journal: Steroids 20050901

Title: Phytoestrogens as inhibitors of fungal 17beta-hydroxysteroid dehydrogenase.

Journal: Steroids 20050801

Title: Vasorelaxing effects of flavonoids: investigation on the possible involvement of potassium channels.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20041001

Title: Synthesis and inhibitory activity against COX-2 catalyzed prostaglandin production of chrysin derivatives.

Journal: Bioorganic & medicinal chemistry letters 20040308

Title: Steroid hormone activity of flavonoids and related compounds.

Journal: Breast cancer research and treatment 20000701

Title: Merlo S, et al. Identification of 5-Methoxyflavone as a Novel DNA Polymerase-Beta Inhibitor and Neuroprotective Agent against Beta-Amyloid Toxicity. J Nat Prod. 2015 Nov 25;78(11):2704-11.

Title: Shanmugasundaram J, et al. Sedative-hypnotic like effect of 5-methoxyflavone in mice and investigation on possible mechanisms by in vivo and in silico methods. Biomed Pharmacother. 2018 Dec;108:85-94.

Title: Wudtiwai B, et al. Methoxyflavone derivatives modulate the effect of TRAIL-induced apoptosis in human leukemic cell lines. J Hematol Oncol. 2011 Dec 21;4:52.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:42079-78-7 Molecular Formula|42079-78-7 MDL|42079-78-7 SMILES|42079-78-7 5-Methoxyflavone