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42924-53-8,MFCD00079518
Catalog No.:AA0070QQ

42924-53-8 | Nabumetone

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Purity
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1mg
98%
in stock  
$6.00   $4.00
- +
10mg
98%
in stock  
$7.00   $5.00
- +
1g
≥98%
in stock  
$46.00   $32.00
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5g
≥98%
in stock  
$149.00   $104.00
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10g
≥98%
in stock  
$202.00   $141.00
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25g
≥98%
in stock  
$360.00   $252.00
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  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA0070QQ
Chemical Name:
Nabumetone
CAS Number:
42924-53-8
Molecular Formula:
C15H16O2
Molecular Weight:
228.2863
MDL Number:
MFCD00079518
SMILES:
COc1ccc2c(c1)ccc(c2)CCC(=O)C
NSC Number:
758623
Properties
Computed Properties
 
Complexity:
262  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
17  
Hydrogen Bond Acceptor Count:
2  
Rotatable Bond Count:
4  
XLogP3:
3.1  

Upstream Synthesis Route

[1]ACSChemicalBiology,2017,vol.12,#9,p.2379-2387

Downstream Synthesis Route

[1]AdvancedSynthesisandCatalysis,2007,vol.349,p.2572-2584

[2]Synthesis,1989,p.869-870

[1]JournalofMedicinalChemistry,1978,vol.21,p.1260-1264

[1]JournalofMedicinalChemistry,1978,vol.21,p.1260-1264

[1]PharmaceuticalResearch,2007,vol.24,p.679-687

[2]JournalofMedicinalChemistry,1978,vol.21,p.1260-1264

[3]ChemicalandPharmaceuticalBulletin,2019,vol.67,p.75-78

[4]Chemistry-AEuropeanJournal,2019,vol.25,p.9001-9005

[1]JournalofMedicinalChemistry,1978,vol.21,p.1260-1264

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Journal: Mediators of inflammation 20060101

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Title: Low direct cytotoxicity of nabumetone on gastric mucosal cells.

Journal: Digestive diseases and sciences 20050901

Title: Photosensitizing properties of 6-methoxy-2-naphthylacetic acid, the major metabolite of the phototoxic non-steroidal anti-inflammatory and analgesic drug nabumetone.

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Title: Prediction of genotoxicity of chemical compounds by statistical learning methods.

Journal: Chemical research in toxicology 20050601

Title: Cyclo-oxygenase 2 inhibitor, nabumetone, inhibits proliferation in chronic myeloid leukemia cell lines.

Journal: Leukemia & lymphoma 20050501

Title: Simplex optimization of the variables affecting the micelle-stabilized room temperature phosphorescence of 6-methoxy-2-naphthylacetic acid and its kinetic determination in human urine.

Journal: Analytical biochemistry 20050401

Title: Patient characteristics associated with outpatient prescriptions for nabumetone and oxaprozin versus celecoxib and rofecoxib.

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Title: Rofecoxib for osteoarthritis.

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Title: The nonsteroidal anti-inflammatory drug, nabumetone, differentially inhibits beta-catenin signaling in the MIN mouse and azoxymethane-treated rat models of colon carcinogenesis.

Journal: Cancer letters 20050120

Title: Pulp-dentine complex changes and root resorption during intrusive orthodontic tooth movement in patients prescribed nabumetone.

Journal: Journal of endodontics 20050101

Title: Subjective impact of osteoarthritis flare-ups on patients' quality of life.

Journal: Health and quality of life outcomes 20050101

Title: Long-term use of non-steroidal anti-inflammatory drugs and the risk of myocardial infarction in the general population.

Journal: BMC medicine 20050101

Title: Application of pentafluorophenyl hydrazine derivatives to the analysis of nabumetone and testosterone in human plasma by liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry.

Journal: Analytical and bioanalytical chemistry 20041201

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Journal: Lakartidningen 20041125

Title: Systematic review: is ingestion of paracetamol or non-steroidal anti-inflammatory drugs associated with exacerbations of inflammatory bowel disease?

Journal: Alimentary pharmacology & therapeutics 20041115

Title: Calculation of cyclodextrin binding affinities: energy, entropy, and implications for drug design.

Journal: Biophysical journal 20041101

Title: Pain management in osteoarthritis: a focus on onset of efficacy--a comparison of rofecoxib, celecoxib, acetaminophen, and nabumetone across four clinical trials.

Journal: The journal of pain : official journal of the American Pain Society 20041101

Title: Effect of the addition of water-soluble polymers on the interfacial properties of aerosol OT vesicles.

Journal: Journal of colloid and interface science 20041015

Title: The upper gastrointestinal safety of rofecoxib vs. NSAIDs: an updated combined analysis.

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Title: Risk of breast cancer among users of aspirin and other anti-inflammatory drugs.

Journal: British journal of cancer 20040802

Title: Regulation of metalloproteinases and NF-kappaB activation in rabbit synovial fibroblasts via E prostaglandins and Erk: contrasting effects of nabumetone and 6MNA.

Journal: British journal of pharmacology 20040701

Title: Incremental cost-effectiveness of cyclooxygenase 2-selective versus nonselective nonsteroidal anti-inflammatory drugs in a cohort of coumarin users: a pharmacoeconomic analysis linked to a case-control study.

Journal: Clinical therapeutics 20040701

Title: Adverse effect of drug-induced emotional problems on work and daily activities. A principal component as an independent predictor of ADRs in Shanghai patients with osteo-arthropathy taking nabumetone.

Journal: International journal of clinical pharmacology and therapeutics 20040601

Title: Efficacy and safety of rofecoxib 12.5 mg versus nabumetone 1,000 mg in patients with osteoarthritis of the knee: a randomized controlled trial.

Journal: Journal of the American Geriatrics Society 20040501

Title: A population based historical cohort study of the mortality associated with nabumetone, Arthrotec, diclofenac, and naproxen.

Journal: The Journal of rheumatology 20040501

Title: Identification and determination of phase II nabumetone metabolites by high-performance liquid chromatography with photodiode array and mass spectrometric detection.

Journal: Journal of chromatography. A 20040326

Title: Risk factors of adverse drug reaction from non-steroidal anti-inflammatory drugs in Shanghai patients with arthropathy.

Journal: Acta pharmacologica Sinica 20040301

Title: General principles of pharmaceutical solid polymorphism: a supramolecular perspective.

Journal: Advanced drug delivery reviews 20040223

Title: In vitro investigation of the effects of nonsteroidal anti-inflammatory drugs, prostaglandin E2, and prostaglandin F2alpha on contractile activity of the third compartment of the stomach of llamas.

Journal: American journal of veterinary research 20040201

Title: Spontaneous reports of hypertension leading to hospitalisation in association with rofecoxib, celecoxib, nabumetone and oxaprozin.

Journal: Drugs & aging 20040101

Title: Effects of dietary anticarcinogens and nonsteroidal anti-inflammatory drugs on rat gastrointestinal UDP-glucuronosyltransferases.

Journal: Anticancer research 20040101

Title: Nabumetone: therapeutic use and safety profile in the management of osteoarthritis and rheumatoid arthritis.

Journal: Drugs 20040101

Title: Safety and efficacy of oral nonsteroidal anti-inflammatory drugs in patients with rheumatoid arthritis : a six-month randomised study.

Journal: Clinical drug investigation 20040101

Title: [Meta-analysis on the effect and adverse reaction on patients with osteoarthritis and rheumatoid arthritis treated with non-steroidal anti-inflammatory drugs].

Journal: Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi 20031101

Title: Selective COX-2 inhibition and cardiovascular effects: a review of the rofecoxib development program.

Journal: American heart journal 20031001

Title: Comparative biotransformation and disposition studies of nabumetone in humans and minipigs using high-performance liquid chromatography with ultraviolet, fluorescence and mass spectrometric detection.

Journal: Journal of pharmaceutical and biomedical analysis 20030808

Title: Selection of drugs to test the specificity of the Tg.AC assay by screening for induction of the gadd153 promoter in vitro.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20030801

Title: Development of apoptosis-resistant dihydrofolate reductase-deficient Chinese hamster ovary cell line.

Journal: Biotechnology and bioengineering 20030630

Title: Risk of cancer in a large cohort of nonaspirin NSAID users: a population-based study.

Journal: British journal of cancer 20030602

Title: Analysis of nabumetone in human plasma by HPLC. Application to single dose pharmacokinetic studies.

Journal: Journal of pharmaceutical and biomedical analysis 20030601

Title: [Nabumetone is an alternative].

Journal: Lakartidningen 20030424

Title: An open label study to establish dosing recommendations for nabumetone in juvenile rheumatoid arthritis.

Journal: The Journal of rheumatology 20030401

Title: Drug-induced erythroderma with high fever--is it drug hypersensitivity syndrome?

Journal: The Journal of dermatology 20030401

Title: Effects of nabumetone, celecoxib, and ibuprofen on blood pressure control in hypertensive patients on angiotensin converting enzyme inhibitors.

Journal: American journal of hypertension 20030201

Title: Non-steroidal anti-inflammatory drug, nabumetone, prevents indometacin-induced gastric damage via inhibition of neutrophil functions.

Journal: The Journal of pharmacy and pharmacology 20030201

Title: Determination of nabumetone in pharmaceutical formulation by flow injection analysis (FIA) with UV-detection.

Journal: Die Pharmazie 20030101

Title: COX-2: where are we in 2003?--distinction from NSAIDs becoming blurred.

Journal: Arthritis research & therapy 20030101

Title: Safe full-dose one-step nabumetone challenge in patients with nonsteroidal anti-inflammatory drug hypersensitivity.

Journal: Allergy and asthma proceedings 20030101

Title: In vitro investigation of the effects of cyclooxygenase-2 inhibitors on contractile activity of the equine dorsal and ventral colon.

Journal: American journal of veterinary research 20021101

Title: Structure-function relationship and role of tumor necrosis factor-alpha-converting enzyme in the down-regulation of L-selectin by non-steroidal anti-inflammatory drugs.

Journal: The Journal of biological chemistry 20021011

Title: Dose-effect relationships of nonsteroidal anti-inflammatory drugs: a literature review.

Journal: Clinical therapeutics 20020801

Title: Medication toxicity among patients with ankylosing spondylitis.

Journal: Arthritis and rheumatism 20020615

Title: The different patterns of blood pressure elevation by rofecoxib and nabumetone.

Journal: Journal of human hypertension 20020601

Title: A comparison of the effects of nabumetone vs meloxicam on serum thromboxane B2 and platelet function in healthy volunteers.

Journal: British journal of clinical pharmacology 20020601

Title: Trends in medication use for osteoarthritis treatment.

Journal: The Journal of rheumatology 20020501

Title: Drug-induced erythroderma with high fever.

Journal: The Journal of dermatology 20020201

Title: Comparison of cardiovascular thrombotic events in patients with osteoarthritis treated with rofecoxib versus nonselective nonsteroidal anti-inflammatory drugs (ibuprofen, diclofenac, and nabumetone).

Journal: The American journal of cardiology 20020115

Title: 2, 4-diamino-6- hydroxy pyrimidine inhibits NSAIDs induced nitrosyl-complex EPR signals and ulcer in rat jejunum.

Journal: BMC gastroenterology 20020101

Title: A comparison of adverse renovascular experiences among osteoarthritis patients treated with rofecoxib and comparator non-selective non-steroidal anti-inflammatory agents.

Journal: Current medical research and opinion 20020101

Title: Nonsteroidal antiinflammatory drug-induced pseudoporphyria: a case series.

Journal: Journal of cutaneous medicine and surgery 20020101

Title: Effects of NSAIDs on cryoprobe-induced gastric ulcer healing in rats.

Journal: Alimentary pharmacology & therapeutics 20011201

Title: Comparison of the efficacy and safety of naproxen CR and nabumetone in the treatment of patients with osteoarthritis of the knee.

Journal: International journal of clinical pharmacology and therapeutics 20011201

Title: Cyclooxygenase-1 and cyclooxygenase-2 selectivity of non-steroidal anti-inflammatory drugs: investigation using human peripheral monocytes.

Journal: The Journal of pharmacy and pharmacology 20011201

Title: Use of nonsteroidal anti-inflammatory drugs and gastroprotective agents before the advent of cyclooxygenase-2-selective inhibitors: analysis of a large United States claims database.

Journal: Clinical therapeutics 20011201

Title: Gastrointestinal medications and procedures in osteoarthritis patients treated with rofecoxib compared with nonselective NSAIDs.

Journal: MedGenMed : Medscape general medicine 20011116

Title: [Side effects cause enormous costs. Expensive arthritis therapy].

Journal: MMW Fortschritte der Medizin 20011115

Title: Cardiovascular thrombotic events in controlled, clinical trials of rofecoxib.

Journal: Circulation 20011106

Title: Nonsteroidal anti-inflammatory drugs for perioperative pain control.

Journal: Medicine and health, Rhode Island 20011001

Title: Current medication choices in juvenile rheumatoid arthritis II--update of a survey performed in 1993.

Journal: Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases 20011001

Title: Cyclooxygenase selectivity of non-steroid anti-inflammatory drugs in humans: ex vivo evaluation.

Journal: European journal of pharmacology 20010824

Title: Inhibitors of cyclooxygenase-2 (COX-2) suppressed the proliferation and differentiation of human leukaemia cell lines.

Journal: European journal of cancer (Oxford, England : 1990) 20010801

Title: Association of immunological disorders in lethal side effect of NSAIDs on beta-glucan-administered mice.

Journal: FEMS immunology and medical microbiology 20010701

Title: Prolonged activation of mitogen-activated protein kinases during NSAID-induced apoptosis in HT-29 colon cancer cells.

Journal: International journal of colorectal disease 20010601

Title: Distal bowel selectivity in the chemoprevention of experimental colon carcinogenesis by the non-steroidal anti-inflammatory drug nabumetone.

Journal: International journal of cancer 20010515

Title: [Comparison of the efficacy and safety of nabumetone and diclofenac sodium in the treatment of patients with rheumatoid arthritis].

Journal: Zhonghua yi xue za zhi 20010510

Title: Chemoprevention of intestinal tumorigenesis by nabumetone: induction of apoptosis and Bcl-2 downregulation.

Journal: British journal of cancer 20010501

Title: Treatment of elderly patients with nabumetone or diclofenac: gastrointestinal safety profile.

Journal: Journal of clinical gastroenterology 20010401

Title: Effect of nabumetone and aspirin on colonic mucosal bleeding time.

Journal: Alimentary pharmacology & therapeutics 20010401

Title: A multicenter, randomized, controlled trial to evaluate the safety profile, tolerability, and efficacy of rofecoxib in advanced elderly patients with osteoarthritis.

Journal: Aging (Milan, Italy) 20010401

Title: [Laparoscopic splenectomy in pediatric hematologic diseases].

Journal: Cirugia pediatrica : organo oficial de la Sociedad Espanola de Cirugia Pediatrica 20010401

Title: Management of nonsteroidal anti-inflammatory drug-related peptic ulcer bleeding.

Journal: The American journal of medicine 20010108

Title: Randomized trial of low-dose misoprostol and naproxen vs. nabumetone to prevent recurrent upper gastrointestinal haemorrhage in users of non-steroidal anti-inflammatory drugs.

Journal: Alimentary pharmacology & therapeutics 20010101

Title: The use of particle beam mass spectrometry for the measurement of impurities in a nabumetone drug substance, not easily amenable to atmospheric pressure ionisation techniques.

Journal: Rapid communications in mass spectrometry : RCM 20010101

Title: Risk of upper gastrointestinal bleeding and perforation associated with low-dose aspirin as plain and enteric-coated formulations.

Journal: BMC clinical pharmacology 20010101

Title: Inclusion complexes of nabumetone with beta-cyclodextrins: thermodynamics and molecular modelling studies. Influence of sodium perchlorate.

Journal: Luminescence : the journal of biological and chemical luminescence 20010101

Title: Rofecoxib: a review of its use in the management of osteoarthritis, acute pain and rheumatoid arthritis.

Journal: Drugs 20010101

Title: The ever-emerging anti-inflammatories. Have there been any real advances?

Journal: Journal of physiology, Paris 20010101

Title: [Evaluation of early biomarkers of cartilage degeneration in the diagnosis and clinico-therapeutic monitoring of primary osteoarthrosis].

Journal: La Clinica terapeutica 20010101

Title: Renal effects of nabumetone, a COX-2 antagonist: impairment of function in isolated perfused rat kidneys contrasts with preserved renal function in vivo.

Journal: Experimental nephrology 20010101

Title: The effects of nabumetone, a cyclooxygenase-2 inhibitor, on cisplatin-induced 5-hydroxytryptamine release from the isolated rat ileum.

Journal: Research communications in molecular pathology and pharmacology 20010101

Title: Non-steroidal anti-inflammatory drugs inhibit the expression of cytokines and induce HSP70 in human monocytes.

Journal: Cytokine 19990501

Title: Nonsteroidal anti-inflammatory drugs enhance glutathione S-transferase theta levels in rat colon.

Journal: Biochimica et biophysica acta 19980824

Title: Non-steroidol anti-inflammatory drug effect on crypt cell proliferation and apoptosis during initiation of rat colon carcinogenesis.

Journal: British journal of cancer 19980201

Title: Differential effects of nonsteroidal anti-inflammatory drugs on constitutive and inducible prostaglandin G/H synthase in cultured bone cells.

Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 19970801

Title: Reversible membranous nephropathy associated with the use of nonsteroidal anti-inflammatory drugs.

Journal: JAMA 19960814

Title: Nabumetone-associated interstitial nephritis.

Journal: Pharmacotherapy 19950101

Title: Nabumetone, a new non-steroidal anti-inflammatory drug: a comparison with naproxen.

Journal: The New Zealand medical journal 19831214

Title: Vural F, et al. Cyclo-oxygenase 2 inhibitor, nabumetone, inhibits proliferation in chronic myeloid leukemia cell lines. Leuk Lymphoma. 2005 May;46(5):753-6.

Title: Melarange R, et al. Anti-inflammatory and gastrointestinal effects of nabumetone or its active metabolite, 6MNA (6-methoxy-2-naphthylacetic acid): comparison with indomethacin. Agents Actions. 1992;Spec No:C82-3.

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Tags:42924-53-8 Molecular Formula|42924-53-8 MDL|42924-53-8 SMILES|42924-53-8 Nabumetone