Title: Heat shock protein 90 inhibitors induce functional inhibition of human natural killer cells in a dose-dependent manner.
Journal: Immunopharmacology and immunotoxicology 20160101
Title: 17-DMAG, an HSP90 Inhibitor, Ameliorates Multiple Organ Dysfunction Syndrome via Induction of HSP70 in Endotoxemic Rats.
Journal: PloS one 20160101
Title: The HSP90 inhibitor alvespimycin enhances the potency of telomerase inhibition by imetelstat in human osteosarcoma.
Journal: Cancer biology & therapy 20150601
Title: Exome sequencing of hepatocellular carcinomas identifies new mutational signatures and potential therapeutic targets.
Journal: Nature genetics 20150501
Title: A physiologically based pharmacokinetic model of alvespimycin in mice and extrapolation to rats and humans.
Journal: British journal of pharmacology 20140601
Title: The apoptotic effect and associated signalling of HSP90 inhibitor 17-DMAG in hepatocellular carcinoma cells.
Journal: Cell biology international 20121001
Title: A phase I dose-escalation trial of trastuzumab and alvespimycin hydrochloride (KOS-1022; 17 DMAG) in the treatment of advanced solid tumors.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20120915
Title: Population pharmacokinetic analysis of 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG) in adult patients with solid tumors.
Journal: Cancer chemotherapy and pharmacology 20120701
Title: HSP90 inhibition by 17-DMAG attenuates oxidative stress in experimental atherosclerosis.
Journal: Cardiovascular research 20120701
Title: Combination therapy with HSP90 inhibitor 17-DMAG reconditions the tumor microenvironment to improve recruitment of therapeutic T cells.
Journal: Cancer research 20120701
Title: Hsp90 inhibition overcomes HGF-triggering resistance to EGFR-TKIs in EGFR-mutant lung cancer by decreasing client protein expression and angiogenesis.
Journal: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 20120701
Title: The effect of inhibition of heat-shock proteins on thiram-induced tibial dyschondroplasia.
Journal: Poultry science 20120701
Title: AKT-aro and HER2-aro, models for de novo resistance to aromatase inhibitors; molecular characterization and inhibitor response studies.
Journal: Breast cancer research and treatment 20120701
Title: Expression and therapeutic relevance of heat-shock protein 90 in pancreatic endocrine tumors.
Journal: Endocrine-related cancer 20120601
Title: In vivo method to monitor changes in HER2 expression using near-infrared fluorescence imaging.
Journal: Molecular imaging 20120601
Title: Inhibition of heat shock protein (molecular weight 90 kDa) attenuates proinflammatory cytokines and prevents lipopolysaccharide-induced liver injury in mice.
Journal: Hepatology (Baltimore, Md.) 20120501
Title: HSP90 inhibition by 17-DMAG reduces inflammation in J774 macrophages through suppression of Akt and nuclear factor-κB pathways.
Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20120501
Title: Heat shock protein 90 inhibition by 17-DMAG lessens disease in the MRL/lpr mouse model of systemic lupus erythematosus.
Journal: Cellular & molecular immunology 20120501
Title: Destabilization of PDK1 by Hsp90 inactivation suppresses hepatitis C virus replication through inhibition of PRK2-mediated viral RNA polymerase phosphorylation.
Journal: Biochemical and biophysical research communications 20120427
Title: Co-inhibition of HSP70/HSP90 synergistically sensitizes nasopharyngeal carcinoma cells to thermotherapy.
Journal: Integrative cancer therapies 20120301
Title: Quantitative proteomics reveals that Hsp90 inhibition preferentially targets kinases and the DNA damage response.
Journal: Molecular & cellular proteomics : MCP 20120301
Title: Optical imaging with her2-targeted affibody molecules can monitor hsp90 treatment response in a breast cancer xenograft mouse model.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20120215
Title: The anti-proliferative effect of heat shock protein 90 inhibitor, 17-DMAG, on non-small-cell lung cancers being resistant to EGFR tyrosine kinase inhibitor.
Journal: Lung cancer (Amsterdam, Netherlands) 20120201
Title: Expression profile of heat shock proteins in acute myeloid leukaemia patients reveals a distinct signature strongly associated with FLT3 mutation status--consequences and potentials for pharmacological intervention.
Journal: British journal of haematology 20120201
Title: Geldanamycin derivative ameliorates high fat diet-induced renal failure in diabetes.
Journal: PloS one 20120101
Title: Effect of inhibition of the ubiquitin-proteasome system and Hsp90 on growth and survival of rhabdomyosarcoma cells in vitro.
Journal: BMC cancer 20120101
Title: One-electron reduction of 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin: a pulse radiolysis study.
Journal: The journal of physical chemistry. A 20110818
Title: Heat-shock protein 90 inhibition in autoimmunity to type VII collagen: evidence that nonmalignant plasma cells are not therapeutic targets.
Journal: Blood 20110609
Title: In vitro metabolism of 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin in human liver microsomes.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20110401
Title: Dasatinib inhibits B cell receptor signalling in chronic lymphocytic leukaemia but novel combination approaches are required to overcome additional pro-survival microenvironmental signals.
Journal: British journal of haematology 20110401
Title: A phase I study of the heat shock protein 90 inhibitor alvespimycin (17-DMAG) given intravenously to patients with advanced solid tumors.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20110315
Title: Prolonged mechanical stretch is associated with upregulation of hypoxia-inducible factors and reduced contraction in rat inferior vena cava.
Journal: Journal of vascular surgery 20110301
Title: eNOS and Hsp90 interaction directly correlates with cord formation in human lymphatic endothelial cells.
Journal: Lymphatic research and biology 20110301
Title: Modulation of α(2C) adrenergic receptor temperature-sensitive trafficking by HSP90.
Journal: Biochimica et biophysica acta 20110201
Title: Blocking the chaperone kinome pathway: mechanistic insights into a novel dual inhibition approach for supra-additive suppression of malignant tumors.
Journal: Biochemical and biophysical research communications 20110107
Title: Autophagy inhibition sensitizes multiple myeloma cells to 17-dimethylaminoethylamino-17-demethoxygeldanamycin-induced apoptosis.
Journal: Leukemia research 20101101
Title: Down-regulation of heat shock protein 70 improves arsenic trioxide and 17-DMAG effects on constitutive signal transducer and activator of transcription 3 activity.
Journal: Cancer chemotherapy and pharmacology 20100901
Title: Heat shock protein 90 inhibition depletes TrkA levels and signaling in human acute leukemia cells.
Journal: Molecular cancer therapeutics 20100801
Title: 17-DMAG targets the nuclear factor-kappaB family of proteins to induce apoptosis in chronic lymphocytic leukemia: clinical implications of HSP90 inhibition.
Journal: Blood 20100708
Title: Reactive oxygen species mediate hepatotoxicity induced by the Hsp90 inhibitor geldanamycin and its analogs.
Journal: Free radical biology & medicine 20100601
Title: Novel HSP90 inhibitors, NVP-AUY922 and NVP-BEP800, radiosensitise tumour cells through cell-cycle impairment, increased DNA damage and repair protraction.
Journal: British journal of cancer 20100525
Title: Heat shock protein 90 inhibitors attenuate inflammatory responses in atherosclerosis.
Journal: Cardiovascular research 20100501
Title: The role of lysosomes in limiting drug toxicity in mice.
Journal: The Journal of pharmacology and experimental therapeutics 20100401
Title: Phase I study of the heat shock protein 90 inhibitor alvespimycin (KOS-1022, 17-DMAG) administered intravenously twice weekly to patients with acute myeloid leukemia.
Journal: Leukemia 20100401
Title: Down-regulation of RIP expression by 17-dimethylaminoethylamino-17-demethoxygeldanamycin promotes TRAIL-induced apoptosis in breast tumor cells.
Journal: Cancer letters 20100128
Title: Heat shock protein 90: inhibitors in clinical trials.
Journal: Journal of medicinal chemistry 20100114
Title: Phase I trial of 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG), a heat shock protein inhibitor, administered twice weekly in patients with advanced malignancies.
Journal: European journal of cancer (Oxford, England : 1990) 20100101
Title: Activating transcription factor-3 (ATF3) functions as a tumor suppressor in colon cancer and is up-regulated upon heat-shock protein 90 (Hsp90) inhibition.
Journal: BMC cancer 20100101
Title: Evidence for a role of heat shock protein-90 in toll like receptor 4 mediated pain enhancement in rats.
Journal: Neuroscience 20091229
Title: Heat shock protein 90 inhibitors: new mode of therapy to overcome endocrine resistance.
Journal: Cancer research 20091115
Title: Anti-proliferative activity of heat shock protein (Hsp) 90 inhibitors via beta-catenin/TCF7L2 pathway in adult T cell leukemia cells.
Journal: Cancer letters 20091018
Title: Monitoring therapeutic response of human ovarian cancer to 17-DMAG by noninvasive PET imaging with (64)Cu-DOTA-trastuzumab.
Journal: European journal of nuclear medicine and molecular imaging 20090901
Title: Heat shock protein 90 inhibitor 17-dimethylaminoethylamino-17-demethoxygeldanamycin enhances EphA2+ tumor cell recognition by specific CD8+ T cells.
Journal: Cancer research 20090901
Title: Geldanamycin analog 17-DMAG inhibits iNOS and caspases in gamma-irradiated human T cells.
Journal: Radiation research 20090901
Title: Co-treatment with heat shock protein 90 inhibitor 17-dimethylaminoethylamino-17-demethoxygeldanamycin (DMAG) and vorinostat: a highly active combination against human mantle cell lymphoma (MCL) cells.
Journal: Cancer biology & therapy 20090701
Title: Targeting focal adhesion kinase with dominant-negative FRNK or Hsp90 inhibitor 17-DMAG suppresses tumor growth and metastasis of SiHa cervical xenografts.
Journal: Cancer research 20090601
Title: Heat shock protein inhibitors, 17-DMAG and KNK437, enhance arsenic trioxide-induced mitotic apoptosis.
Journal: Toxicology and applied pharmacology 20090415
Title: 17-DMAG ameliorates polyglutamine-mediated motor neuron degeneration through well-preserved proteasome function in an SBMA model mouse.
Journal: Human molecular genetics 20090301
Title: Heat shock protein 90-binding agents protect renal cells from oxidative stress and reduce kidney ischemia-reperfusion injury.
Journal: American journal of physiology. Renal physiology 20080801
Title: Formulation of a geldanamycin prodrug in mPEG-b-PCL micelles greatly enhances tolerability and pharmacokinetics in rats.
Journal: Journal of controlled release : official journal of the Controlled Release Society 20080702
Title: Stage 1 testing and pharmacodynamic evaluation of the HSP90 inhibitor alvespimycin (17-DMAG, KOS-1022) by the pediatric preclinical testing program.
Journal: Pediatric blood & cancer 20080701
Title: 17-AAG and 17-DMAG-induced inhibition of cell proliferation through B-Raf downregulation in WT B-Raf-expressing uveal melanoma cell lines.
Journal: Investigative ophthalmology & visual science 20080601
Title: Efficacy of Hsp90 inhibition for induction of apoptosis and inhibition of growth in cervical carcinoma cells in vitro and in vivo.
Journal: Cancer chemotherapy and pharmacology 20080401
Title: Heat shock protein 90beta1 is essential for polyunsaturated fatty acid-induced mitochondrial Ca2+ efflux.
Journal: The Journal of biological chemistry 20080321
Title: Targeting Akt and heat shock protein 90 produces synergistic multiple myeloma cell cytotoxicity in the bone marrow microenvironment.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20080201
Title: Cancer stem cell heterogeneity in hereditary breast cancer.
Journal: Breast cancer research : BCR 20080101
Title: Humoral immune response upon mild heat-shock conditions in Galleria mellonella larvae.
Journal: Journal of insect physiology 20071101
Title: Targeting heat shock protein 90 in pancreatic cancer impairs insulin-like growth factor-I receptor signaling, disrupts an interleukin-6/signal-transducer and activator of transcription 3/hypoxia-inducible factor-1alpha autocrine loop, and reduces orthotopic tumor growth.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20071101
Title: Determination of 17-dimethylaminoethylamino-17-demethoxygeldanamycin in human plasma by liquid chromatography with mass-spectrometric detection.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20071015
Title: Mechanistic studies on Hsp90 inhibition by ansamycin derivatives.
Journal: Journal of molecular biology 20070914
Title: HIF-1alpha and HIF-2alpha play a central role in stretch-induced but not shear-stress-induced angiogenesis in rat skeletal muscle.
Journal: The Journal of physiology 20070901
Title: Perinecrotic hypoxia contributes to ischemia/reperfusion-accelerated outgrowth of colorectal micrometastases.
Journal: The American journal of pathology 20070401
Title: Synergism between arsenic trioxide and heat shock protein 90 inhibitors on signal transducer and activator of transcription protein 3 activity--pharmacodynamic drug-drug interaction modeling.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20070401
Title: Inhibition of heat shock protein 90 impairs epidermal growth factor-mediated signaling in gastric cancer cells and reduces tumor growth and vascularization in vivo.
Journal: Molecular cancer therapeutics 20070301
Title: Hsp90 inhibitors suppress HCV replication in replicon cells and humanized liver mice.
Journal: Biochemical and biophysical research communications 20070223
Title: STAT3 and MAPK signaling maintain overexpression of heat shock proteins 90alpha and beta in multiple myeloma cells, which critically contribute to tumor-cell survival.
Journal: Blood 20070115
Title: Small molecule inducers of heat-shock response reduce polyQ-mediated huntingtin aggregation. A possible therapeutic strategy.
Journal: Neuro-degenerative diseases 20070101
Title: Drug-mediated targeted disruption of multiple protein activities through functional inhibition of the Hsp90 chaperone complex.
Journal: Current medicinal chemistry 20070101
Title: Schedule-dependent synergy between the heat shock protein 90 inhibitor 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin and doxorubicin restores apoptosis to p53-mutant lymphoma cell lines.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20061101
Title: Heat shock protein-90 inhibitors: a chronicle from geldanamycin to today's agents.
Journal: Current opinion in investigational drugs (London, England : 2000) 20060601
Title: Synergistic interactions between DMAG and mitogen-activated protein kinase kinase 1/2 inhibitors in Bcr/abl+ leukemia cells sensitive and resistant to imatinib mesylate.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20060401
Title: Benzoquinone ansamycin heat shock protein 90 inhibitors modulate multiple functions required for tumor angiogenesis.
Journal: Molecular cancer therapeutics 20060301
Title: Determination of the heat shock protein 90 inhibitor 17-dimethylaminoethylamino-17-demethoxygeldanamycin in plasma by liquid chromatography-electrospray mass spectrometry.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060102
Title: Hsp90 inhibitors in the clinic.
Journal: Handbook of experimental pharmacology 20060101
Title: Inhibitors of the HSP90 molecular chaperone: current status.
Journal: Advances in cancer research 20060101
Title: Development and validation of a liquid chromatography/tandem mass spectrometry method for the determination of the novel anticancer agent 17-DMAG in human plasma.
Journal: Rapid communications in mass spectrometry : RCM 20060101
Title: Preclinical toxicity of a geldanamycin analog, 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (17-DMAG), in rats and dogs: potential clinical relevance.
Journal: Cancer chemotherapy and pharmacology 20051201
Title: Induction of the hypoxia-inducible factor system by low levels of heat shock protein 90 inhibitors.
Journal: Cancer research 20051201
Title: ZAP-70 is a novel conditional heat shock protein 90 (Hsp90) client: inhibition of Hsp90 leads to ZAP-70 degradation, apoptosis, and impaired signaling in chronic lymphocytic leukemia.
Journal: Blood 20051001
Title: In vivo antitumor efficacy of 17-DMAG (17-dimethylaminoethylamino-17-demethoxygeldanamycin hydrochloride), a water-soluble geldanamycin derivative.
Journal: Cancer chemotherapy and pharmacology 20050801
Title: Comparison of 17-dimethylaminoethylamino-17-demethoxy-geldanamycin (17DMAG) and 17-allylamino-17-demethoxygeldanamycin (17AAG) in vitro: effects on Hsp90 and client proteins in melanoma models.
Journal: Cancer chemotherapy and pharmacology 20050801
Title: 17-Allyamino-17-demethoxygeldanamycin and 17-NN-dimethyl ethylene diamine-geldanamycin have cytotoxic activity against multiple gynecologic cancer cell types.
Journal: Gynecologic oncology 20050201
Title: Enhanced tumor cell radiosensitivity and abrogation of G2 and S phase arrest by the Hsp90 inhibitor 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20041201
Title: Synthesis and biological activities of novel 17-aminogeldanamycin derivatives.
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Title: Antiangiogenic properties of 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin: an orally bioavailable heat shock protein 90 modulator.
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Title: Clinical trials referral resource. Current clinical trials of 17-AG and 17-DMAG.
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Title: Crystal structure and molecular modeling of 17-DMAG in complex with human Hsp90.
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