480449-71-6,MFCD16038915
Catalog No.:AA00DB31

480449-71-6 | Edoxaban Tosylate

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$89.00   $62.00
- +
5mg
≥98%
in stock  
$340.00   $238.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00DB31
Chemical Name:
Edoxaban Tosylate
CAS Number:
480449-71-6
Molecular Formula:
C31H38ClN7O7S2
Molecular Weight:
720.2591
MDL Number:
MFCD16038915
SMILES:
CN1CCc2c(C1)sc(n2)C(=O)NC1CC(CCC1NC(=O)C(=O)Nc1ccc(cn1)Cl)C(=O)N(C)C.Cc1ccc(cc1)S(=O)(=O)O
Properties
Computed Properties
 
Complexity:
1090  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
3  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
48  
Hydrogen Bond Acceptor Count:
11  
Hydrogen Bond Donor Count:
4  
Isotope Atom Count:
0  
Rotatable Bond Count:
6  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  

Downstream Synthesis Route

[1]CurrentPatentAssignee:CHONGKUNDANGPHARMACEUTICALCORP.-KR2021/30109,2021,ALocationinpatent:Paragraph0164-0280;0289-0338

[2]CurrentPatentAssignee:SKCAPITALPARTNERSLP-US2018/179226,2018,A1Locationinpatent:Paragraph0368

[3]CurrentPatentAssignee:BORYUNGPHARMCO.,LTD.;BORYUNG-WO2022/103239,2022,A1Locationinpatent:Paragraph47-48;141;151-153;154;171-172

[4]CurrentPatentAssignee:DAIICHISANKYOCOMPANY,LIMITED-EP2371830,2011,A1Locationinpatent:Page/Pagecolumn9-10

[5]CurrentPatentAssignee:CHINACHEMICALPHARMACEUTICALGROUP;CHUNGWHACHEMICALSYNTHESISBIOTECH-TWI571460,2017,BLocationinpatent:Paragraph0042-0043

[6]CurrentPatentAssignee:BEIJINGSUNNOVOPHARMACEUTICALRES-CN108484641,2018,ALocationinpatent:Paragraph0066-0069;0097-0098

[7]CurrentPatentAssignee:INNERMONGOLIAJINGDONGPHARMACEUTICAL-CN111393456,2020,ALocationinpatent:Paragraph0099-0101

[8]CurrentPatentAssignee:GLENMARKPHARMACEUTICALSLTD-WO2021/1728,2021,A1Locationinpatent:Paragraph19-20

[9]CurrentPatentAssignee:VIATRISINC-WO2018/11823,2018,A1Locationinpatent:Page/Pagecolumn28

[10]CurrentPatentAssignee:HARBINPHARMACEUTICALGROUPCO.,LTD.-CN114736218,2022,ALocationinpatent:Paragraph0040-0044;0053-0054

[11]CurrentPatentAssignee:DAIICHISANKYOCOMPANY,LIMITED-EP1405852,2004,A1Locationinpatent:Page424

[12]CurrentPatentAssignee:DAIICHISANKYOCOMPANY,LIMITED-EP2407450,2012,A1Locationinpatent:Page/Pagecolumn21-22

[13]CurrentPatentAssignee:DAIICHISANKYOCOMPANY,LIMITED-EP2407457,2012,A1Locationinpatent:Page/Pagecolumn17

[14]CurrentPatentAssignee:DAIICHISANKYOCOMPANY,LIMITED-EP2589590,2013,A1Locationinpatent:Paragraph0146;0147

[15]CurrentPatentAssignee:DAIICHISANKYOCOMPANY,LIMITED-US2013/144061,2013,A1Locationinpatent:Paragraph0264;0265;0266;0267;0268;0269;0270

[16]CurrentPatentAssignee:DAIICHISANKYOCOMPANY,LIMITED-US2015/353577,2015,A1Locationinpatent:Paragraph0099;0100

[17]CurrentPatentAssignee:DAIICHISANKYOCOMPANY,LIMITED-JP5801011,2015,B2Locationinpatent:Page/Pagecolumn0214-0216

[18]CurrentPatentAssignee:SHENZHENKEXINGBIOTECH;SHANDONGKEXINGBIOPRODUCTS-CN104761571,2017,BLocationinpatent:Paragraph0063;0064;0065

[19]CurrentPatentAssignee:CorporacionQuimicoFarmaceuticaEsteveSA-WO2018/83213,2018,A1Locationinpatent:Page/Pagecolumn13

[20]CurrentPatentAssignee:DAIICHISANKYOCOMPANY,LIMITED-US2017/22220,2017,A1Locationinpatent:Paragraph0050;0051;0052;0053;0054;0055;0056

[21]CurrentPatentAssignee:JIANGSUWEIKELMEDICALTECH-CN114349770,2022,ALocationinpatent:Paragraph0057-0062

[22]CurrentPatentAssignee:BORYUNGPHARMCO.,LTD.;BORYUNG-WO2022/103239,2022,A1Locationinpatent:Paragraph47-48;141;151-153-154;171-172

[23]CurrentPatentAssignee:SHANGHAIBIOSBIOTECHNOLOGY-CN115724792,2023,ALocationinpatent:Paragraph0095-0110

[24]CurrentPatentAssignee:BORYUNGPHARMCO.,LTD.;BORYUNG-WO2022/103239,2022,A1Locationinpatent:Paragraph47-48;141;151-153-154;171-172

[25]CurrentPatentAssignee:ZHEJIANGJIUZHOUPHARMCOLTD-CN116332958,2023,ALocationinpatent:Paragraph0054-0056

[1]CurrentPatentAssignee:DAIICHISANKYOCOMPANY,LIMITED-EP2407450,2012,A1

[2]CurrentPatentAssignee:DAIICHISANKYOCOMPANY,LIMITED-EP2407457,2012,A1

[3]CurrentPatentAssignee:DAIICHISANKYOCOMPANY,LIMITED-EP2407457,2012,A1

[4]CurrentPatentAssignee:DAIICHISANKYOCOMPANY,LIMITED-EP2589590,2013,A1

[5]CurrentPatentAssignee:DAIICHISANKYOCOMPANY,LIMITED-US2013/144061,2013,A1

[6]CurrentPatentAssignee:DAIICHISANKYOCOMPANY,LIMITED-US2015/353577,2015,A1

[7]CurrentPatentAssignee:DAIICHISANKYOCOMPANY,LIMITED-JP5801011,2015,B2

[8]CurrentPatentAssignee:SHENZHENKEXINGBIOTECH;SHANDONGKEXINGBIOPRODUCTS-CN104761571,2017,B

[9]CurrentPatentAssignee:BEIJINGSUNNOVOPHARMACEUTICALRES-CN108484641,2018,A

[10]CurrentPatentAssignee:INNERMONGOLIAJINGDONGPHARMACEUTICAL-CN111393456,2020,A

[11]CurrentPatentAssignee:INNERMONGOLIAJINGDONGPHARMACEUTICAL-CN111393456,2020,A

[12]CurrentPatentAssignee:GLENMARKPHARMACEUTICALSLTD-WO2021/1728,2021,A1

[13]CurrentPatentAssignee:GLENMARKPHARMACEUTICALSLTD-WO2021/1728,2021,A1

[14]CurrentPatentAssignee:NANJINGANHONGYUANHUAPHARMACEUTICALINDUSTRYINVESTMENTPARTNERSHIP(LIMITEDPARTNERSHIP)-CN112321613,2021,A

[15]CurrentPatentAssignee:BORYUNG;BORYUNGPHARMCO.,LTD.-WO2022/103239,2022,A1

[16]CurrentPatentAssignee:BORYUNG;BORYUNGPHARMCO.,LTD.-WO2022/103239,2022,A1

[1]CurrentPatentAssignee:DAIICHISANKYOCOMPANY,LIMITED-EP2407450,2012,A1

[2]CurrentPatentAssignee:DAIICHISANKYOCOMPANY,LIMITED-EP2407457,2012,A1

[3]CurrentPatentAssignee:DAIICHISANKYOCOMPANY,LIMITED-EP2407457,2012,A1

[4]CurrentPatentAssignee:DAIICHISANKYOCOMPANY,LIMITED-EP2589590,2013,A1

[5]CurrentPatentAssignee:DAIICHISANKYOCOMPANY,LIMITED-JP5801011,2015,B2

[6]CurrentPatentAssignee:CHUNGWHACHEMICALSYNTHESISBIOTECH;CHINACHEMICALPHARMACEUTICALGROUP-TWI571460,2017,B

[7]CurrentPatentAssignee:SHENZHENKEXINGBIOTECH;SHANDONGKEXINGBIOPRODUCTS-CN104761571,2017,B

[8]CurrentPatentAssignee:BEIJINGSUNNOVOPHARMACEUTICALRES-CN108484641,2018,A

[9]CurrentPatentAssignee:INNERMONGOLIAJINGDONGPHARMACEUTICAL-CN111393456,2020,A

[10]CurrentPatentAssignee:INNERMONGOLIAJINGDONGPHARMACEUTICAL-CN111393456,2020,A

[11]CurrentPatentAssignee:GLENMARKPHARMACEUTICALSLTD-WO2021/1728,2021,A1

[12]CurrentPatentAssignee:GLENMARKPHARMACEUTICALSLTD-WO2021/1728,2021,A1

[1]CurrentPatentAssignee:DAIICHISANKYOCOMPANY,LIMITED-EP2548879,2013,A1Locationinpatent:Paragraph0047-0048

[1]CurrentPatentAssignee:DAIICHISANKYOCOMPANY,LIMITED-US2013/144061,2013,A1

Literature

Title: Pharmacokinetics and Pharmacodynamics of Edoxaban, a Non-Vitamin K Antagonist Oral Anticoagulant that Inhibits Clotting Factor Xa.

Journal: Clinical pharmacokinetics 20160101

Title: Overview of the new oral anticoagulants: opportunities and challenges.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20150501

Title: The role of factor Xa inhibitors in venous thromboembolism treatment.

Journal: Vascular health and risk management 20150101

Title: Characterisation of exposure versus response of edoxaban in patients undergoing total hip replacement surgery.

Journal: Thrombosis and haemostasis 20121101

Title: Prevention of stroke in patients with atrial fibrillation: anticoagulant and antiplatelet options.

Journal: Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing 20121001

Title: Oral direct factor Xa inhibitors.

Journal: Circulation research 20120928

Title: Comparison of antithrombotic and haemorrhagic effects of edoxaban, an oral direct factor Xa inhibitor, with warfarin and enoxaparin in rats.

Journal: Thrombosis research 20120901

Title: The promise of novel direct oral anticoagulants.

Journal: Best practice & research. Clinical haematology 20120901

Title: Edoxaban administration following enoxaparin: a pharmacodynamic, pharmacokinetic, and tolerability assessment in human subjects.

Journal: Thrombosis and haemostasis 20120701

Title: Long-term benefits of preventing venous thromboembolic events.

Journal: Current medical research and opinion 20120601

Title: Current and future alternatives to warfarin for the prevention of stroke in atrial fibrillation.

Journal: Critical pathways in cardiology 20120601

Title: In vitro study of the anticoagulant effects of edoxaban and its effect on thrombin generation in comparison to fondaparinux.

Journal: Thrombosis research 20120401

Title: Randomized, multicenter, warfarin-controlled phase II study of edoxaban in Japanese patients with non-valvular atrial fibrillation.

Journal: Circulation journal : official journal of the Japanese Circulation Society 20120101

Title: Comparison of antithrombotic efficacy between edoxaban, a direct factor Xa inhibitor, and fondaparinux, an indirect factor Xa inhibitor under low and high shear rates.

Journal: Thrombosis and haemostasis 20111201

Title: Antithrombin-independent thrombin inhibitors, but not direct factor Xa inhibitors, enhance thrombin generation in plasma through inhibition of thrombin-thrombomodulin-protein C system.

Journal: Thrombosis and haemostasis 20111201

Title: [Current status and future of anti-Xa inhibitors].

Journal: Rinsho shinkeigaku = Clinical neurology 20111101

Title: The new oral anticoagulants.

Journal: Clinical medicine (London, England) 20111001

Title: Edoxaban for the prevention of thromboembolic events after surgery.

Journal: Drugs of today (Barcelona, Spain : 1998) 20111001

Title: [Thromboembolic prophylaxis 2011: is warfarin on the wane?].

Journal: Giornale italiano di cardiologia (2006) 20110901

Title: Edoxaban: a new oral direct factor xa inhibitor.

Journal: Drugs 20110820

Title: Edoxaban: pharmacological principles, preclinical and early-phase clinical testing.

Journal: Future cardiology 20110701

Title: [New anticoagulants in the prevention and treatment of venous thromboembolism].

Journal: Orvosi hetilap 20110619

Title: Effect of edoxaban on markers of coagulation in venous and shed blood compared with fondaparinux.

Journal: Thrombosis and haemostasis 20110601

Title: Safety of edoxaban, an oral factor Xa inhibitor, in Asian patients with non-valvular atrial fibrillation.

Journal: Thrombosis and haemostasis 20110301

Title: Factor Xa and thrombin as targets for new oral anticoagulants.

Journal: Thrombosis research 20110101

Title: Novel oral factor Xa and thrombin inhibitors in the management of thromboembolism.

Journal: Annual review of medicine 20110101

Title: Edoxaban tosylate.

Journal: American journal of cardiovascular drugs : drugs, devices, and other interventions 20110101

Title: A dose-ranging study evaluating the oral factor Xa inhibitor edoxaban for the prevention of venous thromboembolism in patients undergoing total knee arthroplasty.

Journal: Journal of thrombosis and haemostasis : JTH 20101101

Title: Comparison of a direct Factor Xa inhibitor, edoxaban, with dalteparin and ximelagatran: a randomised controlled trial in healthy elderly adults.

Journal: Thrombosis research 20101001

Title: Evaluation of the novel factor Xa inhibitor edoxaban compared with warfarin in patients with atrial fibrillation: design and rationale for the Effective aNticoaGulation with factor xA next GEneration in Atrial Fibrillation-Thrombolysis In Myocardial Infarction study 48 (ENGAGE AF-TIMI 48).

Journal: American heart journal 20101001

Title: Oral direct factor Xa inhibition with edoxaban for thromboprophylaxis after elective total hip replacement. A randomised double-blind dose-response study.

Journal: Thrombosis and haemostasis 20100901

Title: Randomised, parallel-group, multicentre, multinational phase 2 study comparing edoxaban, an oral factor Xa inhibitor, with warfarin for stroke prevention in patients with atrial fibrillation.

Journal: Thrombosis and haemostasis 20100901

Title: [Do orally active factor Xa (FXa) inhibitors have potential as innovative new anticoagulants? Future perspective from preclinical data].

Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20100801

Title: Clinical safety, tolerability, pharmacokinetics, and pharmacodynamics of the novel factor Xa inhibitor edoxaban in healthy volunteers.

Journal: Journal of clinical pharmacology 20100701

Title: Oral factor Xa inhibitors for the prevention of stroke in atrial fibrillation.

Journal: Current opinion in cardiology 20100701

Title: New anticoagulants for atrial fibrillation.

Journal: Seminars in thrombosis and hemostasis 20090701

Title: DU-176b, a potent and orally active factor Xa inhibitor: in vitro and in vivo pharmacological profiles.

Journal: Journal of thrombosis and haemostasis : JTH 20080901

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Tags:480449-71-6 Molecular Formula|480449-71-6 MDL|480449-71-6 SMILES|480449-71-6 Edoxaban Tosylate
Catalog No.: AA00DB31
480449-71-6,MFCD16038915
480449-71-6 | Edoxaban Tosylate
Pack Size: 1mg
Purity: ≥98%
in stock
$89.00 $62.00
Pack Size: 5mg
Purity: ≥98%
in stock
$340.00 $238.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA00DB31
Chemical Name: Edoxaban Tosylate
CAS Number: 480449-71-6
Molecular Formula: C31H38ClN7O7S2
Molecular Weight: 720.2591
MDL Number: MFCD16038915
SMILES: CN1CCc2c(C1)sc(n2)C(=O)NC1CC(CCC1NC(=O)C(=O)Nc1ccc(cn1)Cl)C(=O)N(C)C.Cc1ccc(cc1)S(=O)(=O)O
Properties
Complexity: 1090  
Covalently-Bonded Unit Count: 2  
Defined Atom Stereocenter Count: 3  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 48  
Hydrogen Bond Acceptor Count: 11  
Hydrogen Bond Donor Count: 4  
Isotope Atom Count: 0  
Rotatable Bond Count: 6  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
Downstream Synthesis Route
480449-70-5    104-15-4    480449-71-6 

[1]CurrentPatentAssignee:CHONGKUNDANGPHARMACEUTICALCORP.-KR2021/30109,2021,ALocationinpatent:Paragraph0164-0280;0289-0338

[2]CurrentPatentAssignee:SKCAPITALPARTNERSLP-US2018/179226,2018,A1Locationinpatent:Paragraph0368

[3]CurrentPatentAssignee:BORYUNGPHARMCO.,LTD.;BORYUNG-WO2022/103239,2022,A1Locationinpatent:Paragraph47-48;141;151-153;154;171-172

[4]CurrentPatentAssignee:DAIICHISANKYOCOMPANY,LIMITED-EP2371830,2011,A1Locationinpatent:Page/Pagecolumn9-10

[5]CurrentPatentAssignee:CHINACHEMICALPHARMACEUTICALGROUP;CHUNGWHACHEMICALSYNTHESISBIOTECH-TWI571460,2017,BLocationinpatent:Paragraph0042-0043

[6]CurrentPatentAssignee:BEIJINGSUNNOVOPHARMACEUTICALRES-CN108484641,2018,ALocationinpatent:Paragraph0066-0069;0097-0098

[7]CurrentPatentAssignee:INNERMONGOLIAJINGDONGPHARMACEUTICAL-CN111393456,2020,ALocationinpatent:Paragraph0099-0101

[8]CurrentPatentAssignee:GLENMARKPHARMACEUTICALSLTD-WO2021/1728,2021,A1Locationinpatent:Paragraph19-20

[9]CurrentPatentAssignee:VIATRISINC-WO2018/11823,2018,A1Locationinpatent:Page/Pagecolumn28

[10]CurrentPatentAssignee:HARBINPHARMACEUTICALGROUPCO.,LTD.-CN114736218,2022,ALocationinpatent:Paragraph0040-0044;0053-0054

[11]CurrentPatentAssignee:DAIICHISANKYOCOMPANY,LIMITED-EP1405852,2004,A1Locationinpatent:Page424

[12]CurrentPatentAssignee:DAIICHISANKYOCOMPANY,LIMITED-EP2407450,2012,A1Locationinpatent:Page/Pagecolumn21-22

[13]CurrentPatentAssignee:DAIICHISANKYOCOMPANY,LIMITED-EP2407457,2012,A1Locationinpatent:Page/Pagecolumn17

[14]CurrentPatentAssignee:DAIICHISANKYOCOMPANY,LIMITED-EP2589590,2013,A1Locationinpatent:Paragraph0146;0147

[15]CurrentPatentAssignee:DAIICHISANKYOCOMPANY,LIMITED-US2013/144061,2013,A1Locationinpatent:Paragraph0264;0265;0266;0267;0268;0269;0270

[16]CurrentPatentAssignee:DAIICHISANKYOCOMPANY,LIMITED-US2015/353577,2015,A1Locationinpatent:Paragraph0099;0100

[17]CurrentPatentAssignee:DAIICHISANKYOCOMPANY,LIMITED-JP5801011,2015,B2Locationinpatent:Page/Pagecolumn0214-0216

[18]CurrentPatentAssignee:SHENZHENKEXINGBIOTECH;SHANDONGKEXINGBIOPRODUCTS-CN104761571,2017,BLocationinpatent:Paragraph0063;0064;0065

[19]CurrentPatentAssignee:CorporacionQuimicoFarmaceuticaEsteveSA-WO2018/83213,2018,A1Locationinpatent:Page/Pagecolumn13

[20]CurrentPatentAssignee:DAIICHISANKYOCOMPANY,LIMITED-US2017/22220,2017,A1Locationinpatent:Paragraph0050;0051;0052;0053;0054;0055;0056

[21]CurrentPatentAssignee:JIANGSUWEIKELMEDICALTECH-CN114349770,2022,ALocationinpatent:Paragraph0057-0062

[22]CurrentPatentAssignee:BORYUNGPHARMCO.,LTD.;BORYUNG-WO2022/103239,2022,A1Locationinpatent:Paragraph47-48;141;151-153-154;171-172

[23]CurrentPatentAssignee:SHANGHAIBIOSBIOTECHNOLOGY-CN115724792,2023,ALocationinpatent:Paragraph0095-0110

[24]CurrentPatentAssignee:BORYUNGPHARMCO.,LTD.;BORYUNG-WO2022/103239,2022,A1Locationinpatent:Paragraph47-48;141;151-153-154;171-172

[25]CurrentPatentAssignee:ZHEJIANGJIUZHOUPHARMCOLTD-CN116332958,2023,ALocationinpatent:Paragraph0054-0056

1210348-34-7    480449-71-6 

[1]CurrentPatentAssignee:DAIICHISANKYOCOMPANY,LIMITED-EP2407450,2012,A1

[2]CurrentPatentAssignee:DAIICHISANKYOCOMPANY,LIMITED-EP2407457,2012,A1

[3]CurrentPatentAssignee:DAIICHISANKYOCOMPANY,LIMITED-EP2407457,2012,A1

[4]CurrentPatentAssignee:DAIICHISANKYOCOMPANY,LIMITED-EP2589590,2013,A1

[5]CurrentPatentAssignee:DAIICHISANKYOCOMPANY,LIMITED-US2013/144061,2013,A1

[6]CurrentPatentAssignee:DAIICHISANKYOCOMPANY,LIMITED-US2015/353577,2015,A1

[7]CurrentPatentAssignee:DAIICHISANKYOCOMPANY,LIMITED-JP5801011,2015,B2

[8]CurrentPatentAssignee:SHENZHENKEXINGBIOTECH;SHANDONGKEXINGBIOPRODUCTS-CN104761571,2017,B

[9]CurrentPatentAssignee:BEIJINGSUNNOVOPHARMACEUTICALRES-CN108484641,2018,A

[10]CurrentPatentAssignee:INNERMONGOLIAJINGDONGPHARMACEUTICAL-CN111393456,2020,A

[11]CurrentPatentAssignee:INNERMONGOLIAJINGDONGPHARMACEUTICAL-CN111393456,2020,A

[12]CurrentPatentAssignee:GLENMARKPHARMACEUTICALSLTD-WO2021/1728,2021,A1

[13]CurrentPatentAssignee:GLENMARKPHARMACEUTICALSLTD-WO2021/1728,2021,A1

[14]CurrentPatentAssignee:NANJINGANHONGYUANHUAPHARMACEUTICALINDUSTRYINVESTMENTPARTNERSHIP(LIMITEDPARTNERSHIP)-CN112321613,2021,A

[15]CurrentPatentAssignee:BORYUNG;BORYUNGPHARMCO.,LTD.-WO2022/103239,2022,A1

[16]CurrentPatentAssignee:BORYUNG;BORYUNGPHARMCO.,LTD.-WO2022/103239,2022,A1

1243308-37-3    480449-71-6 

[1]CurrentPatentAssignee:DAIICHISANKYOCOMPANY,LIMITED-EP2407450,2012,A1

[2]CurrentPatentAssignee:DAIICHISANKYOCOMPANY,LIMITED-EP2407457,2012,A1

[3]CurrentPatentAssignee:DAIICHISANKYOCOMPANY,LIMITED-EP2407457,2012,A1

[4]CurrentPatentAssignee:DAIICHISANKYOCOMPANY,LIMITED-EP2589590,2013,A1

[5]CurrentPatentAssignee:DAIICHISANKYOCOMPANY,LIMITED-JP5801011,2015,B2

[6]CurrentPatentAssignee:CHUNGWHACHEMICALSYNTHESISBIOTECH;CHINACHEMICALPHARMACEUTICALGROUP-TWI571460,2017,B

[7]CurrentPatentAssignee:SHENZHENKEXINGBIOTECH;SHANDONGKEXINGBIOPRODUCTS-CN104761571,2017,B

[8]CurrentPatentAssignee:BEIJINGSUNNOVOPHARMACEUTICALRES-CN108484641,2018,A

[9]CurrentPatentAssignee:INNERMONGOLIAJINGDONGPHARMACEUTICAL-CN111393456,2020,A

[10]CurrentPatentAssignee:INNERMONGOLIAJINGDONGPHARMACEUTICAL-CN111393456,2020,A

[11]CurrentPatentAssignee:GLENMARKPHARMACEUTICALSLTD-WO2021/1728,2021,A1

[12]CurrentPatentAssignee:GLENMARKPHARMACEUTICALSLTD-WO2021/1728,2021,A1

480449-70-5    104-15-4    480449-71-6 

[1]CurrentPatentAssignee:DAIICHISANKYOCOMPANY,LIMITED-EP2548879,2013,A1Locationinpatent:Paragraph0047-0048

17899-48-8    480449-71-6 

[1]CurrentPatentAssignee:DAIICHISANKYOCOMPANY,LIMITED-US2013/144061,2013,A1

Literature fold

Title: Pharmacokinetics and Pharmacodynamics of Edoxaban, a Non-Vitamin K Antagonist Oral Anticoagulant that Inhibits Clotting Factor Xa.

Journal: Clinical pharmacokinetics20160101

Title: Overview of the new oral anticoagulants: opportunities and challenges.

Journal: Arteriosclerosis, thrombosis, and vascular biology20150501

Title: The role of factor Xa inhibitors in venous thromboembolism treatment.

Journal: Vascular health and risk management20150101

Title: Characterisation of exposure versus response of edoxaban in patients undergoing total hip replacement surgery.

Journal: Thrombosis and haemostasis20121101

Title: Prevention of stroke in patients with atrial fibrillation: anticoagulant and antiplatelet options.

Journal: Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing20121001

Title: Oral direct factor Xa inhibitors.

Journal: Circulation research20120928

Title: Comparison of antithrombotic and haemorrhagic effects of edoxaban, an oral direct factor Xa inhibitor, with warfarin and enoxaparin in rats.

Journal: Thrombosis research20120901

Title: The promise of novel direct oral anticoagulants.

Journal: Best practice & research. Clinical haematology20120901

Title: Edoxaban administration following enoxaparin: a pharmacodynamic, pharmacokinetic, and tolerability assessment in human subjects.

Journal: Thrombosis and haemostasis20120701

Title: Long-term benefits of preventing venous thromboembolic events.

Journal: Current medical research and opinion20120601

Title: Current and future alternatives to warfarin for the prevention of stroke in atrial fibrillation.

Journal: Critical pathways in cardiology20120601

Title: In vitro study of the anticoagulant effects of edoxaban and its effect on thrombin generation in comparison to fondaparinux.

Journal: Thrombosis research20120401

Title: Randomized, multicenter, warfarin-controlled phase II study of edoxaban in Japanese patients with non-valvular atrial fibrillation.

Journal: Circulation journal : official journal of the Japanese Circulation Society20120101

Title: Comparison of antithrombotic efficacy between edoxaban, a direct factor Xa inhibitor, and fondaparinux, an indirect factor Xa inhibitor under low and high shear rates.

Journal: Thrombosis and haemostasis20111201

Title: Antithrombin-independent thrombin inhibitors, but not direct factor Xa inhibitors, enhance thrombin generation in plasma through inhibition of thrombin-thrombomodulin-protein C system.

Journal: Thrombosis and haemostasis20111201

Title: [Current status and future of anti-Xa inhibitors].

Journal: Rinsho shinkeigaku = Clinical neurology20111101

Title: The new oral anticoagulants.

Journal: Clinical medicine (London, England)20111001

Title: Edoxaban for the prevention of thromboembolic events after surgery.

Journal: Drugs of today (Barcelona, Spain : 1998)20111001

Title: [Thromboembolic prophylaxis 2011: is warfarin on the wane?].

Journal: Giornale italiano di cardiologia (2006)20110901

Title: Edoxaban: a new oral direct factor xa inhibitor.

Journal: Drugs20110820

Title: Edoxaban: pharmacological principles, preclinical and early-phase clinical testing.

Journal: Future cardiology20110701

Title: [New anticoagulants in the prevention and treatment of venous thromboembolism].

Journal: Orvosi hetilap20110619

Title: Effect of edoxaban on markers of coagulation in venous and shed blood compared with fondaparinux.

Journal: Thrombosis and haemostasis20110601

Title: Safety of edoxaban, an oral factor Xa inhibitor, in Asian patients with non-valvular atrial fibrillation.

Journal: Thrombosis and haemostasis20110301

Title: Factor Xa and thrombin as targets for new oral anticoagulants.

Journal: Thrombosis research20110101

Title: Novel oral factor Xa and thrombin inhibitors in the management of thromboembolism.

Journal: Annual review of medicine20110101

Title: Edoxaban tosylate.

Journal: American journal of cardiovascular drugs : drugs, devices, and other interventions20110101

Title: A dose-ranging study evaluating the oral factor Xa inhibitor edoxaban for the prevention of venous thromboembolism in patients undergoing total knee arthroplasty.

Journal: Journal of thrombosis and haemostasis : JTH20101101

Title: Comparison of a direct Factor Xa inhibitor, edoxaban, with dalteparin and ximelagatran: a randomised controlled trial in healthy elderly adults.

Journal: Thrombosis research20101001

Title: Evaluation of the novel factor Xa inhibitor edoxaban compared with warfarin in patients with atrial fibrillation: design and rationale for the Effective aNticoaGulation with factor xA next GEneration in Atrial Fibrillation-Thrombolysis In Myocardial Infarction study 48 (ENGAGE AF-TIMI 48).

Journal: American heart journal20101001

Title: Oral direct factor Xa inhibition with edoxaban for thromboprophylaxis after elective total hip replacement. A randomised double-blind dose-response study.

Journal: Thrombosis and haemostasis20100901

Title: Randomised, parallel-group, multicentre, multinational phase 2 study comparing edoxaban, an oral factor Xa inhibitor, with warfarin for stroke prevention in patients with atrial fibrillation.

Journal: Thrombosis and haemostasis20100901

Title: [Do orally active factor Xa (FXa) inhibitors have potential as innovative new anticoagulants? Future perspective from preclinical data].

Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica20100801

Title: Clinical safety, tolerability, pharmacokinetics, and pharmacodynamics of the novel factor Xa inhibitor edoxaban in healthy volunteers.

Journal: Journal of clinical pharmacology20100701

Title: Oral factor Xa inhibitors for the prevention of stroke in atrial fibrillation.

Journal: Current opinion in cardiology20100701

Title: New anticoagulants for atrial fibrillation.

Journal: Seminars in thrombosis and hemostasis20090701

Title: DU-176b, a potent and orally active factor Xa inhibitor: in vitro and in vivo pharmacological profiles.

Journal: Journal of thrombosis and haemostasis : JTH20080901

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