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49627-27-2,MFCD00869764
Catalog No.:AA006ZF1

49627-27-2 | 1H-Indene-3-aceticacid, 5-fluoro-2-methyl-1-[[4-(methylthio)phenyl]methylene]-, (1Z)-

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10mg
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50mg
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100mg
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA006ZF1
Chemical Name:
1H-Indene-3-aceticacid, 5-fluoro-2-methyl-1-[[4-(methylthio)phenyl]methylene]-, (1Z)-
CAS Number:
49627-27-2
Molecular Formula:
C20H17FO2S
Molecular Weight:
340.4112
MDL Number:
MFCD00869764
SMILES:
CSc1ccc(cc1)/C=C/1\c2ccc(cc2C(=C1C)CC(=O)O)F
NSC Number:
747692
Properties
Computed Properties
 
Complexity:
546  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
4  
XLogP3:
4.8  

Literature

Title: Silibinin induces apoptosis of HT29 colon carcinoma cells through early growth response-1 (EGR-1)-mediated non-steroidal anti-inflammatory drug-activated gene-1 (NAG-1) up-regulation.

Journal: Chemico-biological interactions 20140325

Title: Entrapment of human flavin-containing monooxygenase 3 in the presence of gold nanoparticles: TEM, FTIR and electrocatalysis.

Journal: Biochimica et biophysica acta 20121201

Title: Assessment of the involvement of oxidative stress and Mitogen-Activated Protein Kinase signaling pathways in the cytotoxic effects of arsenic trioxide and its combination with sulindac or its metabolites: sulindac sulfide and sulindac sulfone on human leukemic cell lines.

Journal: Medical oncology (Northwood, London, England) 20120601

Title: Docosahexaenoic acid sensitizes colon cancer cells to sulindac sulfide-induced apoptosis.

Journal: Oncology reports 20120601

Title: First and second generation γ-secretase modulators (GSMs) modulate amyloid-β (Aβ) peptide production through different mechanisms.

Journal: The Journal of biological chemistry 20120406

Title: Cyclooxygenase-1-selective inhibitors based on the (E)-2'-des-methyl-sulindac sulfide scaffold.

Journal: Journal of medicinal chemistry 20120308

Title: In vitro drug metabolism by C-terminally truncated human flavin-containing monooxygenase 3.

Journal: Biochemical pharmacology 20120215

Title: DNA methylation-mediated silencing of nonsteroidal anti-inflammatory drug-activated gene (NAG-1/GDF15) in glioma cell lines.

Journal: International journal of cancer 20120115

Title: The molecular basis for inhibition of sulindac and its metabolites towards human aldose reductase.

Journal: FEBS letters 20120102

Title: Substrate sequence influences γ-secretase modulator activity, role of the transmembrane domain of the amyloid precursor protein.

Journal: The Journal of biological chemistry 20111118

Title: Functional characterization of peroxisome proliferator-activated receptor-β/δ expression in colon cancer.

Journal: Molecular carcinogenesis 20111101

Title: The non-steroidal anti-inflammatory drugs Sulindac sulfide and Diclofenac induce apoptosis and differentiation in human acute myeloid leukemia cells through an AP-1 dependent pathway.

Journal: Apoptosis : an international journal on programmed cell death 20110901

Title: FOXO3 is inhibited by oncogenic PI3K/Akt signaling but can be reactivated by the NSAID sulindac sulfide.

Journal: The Journal of clinical endocrinology and metabolism 20110901

Title: Inhibition of PDE5 by sulindac sulfide selectively induces apoptosis and attenuates oncogenic Wnt/β-catenin-mediated transcription in human breast tumor cells.

Journal: Cancer prevention research (Philadelphia, Pa.) 20110801

Title: Sulindac and its metabolites: sulindac sulfide and sulindac sulfone enhance cytotoxic effects of arsenic trioxide on leukemic cell lines.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20110801

Title: Studies on the metabolism and biological activity of the epimers of sulindac.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20110601

Title: Sulindac sulfide induces autophagic death in gastric epithelial cells via survivin down-regulation: a mechanism of NSAIDs-induced gastric injury.

Journal: Biochemical pharmacology 20110601

Title: The dietary compounds resveratrol and genistein induce activating transcription factor 3 while suppressing inhibitor of DNA binding/differentiation-1.

Journal: Journal of medicinal food 20110601

Title: Inhibition of amyloidogenesis by nonsteroidal anti-inflammatory drugs and their hybrid nitrates.

Journal: Journal of medicinal chemistry 20110414

Title: Optimisation and validation of a fast HPLC method for the quantification of sulindac and its related impurities.

Journal: Journal of pharmaceutical and biomedical analysis 20110325

Title: [Antitumor effects of sulindac in ovarian cell cultures].

Journal: Ginekologia polska 20110301

Title: Role of nonsteroidal anti-inflammatory drug-activated gene-1 in docetaxel-induced cell death of human colorectal cancer cells with different p53 status.

Journal: Archives of pharmacal research 20110201

Title: Sulindac sulfide reverses aberrant self-renewal of progenitor cells induced by the AML-associated fusion proteins PML/RARα and PLZF/RARα.

Journal: PloS one 20110101

Title: Combinatorial effect of non-steroidal anti-inflammatory drugs and NF-κB inhibitors in ovarian cancer therapy.

Journal: PloS one 20110101

Title: Effect of sulindac sulfide on metallohydrolases in the human colon cancer cell line HT-29.

Journal: PloS one 20110101

Title: Therapeutic potential of sulindac hydroxamic acid against human pancreatic and colonic cancer cells.

Journal: European journal of medicinal chemistry 20101101

Title: Colon tumor cell growth-inhibitory activity of sulindac sulfide and other nonsteroidal anti-inflammatory drugs is associated with phosphodiesterase 5 inhibition.

Journal: Cancer prevention research (Philadelphia, Pa.) 20101001

Title: Sulindac and its metabolites inhibit multiple transport proteins in rat and human hepatocytes.

Journal: The Journal of pharmacology and experimental therapeutics 20100801

Title: Induction of p53-independent apoptosis by a novel synthetic hexahydrocannabinol analog is mediated via Sp1-dependent NSAID-activated gene-1 in colon cancer cells.

Journal: Biochemical pharmacology 20100701

Title: Design, synthesis, and biological evaluation of a novel class of gamma-secretase modulators with PPARgamma activity.

Journal: Journal of medicinal chemistry 20100624

Title: Oxidative stress is important in the pathogenesis of liver injury induced by sulindac and lipopolysaccharide cotreatment.

Journal: Toxicology 20100604

Title: The integrated stress response-associated signals modulates intestinal tumor cell growth by NSAID-activated gene 1 (NAG-1/MIC-1/PTGF-beta).

Journal: Carcinogenesis 20100401

Title: Sulindac metabolites induce proteosomal and lysosomal degradation of the epidermal growth factor receptor.

Journal: Cancer prevention research (Philadelphia, Pa.) 20100401

Title: Sulindac sulfide suppresses 5-lipoxygenase at clinically relevant concentrations.

Journal: Cellular and molecular life sciences : CMLS 20100301

Title: The cyclooxygenase inhibitor sulindac sulfide inhibits EP4 expression and suppresses the growth of glioblastoma cells.

Journal: Cancer prevention research (Philadelphia, Pa.) 20091201

Title: Sulindac sulfide selectively inhibits growth and induces apoptosis of human breast tumor cells by phosphodiesterase 5 inhibition, elevation of cyclic GMP, and activation of protein kinase G.

Journal: Molecular cancer therapeutics 20091201

Title: Up-regulation of GADD45alpha expression by NSAIDs leads to apoptotic and necrotic colon cancer cell deaths.

Journal: Apoptosis : an international journal on programmed cell death 20091101

Title: The influence of double bond geometry in the inhibition of cyclooxygenases by sulindac derivatives.

Journal: Bioorganic & medicinal chemistry letters 20090615

Title: Inhibitory effect of nonsteroidal anti-inflammatory drugs on adenosine transport in vascular smooth muscle cells.

Journal: European journal of pharmacology 20090610

Title: Inhibitory effects of 5-fluorouracil and oxaliplatin on human colorectal cancer cell survival are synergistically enhanced by sulindac sulfide.

Journal: Anticancer research 20090101

Title: Phosphatidylinositol acts through mitogen-activated protein kinase to stimulate hepatic apolipoprotein A-I secretion.

Journal: Metabolism: clinical and experimental 20081201

Title: Nonsteroidal anti-inflammatory drugs induced endothelial apoptosis by perturbing peroxisome proliferator-activated receptor-delta transcriptional pathway.

Journal: Molecular pharmacology 20081101

Title: Sulindac derivatives that activate the peroxisome proliferator-activated receptor gamma but lack cyclooxygenase inhibition.

Journal: Journal of medicinal chemistry 20080828

Title: Antiproliferative effect of sulindac in colonic neoplasia prevention: role of COOH-terminal Src kinase.

Journal: Molecular cancer therapeutics 20080701

Title: Cyclooxygenase inhibitors block uterine tumorigenesis in HMGA1a transgenic mice and human xenografts.

Journal: Molecular cancer therapeutics 20080701

Title: Interactions of sulindac and its metabolites with phospholipid membranes: an explanation for the peroxidation protective effect of the bioactive metabolite.

Journal: Free radical research 20080701

Title: Independent generation of Abeta42 and Abeta38 peptide species by gamma-secretase.

Journal: The Journal of biological chemistry 20080620

Title: Effects of sulindac sulfide on the membrane architecture and the activity of gamma-secretase.

Journal: Neuropharmacology 20080501

Title: Cyclooxygenase inhibitors induce apoptosis in sinonasal cancer cells by increased expression of nonsteroidal anti-inflammatory drug-activated gene.

Journal: International journal of cancer 20080415

Title: Growth compensatory role of sulindac sulfide-induced thrombospondin-1 linked with ERK1/2 and RhoA GTPase signaling pathways.

Journal: Life sciences 20080312

Title: Sulindac and its metabolites induce carcinogen metabolizing enzymes in human colon cancer cells.

Journal: International journal of cancer 20080301

Title: Antitumorigenic effects of peroxisome proliferator-activated receptor-gamma in non-small-cell lung cancer cells are mediated by suppression of cyclooxygenase-2 via inhibition of nuclear factor-kappaB.

Journal: Molecular pharmacology 20080301

Title: Non-steroidal anti-inflammatory drugs have potent anti-fibrillogenic and fibril-destabilizing effects for alpha-synuclein fibrils in vitro.

Journal: Neuropharmacology 20080301

Title: Generation of Abeta38 and Abeta42 is independently and differentially affected by familial Alzheimer disease-associated presenilin mutations and gamma-secretase modulation.

Journal: The Journal of biological chemistry 20080111

Title: Unique MAP Kinase binding sites.

Journal: Biochimica et biophysica acta 20080101

Title: Malignant transformation of normal enterocytes following downregulation of Bak expression.

Journal: Digestion 20080101

Title: Mitochondrial Ca2+ overload underlies Abeta oligomers neurotoxicity providing an unexpected mechanism of neuroprotection by NSAIDs.

Journal: PloS one 20080101

Title: Neuro-inflammation induced by lipopolysaccharide causes cognitive impairment through enhancement of beta-amyloid generation.

Journal: Journal of neuroinflammation 20080101

Title: Signal peptide peptidase and gamma-secretase share equivalent inhibitor binding pharmacology.

Journal: The Journal of biological chemistry 20071221

Title: Relative non-steroidal anti-inflammatory drug (NSAID) antiproliferative activity is mediated through p21-induced G1 arrest and E2F inhibition.

Journal: Molecular carcinogenesis 20071001

Title: Up-regulation of early growth response gene 1 (EGR-1) via ERK1/2 signals attenuates sulindac sulfide-mediated cytotoxicity in the human intestinal epithelial cells.

Journal: Toxicology and applied pharmacology 20070901

Title: Insensitivity to Abeta42-lowering nonsteroidal anti-inflammatory drugs and gamma-secretase inhibitors is common among aggressive presenilin-1 mutations.

Journal: The Journal of biological chemistry 20070824

Title: Desmethyl derivatives of indomethacin and sulindac as probes for cyclooxygenase-dependent biology.

Journal: ACS chemical biology 20070720

Title: Survivin is a downstream target and effector of sulindac-sensitive oncogenic Stat3 signalling in head and neck cancer.

Journal: International journal of oral and maxillofacial surgery 20070701

Title: Genetic polymorphisms of human flavin-containing monooxygenase 3: implications for drug metabolism and clinical perspectives.

Journal: Pharmacogenomics 20070601

Title: Nonsteroidal anti-inflammatory drugs induce colorectal cancer cell apoptosis by suppressing 14-3-3epsilon.

Journal: Cancer research 20070401

Title: Effect of genetic variants of the human flavin-containing monooxygenase 3 on N- and S-oxygenation activities.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20070301

Title: Differential activity of sulindac metabolites against squamous cell carcinoma of the head and neck is mediated by p21waf1/cip1 induction and cell cycle inhibition.

Journal: Cancer biology & therapy 20070101

Title: Intra- or intercomplex binding to the gamma-secretase enzyme. A model to differentiate inhibitor classes.

Journal: The Journal of biological chemistry 20061020

Title: Arachidonic acid-induced gene expression in colon cancer cells.

Journal: Carcinogenesis 20061001

Title: Mitochondrial uncoupling by the sulindac metabolite, sulindac sulfide.

Journal: Basic & clinical pharmacology & toxicology 20061001

Title: Proapoptotic activity of NAG-1 is cell type specific and not related to COX-2 expression.

Journal: Apoptosis : an international journal on programmed cell death 20060701

Title: Capillary electrophoresis combining field-amplified sample stacking and electroosmotic flow suppressant for analysis of sulindac and its two metabolites in plasma.

Journal: Journal of chromatography. A 20060630

Title: Differential targeting of protein kinase B in cell death induced by sulindac and its metabolite sulindac sulfide.

Journal: International journal of oncology 20060601

Title: Sulindac sulfide and exisulind inhibit expression of the estrogen and progesterone receptors in human breast cancer cells.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20060601

Title: The geminal dimethyl analogue of Flurbiprofen as a novel Abeta42 inhibitor and potential Alzheimer's disease modifying agent.

Journal: Bioorganic & medicinal chemistry letters 20060415

Title: Id-1 gene downregulation by sulindac sulfide and its upregulation during tumor development in gastric cancer.

Journal: International journal of cancer 20060315

Title: Antiangiogenic effect of sulindac sulfide could be secondary to induction of apoptosis and cell cycle arrest.

Journal: Anticancer research 20060101

Title: Both PPARgamma and PPARdelta influence sulindac sulfide-mediated p21WAF1/CIP1 upregulation in a human prostate epithelial cell line.

Journal: Oncogene 20051208

Title: Transcriptional regulation of activating transcription factor 3 involves the early growth response-1 gene.

Journal: The Journal of pharmacology and experimental therapeutics 20051101

Title: Indole-3-acetic acid antagonists of the prostaglandin D2 receptor CRTH2.

Journal: Journal of medicinal chemistry 20051006

Title: Sulindac sulfide-induced apoptosis is enhanced by a small-molecule Bcl-2 inhibitor and by TRAIL in human colon cancer cells overexpressing Bcl-2.

Journal: Molecular cancer therapeutics 20051001

Title: Suppression of tumor cell invasion by cyclooxygenase inhibitors is mediated by thrombospondin-1 via the early growth response gene Egr-1.

Journal: Molecular cancer therapeutics 20051001

Title: Activation of protein kinase G up-regulates expression of 15-lipoxygenase-1 in human colon cancer cells.

Journal: Cancer research 20050915

Title: Random mutagenesis of presenilin-1 identifies novel mutants exclusively generating long amyloid beta-peptides.

Journal: The Journal of biological chemistry 20050513

Title: The anti-invasive activity of cyclooxygenase inhibitors is regulated by the transcription factor ATF3 (activating transcription factor 3).

Journal: Molecular cancer therapeutics 20050501

Title: Uncoupling of oxidative phosphorylation and Smac/DIABLO release are not sufficient to account for induction of apoptosis by sulindac sulfide in human colorectal cancer cells.

Journal: International journal of oncology 20050401

Title: Structural determinants of arylacetic acid nonsteroidal anti-inflammatory drugs necessary for binding and activation of the prostaglandin D2 receptor CRTH2.

Journal: Molecular pharmacology 20050301

Title: The conventional nonsteroidal anti-inflammatory drug sulindac sulfide arrests ovarian cancer cell growth via the expression of NAG-1/MIC-1/GDF-15.

Journal: Molecular cancer therapeutics 20050301

Title: Mechanisms of sulindac-induced apoptosis and cell cycle arrest.

Journal: Cancer letters 20050227

Title: Cyclooxygenase inhibitors induce the expression of the tumor suppressor gene EGR-1, which results in the up-regulation of NAG-1, an antitumorigenic protein.

Journal: Molecular pharmacology 20050201

Title: Sulindac sulfide-induced apoptosis in sinonasal cancer cells.

Journal: Acta oto-laryngologica 20050201

Title: The cyclooxygenase inhibitor indomethacin modulates gene expression and represses the extracellular matrix protein laminin gamma1 in human glioblastoma cells.

Journal: Experimental cell research 20050115

Title: Selective inhibitors of MEK1/ERK44/42 and p38 mitogen-activated protein kinases potentiate apoptosis induction by sulindac sulfide in human colon carcinoma cells.

Journal: Molecular cancer therapeutics 20050101

Title: Cyclooxygenase inhibitors induce apoptosis in oral cavity cancer cells by increased expression of nonsteroidal anti-inflammatory drug-activated gene.

Journal: Biochemical and biophysical research communications 20041224

Title: Selective nonsteroidal anti-inflammatory drugs induce thymosin beta-4 and alter actin cytoskeletal organization in human colorectal cancer cells.

Journal: The Journal of pharmacology and experimental therapeutics 20041201

Title: Inhibition of extracellular-signal regulated kinases 1/2 is required for apoptosis of human colon cancer cells in vitro by sulindac metabolites.

Journal: Cancer research 20041115

Title: Non-steroidal anti-inflammatory drug activated gene (NAG-1) expression is closely related to death receptor-4 and -5 induction, which may explain sulindac sulfide induced gastric cancer cell apoptosis.

Journal: Carcinogenesis 20041001

Title: Purification and characterization of the human gamma-secretase complex.

Journal: Biochemistry 20040803

Title: Glutathione-S-transferase P1-1 protects aberrant crypt foci from apoptosis induced by deoxycholic acid.

Journal: Gastroenterology 20040801

Title: Effect of nonsteroidal anti-inflammatory drugs on beta-catenin protein levels and catenin-related transcription in human colorectal cancer cells.

Journal: British journal of cancer 20040705

Title: Combined effect of arsenic trioxide and sulindac sulfide in A549 human lung cancer cells in vitro.

Journal: Journal of experimental & clinical cancer research : CR 20040601

Title: Sulindac sulfide and caffeic acid phenethyl ester suppress the motility of lung adenocarcinoma cells promoted by transforming growth factor-beta through Akt inhibition.

Journal: Journal of cancer research and clinical oncology 20040301

Title: Sulindac targets nuclear beta-catenin accumulation and Wnt signalling in adenomas of patients with familial adenomatous polyposis and in human colorectal cancer cell lines.

Journal: British journal of cancer 20040112

Title: Modulation of beta-amyloid metabolism by non-steroidal anti-inflammatory drugs in neuronal cell cultures.

Journal: Journal of neurochemistry 20040101

Title: Reduction of Sulindac to its active metabolite, sulindac sulfide: assay and role of the methionine sulfoxide reductase system.

Journal: Biochemical and biophysical research communications 20031226

Title: Cox-2 is needed but not sufficient for apoptosis induced by Cox-2 selective inhibitors in colon cancer cells.

Journal: Apoptosis : an international journal on programmed cell death 20031201

Title: Nonsteroidal anti-inflammatory drugs can lower amyloidogenic Abeta42 by inhibiting Rho.

Journal: Science (New York, N.Y.) 20031114

Title: The metabolism of sulindac enhances its scavenging activity against reactive oxygen and nitrogen species.

Journal: Free radical biology & medicine 20031101

Title: Exisulind and related compounds inhibit expression and function of the androgen receptor in human prostate cancer cells.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20031015

Title: Sulindac metabolites induce caspase- and proteasome-dependent degradation of beta-catenin protein in human colon cancer cells.

Journal: Molecular cancer therapeutics 20030901

Title: Evidence that nonsteroidal anti-inflammatory drugs decrease amyloid beta 42 production by direct modulation of gamma-secretase activity.

Journal: The Journal of biological chemistry 20030822

Title: Abeta42-lowering nonsteroidal anti-inflammatory drugs preserve intramembrane cleavage of the amyloid precursor protein (APP) and ErbB-4 receptor and signaling through the APP intracellular domain.

Journal: The Journal of biological chemistry 20030815

Title: Gene modulation by the cyclooxygenase inhibitor, sulindac sulfide, in human colorectal carcinoma cells: possible link to apoptosis.

Journal: The Journal of biological chemistry 20030711

Title: Sulindac sulfide is a noncompetitive gamma-secretase inhibitor that preferentially reduces Abeta 42 generation.

Journal: The Journal of biological chemistry 20030516

Title: Mesalazine causes a mitotic arrest and induces caspase-dependent apoptosis in colon carcinoma cells.

Journal: Carcinogenesis 20030301

Title: Sulindac sulfide inhibits epidermal growth factor-induced phosphorylation of extracellular-regulated kinase 1/2 and Bad in human colon cancer cells.

Journal: Cancer research 20030201

Title: Peroxisome proliferator-activated receptor-gamma is a target of nonsteroidal anti-inflammatory drugs mediating cyclooxygenase-independent inhibition of lung cancer cell growth.

Journal: Molecular pharmacology 20021101

Title: Cyclooxygenase-2 overexpression reduces apoptotic susceptibility by inhibiting the cytochrome c-dependent apoptotic pathway in human colon cancer cells.

Journal: Cancer research 20021101

Title: Apo2L/TRAIL differentially modulates the apoptotic effects of sulindac and a COX-2 selective non-steroidal anti-inflammatory agent in Bax-deficient cells.

Journal: Oncogene 20020905

Title: Cyclooxygenase-2 overexpression inhibits death receptor 5 expression and confers resistance to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human colon cancer cells.

Journal: Cancer research 20020901

Title: Constitutive activation of NF-kappaB in Ki-ras-transformed prostate epithelial cells.

Journal: Oncogene 20020704

Title: Sulindac derivative-induced apoptosis in a human umbilical vein endothelial cell line ECV304.

Journal: Chinese medical journal 20020701

Title: PPARgamma-mediated antineoplastic effect of NSAID sulindac on human oral squamous carcinoma cells.

Journal: International journal of cancer 20020420

Title: Diallyl disulfide (DADS) induces the antitumorigenic NSAID-activated gene (NAG-1) by a p53-dependent mechanism in human colorectal HCT 116 cells.

Journal: The Journal of nutrition 20020401

Title: Requirement of BAX for TRAIL/Apo2L-induced apoptosis of colorectal cancers: synergism with sulindac-mediated inhibition of Bcl-x(L).

Journal: Cancer research 20020315

Title: Resveratrol enhances the expression of non-steroidal anti-inflammatory drug-activated gene (NAG-1) by increasing the expression of p53.

Journal: Carcinogenesis 20020301

Title: New indene-derivatives with anti-proliferative properties.

Journal: Bioorganic & medicinal chemistry letters 20020225

Title: Inhibition of cell transformation by sulindac sulfide is confined to specific oncogenic pathways.

Journal: Cancer letters 20020110

Title: Sulindac induces apoptosis, inhibits proliferation and activates caspase-3 in Hep G2 cells.

Journal: Anticancer research 20020101

Title: Progression and NSAID-induced apoptosis in malignant melanomas are independent of cyclooxygenase II.

Journal: Melanoma research 20011201

Title: A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity.

Journal: Nature 20011108

Title: A Fas-associated death domain protein-dependent mechanism mediates the apoptotic action of non-steroidal anti-inflammatory drugs in the human leukemic Jurkat cell line.

Journal: The Journal of biological chemistry 20011019

Title: Sulindac sulfide-induced apoptosis involves death receptor 5 and the caspase 8-dependent pathway in human colon and prostate cancer cells.

Journal: Cancer research 20010915

Title: Autophagy delays sulindac sulfide-induced apoptosis in the human intestinal colon cancer cell line HT-29.

Journal: Experimental cell research 20010815

Title: Inhibition of store-operated calcium entry contributes to the anti-proliferative effect of non-steroidal anti-inflammatory drugs in human colon cancer cells.

Journal: International journal of cancer 20010615

Title: Inhibition of extracellular signal-regulated kinase 1/2 phosphorylation and induction of apoptosis by sulindac metabolites.

Journal: Cancer research 20010215

Title: Chemoprevention of intestinal polyposis in the Apcdelta716 mouse by rofecoxib, a specific cyclooxygenase-2 inhibitor.

Journal: Cancer research 20010215

Title: Antiproliferative effects of S-allylmercaptocysteine on colon cancer cells when tested alone or in combination with sulindac sulfide.

Journal: Cancer research 20010115

Title: Induction of apoptosis by sulindac sulfide in HL60 cells is enhanced by p21CiP1 or p27KiP1.

Journal: Anticancer research 20010101

Title: Growth-suppressive effect of non-steroidal anti-inflammatory drugs on 11 colon-cancer cell lines and fluorescence differential display of genes whose expression is influenced by sulindac.

Journal: International journal of cancer 20001215

Title: Sulindac sulfone inhibits K-ras-dependent cyclooxygenase-2 expression in human colon cancer cells.

Journal: Cancer research 20001201

Title: Cyclic GMP mediates apoptosis induced by sulindac derivatives via activation of c-Jun NH2-terminal kinase 1.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20001001

Title: Two opposing effects of non-steroidal anti-inflammatory drugs on the expression of the inducible cyclooxygenase. Mediation through different signaling pathways.

Journal: The Journal of biological chemistry 20000908

Title: Par-4, a proapoptotic gene, is regulated by NSAIDs in human colon carcinoma cells.

Journal: Gastroenterology 20000601

Title: The effect of NSAIDs and a COX-2 specific inhibitor on Helicobacter pylori-induced PGE2 and HGF in human gastric fibroblasts.

Journal: Alimentary pharmacology & therapeutics 20000401

Title: Colon cancer chemopreventive drugs modulate integrin-mediated signaling pathways.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20000301

Title: PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs.

Journal: Cell 19991029

Title: Increased cyclooxygenase-2 expression in human pancreatic carcinomas and cell lines: growth inhibition by nonsteroidal anti-inflammatory drugs.

Journal: Cancer research 19990901

Title: Chemopreventive efficacy of sulindac sulfone against colon cancer depends on time of administration during carcinogenic process.

Journal: Cancer research 19990715

Title: Apoptosis primarily accounts for the growth-inhibitory properties of sulindac metabolites and involves a mechanism that is independent of cyclooxygenase inhibition, cell cycle arrest, and p53 induction.

Journal: Cancer research 19970615

Title: Takahashi Y, et al. Sulindac sulfide is a noncompetitive gamma-secretase inhibitor that preferentially reduces Abeta 42 generation. J Biol Chem. 2003 May 16;278(20):18664-70.

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SDS
Tags:49627-27-2 Molecular Formula|49627-27-2 MDL|49627-27-2 SMILES|49627-27-2 1H-Indene-3-aceticacid, 5-fluoro-2-methyl-1-[[4-(methylthio)phenyl]methylene]-, (1Z)-