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512-04-9,MFCD00016887
Catalog No.:AA0037NF

512-04-9 | Diosgenin

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Purity
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5g
98%
in stock  
$14.00   $10.00
- +
25g
98%
in stock  
$26.00   $18.00
- +
100g
98%
in stock  
$83.00   $58.00
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500g
98%
in stock  
$269.00   $188.00
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  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA0037NF
Chemical Name:
Diosgenin
CAS Number:
512-04-9
Molecular Formula:
C27H42O3
Molecular Weight:
414.6206
MDL Number:
MFCD00016887
SMILES:
C[C@@H]1CC[C@@]2(OC1)O[C@@H]1[C@H]([C@@H]2C)[C@@]2([C@@H](C1)[C@@H]1CC=C3[C@]([C@H]1CC2)(C)CC[C@@H](C3)O)C
Properties
Properties
 
BP:
527.1°C at 760 mmHg  
Form:
Solid  
MP:
205-208°C  
Refractive Index:
1.4700 (estimate)  
Solubility:
chloroform: 20 mg/mL, clear, slightly yellow  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
746  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
11  
Heavy Atom Count:
30  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
XLogP3:
5.7  

Upstream Synthesis Route

[1]CarbohydrateResearch,1998,vol.306,#1-2,p.189-195

[1]MedicinalChemistryResearch,2011,vol.20,#7,p.817-825

Downstream Synthesis Route
14227-66-8    512-04-9   
C53H76O20 

[1]JournalofMedicinalChemistry,1997,vol.40,p.2547-2554

64-17-5    512-04-9   
palladium/charcoal 
  77-60-1 

[1]YakugakuZasshi/JournalofthePharmaceuticalSocietyofJapan,1936,vol.56,p.931,937    dtsch.Ref.:J.pharm.Soc.Japan,1937,vol.57,p.9,15    ChemischesZentralblatt,1937,vol.108,p.4238

64-19-7    512-04-9   
palladium/charcoal 
  77-60-1 

[1]YakugakuZasshi/JournalofthePharmaceuticalSocietyofJapan,1936,vol.56,p.931,937    dtsch.Ref.:J.pharm.Soc.Japan,1937,vol.57,p.9,15    ChemischesZentralblatt,1937,vol.108,p.4238

64-17-5    512-04-9   
platinum 
  77-60-1 

[1]YakugakuZasshi/JournalofthePharmaceuticalSocietyofJapan,1936,vol.56,p.931,937    dtsch.Ref.:J.pharm.Soc.Japan,1937,vol.57,p.9,15    ChemischesZentralblatt,1937,vol.108,p.4238

64-19-7    512-04-9   
platinum 
  77-60-1 

[1]YakugakuZasshi/JournalofthePharmaceuticalSocietyofJapan,1936,vol.56,p.931,937    dtsch.Ref.:J.pharm.Soc.Japan,1937,vol.57,p.9,15    ChemischesZentralblatt,1937,vol.108,p.4238

Literature

Title: Protective effects of dioscin against doxorubicin-induced nephrotoxicity via adjusting FXR-mediated oxidative stress and inflammation.

Journal: Toxicology 20170301

Title: Polyphyllin I induces cell cycle arrest and apoptosis in human myeloma cells via modulating β-catenin signaling pathway.

Journal: European journal of haematology 20161001

Title: Dioscin protects against ANIT-induced cholestasis via regulating Oatps, Mrp2 and Bsep expression in rats.

Journal: Toxicology and applied pharmacology 20160815

Title: Effect of diosgenin on metabolic dysfunction: Role of ERβ in the regulation of PPARγ.

Journal: Toxicology and applied pharmacology 20151201

Title: Transmembrane transport of steviol glucuronide and its potential interaction with selected drugs and natural compounds.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20151201

Title: Isolation and prevention of calcium oxalate-induced apoptotic death and oxidative stress in MDCK cells by diosgenin.

Journal: Chemico-biological interactions 20141205

Title: Dioscin inhibits colon tumor growth and tumor angiogenesis through regulating VEGFR2 and AKT/MAPK signaling pathways.

Journal: Toxicology and applied pharmacology 20141201

Title: Dioscin enhances methotrexate absorption by down-regulating MDR1 in vitro and in vivo.

Journal: Toxicology and applied pharmacology 20140601

Title: Protective effects of dioscin against alcohol-induced liver injury.

Journal: Archives of toxicology 20140301

Title: Dioscin promotes osteoblastic proliferation and differentiation via Lrp5 and ER pathway in mouse and human osteoblast-like cell lines.

Journal: Journal of biomedical science 20140101

Title: PPAR's and Diosgenin a chemico biological insight in NIDDM.

Journal: Chemico-biological interactions 20131125

Title: Cytotoxicity of dioscin in human gastric carcinoma cells through death receptor and mitochondrial pathways.

Journal: Journal of applied toxicology : JAT 20130801

Title: Dioscin's antiviral effect in vitro.

Journal: Virus research 20130301

Title: The antifungal activity and membrane-disruptive action of dioscin extracted from Dioscorea nipponica.

Journal: Biochimica et biophysica acta 20130301

Title: Caveats of using acetaminophen hepatotoxicity models for natural product testing.

Journal: Toxicology letters 20121123

Title: Dioscin, a natural steroid saponin, shows remarkable protective effect against acetaminophen-induced liver damage in vitro and in vivo.

Journal: Toxicology letters 20121002

Title: Cytotoxicity and apoptosis-inducing effect of steroidal saponins from Dioscorea zingiberensis Wright against cancer cells.

Journal: Steroids 20121001

Title: Molluscicidal activity of Balanites aegyptiaca against Monacha cartusiana.

Journal: Pharmaceutical biology 20121001

Title: Beneficial role of diosgenin on oxidative stress in aorta of streptozotocin induced diabetic rats.

Journal: European journal of pharmacology 20120915

Title: Simultaneous quantification of Polyphyllin D and Paris H, two potential antitumor active components in Paris polyphylla by liquid chromatography-tandem mass spectrometry and the application to pharmacokinetics in rats.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120915

Title: Dioscin: a synergistic tyrosinase inhibitor from the roots of Smilax china.

Journal: Food chemistry 20120915

Title: Solanum incanum and S. heteracanthum as sources of biologically active steroid glycosides: confirmation of their synonymy.

Journal: Fitoterapia 20120901

Title: Application of hypoiodite-mediated aminyl radical cyclization to synthesis of solasodine acetate.

Journal: Steroids 20120901

Title: Steroidal saponins from Paris polyphylla var. yunnanensis.

Journal: Phytochemistry 20120901

Title: Diosgenin ameliorates palmitate-induced endothelial dysfunction and insulin resistance via blocking IKKβ and IRS-1 pathways.

Journal: Atherosclerosis 20120801

Title: Synthesis and selective anticancer activity of steroidal glycoconjugates.

Journal: European journal of medicinal chemistry 20120801

Title: Diosgenin hemihydrate.

Journal: Acta crystallographica. Section E, Structure reports online 20120801

Title: Paris saponin II of Rhizoma Paridis--a novel inducer of apoptosis in human ovarian cancer cells.

Journal: Bioscience trends 20120801

Title: Small molecular weight PEGylation of diosgenin in an in vivo animal study for diabetic auditory impairment treatment.

Journal: Bioorganic & medicinal chemistry letters 20120715

Title: Diosgenin promotes oligodendrocyte progenitor cell differentiation through estrogen receptor-mediated ERK1/2 activation to accelerate remyelination.

Journal: Glia 20120701

Title: In vitro propagation of Dioscorea alata var. purpurae.

Journal: Applied biochemistry and biotechnology 20120701

Title: Chemical characteristics of saponins from Paris fargesii var. brevipetala and cytotoxic activity of its main ingredient, paris saponin H.

Journal: Fitoterapia 20120601

Title: Cationic lipids containing cyclen and ammonium moieties as gene delivery vectors.

Journal: Chemical biology & drug design 20120601

Title: A 90-day subchronic toxicological assessment of dioscin, a natural steroid saponin, in Sprague-Dawley rats.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120501

Title: Behavioral and IL-2 responses to diosgenin in ovariectomized rats.

Journal: The Chinese journal of physiology 20120430

Title: Anti-tumour and anti-oxidative potential of diosgenin against 7, 12-dimethylbenz(a)anthracene induced experimental oral carcinogenesis.

Journal: Pathology oncology research : POR 20120401

Title: Regioselective cleavage of 22-oxo-23-spiroketals. Novel cholestanic frameworks with pyranone and cyclopentenone E rings on the side chain.

Journal: Steroids 20120401

Title: [Novel derivatives of diosgenin: design, synthesis and anti-tumor activity].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20120401

Title: Antitumor promoting potential of selected phytochemicals derived from spices: a review.

Journal: European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 20120301

Title: A novel β-glucosidase from Aspergillus fumigates releases diosgenin from spirostanosides of Dioscorea zingiberensis C. H. Wright (DZW).

Journal: World journal of microbiology & biotechnology 20120301

Title: Diosgenin induces apoptosis in IGF-1-stimulated human thyrocytes through two caspase-dependent pathways.

Journal: Biochemical and biophysical research communications 20120210

Title: Improved production of transgenic Dioscorea zingiberensis (Dioscoreaceae) by Agrobacterium tumefaciens-mediated transformation.

Journal: Genetics and molecular research : GMR 20120203

Title: Triterpene saponins of Quillaja saponaria show strong aphicidal and deterrent activity against the pea aphid Acyrthosiphon pisum.

Journal: Pest management science 20120201

Title: Dioscin induces cancer cell apoptosis through elevated oxidative stress mediated by downregulation of peroxiredoxins.

Journal: Cancer biology & therapy 20120201

Title: Caprospinol: discovery of a steroid drug candidate to treat Alzheimer's disease based on 22R-hydroxycholesterol structure and properties.

Journal: Journal of neuroendocrinology 20120101

Title: Antidiabetic Activity of Gnidia glauca and Dioscorea bulbifera: Potent Amylase and Glucosidase Inhibitors.

Journal: Evidence-based complementary and alternative medicine : eCAM 20120101

Title: Effects of auxins on the production of steroidal alkaloids in rapidly proliferating tissue and cell cultures of Solanum lyratum.

Journal: Phytochemical analysis : PCA 20120101

Title: Saponins do not affect the ecdysteroid receptor complex but cause membrane permeation in insect culture cell lines.

Journal: Journal of insect physiology 20120101

Title: Cancer cell signaling pathways targeted by spice-derived nutraceuticals.

Journal: Nutrition and cancer 20120101

Title: Conversion of spirostane and solanidane into pregnane (1)introduction of oxygen function into C-23.

Journal: Chemical & pharmaceutical bulletin 20120101

Title: Anti-tumour and immunomodulating activities of diosgenin, a naturally occurring steroidal saponin.

Journal: Natural product research 20120101

Title: Study of lipid profile and parieto-temporal lipid peroxidation in AlCl₃ mediated neurotoxicity. Modulatory effect of fenugreek seeds.

Journal: Lipids in health and disease 20120101

Title: Synthesis of silver nanoparticles using Dioscorea bulbifera tuber extract and evaluation of its synergistic potential in combination with antimicrobial agents.

Journal: International journal of nanomedicine 20120101

Title: Current approaches toward production of secondary plant metabolites.

Journal: Journal of pharmacy & bioallied sciences 20120101

Title: Antimicrobial activity of sesquiterpene lactones isolated from traditional medicinal plant, Costus speciosus (Koen ex.Retz.) Sm.

Journal: BMC complementary and alternative medicine 20120101

Title: Application of high-speed countercurrent chromatography-evaporative light scattering detection for the separation of seven steroidal saponins from Dioscorea villosa.

Journal: Phytochemical analysis : PCA 20120101

Title: Phytochemicals from plants to combat cardiovascular disease.

Journal: Current medicinal chemistry 20120101

Title: Two new steroidal saponins from the biotransformation product of the rhizomes of Dioscorea nipponica.

Journal: Journal of Asian natural products research 20120101

Title: Solanum lyratum Extracts Induce Extrinsic and Intrinsic Pathways of Apoptosis in WEHI-3 Murine Leukemia Cells and Inhibit Allograft Tumor.

Journal: Evidence-based complementary and alternative medicine : eCAM 20120101

Title: Functional herbal food ingredients used in type 2 diabetes mellitus.

Journal: Pharmacognosy reviews 20120101

Title: Diosgenin Induces Apoptosis in HepG2 Cells through Generation of Reactive Oxygen Species and Mitochondrial Pathway.

Journal: Evidence-based complementary and alternative medicine : eCAM 20120101

Title: Effects of various asparagus production methods on rutin and protodioscin contents in spears and cladophylls.

Journal: Bioscience, biotechnology, and biochemistry 20120101

Title: Extraction optimization of water-extracted mycelial polysaccharide from endophytic fungus Fusarium oxysporum Dzf17 by response surface methodology.

Journal: International journal of molecular sciences 20120101

Title: Anti-proliferation and anti-invasion effects of diosgenin on gastric cancer BGC-823 cells with HIF-1α shRNAs.

Journal: International journal of molecular sciences 20120101

Title: Diosgenin is an exogenous activator of 1,25D₃-MARRS/Pdia3/ERp57 and improves Alzheimer's disease pathologies in 5XFAD mice.

Journal: Scientific reports 20120101

Title: Antineoplastic and apoptotic potential of traditional medicines thymoquinone and diosgenin in squamous cell carcinoma.

Journal: PloS one 20120101

Title: Enhancement of diosgenin production in Dioscorea zingiberensis cell cultures by oligosaccharides from its endophytic fungus Fusarium oxysporum Dzf17.

Journal: Molecules (Basel, Switzerland) 20111219

Title: Paris saponin I induces G₂/M cell cycle arrest and apoptosis in human gastric carcinoma SGC7901 cells.

Journal: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20111201

Title: Diosgenin stimulates osteogenic activity by increasing bone matrix protein synthesis and bone-specific transcription factor Runx2 in osteoblastic MC3T3-E1 cells.

Journal: The Journal of nutritional biochemistry 20111101

Title: Microbial transformations of diosgenin by the white-rot basidiomycete Coriolus versicolor.

Journal: Journal of natural products 20111028

Title: Effects of polysaccharide elicitors from endophytic Fusarium oxysporium Dzf17 on growth and diosgenin production in cell suspension culture of Dioscorea zingiberensis.

Journal: Molecules (Basel, Switzerland) 20111026

Title: Paris chinensis dioscin induces G2/M cell cycle arrest and apoptosis in human gastric cancer SGC-7901 cells.

Journal: World journal of gastroenterology 20111021

Title: Relative feeding and development of armyworm on switchgrass and corn, and its potential effects on switchgrass grown for biomass.

Journal: Journal of economic entomology 20111001

Title: Osteoprotective effect of Monascus-fermented dioscorea in ovariectomized rat model of postmenopausal osteoporosis.

Journal: Journal of agricultural and food chemistry 20110914

Title: Polyphyllin D, a steroidal saponin from Paris polyphylla, inhibits endothelial cell functions in vitro and angiogenesis in zebrafish embryos in vivo.

Journal: Journal of ethnopharmacology 20110901

Title: Synthesis and biological evaluation of the glycoside (25R)-3β,16β-diacetoxy-22-oxocholest-5-en-26-yl β-d-glucopyranoside: a selective anticancer agent in cervicouterine cell lines.

Journal: European journal of medicinal chemistry 20110901

Title: Cationic lipids containing protonated cyclen and different hydrophobic groups linked by uracil-PNA monomer: synthesis and application for gene delivery.

Journal: European journal of medicinal chemistry 20110901

Title: Pedalium murex Linn.: an overview of its phytopharmacological aspects.

Journal: Asian Pacific journal of tropical medicine 20110901

Title: In vitro & in vivo estrogenic activity of glycoside fractions of Solanum nigrum fruit.

Journal: The Indian journal of medical research 20110901

Title: Novel cationic lipids possessing protonated cyclen and imidazolium salt for gene delivery.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20110801

Title: Synthesis, antiproliferative activity, acute toxicity and assessment of the antiandrogenic activities of new androstane derivatives.

Journal: Archives of pharmacal research 20110701

Title: Cytotoxicity of active ingredients extracted from plants of the Brazilian 'Cerrado'.

Journal: Natural product communications 20110701

Title: [Anti-inflammatory and analgesic effects of saponins from D. zingiberensis C. H. Wright and diosgenin derivative on mice].

Journal: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20110701

Title: Chemoprevention of azoxymethane/dextran sodium sulfate-induced mouse colon carcinogenesis by freeze-dried yam sanyaku and its constituent diosgenin.

Journal: Cancer prevention research (Philadelphia, Pa.) 20110601

Title: The effects of wild ginger (Costus speciosus (Koen) Smith) rhizome extract and diosgenin on rat uterine contractions.

Journal: Reproductive sciences (Thousand Oaks, Calif.) 20110601

Title: Identification of antiplatelet and acetylcholinesterase inhibitory constituents in betel nut.

Journal: Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20110601

Title: Effects of diosgenin on cell proliferation induced by IGF-1 in primary human thyrocytes.

Journal: Archives of pharmacal research 20110601

Title: Diosgenin suppresses hepatocyte growth factor (HGF)-induced epithelial-mesenchymal transition by down-regulation of Mdm2 and vimentin.

Journal: Journal of agricultural and food chemistry 20110525

Title: Total synthesis of solamargine.

Journal: Bioorganic & medicinal chemistry letters 20110515

Title: [Structure-activity relationship of diosgenin derivatives as Bcl-2 antagonists].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20110501

Title: [Studies on the chemical constituents from the flowers of Ophiopogon japonicus].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20110501

Title: Diosgenin, a plant-derived sapogenin, exhibits antiviral activity in vitro against hepatitis C virus.

Journal: Journal of natural products 20110425

Title: Anti-thrombosis effect of diosgenin extract from Dioscorea zingiberensis C.H. Wright in vitro and in vivo.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20110415

Title: Effect of Dioscorea opposita Thunb. (yam) supplementation on physicochemical and sensory characteristics of yogurt.

Journal: Journal of dairy science 20110401

Title: [Determination of diosgenin and ruscogenin in Radix Ophiopogonis by nonaqueous capillary electrophoresis].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20110401

Title: [Effects of organic solvents on proliferation of Hela cells line].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20110401

Title: The hypocholesterolemic and antioxidative effect of dietary diosgenin and chromium chloride supplementation on high-cholesterol fed Japanese quails.

Journal: Pakistan journal of biological sciences : PJBS 20110401

Title: Formosanin C-inhibited pulmonary metastasis through repression of matrix metalloproteinases on mouse lung adenocarcinoma.

Journal: Cancer biology & therapy 20110315

Title: Reversal effect of Dioscin on multidrug resistance in human hepatoma HepG2/adriamycin cells.

Journal: European journal of pharmacology 20110305

Title: Application of proteomic and bioinformatic techniques for studying the hepatoprotective effect of dioscin against CCl₄-induced liver damage in mice.

Journal: Planta medica 20110301

Title: Diosgenin modulates vascular smooth muscle cell function by regulating cell viability, migration, and calcium homeostasis.

Journal: The Journal of pharmacology and experimental therapeutics 20110301

Title: Microbial transformation of diosgenin by filamentous fungus Cunninghamella echinulata.

Journal: Journal of Asian natural products research 20110301

Title: Biochemical monitoring in fenugreek to develop functional food and medicinal plant variants.

Journal: New biotechnology 20110227

Title: Diosgenin induces death receptor-5 through activation of p38 pathway and promotes TRAIL-induced apoptosis in colon cancer cells.

Journal: Cancer letters 20110227

Title: The effect of fenugreek on the gene expression of arachidonic acid metabolizing enzymes.

Journal: Phytotherapy research : PTR 20110201

Title: Synthesis of new symmetrical bis-steroidal pyrazine analogues from diosgenin.

Journal: Steroids 20110201

Title: Plant-derived bioactive compounds produced by endophytic fungi.

Journal: Mini reviews in medicinal chemistry 20110201

Title: The synthesis of cholestane and furostan saponin analogues and the determination of sapogenin's absolute configuration at C-22.

Journal: Steroids 20110101

Title: Simultaneous analysis of diosgenin and sarsasapogenin in Asparagus officinalis byproduct by thin-layer chromatography.

Journal: Phytochemical analysis : PCA 20110101

Title: Antiproliferative effects of some novel synthetic solanidine analogs on HL-60 human leukemia cells in vitro.

Journal: Steroids 20110101

Title: Toxic compound, anti-nutritional factors and functional properties of protein isolated from detoxified Jatropha curcas seed cake.

Journal: International journal of molecular sciences 20110101

Title: New challenges in the new year for Phcog Mag.: 5 years of quality publication.

Journal: Pharmacognosy magazine 20110101

Title: A growth factor attenuates HIV-1 Tat and morphine induced damage to human neurons: implication in HIV/AIDS-drug abuse cases.

Journal: PloS one 20110101

Title: Traditional chinese medicines in treatment of patients with type 2 diabetes mellitus.

Journal: Evidence-based complementary and alternative medicine : eCAM 20110101

Title: Diosgenin ameliorates cognition deficit and attenuates oxidative damage in senescent mice induced by D-galactose.

Journal: The American journal of Chinese medicine 20110101

Title: Diosgenin, a steroidal saponin, inhibits migration and invasion of human prostate cancer PC-3 cells by reducing matrix metalloproteinases expression.

Journal: PloS one 20110101

Title: In Vitro and In Vivo Antimalarial Activity Assays of Seeds from Balanites aegyptiaca: Compounds of the Extract Show Growth Inhibition and Activity against Plasmodial Aminopeptidase.

Journal: Journal of parasitology research 20110101

Title: Antihypertriglyceridemia and anti-inflammatory activities of monascus-fermented dioscorea in streptozotocin-induced diabetic rats.

Journal: Experimental diabetes research 20110101

Title: Dioscorea phytocompounds enhance murine splenocyte proliferation ex vivo and improve regeneration of bone marrow cells in vivo.

Journal: Evidence-based complementary and alternative medicine : eCAM 20110101

Title: Effects of diosgenin on myometrial matrix metalloproteinase-2 and -9 activity and expression in ovariectomized rats.

Journal: International journal of biological sciences 20110101

Title: Influence of Momordica charantia on oxidative stress-induced perturbations in brain monoamines and plasma corticosterone in albino rats.

Journal: Indian journal of pharmacology 20110101

Title: Apoptosis of human ovarian cancer cells induced by Paris chinensis dioscin via a Ca(2+)-mediated mitochondrion pathway.

Journal: Asian Pacific journal of cancer prevention : APJCP 20110101

Title: Diosgenin from Dioscorea nipponica ameliorates diabetic neuropathy by inducing nerve growth factor.

Journal: Biological & pharmaceutical bulletin 20110101

Title: A potent inhibitor of SIK2, 3, 3', 7-trihydroxy-4'-methoxyflavon (4'-O-methylfisetin), promotes melanogenesis in B16F10 melanoma cells.

Journal: PloS one 20110101

Title: The chloroform fraction of Solanum nigrum suppresses nitric oxide and tumor necrosis factor-α in LPS-stimulated mouse peritoneal macrophages through inhibition of p38, JNK and ERK1/2.

Journal: The American journal of Chinese medicine 20110101

Title: Fractalkine/CX3CL1 protects striatal neurons from synergistic morphine and HIV-1 Tat-induced dendritic losses and death.

Journal: Molecular neurodegeneration 20110101

Title: A review on Balanites aegyptiaca Del (desert date): phytochemical constituents, traditional uses, and pharmacological activity.

Journal: Pharmacognosy reviews 20110101

Title: Dose-dependent effects, safety and tolerability of fenugreek in diet-induced metabolic disorders in rats.

Journal: Lipids in health and disease 20110101

Title: Alzheimer's Disease: APP, Gamma Secretase, APOE, CLU, CR1, PICALM, ABCA7, BIN1, CD2AP, CD33, EPHA1, and MS4A2, and Their Relationships with Herpes Simplex, C. Pneumoniae, Other Suspect Pathogens, and the Immune System.

Journal: International journal of Alzheimer's disease 20110101

Title: Anthelmintic activity of steroidal saponins from Paris polyphylla.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20101201

Title: Diosgenin present in fenugreek improves glucose metabolism by promoting adipocyte differentiation and inhibiting inflammation in adipose tissues.

Journal: Molecular nutrition & food research 20101101

Title: Determination of diosgenin content in medicinal plants with enzyme-linked immunosorbent assay.

Journal: Planta medica 20101101

Title: Effects of polyphyllin I on growth inhibition of human non-small lung cancer cells and in xenograft.

Journal: Acta biochimica et biophysica Sinica 20101101

Title: Antihyperlipidemic effect of protodioscin, an active ingredient isolated from the rhizomes of Dioscorea nipponica.

Journal: Planta medica 20101001

Title: Chemical study and medical application of saponins as anti-cancer agents.

Journal: Fitoterapia 20101001

Title: Investigating the relationship between cell cycle stage and diosgenin-induced megakaryocytic differentiation of HEL cells using sedimentation field-flow fractionation.

Journal: Analytical and bioanalytical chemistry 20101001

Title: Targeting inflammatory pathways by triterpenoids for prevention and treatment of cancer.

Journal: Toxins 20101001

Title: [Protein and creatine supplements and erroneous diagnosis of kidney diseases].

Journal: Praxis 20100908

Title: Diosgenin inhibits macrophage-derived inflammatory mediators through downregulation of CK2, JNK, NF-kappaB and AP-1 activation.

Journal: International immunopharmacology 20100901

Title: Top 10 botanical ingredients in 2010 anti-aging creams.

Journal: Journal of cosmetic dermatology 20100901

Title: [Them man and the root bulb that gave the idea of the oral contraceptive pill].

Journal: Lakartidningen 20100901

Title: Apoptosis inducing activity of steroidal constituents from Solanum xanthocarpum and Asparagus racemosus.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20100801

Title: A sensitive indirect competitive enzyme-linked immunosorbent assay for the detection of sarsasapogenin in rat plasma.

Journal: Acta pharmacologica Sinica 20100801

Title: Steroidal saponins from two species of Dracaena.

Journal: Journal of natural products 20100723

Title: One unique steroidal sapogenin obtained through the microbial transformation of ruscogenin by Phytophthora cactorum ATCC 32134 and its potential inhibitory effect on tissue factor (TF) procoagulant activity.

Journal: Bioorganic & medicinal chemistry letters 20100715

Title: Diosgenin, a steroidal saponin, inhibits STAT3 signaling pathway leading to suppression of proliferation and chemosensitization of human hepatocellular carcinoma cells.

Journal: Cancer letters 20100628

Title: Diosgenin, a plant-derived sapogenin, enhances regulatory T-cell immunity in the intestine of mice with food allergy.

Journal: Journal of natural products 20100625

Title: Some biomedical applications of Balanites aegyptiaca grown naturally in radioactive area, Southeastern Desert, Egypt.

Journal: Journal of hazardous materials 20100615

Title: Process optimization for the production of diosgenin with Trichoderma reesei.

Journal: Bioprocess and biosystems engineering 20100601

Title: Diosgenin attenuates inflammatory changes in the interaction between adipocytes and macrophages.

Journal: Molecular nutrition & food research 20100601

Title: Synthesis, antiproliferative, acute toxicity and assessment of antiandrogenic activities of some newly synthesized steroidal lactams.

Journal: European journal of medicinal chemistry 20100601

Title: New dioscin-glycosidase hydrolyzing multi-glycosides of dioscin from Absidia strain.

Journal: Journal of microbiology and biotechnology 20100601

Title: Cyclooxygenase-2 and 5-lipoxygenase pathways in diosgenin-induced apoptosis in HT-29 and HCT-116 colon cancer cells.

Journal: International journal of oncology 20100501

Title: Pharmacokinetics of methyl protodioscin in rats.

Journal: Die Pharmazie 20100501

Title: Synthesis of 26-hydroxy-22-oxocholestanic frameworks from diosgenin and hecogenin and their in vitro antiproliferative and apoptotic activity on human cervical cancer CaSki cells.

Journal: Bioorganic & medicinal chemistry 20100401

Title: Structural requirement of spirostanol glycosides for rat uterine contractility and mode of their synergism.

Journal: The Journal of pharmacy and pharmacology 20100401

Title: [Effect and mechanism of methyl protodioscin in protecting cardiomyocytes against anoxia/reoxygenation injury].

Journal: Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20100401

Title: Protective effects of diosgenin in the hyperlipidemic rat model and in human vascular endothelial cells against hydrogen peroxide-induced apoptosis.

Journal: Chemico-biological interactions 20100330

Title: Two 22S-solanidine-type steroidal alkaloids from Fritillaria anhuiensis.

Journal: Fitoterapia 20100301

Title: Synthesis and anti-glioma activity of 25(R)-spirostan-3beta,5alpha,6beta,19-tetrol.

Journal: Steroids 20100301

Title: Deacylation reactions of 20-acetyl dinorcholanic lactones and 20,23-diacetyl furost-22-enes.

Journal: Steroids 20100301

Title: Hydroxylation of diosgenin by Absidia coerulea.

Journal: Natural product communications 20100301

Title: Cholesterol oxidase ChoL is a critical enzyme that catalyzes the conversion of diosgenin to 4-ene-3-keto steroids in Streptomyces virginiae IBL-14.

Journal: Applied microbiology and biotechnology 20100201

Title: Production of diosgenin from Dioscorea zingiberensis tubers through enzymatic saccharification and microbial transformation.

Journal: Applied microbiology and biotechnology 20100201

Title: Caprospinol reduces amyloid deposits and improves cognitive function in a rat model of Alzheimer's disease.

Journal: Neuroscience 20100120

Title: Qualitative and quantitative analysis of steroidal saponins in crude extracts from Paris polyphylla var. yunnanensis and P. polyphylla var. chinensis by high performance liquid chromatography coupled with mass spectrometry.

Journal: Journal of pharmaceutical and biomedical analysis 20100105

Title: Hemolytic mechanism of dioscin proposed by molecular dynamics simulations.

Journal: Journal of molecular modeling 20100101

Title: Biotransformation of steriodal saponins in Dioscorea zingiberensis C. H. Wright to diosgenin by Trichoderma harzianum.

Journal: Applied microbiology and biotechnology 20100101

Title: [Effects of methyl protodioscin on [Ca2+]i and ATPase activity in cardiomyocytes and analysis of mechanisms].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100101

Title: Functional food targeting the regulation of obesity-induced inflammatory responses and pathologies.

Journal: Mediators of inflammation 20100101

Title: In vitro tetraploid induction and generation of tetraploids from mixoploids in Dioscorea zingiberensis.

Journal: Pharmacognosy magazine 20100101

Title: Antiproliferative effect of Tualang honey on oral squamous cell carcinoma and osteosarcoma cell lines.

Journal: BMC complementary and alternative medicine 20100101

Title: Inhibition of TNF-α-induced adhesion molecule expression by diosgenin in mouse vascular smooth muscle cells via downregulation of the MAPK, Akt and NF-κB signaling pathways.

Journal: Vascular pharmacology 20100101

Title: The effects of a commercially available botanical supplement on strength, body composition, power output, and hormonal profiles in resistance-trained males.

Journal: Journal of the International Society of Sports Nutrition 20100101

Title: Synthesis and characterization of new aromatic esters based on 4,16-pregnadiene-6,20-dione skeleton.

Journal: Chemistry Central journal 20100101

Title: The role of lipid and carbohydrate digestive enzyme inhibitors in the management of obesity: a review of current and emerging therapeutic agents.

Journal: Diabetes, metabolic syndrome and obesity : targets and therapy 20100101

Title: Development of a rapid HPLC-UV method for simultaneous quantification of protodioscin and rutin in white and green asparagus spears.

Journal: Journal of food science 20100101

Title: Chemical constituents of Asparagus.

Journal: Pharmacognosy reviews 20100101

Title: Assessment of anti-nociceptive efficacy of costus speciosus rhizome in swiss albino mice.

Journal: Journal of advanced pharmaceutical technology & research 20100101

Title: Acute toxicity and sub-chronic toxicity of steroidal saponins from Dioscorea zingiberensis C.H.Wright in rodents.

Journal: Journal of ethnopharmacology 20091210

Title: Structural analogues of diosgenyl saponins: synthesis and anticancer activity.

Journal: Bioorganic & medicinal chemistry 20091115

Title: Colic caused by Panicum maximum toxicosis in equidae in northern Brazil.

Journal: Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc 20091101

Title: Enhancement of diosgenin production in Dioscorea zingiberensis cell culture by oligosaccharide elicitor from its endophytic fungus Fusarium oxysporum Dzf17.

Journal: Natural product communications 20091101

Title: Diosgenin attenuates allergen-induced intestinal inflammation and IgE production in a murine model of food allergy.

Journal: Planta medica 20091001

Title: [Determination of pseudoprodioscin in Dioscorea panthaica by HPLC].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20091001

Title: Diosgenin targets Akt-mediated prosurvival signaling in human breast cancer cells.

Journal: International journal of cancer 20090815

Title: New microbiological transformations of steroids by Streptomyces virginiae IBL-14.

Journal: Environmental science & technology 20090801

Title: Antilipoperoxidative and membrane stabilizing effect of diosgenin, in experimentally induced myocardial infarction.

Journal: Molecular and cellular biochemistry 20090701

Title: A proteomic approach to the identification of molecular targets in subsequent apoptosis of HEL cells after diosgenin-induced megakaryocytic differentiation.

Journal: Journal of cellular biochemistry 20090701

Title: [Seedling botanical characters and determination of effective components on Dioscorea zingerbrensis by space mutation].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090701

Title: [Chemical constituents from herb of Solanum lyratum].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090701

Title: Novel effects of diosgenin on skin aging.

Journal: Steroids 20090601

Title: [Analysis of biochemical indices and efficient ingredients in autotetraploid of Dioscorea zingibiernsis].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20090601

Title: Methyl 3β-methoxy-carbon-yloxy-4,4-di-methyl-17-oxo-16α-(3-oxobut-yl)-16β-carboxylate.

Journal: Acta crystallographica. Section E, Structure reports online 20090601

Title: Synthesis and cytotoxicities of icogenin analogues with disaccharide residues.

Journal: Bioorganic & medicinal chemistry letters 20090515

Title: Development and validation of a sensitive and rapid non-aqueous LC-ESI-MS/MS method for measurement of diosgenin in the plasma of normal and hyperlipidemic rats: a comparative study.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090515

Title: Diosgenin stimulation of fecal cholesterol excretion in mice is not NPC1L1 dependent.

Journal: Journal of lipid research 20090501

Title: Analysis of relationship between cell cycle stage and apoptosis induction in K562 cells by sedimentation field-flow fractionation.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090415

Title: Molecularly imprinted layer-coated silica nanoparticles toward highly selective separation of active diosgenin from Dioscorea nipponica Makino.

Journal: Journal of chromatography. A 20090320

Title: Synthesis and biological activity of the (25R)-cholesten-26-oic acids--ligands for the hormonal receptor DAF-12 in Caenorhabditis elegans.

Journal: Organic & biomolecular chemistry 20090307

Title: Formosanin C-induced apoptosis requires activation of caspase-2 and change of mitochondrial membrane potential.

Journal: Cancer science 20090301

Title: Caprospinol: moving from a neuroactive steroid to a neurotropic drug.

Journal: Expert opinion on investigational drugs 20090301

Title: In vitro and in vivo anticancer activity of steroid saponins of Paris polyphylla var. yunnanensis.

Journal: Experimental oncology 20090301

Title: N-tert-Butyl-5α-androstane-17β-carboxamide.

Journal: Acta crystallographica. Section E, Structure reports online 20090301

Title: Fenugreek: a naturally occurring edible spice as an anticancer agent.

Journal: Cancer biology & therapy 20090201

Title: New thinking in the development of novel derivatization reagents for liquid chromatography-mass spectrometric detection.

Journal: Biomedical chromatography : BMC 20090101

Title: Steroidal saponins and cytoxicity of the wild edible vegetable-Smilacina atropurpurea.

Journal: Steroids 20090101

Title: Selective modulation of P-glycoprotein activity by steroidal saponines from Paris polyphylla.

Journal: Fitoterapia 20090101

Title: Cancer chemopreventive and therapeutic effects of diosgenin, a food saponin.

Journal: Nutrition and cancer 20090101

Title: Microbial biotransformation: recent developments on steroid drugs.

Journal: Recent patents on biotechnology 20090101

Title: Polyphyllin D exerts potent anti-tumour effects on Lewis cancer cells under hypoxic conditions.

Journal: The Journal of international medical research 20090101

Title: Yam (Dioscorea pseudojaponica Yamamoto) ameliorates cognition deficit and attenuates oxidative damage in senescent mice induced by D-galactose.

Journal: The American journal of Chinese medicine 20090101

Title: Distribution of glycoalkaloids in potato tubers of 59 accessions of two wild and five cultivated Solanum species.

Journal: Journal of agricultural and food chemistry 20081224

Title: [Steroidal saponins from the plant Agave brittoniana with activity against the parasite Trichomona vaginalis].

Journal: Revista de biologia tropical 20081201

Title: The best utilization of D. zingiberensis C.H. Wright by an eco-friendly process.

Journal: Bioresource technology 20081001

Title: Potential of spice-derived phytochemicals for cancer prevention.

Journal: Planta medica 20081001

Title: Efficient protocol for purification of diosgenin and two fatty acids from Rhizoma dioscoreae by SFE coupled with high-speed counter-current chromatography and evaporative light scattering detection.

Journal: Journal of separation science 20081001

Title: Increased cyclooxygenase-2 and thromboxane synthase expression is implicated in diosgenin-induced megakaryocytic differentiation in human erythroleukemia cells.

Journal: Analytical biochemistry 20080901

Title: Cancer is a preventable disease that requires major lifestyle changes.

Journal: Pharmaceutical research 20080901

Title: Proteomic and transcriptomic study on the action of a cytotoxic saponin (Polyphyllin D): induction of endoplasmic reticulum stress and mitochondria-mediated apoptotic pathways.

Journal: Proteomics 20080801

Title: Tomatidine inhibits iNOS and COX-2 through suppression of NF-kappaB and JNK pathways in LPS-stimulated mouse macrophages.

Journal: FEBS letters 20080709

Title: Synthesis of bis-diosgenin pyrazine dimers: new cephalostatin analogs.

Journal: Steroids 20080701

Title: Preparative separation of dioscin derivatives from Dioscorea villosa by centrifugal partition chromatography coupled with evaporative light scattering detection.

Journal: Journal of separation science 20080701

Title: [Study on optimization of the hydrolysis process of dioscin catalyzed by hydrochloric acid].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20080701

Title: Study of diosgenin-induced apoptosis kinetics in K562 cells by Sedimentation Field Flow Fractionation.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080615

Title: Efficient synthesis of alpha- and beta-chacotriosyl glycosides using appropriate donors, and their cytotoxic activity.

Journal: Carbohydrate research 20080609

Title: Effects of yam and diosgenin on calpain systems in skeletal muscle of ovariectomized rats.

Journal: Taiwanese journal of obstetrics & gynecology 20080601

Title: [Determination of plasma protein binding rate of methyl protodioscin with ultrafiltration].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080601

Title: [Isolation and identification of major steroidal saponins of Paris polyphylla Smith var stenophylla Franch].

Journal: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20080501

Title: Development and validation of a liquid chromatography/tandem mass spectrometry assay for the quantification of methyl protodioscin in rat plasma: application to a pharmacokinetic study.

Journal: Biomedical chromatography : BMC 20080401

Title: Polyphyllin D induces mitochondrial fragmentation and acts directly on the mitochondria to induce apoptosis in drug-resistant HepG2 cells.

Journal: Cancer letters 20080318

Title: Synthesis and cytotoxic activity of diosgenyl saponin analogues.

Journal: Bioorganic & medicinal chemistry 20080315

Title: Balanitin-6 and -7: diosgenyl saponins isolated from Balanites aegyptiaca Del. display significant anti-tumor activity in vitro and in vivo.

Journal: International journal of oncology 20080101

Title: Salinity stress enhances production of solasodine in Solanum nigrum L.

Journal: Chemical & pharmaceutical bulletin 20080101

Title: Biotransformation of cholesterol to diosgenin by freely suspended and immobilised cells of Dioscorea bulbifera L.

Journal: Journal of Asian natural products research 20080101

Title: [Research on the application of supercritical fluid extraction of diosgenin of Smilax china].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20080101

Title: Synthesis, cytotoxicity, and hemolytic activity of 6'-O-substituted dioscin derivatives.

Journal: Carbohydrate research 20071228

Title: Diosgenin, a naturally occurring steroid, suppresses fatty acid synthase expression in HER2-overexpressing breast cancer cells through modulating Akt, mTOR and JNK phosphorylation.

Journal: FEBS letters 20071222

Title: Identification and characterization of several dietary alkaloids as weak inhibitors of hedgehog signaling.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20071201

Title: Biotransformation of diosgenin to nuatigenin-type steroid by a newly isolated strain, Streptomyces virginiae IBL-14.

Journal: Applied microbiology and biotechnology 20071201

Title: Dioscin (saponin)-induced generation of reactive oxygen species through mitochondria dysfunction: a proteomic-based study.

Journal: Journal of proteome research 20071201

Title: Antioxidative and hypolipidemic effects of diosgenin, a steroidal saponin of yam (Dioscorea spp.), on high-cholesterol fed rats.

Journal: Bioscience, biotechnology, and biochemistry 20071201

Title: Induction of growth hormone release by dioscin from Dioscorea batatas DECNE.

Journal: Journal of biochemistry and molecular biology 20071130

Title: Mechanisms involved in the vasodilator effect induced by diosgenin in rat superior mesenteric artery.

Journal: European journal of pharmacology 20071128

Title: Synthesis of neosaponins and neoglycolipids containing a chacotriosyl moiety.

Journal: Carbohydrate research 20071105

Title: Diosgenin, a naturally occurring steroid [corrected] saponin suppresses 3-hydroxy-3-methylglutaryl CoA reductase expression and induces apoptosis in HCT-116 human colon carcinoma cells.

Journal: Cancer letters 20071008

Title: Inhibition of human rheumatoid arthritis synovial cell survival by hecogenin and tigogenin is associated with increased apoptosis, p38 mitogen-activated protein kinase activity and upregulation of cyclooxygenase-2.

Journal: International journal of molecular medicine 20071001

Title: Characterization of steroidal saponins in crude extract from Dioscorea nipponica Makino by liquid chromatography tandem multi-stage mass spectrometry.

Journal: Analytica chimica acta 20070905

Title: Ultrastructural and intracellular chemical changes of a novel halophilic strain V430 of Staphylococcus saprophyticus under CaCl2 stress.

Journal: Applied biochemistry and biotechnology 20070901

Title: [Studies on chemical constituents of Liriope platyphylla].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20070901

Title: [Selection of the microorganism for dioscin hydrolyze].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20070801

Title: Sedimentation field flow fractionation to study human erythroleukemia cell megakaryocytic differentiation after short period diosgenin induction.

Journal: Journal of chromatography. A 20070720

Title: Bioidentical hormones for menopausal hormone therapy: variation on a theme.

Journal: Journal of general internal medicine 20070701

Title: Diosgenin inhibits melanogenesis through the activation of phosphatidylinositol-3-kinase pathway (PI3K) signaling.

Journal: Life sciences 20070627

Title: Immuno-stimulating properties of diosgenyl saponins isolated from Paris polyphylla.

Journal: Bioorganic & medicinal chemistry letters 20070501

Title: Diosgenin, a steroidal sapogenin, enhances antigen-specific IgG2a and interferon-gamma expression in ovalbumin-sensitized BALB/c mice.

Journal: Planta medica 20070501

Title: Determination of protodioscin in rat plasma by liquid chromatography-tandem mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070401

Title: Genetic fidelity of in vitro regenerants, encapsulation of shoot tips and high diosgenin content in Dioscorea bulbifera L., a potential alternative source of diosgenin.

Journal: Biotechnology letters 20070401

Title: Nitric oxide inhibitory substances from the rhizomes of Dioscorea membranacea.

Journal: Journal of ethnopharmacology 20070212

Title: Medicinal flowers. XII.(1)) New spirostane-type steroid saponins with antidiabetogenic activity from Borassus flabellifer.

Journal: Chemical & pharmaceutical bulletin 20070201

Title: Biological activities and syntheses of steroidal saponins: the shark-repelling pavoninins.

Journal: Lipids 20070201

Title: CHIH-DFT determination of the molecular structure and IR and UV spectra of solanidine.

Journal: Journal of molecular modeling 20070101

Title: MAP kinase subtypes and Akt regulate diosgenin-induced apoptosis of rheumatoid synovial cells in association with COX-2 expression and prostanoid production.

Journal: International journal of molecular medicine 20070101

Title: Efficient synthesis of solasodine, O-acetylsolasodine, and soladulcidine as anticancer steroidal alkaloids.

Journal: Chemistry & biodiversity 20070101

Title: Influence of plant matrix on microwave-assisted extraction process. The case of diosgenin extracted from fenugreek (Trigonella foenum-graecum L.).

Journal: Phytochemical analysis : PCA 20070101

Title: A validated quantitative thin-layer chromatographic method for estimation of diosgenin in various plant samples, extract, and market formulation.

Journal: Journal of AOAC International 20070101

Title: Ethnobotanical remarks on Central and Southern Italy.

Journal: Journal of ethnobiology and ethnomedicine 20070101

Title: Determination of saponins in the kernel cake of Balanites aegyptiaca by HPLC-ESI/MS.

Journal: Phytochemical analysis : PCA 20070101

Title: Psychoimmunological effects of dioscorea in ovariectomized rats: role of anxiety level.

Journal: Annals of general psychiatry 20070101

Title: Large scale analysis of genes contributing to the herbal preparation dependent hippocampal plasticity in postischemic rehabilitation.

Journal: Vascular pharmacology 20070101

Title: Effects of domestic processing on steroidal saponins in Taiwanese yam cultivar (Dioscorea pseudojaponica Yamamoto).

Journal: Journal of agricultural and food chemistry 20061227

Title: Anti-allergic substances from the rhizomes of Dioscorea membranacea.

Journal: Bioorganic & medicinal chemistry 20061215

Title: Synthesis of three natural diosgenyl glycosides.

Journal: Journal of Asian natural products research 20061201

Title: Synthesis and cytotoxicities of dioscin derivatives with decorated chacotriosyl residues.

Journal: Bioorganic & medicinal chemistry letters 20061101

Title: Determination of ruscogenin in crude Chinese medicines and biological samples by immunoassay.

Journal: Analytical and bioanalytical chemistry 20061101

Title: [Study on steroidal compounds from Dioscorea zingiberensis].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20061101

Title: [Study on steroidal saponins of Dioscorea septemloba thunb].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20061101

Title: Diabetes and sport: managing the complex interactions.

Journal: British journal of hospital medicine (London, England : 2005) 20061001

Title: Intestinal lipids and minerals in streptozotocin-induced diabetic rats fed bitter yam (Dioscorea polygonoides) sapogenin extract.

Journal: Pakistan journal of pharmaceutical sciences 20061001

Title: Pre-apoptotic sub-population cell sorting from diosgenin apoptosis induced 1547 cells by Sedimentation Field-Flow Fractionation. The effect of channel thickness on sorting performance.

Journal: Journal of chromatography. A 20060922

Title: Methyl protodioscin induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells.

Journal: Cancer letters 20060908

Title: The mechanism of ABCG5/ABCG8 in biliary cholesterol secretion in mice.

Journal: Journal of lipid research 20060901

Title: Structural identification of methyl protodioscin metabolites in rats' urine and their antiproliferative activities against human tumor cell lines.

Journal: Steroids 20060901

Title: Metabolism of tomato steroidal glycosides in humans.

Journal: Chemical & pharmaceutical bulletin 20060901

Title: Megakaryocyte cell sorting from diosgenin-differentiated human erythroleukemia cells by sedimentation field-flow fractionation.

Journal: Analytical biochemistry 20060801

Title: Short synthesis of 16beta-hydroxy-5alpha-cholestane-3,6-dione a novel cytotoxic marine oxysterol.

Journal: Steroids 20060701

Title: Increased vulnerability of ApoE4 neurons to HIV proteins and opiates: protection by diosgenin and L-deprenyl.

Journal: Neurobiology of disease 20060701

Title: Microbial metabolism of methyl protodioscin by Aspergillus niger culture--a new androstenedione producing way from steroid.

Journal: The Journal of steroid biochemistry and molecular biology 20060701

Title: Facile conversion of spirostan saponin into furostan saponin: synthesis of methyl protodioscin and its 26-thio-analogue.

Journal: Organic letters 20060622

Title: [Effect of potassium level on output and diosgenin content of Dioscorea zingiberensisg].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20060601

Title: Molecular targets of dietary agents for prevention and therapy of cancer.

Journal: Biochemical pharmacology 20060514

Title: Effect of ethanol extract of dried Chinese yam (Dioscorea batatas) flour containing dioscin on gastrointestinal function in rat model.

Journal: Archives of pharmacal research 20060501

Title: Intestinal disaccharidases and some renal enzymes in streptozotocin-induced diabetic rats fed sapogenin extract from bitter yam (Dioscorea polygonoides).

Journal: Life sciences 20060425

Title: Proteomic approach to study the cytotoxicity of dioscin (saponin).

Journal: Proteomics 20060401

Title: Diosgenin, a plant-derived sapogenin, stimulates Ca2+-activated K+ current in human cortical HCN-1A neuronal cells.

Journal: Planta medica 20060401

Title: [Study on fertillizer application techniques of annual Dioscoreae zingiberensis].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20060401

Title: Diosgenin inhibits osteoclastogenesis, invasion, and proliferation through the downregulation of Akt, I kappa B kinase activation and NF-kappa B-regulated gene expression.

Journal: Oncogene 20060309

Title: Steroidal saponins from roots of Asparagus officinalis.

Journal: Steroids 20060201

Title: Role of MAPKs and NF-kappaB in diosgenin-induced megakaryocytic differentiation and subsequent apoptosis in HEL cells.

Journal: International journal of oncology 20060101

Title: Reactions of 26-iodopseudodiosgenin and 26-iodopseudodiosgenone with various nucleophiles and pharmacological activities of the products.

Journal: Chemical & pharmaceutical bulletin 20060101

Title: Diosgenin glucuronides from Solanum lyratum and their cytotoxicity against tumor cell lines.

Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences 20060101

Title: HIV neurotoxicity: potential therapeutic interventions.

Journal: Journal of biomedicine & biotechnology 20060101

Title: Structural requirements of cholesterol for binding to Vibrio cholerae hemolysin.

Journal: Microbiology and immunology 20060101

Title: Diosgenin contents and DNA fingerprint screening of various yam (Dioscorea sp.) genotypes.

Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences 20060101

Title: Synthesis of the shark repellent pavoninin-4.

Journal: The Journal of organic chemistry 20051223

Title: Synthesis of 7alpha-hydroxy-dehydroepiandrosterone and 7beta-hydroxy-dehydroepiandrosterone.

Journal: Steroids 20051215

Title: Diosgenin, a plant steroid, induces apoptosis in COX-2 deficient K562 cells with activation of the p38 MAP kinase signalling and inhibition of NF-kappaB binding.

Journal: International journal of molecular medicine 20051201

Title: [Research on correlations of quality and growing environment of Smilax China].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20051201

Title: Hypoglycemic effects of steroidal sapogenins isolated from Jamaican bitter yam, Dioscorea polygonoides.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20051101

Title: Effects of polyphyllin D, a steroidal saponin in Paris polyphylla, in growth inhibition of human breast cancer cells and in xenograft.

Journal: Cancer biology & therapy 20051101

Title: Diosgenin induces hypoxia-inducible factor-1 activation and angiogenesis through estrogen receptor-related phosphatidylinositol 3-kinase/Akt and p38 mitogen-activated protein kinase pathways in osteoblasts.

Journal: Molecular pharmacology 20051001

Title: Alteration of the expression of adenosine triphosphate-binding cassette transporters associated with bile acid and cholesterol transport in the rat liver and intestine during cholestasis.

Journal: Journal of gastroenterology and hepatology 20050901

Title: [Study on chemical constituents in total saponin from Trigonella foenum-graecum].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20050901

Title: Purification and characterization of dioscin-alpha-L-rhamnosidase from pig liver.

Journal: Chemical & pharmaceutical bulletin 20050801

Title: Characterization of the pharmacokinetics of dioscin in rat.

Journal: Steroids 20050701

Title: Preparations of vitamin D analogs, spirostanols and furostanols from diosgenin and their cytotoxic activities.

Journal: European journal of medicinal chemistry 20050701

Title: Liquid-liquid systems for acid hydrolysis of glycoalkaloids from Solanum tuberosum L. tuber sprouts and solanidine extraction.

Journal: Medical science monitor : international medical journal of experimental and clinical research 20050701

Title: Methyl protodioscin induces G2/M arrest and apoptosis in K562 cells with the hyperpolarization of mitochondria.

Journal: Cancer letters 20050628

Title: Abiotic metal stress enhances diosgenin yield in Dioscorea bulbifera L. cultures.

Journal: Plant cell reports 20050601

Title: Electrochemical study of breast cancer cells MCF-7 and its application in evaluating the effect of diosgenin.

Journal: Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20050501

Title: Antineoplastic agents. 534. isolation and structure of sansevistatins 1 and 2 from the African Sansevieria ehrenbergii.

Journal: Journal of natural products 20050501

Title: [Effect of intestinal bacteria on metabolism of ophiopognin saponin D' in rats].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20050401

Title: Determination of dioscin in rat plasma by liquid chromatography-tandem mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050325

Title: Expression of ABCG5 and ABCG8 is required for regulation of biliary cholesterol secretion.

Journal: The Journal of biological chemistry 20050311

Title: Elicitation of diosgenin production in Dioscorea floribunda by ethylene-generating agent.

Journal: Fitoterapia 20050301

Title: Changes in some liver enzymes in streptozotocin-induced diabetic rats fed sapogenin extract from bitter yam (Dioscorea polygonoides) or commercial diosgenin.

Journal: The West Indian medical journal 20050301

Title: [Separation and identification of diosgenin in Trigonella foenum-graecum L. and its compound preparation by gradient thin-layer chromatography].

Journal: Se pu = Chinese journal of chromatography 20050301

Title: Fluorophore-appended steroidal saponin (dioscin and polyphyllin D) derivatives.

Journal: Organic letters 20050217

Title: Structure-function relationship for saponin effects on cell cycle arrest and apoptosis in the human 1547 osteosarcoma cells: a molecular modelling approach of natural molecules structurally close to diosgenin.

Journal: Bioorganic & medicinal chemistry 20050215

Title: Effects of steroidal glycoalkaloids from potatoes (Solanum tuberosum) on in vitro bovine embryo development.

Journal: Animal reproduction science 20050201

Title: [Steroidal constituents from Dioscorea parviflora].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20050201

Title: Polyphyllin D is a potent apoptosis inducer in drug-resistant HepG2 cells.

Journal: Cancer letters 20050120

Title: Diosgenin induces cell cycle arrest and apoptosis in human leukemia K562 cells with the disruption of Ca2+ homeostasis.

Journal: Cancer chemotherapy and pharmacology 20050101

Title: Diosgenin-induced biliary cholesterol secretion in mice requires Abcg8.

Journal: Hepatology (Baltimore, Md.) 20050101

Title: Discovery of structurally diverse natural product antagonists of chemokine receptor CXCR3.

Journal: Molecular diversity 20050101

Title: A novel glucosyltransferase involved in steroid saponin biosynthesis in Solanum aculeatissimum.

Journal: Plant molecular biology 20050101

Title: Diosgenin dose-dependent apoptosis and differentiation induction in human erythroleukemia cell line and sedimentation field-flow fractionation monitoring.

Journal: Analytical biochemistry 20041215

Title: Supercritical fluid extraction of sapogenins from tubers of Smilax china.

Journal: Fitoterapia 20041201

Title: Clemmensen reduction of diosgenin and kryptogenin: synthesis of [16,16,22,22,23,23-(2)H(6)]-(25R)-26-hydroxycholesterol.

Journal: Steroids 20041201

Title: [Effect of N, P, K on rhizome yield and diosgenin content of Dioscorea zingiberensis].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20041201

Title: Activation of iberiotoxin-sensitive, Ca2+-activated K+ channels of porcine isolated left anterior descending coronary artery by diosgenin.

Journal: European journal of pharmacology 20041011

Title: Cytotoxicity of the phytosterol diosgenin and its derivatives in rat cultured hepatocytes and V79 fibroblasts.

Journal: Human & experimental toxicology 20041001

Title: SdFFF monitoring of cellular apoptosis induction by diosgenin and different inducers in the human 1547 osteosarcoma cell line.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040905

Title: Diosgenin induces cell cycle arrest and apoptosis in HEL cells with increase in intracellular calcium level, activation of cPLA2 and COX-2 overexpression.

Journal: International journal of oncology 20040901

Title: Phytochemical analysis and anti-allergic study of Agave intermixta Trel. and Cissus sicyoides L.

Journal: The Journal of pharmacy and pharmacology 20040901

Title: Facile synthesis of saponins containing 2,3-branched oligosaccharides by using partially protected glycosyl donors.

Journal: The Journal of organic chemistry 20040806

Title: Diosgenin, a steroid saponin of Trigonella foenum graecum (Fenugreek), inhibits azoxymethane-induced aberrant crypt foci formation in F344 rats and induces apoptosis in HT-29 human colon cancer cells.

Journal: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20040801

Title: Diosgenin induces apoptosis in HeLa cells via activation of caspase pathway.

Journal: Acta pharmacologica Sinica 20040801

Title: Synthesis of bidesmosidic dihydrodiosgenin saponins bearing a 3-O-beta-chacotriosyl moiety.

Journal: Carbohydrate research 20040712

Title: Microbial metabolism of pseudoprotodioscin.

Journal: Planta medica 20040701

Title: The mitotic-arresting and apoptosis-inducing effects of diosgenyl saponins on human leukemia cell lines.

Journal: Biological & pharmaceutical bulletin 20040701

Title: Diosgenin-3-O-alpha-L-rhamnopyranosyl-(1 --> 4)-beta-D-glucopyranoside obtained as a new anticancer agent from Dioscorea futschauensis induces apoptosis on human colon carcinoma HCT-15 cells via mitochondria-controlled apoptotic pathway.

Journal: Journal of Asian natural products research 20040601

Title: Induction of antiproliferative effect by diosgenin through activation of p53, release of apoptosis-inducing factor (AIF) and modulation of caspase-3 activity in different human cancer cells.

Journal: Cell research 20040601

Title: [Studies on the dynamic trends of diosgenin content in vegetative organs of Dioscorea zingiberensis].

Journal: Shi yan sheng wu xue bao 20040601

Title: Microarray analysis of gene expression on herbal glycoside recipes improving deficient ability of spatial learning memory in ischemic mice.

Journal: Journal of neurochemistry 20040301

Title: In vivo antiosteoporotic activity of a fraction of Dioscorea spongiosa and its constituent, 22-O-methylprotodioscin.

Journal: Planta medica 20040301

Title: Alpha-hydroxylation at C-15 and C-16 in cholesterol: synthesis of (25R)-5alpha-cholesta-3beta,15alpha,26-triol and (25R)-5alpha-cholesta-3beta,16alpha,26-triol from diosgenin.

Journal: Organic letters 20040122

Title: Antifungal steroid saponins from Dioscorea cayenensis.

Journal: Planta medica 20040101

Title: A mouse model of sitosterolemia: absence of Abcg8/sterolin-2 results in failure to secrete biliary cholesterol.

Journal: BMC medicine 20040101

Title: Diosgenin, a plant steroid, induces apoptosis in human rheumatoid arthritis synoviocytes with cyclooxygenase-2 overexpression.

Journal: Arthritis research & therapy 20040101

Title: Final report of the amended safety assessment of Dioscorea Villosa (Wild Yam) root extract.

Journal: International journal of toxicology 20040101

Title: Synthesis of rhamnosylated diosgenyl glucosides as mimetics of cytostatic steroidal saponins from Ornithogalum saindersiae and Galtonia candicans.

Journal: Organic & biomolecular chemistry 20031221

Title: Isolation and identification of steroidal saponins in Taiwanese yam cultivar (Dioscorea pseudojaponica Yamamoto).

Journal: Journal of agricultural and food chemistry 20031022

Title: Quantification of protodioscin and rutin in asparagus shoots by LC/MS and HPLC methods.

Journal: Journal of agricultural and food chemistry 20031008

Title: [Study on the production condition of extraction in combination hydrolysis in situ for isolating diosgenin].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20031001

Title: Furostanol saponins from Tribulus terrestris.

Journal: Fitoterapia 20030901

Title: A new steroidal saponin from Dioscorea zingiberensis Wright.

Journal: Natural product research 20030801

Title: [Apoptosis of human chronic myeloid leukemia k562 cell induced by prosapogenin B of dioscin (P.B) in vitro].

Journal: Ai zheng = Aizheng = Chinese journal of cancer 20030801

Title: Regulation of biliary cholesterol secretion is associated with abcg5 and abcg8 expressions in the rats: effects of diosgenin and ethinyl estradiol.

Journal: Hepatology research : the official journal of the Japan Society of Hepatology 20030801

Title: In vitro micropropagation, differentiation of aerial bulbils and tubers and diosgenin content in Dioscorea bulbifera.

Journal: Planta medica 20030801

Title: Anti-obesity effect of Dioscorea nipponica Makino with lipase-inhibitory activity in rodents.

Journal: Bioscience, biotechnology, and biochemistry 20030701

Title: [Sports and doping].

Journal: Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology 20030701

Title: Relation between hepatic expression of ATP-binding cassette transporters G5 and G8 and biliary cholesterol secretion in mice.

Journal: Journal of hepatology 20030601

Title: The cytotoxicity of methyl protodioscin against human cancer cell lines in vitro.

Journal: Cancer investigation 20030601

Title: Total synthesis of methyl protodioscin: a potent agent with antitumor activity.

Journal: The Journal of organic chemistry 20030502

Title: [Advances in the study on Dioscorea zingiberensis C.H. Wright].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20030501

Title: The synthesis of gracillin and dioscin: two typical representatives of spirostanol glycosides.

Journal: Carbohydrate research 20030404

Title: Structural features of sterols required to inhibit human sperm capacitation.

Journal: Biology of reproduction 20030401

Title: Different contribution of apoptosis to the antiproliferative effects of diosgenin and other plant steroids, hecogenin and tigogenin, on human 1547 osteosarcoma cells.

Journal: International journal of oncology 20030401

Title: Sexual effects of puncturevine (Tribulus terrestris) extract (protodioscin): an evaluation using a rat model.

Journal: Journal of alternative and complementary medicine (New York, N.Y.) 20030401

Title: Solanidine hydrolytic extraction and separation from the potato (Solanum tuberosum L.) vines by using solid-liquid-liquid systems.

Journal: Journal of agricultural and food chemistry 20030326

Title: Protective effects of steroid saponins from Paris polyphylla var. yunnanensis on ethanol- or indomethacin-induced gastric mucosal lesions in rats: structural requirement for activity and mode of action.

Journal: Bioorganic & medicinal chemistry letters 20030324

Title: Ovine metabolism of diosgenin coated on cellulose in relation to hepatogenous photosensitization of ruminants.

Journal: Veterinary and human toxicology 20030201

Title: Regioselective cleavage of rings E and F in sarsasapogenin.

Journal: Steroids 20030201

Title: Oxidative stress in HIV demented patients and protection ex vivo with novel antioxidants.

Journal: Neurology 20030128

Title: Synthesis of monomethylated dioscin derivatives and their antitumor activities.

Journal: Carbohydrate research 20030120

Title: Synthesis and induction of apoptosis in B cell chronic leukemia by diosgenyl 2-amino-2-deoxy-beta-D-glucopyranoside hydrochloride and its derivatives.

Journal: Carbohydrate research 20030120

Title: Effect of feeding solanidine, solasodine and tomatidine to non-pregnant and pregnant mice.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20030101

Title: Protodioscin isolated from fenugreek (Trigonella foenumgraecum L.) induces cell death and morphological change indicative of apoptosis in leukemic cell line H-60, but not in gastric cancer cell line KATO III.

Journal: International journal of molecular medicine 20030101

Title: Biological activities of synthetic saponins and cardiac glycosides.

Journal: Phytotherapy research : PTR 20030101

Title: The effects of sustained delivery of diosgenin on the adrenal gland of female rats.

Journal: Biomedical sciences instrumentation 20030101

Title: Structural changes in the kidney associated with ovariectomy and diosgenin replacement therapy in adult female rats.

Journal: Biomedical sciences instrumentation 20030101

Title: Genetic stability assessment of plants regenerated from cryopreserved embryogenic tissues of Dioscorea bulbifera l. Using RAPD, biochemical and morphological analysis.

Journal: Cryo letters 20030101

Title: Electrospray ionization mass spectrometry of AZT H-phosphonates conjugated with steroids.

Journal: Rapid communications in mass spectrometry : RCM 20030101

Title: Glycosyl trifluoroacetimidates. 2. Synthesis of dioscin and xiebai saponin I.

Journal: The Journal of organic chemistry 20021213

Title: Synthesis of (25R)-26-hydroxycholesterol.

Journal: Steroids 20021201

Title: Studies toward the synthesis of the shark repellent pavoninin-5.

Journal: Lipids 20021201

Title: A facile approach to diosgenin and furostan type saponins bearing a 3beta-chacotriose moiety.

Journal: Carbohydrate research 20021119

Title: Variation in diosgenin levels among 10 accessions of fenugreek seeds produced in western Canada.

Journal: Journal of agricultural and food chemistry 20021009

Title: Determination of aculeatisides based on immunoassay using a polyclonal antibody against aculeatiside A.

Journal: The Analyst 20021001

Title: [The antitumor activity of Diosgenin in vivo and in vitro].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20021001

Title: Sonic hedgehog activates mesenchymal Gli1 expression during prostate ductal bud formation.

Journal: Developmental biology 20020915

Title: [Study on hydrolysis conditions of Dioscorea nipponica with uniform design method].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20020901

Title: [Study on chemical constituents of rhizome of Anemone raddeana].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20020901

Title: [Intestinal bacteria metabolism of TSDP and characterization of metabolites in rats].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20020901

Title: Preparations of heterospirostanols and their pharmacological activities.

Journal: European journal of medicinal chemistry 20020801

Title: [Comparative study on anti-hypercholesterolemia activity of diosgenin and total saponin of Dioscorea panthaica].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20020701

Title: Evaluation of the potential cancer chemotherapeutic efficacy of natural product isolates employing in vivo hollow fiber tests.

Journal: Journal of natural products 20020601

Title: Protodioscin (NSC-698 796): its spectrum of cytotoxicity against sixty human cancer cell lines in an anticancer drug screen panel.

Journal: Planta medica 20020401

Title: Molecular cloning and functional expression of cDNAs encoding oxidosqualene cyclases from Costus speciosus.

Journal: Biological & pharmaceutical bulletin 20020401

Title: [Isolation and identification of steroidal saponins in total saponin from Dioscorea nipponica Makino].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20020401

Title: [Advances in the study of Paris L. and its uses].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20020301

Title: Meiosis activating sterols derived from diosgenin.

Journal: Bioorganic & medicinal chemistry letters 20020225

Title: Chemical toxins and body defences.

Journal: Biologist (London, England) 20020201

Title: Apoptosis induced by dioscin in Hela cells.

Journal: Biological & pharmaceutical bulletin 20020201

Title: Influence of different light intensities on the content of diosgenin, lipids, carotenoids and fatty acids in leaves of Dioscorea zingiberensis.

Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences 20020101

Title: Low temperature crystal structure of natural diosgenone.

Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences 20020101

Title: Phospholipids modulate the substrate specificity of soluble UDP-glucose:steroid glucosyltransferase from eggplant leaves.

Journal: Phytochemistry 20011101

Title: The isolation and identification of steroidal sapogenins in switchgrass.

Journal: Journal of natural toxins 20011101

Title: Cytotoxic activities and structure-cytotoxic relationships of steroidal saponins.

Journal: Biological & pharmaceutical bulletin 20011101

Title: A plant steroid, diosgenin, induces apoptosis, cell cycle arrest and COX activity in osteosarcoma cells.

Journal: FEBS letters 20011012

Title: [Screening of steroidal saponins from the bulbs of Lilium brownii var. colchesteri by combination of high performance liquid chromatography-electrospray ionization mass spectrometry and electron impact mass spectrometry].

Journal: Se pu = Chinese journal of chromatography 20010901

Title: Regulation of biliary cholesterol secretion is independent of hepatocyte canalicular membrane lipid composition: a study in the diosgenin-fed rat model.

Journal: Journal of hepatology 20010801

Title: [The change of diosgenin content in cultivated Dioscorea zingiberensis and D. panthaica from Guizhou province].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20010801

Title: Effects of wild yam extract on menopausal symptoms, lipids and sex hormones in healthy menopausal women.

Journal: Climacteric : the journal of the International Menopause Society 20010601

Title: An improved synthesis of the saponin, polyphyllin D.

Journal: Carbohydrate research 20010309

Title: Effects of two saponins extracted from the polygonatum Zanlanscianense pamp on the human leukemia (HL-60) cells.

Journal: Biological & pharmaceutical bulletin 20010201

Title: Release of intermediate reactive hydrogen peroxide by macrophage cells activated by natural products.

Journal: Biological & pharmaceutical bulletin 20010201

Title: The prevention of osteoporotic progression by means of steroid loaded TCPL drug delivery systems.

Journal: Biomedical sciences instrumentation 20010101

Title: The use of estrogen, DHEA, and diosgenin in a sustained delivery setting as a novel treatment approach for osteoporosis in the ovariectomized adult rat model.

Journal: Biomedical sciences instrumentation 20010101

Title: Inhibitory effect of steroidal alkaloids on drug transport and multidrug resistance in human cancer cells.

Journal: Anticancer research 20010101

Title: C-27 and C-3 glucosylation of diosgenin by cell suspension cultures of Costus speciosus.

Journal: Journal of Asian natural products research 20010101

Title: 13C cross-polarization MAS NMR study of some steroidal sapogenins.

Journal: Solid state nuclear magnetic resonance 20010101

Title: Medicinal and ethnoveterinary remedies of hunters in Trinidad.

Journal: BMC complementary and alternative medicine 20010101

Title: [Forgotten episodes of the birth of cortisone].

Journal: Yakushigaku zasshi 20010101

Title: In vitro effect of fenugreek extracts on intestinal sodium-dependent glucose uptake and hepatic glycogen phosphorylase A.

Journal: International journal of experimental diabetes research 20010101

Title: Effects of diosgenin, a plant-derived steroid, on bile secretion and hepatocellular cholestasis induced by estrogens in the rat.

Journal: Hepatology (Baltimore, Md.) 19980701

Title: Li F, et al. Diosgenin, a steroidal saponin, inhibits STAT3 signaling pathway leading to suppression of proliferation and chemosensitization of human hepatocellular carcinoma cells. Cancer Lett. 2010 Jun 28;292(2):197-207.

Title: Tohda C, et al. Diosgenin is an exogenous activator of 1,25D₃-MARRS/Pdia3/ERp57 and improves Alzheimer's disease pathologies in 5XFAD mice. Sci Rep. 2012;2:535.

Title: Jeremy E. Chojnacki, et al. Bivalent ligands incorporating curcumin and diosgenin asmultifunctional compounds against Alzheimer’s disease. Bioorganic & Medicinal Chemistry, 23 (2015) 7324–7331

Title: Wang X, et al. Effect of diosgenin on metabolic dysfunction: Role of ERβ in the regulation of PPARγ. Toxicol Appl Pharmacol. 2015 Dec 1;289(2):286-96.

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Tags:512-04-9 Molecular Formula|512-04-9 MDL|512-04-9 SMILES|512-04-9 Diosgenin