Home Other Building Blocks 5465-86-1
5465-86-1,MFCD00817920
Catalog No.:AA003LN2

5465-86-1 | Ml 204

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$6.00   $4.00
- +
5mg
98%
in stock  
$16.00   $11.00
- +
10mg
98%
in stock  
$23.00   $16.00
- +
25mg
98%
in stock  
$38.00   $27.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA003LN2
Chemical Name:
Ml 204
CAS Number:
5465-86-1
Molecular Formula:
C15H18N2
Molecular Weight:
226.3168
MDL Number:
MFCD00817920
SMILES:
Cc1cc(nc2c1cccc2)N1CCCCC1
NSC Number:
25850
Properties
Properties
 
BP:
404.4°C at 760 mmHg  
Form:
Solid  
MP:
72-73℃  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
247  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
17  
Hydrogen Bond Acceptor Count:
2  
Rotatable Bond Count:
1  
XLogP3:
3.9  

Downstream Synthesis Route

[1]SyntheticCommunications,2000,vol.30,p.4479-4488

[2]Patent:EP2790687,2018,B1.Locationinpatent:Paragraph0046-0047

[3]Patent:JP2015/500345,2015,A.Locationinpatent:Paragraph0042-0043

110-89-4   
1-isocyano-2-(2-methoxy-1-methylethenyl)benzene 
  5465-86-1 

[1]Tetrahedron,2004,vol.60,p.11639-11645

[1]Tetrahedron,2004,vol.60,p.11639-11645

[1]Tetrahedron,2004,vol.60,p.11639-11645

Literature

Title: Aflatoxin B1 disrupts transient receptor potential channel activity and increases COX-2 expression in JEG-3 placental cells.

Journal: Chemico-biological interactions 20161225

Title: Zeranol induces COX-2 expression through TRPC-3 activation in the placental cells JEG-3.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20160901

Title: Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels.

Journal: The Journal of biological chemistry 20110923

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Miller M, et al. Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels. J Biol Chem. 2011 Sep 23;286(38):33436-46.

Title: Miller MR, et al. Novel Chemical Inhibitor of TRPC4 Channels. Probe Reports from the NIH Molecular Libraries Program [Internet

Title: Thomas Schaldecker, et al. Inhibition of the TRPC5 ion channel protects the kidney filter. J Clin Invest. 2013 Dec 2; 123(12): 5298–5309.

Title: Domingos M S Pereira, et al. Transient Receptor Potential Canonical Channels 4 and 5 Mediate Escherichia coli-Derived Thioredoxin Effects in Lipopolysaccharide-Injected Mice. Oxid Med Cell Longev. 2018 Jun 10;2018:4904696.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:5465-86-1 Molecular Formula|5465-86-1 MDL|5465-86-1 SMILES|5465-86-1 Ml 204