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55056-80-9,MFCD03427682
Catalog No.:AA00IKJ6

55056-80-9 | Protodioscin

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1mg
≥95%
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5mg
99%(HPLC)
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10mg
99%(HPLC)
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$153.00   $107.00
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25mg
99%(HPLC)
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50mg
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00IKJ6
Chemical Name:
Protodioscin
CAS Number:
55056-80-9
Molecular Formula:
C51H84O22
Molecular Weight:
1049.1995
MDL Number:
MFCD03427682
SMILES:
OC[C@H]1O[C@@H](O[C@H]2CC[C@]3(C(=CC[C@@H]4[C@@H]3CC[C@]3([C@H]4C[C@H]4[C@@H]3[C@H](C)[C@@](O4)(O)CC[C@H](CO[C@@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O)C)C)C2)C)[C@@H]([C@H]([C@@H]1O[C@@H]1O[C@@H](C)[C@@H]([C@H]([C@H]1O)O)O)O)O[C@@H]1O[C@@H](C)[C@@H]([C@H]([C@H]1O)O)O
Properties
Computed Properties
 
Complexity:
1900  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
31  
Heavy Atom Count:
73  
Hydrogen Bond Acceptor Count:
22  
Hydrogen Bond Donor Count:
13  
Rotatable Bond Count:
14  
XLogP3:
-1.3  

Literature

Title: Solanum incanum and S. heteracanthum as sources of biologically active steroid glycosides: confirmation of their synonymy.

Journal: Fitoterapia 20120901

Title: Genetic variation of Fusarium oxysporum isolates forming fumonisin B(1) and moniliformin.

Journal: Journal of applied genetics 20120501

Title: Effect of aqueous extract of Arctium lappa L. (burdock) roots on the sexual behavior of male rats.

Journal: BMC complementary and alternative medicine 20120101

Title: Evaluation of the aphrodisiac activity of Tribulus terrestris Linn. in sexually sluggish male albino rats.

Journal: Journal of pharmacology & pharmacotherapeutics 20120101

Title: Fenugreek with reduced bitterness prevents diet-induced metabolic disorders in rats.

Journal: Lipids in health and disease 20120101

Title: Effects of various asparagus production methods on rutin and protodioscin contents in spears and cladophylls.

Journal: Bioscience, biotechnology, and biochemistry 20120101

Title: Relative feeding and development of armyworm on switchgrass and corn, and its potential effects on switchgrass grown for biomass.

Journal: Journal of economic entomology 20111001

Title: Differential activity of multiple saponins against omnivorous insects with varying feeding preferences.

Journal: Journal of chemical ecology 20110501

Title: The effect of fenugreek on the gene expression of arachidonic acid metabolizing enzymes.

Journal: Phytotherapy research : PTR 20110201

Title: Effect of Aqueous Extract of Massularia acuminata Stem on Sexual Behaviour of Male Wistar Rats.

Journal: Evidence-based complementary and alternative medicine : eCAM 20110101

Title: Thujone-Rich Fraction of Thuja occidentalis Demonstrates Major Anti-Cancer Potentials: Evidences from In Vitro Studies on A375 Cells.

Journal: Evidence-based complementary and alternative medicine : eCAM 20110101

Title: Effect of aqueous extract of Tribulus terrestris on oxalate-induced oxidative stress in rats.

Journal: Indian journal of nephrology 20110101

Title: Protective effect of an aphrodisiac herb Tribulus terrestris Linn on cadmium-induced testicular damage.

Journal: Indian journal of pharmacology 20110101

Title: Anti-thrombotic activity and chemical characterization of steroidal saponins from Dioscorea zingiberensis C.H. Wright.

Journal: Fitoterapia 20101201

Title: Qualitative and quantitative determination of major saponins in Paris and Trillium by HPLC-ELSD and HPLC-MS/MS.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20101101

Title: Antihyperlipidemic effect of protodioscin, an active ingredient isolated from the rhizomes of Dioscorea nipponica.

Journal: Planta medica 20101001

Title: Ligand fishing from Dioscorea nipponica extract using human serum albumin functionalized magnetic nanoparticles.

Journal: Journal of chromatography. A 20100709

Title: Pharmacokinetics of methyl protodioscin in rats.

Journal: Die Pharmazie 20100501

Title: [Effects of methyl protodioscin on [Ca2+]i and ATPase activity in cardiomyocytes and analysis of mechanisms].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100101

Title: Development of a rapid HPLC-UV method for simultaneous quantification of protodioscin and rutin in white and green asparagus spears.

Journal: Journal of food science 20100101

Title: A new spirostanol glycoside from fruits of Solanum indicum L.

Journal: Chemical & pharmaceutical bulletin 20090701

Title: Steroidal saponins from Smilax excelsa rhizomes.

Journal: Natural product research 20090101

Title: Distribution of steroidal saponins in Tribulus terrestris from different geographical regions.

Journal: Phytochemistry 20080101

Title: The hormonal effects of Tribulus terrestris and its role in the management of male erectile dysfunction--an evaluation using primates, rabbit and rat.

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 20080101

Title: Determination of protodioscin in rat plasma by liquid chromatography-tandem mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070401

Title: [Study on steroidal saponins of Dioscorea septemloba thunb].

Journal: Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20061101

Title: Methyl protodioscin induces G2/M cell cycle arrest and apoptosis in HepG2 liver cancer cells.

Journal: Cancer letters 20060908

Title: Structural identification of methyl protodioscin metabolites in rats' urine and their antiproliferative activities against human tumor cell lines.

Journal: Steroids 20060901

Title: Microbial metabolism of methyl protodioscin by Aspergillus niger culture--a new androstenedione producing way from steroid.

Journal: The Journal of steroid biochemistry and molecular biology 20060701

Title: Methyl protodioscin induces G2/M arrest and apoptosis in K562 cells with the hyperpolarization of mitochondria.

Journal: Cancer letters 20050628

Title: Synthesis of bidesmosidic dihydrodiosgenin saponins bearing a 3-O-beta-chacotriosyl moiety.

Journal: Carbohydrate research 20040712

Title: Microbial metabolism of pseudoprotodioscin.

Journal: Planta medica 20040701

Title: Steroidal saponins from Dioscorea panthaica and their cytotoxic activity.

Journal: Die Pharmazie 20040401

Title: Quantification of protodioscin and rutin in asparagus shoots by LC/MS and HPLC methods.

Journal: Journal of agricultural and food chemistry 20031008

Title: Furostanol saponins from Tribulus terrestris.

Journal: Fitoterapia 20030901

Title: The cytotoxicity of methyl protodioscin against human cancer cell lines in vitro.

Journal: Cancer investigation 20030601

Title: Total synthesis of methyl protodioscin: a potent agent with antitumor activity.

Journal: The Journal of organic chemistry 20030502

Title: Sexual effects of puncturevine (Tribulus terrestris) extract (protodioscin): an evaluation using a rat model.

Journal: Journal of alternative and complementary medicine (New York, N.Y.) 20030401

Title: Protodioscin isolated from fenugreek (Trigonella foenumgraecum L.) induces cell death and morphological change indicative of apoptosis in leukemic cell line H-60, but not in gastric cancer cell line KATO III.

Journal: International journal of molecular medicine 20030101

Title: Aphrodisiac properties of Tribulus Terrestris extract (Protodioscin) in normal and castrated rats.

Journal: Life sciences 20020809

Title: Protodioscin (NSC-698 796): its spectrum of cytotoxicity against sixty human cancer cell lines in an anticancer drug screen panel.

Journal: Planta medica 20020401

Title: Two new sulfated furostanol saponins from Tribulus terrestris.

Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences 20020101

Title: Determination of steroidal saponins in Tribulus terrestris by reversed-phase high-performance liquid chromatography and evaporative light scattering detection.

Journal: Journal of pharmaceutical sciences 20011101

Title: Shen J, et al. Protodioscin ameliorates fructose-induced renal injury via inhibition of the mitogen activated protein kinase pathway. Phytomedicine. 2016 Nov 15;23(12):1504-1510.

Title: Zhang X, et al. Potential neuroprotection of protodioscin against cerebral ischemia-reperfusion injury in rats through intervening inflammation and apoptosis. Steroids. 2016 Sep;113:52-63

Title: Wang T, et al. Antihyperlipidemic effect of protodioscin, an active ingredient isolated from the rhizomes of Dioscorea nipponica. Planta Med. 2010 Oct;76(15):1642-6

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