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5611-51-8,MFCD00867440
Catalog No.:AA01CCKS

5611-51-8 | Pregna-1,4-diene-3,20-dione,21-(3,3-dimethyl-1-oxobutoxy)-9-fluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-, (11b,16a)-

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1g
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$1,040.00   $728.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA01CCKS
Chemical Name:
Pregna-1,4-diene-3,20-dione,21-(3,3-dimethyl-1-oxobutoxy)-9-fluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-, (11b,16a)-
CAS Number:
5611-51-8
Molecular Formula:
C30H41FO7
Molecular Weight:
532.6407
MDL Number:
MFCD00867440
SMILES:
O=C(CC(C)(C)C)OCC(=O)[C@@]12OC(O[C@@H]1C[C@@H]1[C@]2(C)C[C@H](O)[C@]2([C@H]1CCC1=CC(=O)C=C[C@]21C)F)(C)C
Properties
Computed Properties
 
Complexity:
1130  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
8  
Heavy Atom Count:
38  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
6  
XLogP3:
4.8  

Literature

Title: Intra-articular corticosteroid injections to the temporomandibular joints are safe and appear to be effective therapy in children with juvenile idiopathic arthritis.

Journal: Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 20120801

Title: A dose schedule for intraarticular steroids in juvenile arthritis.

Journal: The Journal of rheumatology 20120201

Title: Accuracy of intra-articular injection of the glenohumeral joint: a modified anterior approach.

Journal: Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association 20111001

Title: Outcome and predicting factors of single and multiple intra-articular corticosteroid injections in children with juvenile idiopathic arthritis.

Journal: Rheumatology (Oxford, England) 20110901

Title: The effect of intra-articular triamcinolone preparations on blood glucose levels in diabetic patients: a controlled study.

Journal: Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases 20110901

Title: Can simple ultrasonography predict the clinical effect of intra-articular injection therapy of the knee joint?

Journal: Clinical rheumatology 20110601

Title: Effectiveness of radiation synovectomy with Yttrium-90 and Samarium-153 particulate hydroxyapatite in rheumatoid arthritis patients with knee synovitis: a controlled, randomized, double-blinded trial.

Journal: Clinical rheumatology 20110101

Title: Intra-articular corticoid injection induces circulating glucocorticoid bioactivity and systemic immune activation in juvenile idiopathic arthritis.

Journal: Scandinavian journal of rheumatology 20110101

Title: Intralesional injection of triamcinolone hexacetonide as an alternative treatment for central giant-cell granuloma in 21 cases.

Journal: International journal of oral and maxillofacial surgery 20101201

Title: Joint lavage associated with triamcinolone hexacetonide injection in knee osteoarthritis: a randomized double-blind controlled study.

Journal: Clinical rheumatology 20101101

Title: Use of glucocorticoids in rheumatoid arthritis - pratical modalities of glucocorticoid therapy: recommendations for clinical practice based on data from the literature and expert opinion.

Journal: Joint, bone, spine : revue du rhumatisme 20101001

Title: Synovial biopsy findings in arthritis associated with hepatitis C virus infection.

Journal: The Journal of rheumatology 20100601

Title: Effectiveness of radiation synovectomy with samarium-153 particulate hydroxyapatite in rheumatoid arthritis patients with knee synovitis: a controlled randomized double-blind trial.

Journal: Clinics (Sao Paulo, Brazil) 20091201

Title: Lipoatrophy resulting from steroid injection into the temporomandibular joint.

Journal: Arthritis and rheumatism 20091101

Title: The Clinical Picture - Soft tissue atrophy after corticosteroid injection.

Journal: Cleveland Clinic journal of medicine 20090601

Title: Accuracy of intra-articular injections in peripheral joints performed blindly in patients with rheumatoid arthritis.

Journal: Rheumatology (Oxford, England) 20081201

Title: Subcutaneous calcification following injection of triamcinolone hexacetonide for plantar fasciitis.

Journal: Rheumatology (Oxford, England) 20081201

Title: Quantitative histological changes of repeated antigen-induced arthritis in the temporomandibular joints of rabbits treated with intra-articular corticosteroid.

Journal: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 20080801

Title: Reduced mandibular growth in experimental arthritis in the temporomandibular joint treated with intra-articular corticosteroid.

Journal: European journal of orthodontics 20080401

Title: Safety and pharmokinetics of triamcinolone hexacetonide in rabbit eyes.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20080401

Title: Serum levels of sex steroid hormones and matrix metalloproteinases after intra-articular glucocorticoid treatment in female patients with rheumatoid arthritis.

Journal: Annals of the rheumatic diseases 20080301

Title: The intra-articular distribution of 90yttrium does not influence the clinical outcome of radiation synovectomy of the knee.

Journal: Annals of the rheumatic diseases 20070801

Title: Effects of intra-articular corticosteroids and anti-TNF therapy on neutrophil activation in rheumatoid arthritis.

Journal: Annals of the rheumatic diseases 20070801

Title: Steroid injection for osteoarthritis of the hip: a randomized, double-blind, placebo-controlled trial.

Journal: Arthritis and rheumatism 20070701

Title: Cortisol metabolism by 11 beta-hydroxysteroid dehydrogenase as a novel target in the treatment of inflammation- or immune-mediated bone loss: comment on the article by Makrygiannakis et al.

Journal: Arthritis and rheumatism 20070101

Title: Intra-tendon sheath injection for trigger finger: the randomized controlled trial.

Journal: Hand surgery : an international journal devoted to hand and upper limb surgery and related research : journal of the Asia-Pacific Federation of Societies for Surgery of the Hand 20070101

Title: Benefit of intraarticular corticosteroid injection under fluoroscopic guidance for subtalar arthritis in juvenile idiopathic arthritis.

Journal: The Journal of rheumatology 20061101

Title: Glucocorticoid resorption and influence on the hypothalamic-pituitary-adrenal axis after intra-articular treatment of the knee in resting and mobile patients.

Journal: Annals of the rheumatic diseases 20060701

Title: Intraarticular corticosteroids decrease synovial RANKL expression in inflammatory arthritis.

Journal: Arthritis and rheumatism 20060501

Title: Carbonated apatite-induced arthropathy: a consideration in cases of polyarthritis.

Journal: Nature clinical practice. Rheumatology 20060501

Title: Polyarthritis and familial pulmonary fibrosis in a child.

Journal: Joint, bone, spine : revue du rhumatisme 20060301

Title: Intraarticular glucocorticoid treatment reduces inflammation in synovial cell infiltrations more efficiently than in synovial blood vessels.

Journal: Arthritis and rheumatism 20051201

Title: Polyarticular corticosteroid injection versus systemic administration in treatment of rheumatoid arthritis patients: a randomized controlled study.

Journal: The Journal of rheumatology 20050901

Title: [Calcification following intradiscal injection, a continuing problem?].

Journal: Presse medicale (Paris, France : 1983) 20050702

Title: Comparison of the intraarticular effectiveness of triamcinolone hexacetonide and triamcinolone acetonide in treatment of juvenile rheumatoid arthritis.

Journal: The Journal of rheumatology 20041201

Title: Triamcinolone acetonide and hexacetonide intra-articular treatment of symmetrical joints in juvenile idiopathic arthritis: a double-blind trial.

Journal: Rheumatology (Oxford, England) 20041001

Title: A randomised controlled trial of intra-articular corticosteroid injection of the carpometacarpal joint of the thumb in osteoarthritis.

Journal: Annals of the rheumatic diseases 20041001

Title: The effect of triamcinolone hexacetonide on the spontaneous and mechanically-induced ectopic discharge following lingual nerve injury in the ferret.

Journal: Pain 20041001

Title: Contrast-enhanced power Doppler sonography of knee synovitis in rheumatoid arthritis: assessment of therapeutic response.

Journal: Clinical rheumatology 20040801

Title: Intra-articular methotrexate in knee synovitis.

Journal: Rheumatology (Oxford, England) 20040601

Title: Intra-articular steroids in knee osteoarthritis: a comparative study of triamcinolone hexacetonide and methylprednisolone acetate.

Journal: Clinical rheumatology 20040401

Title: Arthritis induced by corticosteroid crystals.

Journal: The Journal of rheumatology 20040301

Title: A randomized, single-blind comparison of the efficacy and tolerability of hylan G-F 20 and triamcinolone hexacetonide in patients with osteoarthritis of the knee.

Journal: The Journal of rheumatology 20040201

Title: Contrast-enhanced MRI compared to histological findings in the temporomandibular joint of antigen-induced arthritis in young rabbits.

Journal: Clinical and experimental rheumatology 20040101

Title: Peripheral mechanisms for the initiation of pain following trigeminal nerve injury.

Journal: Journal of orofacial pain 20040101

Title: Comparison of intra-articular triamcinolone hexacetonide and triamcinolone acetonide in oligoarticular juvenile idiopathic arthritis.

Journal: Rheumatology (Oxford, England) 20031001

Title: Randomised controlled study of postinjection immobilisation after intra-articular glucocorticoid treatment for wrist synovitis.

Journal: Annals of the rheumatic diseases 20031001

Title: Intra-articular corticosteroid injections in juvenile idiopathic arthritis.

Journal: Archives of disease in childhood 20030301

Title: Intraarticular corticosteroids, supervised physiotherapy, or a combination of the two in the treatment of adhesive capsulitis of the shoulder: a placebo-controlled trial.

Journal: Arthritis and rheumatism 20030301

Title: [Use of corticosteroids after esophageal dilations on patients with corrosive stenosis: prospective, randomized and double-blind study].

Journal: Revista da Associacao Medica Brasileira (1992) 20030101

Title: [Intra-articular steroid therapy for inflammatory rheumatic diseases in children and adolescents].

Journal: Der Orthopade 20021201

Title: Use of triamcinolone hexacetonide for the treatment of osteoarthritis of the hip: comment on the letter by Margules.

Journal: Arthritis and rheumatism 20020901

Title: The efficacy and safety of intraarticular corticosteroid therapy for coxitis in juvenile rheumatoid arthritis.

Journal: Arthritis and rheumatism 20020601

Title: Macrophage migration inhibitory factor in patients with juvenile idiopathic arthritis.

Journal: Arthritis and rheumatism 20020101

Title: Treatment of juvenile idiopathic arthritis with intra-articular triamcinolone hexacetonide: evaluation of clinical effectiveness correlated with circulating ANA and T gamma/delta + and B CD5+ lymphocyte populations of synovial fluid.

Journal: Clinical and experimental rheumatology 20020101

Title: The role of ultrasonography in the diagnosis and management of idiopathic plantar fasciitis.

Journal: Rheumatology (Oxford, England) 20010901

Title: Isolated temporomandibular synovitis as unique presentation of juvenile idiopathic arthritis.

Journal: The Journal of rheumatology 20010701

Title: An attempt to develop a model to study the effects of intrathecal steroids.

Journal: European journal of anaesthesiology 19860301

Title: Masseter myopathy following systemic corticosteroid administration: an experimental study.

Journal: Oral surgery, oral medicine, and oral pathology 19801201

Title: Williams JM, et al. Triamcinolone hexacetonide protects against fibrillation and osteophyte formation following chemically induced articular cartilage damage. Arthritis Rheum. 1985 Nov;28(11):1267-74.

Title: Abd-El-Barr MM, et al. Safety and pharmokinetics of triamcinolone hexacetonide in rabbit eyes. J Ocul Pharmacol Ther. 2008 Apr;24(2):197-205.

Title: Yates JM, et al. The effect of triamcinolone hexacetonide on the spontaneous and mechanically-induced ectopic discharge following lingual nerve injury in the ferret. Pain. 2004 Oct;111(3):261-9.

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Tags:5611-51-8 Molecular Formula|5611-51-8 MDL|5611-51-8 SMILES|5611-51-8 Pregna-1,4-diene-3,20-dione,21-(3,3-dimethyl-1-oxobutoxy)-9-fluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-, (11b,16a)-