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57-64-7,MFCD00135659
Catalog No.:AA00E8NT

57-64-7 | PHYSOSTIGMINE SALICYLATE

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Purity
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25mg
≥95%
in stock  
$122.00   $85.00
- +
50mg
≥95%
in stock  
$218.00   $152.00
- +
100mg
≥95%
in stock  
$338.00   $236.00
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250mg
≥95%
in stock  
$783.00   $548.00
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  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00E8NT
Chemical Name:
PHYSOSTIGMINE SALICYLATE
CAS Number:
57-64-7
Molecular Formula:
C22H27N3O5
Molecular Weight:
413.4669
MDL Number:
MFCD00135659
SMILES:
OC(=O)c1ccccc1O.CNC(=O)Oc1ccc2c(c1)[C@]1(C)CCN([C@@H]1N2C)C
NSC Number:
757275
Properties
Properties
 
Form:
Solid  
MP:
181-183 °C  

Computed Properties
 
Complexity:
535  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
30  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
3  

Literature

Title: Possible interaction of cholinergic and GABAergic systems between MS and CA1 upon memory acquisition in rats.

Journal: Behavioural brain research 20121201

Title: Selenium induces cholinergic motor neuron degeneration in Caenorhabditis elegans.

Journal: Neurotoxicology 20121001

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Rational design and synthesis of highly potent anti-acetylcholinesterase activity huperzine A derivatives.

Journal: Bioorganic & medicinal chemistry 20091001

Title: Development and optimization of a sublingual tablet formulation for physostigmine salicylate.

Journal: Acta pharmaceutica (Zagreb, Croatia) 20090901

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Anticholinesterase activity of compounds related to geneserine tautomers. N-Oxides and 1,2-oxazines.

Journal: Journal of medicinal chemistry 20020815

Title: [Anticholinergic syndrome after postoperative dimenhydrinate administration].

Journal: HNO 20011201

Title: Reciprocal changes in psychosis and mood after physostigmine in a patient with Alzheimer's disease.

Journal: Archives of general psychiatry 19911201

Title: High doses of soman protect against organophosphorus-induced delayed polyneuropathy but tabun does not.

Journal: Toxicology and applied pharmacology 19880101

Title: Physostigmine versus naloxone in heroin-overdose.

Journal: Journal of toxicology. Clinical toxicology 19830101

Title: Time dependent changes in anterograde scopolamine-induced amnesia in rats.

Journal: Pharmacology, biochemistry, and behavior 19810301

Title: On the interaction of drugs with the cholinergic nervous system--V. Characterization of some effects induced by physostigmine in mice: in vivo and in vitro studies.

Journal: Biochemical pharmacology 19780115

Title: Physostigmine treatment of delirium induced by anticholinergics.

Journal: American family physician 19760501

Title: Physostigmine effects on phenothiazine-induced extrapyramidal reactions.

Journal: Archives of neurology 19731201

Title: Reversal of postoperative reactions to scopolamine with physostigmine.

Journal: Anesthesia and analgesia 19730101

Title: Reversal of central anticholinergic syndrome in man by physostigmine.

Journal: JAMA 19681125

Title: Haase U, et al. Pharmakotherapie--physostigmin post OP [Pharmacotherapy--physostigmine administered post-operatively Anasthesiol Intensivmed Notfallmed Schmerzther. 2007;42(3):188‐189.

Title: Dong H, et al, Bertchume A, Vallera D, Csernansky JG. Acetylcholinesterase inhibitors ameliorate behavioral deficits in the Tg2576 mouse model of Alzheimer's disease. Psychopharmacology (Berl). 2005;181(1):145‐152.

Title: Frascogna N. Physostigmine: is there a role for this antidote in pediatric poisonings?. Curr Opin Pediatr. 2007;19(2):201‐205.

Title: Jonathan D Kenny, et al. Physostigmine and Methylphenidate Induce Distinct Arousal States During Isoflurane General Anesthesia in Rats. Anesth Analg. 2016 Nov;123(5):1210-1219.

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SDS
Tags:57-64-7 Molecular Formula|57-64-7 MDL|57-64-7 SMILES|57-64-7 PHYSOSTIGMINE SALICYLATE