604-59-1 | Alpha-naphthoflavone

Title: In vivo exposure to hydroquinone during the early phase of collagen-induced arthritis aggravates the disease.

Journal: Toxicology 20180901

Title: Changes in the expression of genes involved in the ovarian function of rats caused by daily exposure to 3-methylcholanthrene and their prevention by α-naphthoflavone.

Journal: Archives of toxicology 20180201

Title: Apoptosis induction and inhibition of HeLa cell proliferation by alpha-naphthoflavone and resveratrol are aryl hydrocarbon receptor-independent.

Journal: Chemico-biological interactions 20180201

Title: Resveratrol supports and alpha-naphthoflavone disrupts growth of human ovarian follicles in an in vitro tissue culture model.

Journal: Toxicology and applied pharmacology 20180101

Title: The inhibitory effects of β-caryophyllene, β-caryophyllene oxide and α-humulene on the activities of the main drug-metabolizing enzymes in rat and human liver in vitro.

Journal: Chemico-biological interactions 20171225

Title: Steviol, an aglycone of steviol glycoside sweeteners, interacts with the pregnane X (PXR) and aryl hydrocarbon (AHR) receptors in detoxification regulation.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20171101

Title: Combined Docking and Quantum Chemical Study on CYP-Mediated Metabolism of Estrogens in Man.

Journal: Chemical research in toxicology 20170220

Title: Comparative Developmental Toxicity of Flavonoids Using an Integrative Zebrafish System.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20161101

Title: Hexachlorobenzene modulates the crosstalk between the aryl hydrocarbon receptor and transforming growth factor-β1 signaling, enhancing human breast cancer cell migration and invasion.

Journal: Toxicology 20160729

Title: Inhibition of the aryl hydrocarbon receptor prevents Western diet-induced obesity. Model for AHR activation by kynurenine via oxidized-LDL, TLR2/4, TGFβ, and IDO1.

Journal: Toxicology and applied pharmacology 20160601

Title: The systemic and gonadal toxicity of 3-methylcholanthrene is prevented by daily administration of α-naphthoflavone.

Journal: Toxicology 20160415

Title: 2,3',4,4',5-Pentachlorobiphenyl Induces Inflammatory Responses in the Thyroid Through JNK and Aryl Hydrocarbon Receptor-Mediated Pathway.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20160201

Title: Tetrandrine ameliorates collagen-induced arthritis in mice by restoring the balance between Th17 and Treg cells via the aryl hydrocarbon receptor.

Journal: Biochemical pharmacology 20160201

Title: Cytochrome P450 inhibition potential of new psychoactive substances of the tryptamine class.

Journal: Toxicology letters 20160122

Title: Transactivation Assays to Assess Canine and Rodent Pregnane X Receptor (PXR) and Constitutive Androstane Receptor (CAR) Activation.

Journal: PloS one 20160101

Title: Hexachlorobenzene promotes angiogenesis in vivo, in a breast cancer model and neovasculogenesis in vitro, in the human microvascular endothelial cell line HMEC-1.

Journal: Toxicology letters 20151119

Title: Benzo[a]pyrene-induced nitric oxide production acts as a survival signal targeting mitochondrial membrane potential.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20151001

Title: Aryl Hydrocarbon Receptor Ligand 5F 203 Induces Oxidative Stress That Triggers DNA Damage in Human Breast Cancer Cells.

Journal: Chemical research in toxicology 20150518

Title: Norisoboldine, an Anti-Arthritis Alkaloid Isolated from Radix Linderae, Attenuates Osteoclast Differentiation and Inflammatory Bone Erosion in an Aryl Hydrocarbon Receptor-Dependent Manner.

Journal: International journal of biological sciences 20150101

Title: Benzo[a]pyrene sensitizes MCF7 breast cancer cells to induction of G1 arrest by the natural flavonoid eupatorin-5-methyl ether, via activation of cell signaling proteins and CYP1-mediated metabolism.

Journal: Toxicology letters 20141015

Title: Individual and joint toxic effects of cadmium sulfate and α-naphthoflavone on the development of zebrafish embryo.

Journal: Journal of Zhejiang University. Science. B 20140901

Title: Inhibition of cytochrome P450s enhances (+)-usnic acid cytotoxicity in primary cultured rat hepatocytes.

Journal: Journal of applied toxicology : JAT 20140801

Title: Assessment of the potential of polyphenols as a CYP17 inhibitor free of adverse corticosteroid elevation.

Journal: Biochemical pharmacology 20140801

Title: Aldrin epoxidation in flathead mullet (Mugil cephalus): possible involvement of CYP1A and CYP3A.

Journal: Journal of biochemical and molecular toxicology 20140601

Title: Low-dose benzo(a)pyrene and its epoxide metabolite inhibit myogenic differentiation in human skeletal muscle-derived progenitor cells.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20140401

Title: Differentiation of human placental BeWo cells by the environmental contaminant benzo(a)pyrene.

Journal: Chemico-biological interactions 20140305

Title: Areca nut components affect COX-2, cyclin B1/cdc25C and keratin expression, PGE2 production in keratinocyte is related to reactive oxygen species, CYP1A1, Src, EGFR and Ras signaling.

Journal: PloS one 20140101

Title: Classification of polycyclic aromatic hydrocarbons based on mutagenicity in lung tissue through DNA microarray.

Journal: Environmental toxicology 20131101

Title: TCDD induces the expression of insulin-like growth factor binding protein 4 in 5L rat hepatoma cells: a cautionary tale of the use of this cell line in studies on dioxin toxicity.

Journal: Toxicology 20130705

Title: Pyranoflavones: a group of small-molecule probes for exploring the active site cavities of cytochrome P450 enzymes 1A1, 1A2, and 1B1.

Journal: Journal of medicinal chemistry 20130523

Title: Action of hexachlorobenzene on tumor growth and metastasis in different experimental models.

Journal: Toxicology and applied pharmacology 20130501

Title: Characterization of chicken cytochrome P450 1A4 and 1A5: inter-paralog comparisons of substrate preference and inhibitor selectivity.

Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20130501

Title: Synthesis and evaluation of non-dimeric HCV NS5A inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20130401

Title: 2,3,7,8-Tetrachlorodibenzo-p-dioxin-mediated production of reactive oxygen species is an essential step in the mechanism of action to accelerate human keratinocyte differentiation.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20130301

Title: Interactions of pharmaceuticals and other xenobiotics on key detoxification mechanisms and cytoskeleton in Poeciliopsis lucida hepatocellular carcinoma, PLHC-1 cell line.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20130201

Title: Coplanar polychlorinated biphenyls impair glucose homeostasis in lean C57BL/6 mice and mitigate beneficial effects of weight loss on glucose homeostasis in obese mice.

Journal: Environmental health perspectives 20130101

Title: Aryl-hydrocarbon receptor activity modulates prolactin expression in the pituitary.

Journal: Toxicology and applied pharmacology 20121115

Title: Multiple anti-inflammatory pathways triggered by resveratrol lead to amelioration of staphylococcal enterotoxin B-induced lung injury.

Journal: British journal of pharmacology 20121101

Title: A potentiator induces conformational changes on the recombinant CFTR nucleotide binding domains in solution.

Journal: Cellular and molecular life sciences : CMLS 20121101

Title: Vitamin D receptor activation enhances benzo[a]pyrene metabolism via CYP1A1 expression in macrophages.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20121101

Title: Identification of CYP isozymes involved in benzbromarone metabolism in human liver microsomes.

Journal: Biopharmaceutics & drug disposition 20121101

Title: Dibenzofuran induces oxidative stress, disruption of trans-mitochondrial membrane potential (ΔΨm) and G1 arrest in human hepatoma cell line.

Journal: Toxicology letters 20121017

Title: PCB126 induces apoptosis of chondrocytes via ROS-dependent pathways.

Journal: Osteoarthritis and cartilage 20121001

Title: Aryl hydrocarbon receptor-independent up-regulation of intracellular calcium concentration by environmental polycyclic aromatic hydrocarbons in human endothelial HMEC-1 cells.

Journal: Environmental toxicology 20120901

Title: Bioactivation of the citrus flavonoid nobiletin by CYP1 enzymes in MCF7 breast adenocarcinoma cells.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120901

Title: Active intestinal absorption of fluoroquinolone antibacterial agent ciprofloxacin by organic anion transporting polypeptide, Oatp1a5.

Journal: Biopharmaceutics & drug disposition 20120901

Title: Synthesis and evaluation of novel potent HCV NS5A inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20120715

Title: Aryl hydrocarbon receptor activation by aminoflavone: new molecular target for renal cancer treatment.

Journal: International journal of oncology 20120701

Title: The role of cytochrome P4501A activity inhibition in three- to five-ringed polycyclic aromatic hydrocarbons embryotoxicity of marine medaka (Oryzias melastigma).

Journal: Marine pollution bulletin 20120701

Title: Anti-ageing effects of alpha-naphthoflavone on normal and UVB-irradiated human skin fibroblasts.

Journal: Experimental dermatology 20120701

Title: Progesterone receptor is involved in 2,3,7,8-tetrachlorodibenzo-p-dioxin-stimulated breast cancer cells proliferation.

Journal: Cancer letters 20120628

Title: Inflammatory pathway genes belong to major targets of persistent organic pollutants in adipose cells.

Journal: Environmental health perspectives 20120401

Title: Cancer prevention mediated by caffeic acid phenethyl ester involves cyp2b1/2 modulation in hepatocarcinogenesis.

Journal: Toxicologic pathology 20120401

Title: The molecular basis for the inhibition of human cytochrome P450 1A2 by oroxylin and wogonin.

Journal: European biophysics journal : EBJ 20120301

Title: Identification of the couple GSK3α/c-Myc as a new regulator of hexokinase II in benzo[a]pyrene-induced apoptosis.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20120201

Title: Flavonoids exhibit diverse effects on CYP11B1 expression and cortisol synthesis.

Journal: Toxicology and applied pharmacology 20120201

Title: CYP1B1 detection.

Journal: Current protocols in toxicology 20120201

Title: Bupropion hydroxylation as a selective marker of rat CYP2B1 catalytic activity.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20120101

Title: Induction of NAD(P)H-quinone oxidoreductase 1 by antioxidants in female ACI rats is associated with decrease in oxidative DNA damage and inhibition of estrogen-induced breast cancer.

Journal: Carcinogenesis 20120101

Title: Synthesis of methoxybenzoflavones and assignments of their NMR data.

Journal: Magnetic resonance in chemistry : MRC 20120101

Title: PCB 126 and other dioxin-like PCBs specifically suppress hepatic PEPCK expression via the aryl hydrocarbon receptor.

Journal: PloS one 20120101

Title: [Tissue-specific expression of hormonal carcinogenesis target genes in rats treated with polycyclic aromatic hydrocarbons].

Journal: Biomeditsinskaia khimiia 20120101

Title: A cell-based, microplate colorimetric screen identifies 7,8-benzoflavone and green tea gallate catechins as inhibitors of the hepatitis C virus.

Journal: Biological & pharmaceutical bulletin 20120101

Title: In vitro characterization of the oxidation of a pyridinium metabolite of haloperidol by human placenta: the effect of smoking.

Journal: Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20120101

Title: Aryl hydrocarbon receptor deficiency enhances insulin sensitivity and reduces PPAR-α pathway activity in mice.

Journal: Environmental health perspectives 20111201

Title: Allosteric activation of cytochrome P450 3A4 by α-naphthoflavone: branch point regulation revealed by isotope dilution analysis.

Journal: Biochemistry 20111122

Title: In vitro metabolism of nobiletin, a polymethoxy-flavonoid, by human liver microsomes and cytochrome P450.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20111101

Title: 2,3,7,8-Tetrachlorodibenzo-p-dioxin increases the expression of genes in the human epidermal differentiation complex and accelerates epidermal barrier formation.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20111101

Title: Role of P450 1A1 and P450 1A2 in bioactivation versus detoxication of the renal carcinogen aristolochic acid I: studies in Cyp1a1-/-, Cyp1a2-/-, and Cyp1a1/1a2-/- mice.

Journal: Chemical research in toxicology 20111017

Title: Relationship between the structures of flavonoids and their NF-κB-dependent transcriptional activities.

Journal: Bioorganic & medicinal chemistry letters 20111015

Title: Gene expression and inducibility of the aryl hydrocarbon receptor-dependent pathway in cultured bovine blood lymphocytes.

Journal: Toxicology letters 20111010

Title: Inhibition of cytochrome P450 2A participating in coumarin 7-hydroxylation in pig liver microsomes.

Journal: Journal of veterinary pharmacology and therapeutics 20111001

Title: Lactobacillus bulgaricus OLL1181 activates the aryl hydrocarbon receptor pathway and inhibits colitis.

Journal: Immunology and cell biology 20111001

Title: Identification of the human liver cytochrome P450 isoenzymes responsible for the 5-methylhydroxylation of the novel anti-fibrotic drug AKF-PD.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20111001

Title: The p38 MAPK inhibitor SB203580 induces cytochrome P450 1A1 gene expression in murine and human hepatoma cell lines through ligand-dependent aryl hydrocarbon receptor activation.

Journal: Chemical research in toxicology 20110919

Title: The effect of St John's wort (hypericum perforatum) on cytochrome p450 1a2 activity in perfused rat liver.

Journal: Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia 20110901

Title: Nitric oxide donor, V-PROLI/NO, provides protection against arsenical induced toxicity in rat liver cells: requirement for Cyp1a1.

Journal: Chemico-biological interactions 20110815

Title: Cytochromes P450 catalyze the reduction of α,β-unsaturated aldehydes.

Journal: Chemical research in toxicology 20110815

Title: Hepatic cytochrome P450s attenuate the cytotoxicity induced by leflunomide and its active metabolite A77 1726 in primary cultured rat hepatocytes.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20110801

Title: The role of CYP1A inhibition in the embryotoxic interactions between hypoxia and polycyclic aromatic hydrocarbons (PAHs) and PAH mixtures in zebrafish (Danio rerio).

Journal: Ecotoxicology (London, England) 20110801

Title: Metabolism of dl-praeruptorin A in rat liver microsomes using HPLC-electrospray ionization tandem mass spectrometry.

Journal: Archives of pharmacal research 20110801

Title: Identification of a high-affinity ligand that exhibits complete aryl hydrocarbon receptor antagonism.

Journal: The Journal of pharmacology and experimental therapeutics 20110701

Title: The inhibition study of human UDP-glucuronosyltransferases with cytochrome P450 selective substrates and inhibitors.

Journal: Journal of enzyme inhibition and medicinal chemistry 20110601

Title: SCYX-7158, an orally-active benzoxaborole for the treatment of stage 2 human African trypanosomiasis.

Journal: PLoS neglected tropical diseases 20110601

Title: Aflatoxin B1--a potential endocrine disruptor--up-regulates CYP19A1 in JEG-3 cells.

Journal: Toxicology letters 20110510

Title: Activation of c-Src/HER1/STAT5b and HER1/ERK1/2 signaling pathways and cell migration by hexachlorobenzene in MDA-MB-231 human breast cancer cell line.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20110401

Title: Daily treatment with α-naphthoflavone enhances follicular growth and ovulation rate in the rat.

Journal: Toxicology and applied pharmacology 20110401

Title: Identification and induction of cytochrome P450s involved in the metabolism of flavone-8-acetic acid in mice.

Journal: Drug metabolism letters 20110401

Title: Suppression of cytokine-mediated complement factor gene expression through selective activation of the Ah receptor with 3',4'-dimethoxy-α-naphthoflavone.

Journal: Molecular pharmacology 20110301

Title: Structural characterization of the complex between alpha-naphthoflavone and human cytochrome P450 1B1.

Journal: The Journal of biological chemistry 20110218

Title: Analysis of heterotropic cooperativity in cytochrome P450 3A4 using alpha-naphthoflavone and testosterone.

Journal: The Journal of biological chemistry 20110218

Title: The AhR is constitutively activated and affects granulosa cell features in the human cell line KGN.

Journal: Molecular human reproduction 20110201

Title: Aryl hydrocarbon receptor-mediated up-regulation of ATP-driven xenobiotic efflux transporters at the blood-brain barrier.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20110201

Title: In vitro biotransformation and investigation of metabolic enzymes possibly responsible for the metabolism of bisdesoxyolaquindox in the liver fractions of rats, chicken, and pigs.

Journal: Toxicology 20110111

Title: Flavonoids lower Alzheimer's Aβ production via an NFκB dependent mechanism.

Journal: Bioinformation 20110101

Title: Partial inhibition of estrogen-induced mammary carcinogenesis in rats by tamoxifen: balance between oxidant stress and estrogen responsiveness.

Journal: PloS one 20110101

Title: Structure-function relationships of inhibition of human cytochromes P450 1A1, 1A2, 1B1, 2C9, and 3A4 by 33 flavonoid derivatives.

Journal: Chemical research in toxicology 20101220

Title: Benzo[a]pyrene inhibits angiogenic factors-induced alphavbeta3 integrin expression, neovasculogenesis, and angiogenesis in human umbilical vein endothelial cells.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20101201

Title: Cytochrome P450-mediated hepatic metabolism of new fluorescent substrates in cats and dogs.

Journal: Journal of veterinary pharmacology and therapeutics 20101201

Title: Bioactivation of aflatoxin B1 by turkey liver microsomes: responsible cytochrome P450 enzymes.

Journal: British poultry science 20101201

Title: Preferential induction of the AhR gene battery in HepaRG cells after a single or repeated exposure to heterocyclic aromatic amines.

Journal: Toxicology and applied pharmacology 20101115

Title: PKC-δ mediates TCDD-induced apoptosis of chondrocyte in ROS-dependent manner.

Journal: Chemosphere 20101101

Title: The role of cyclooxygenase-2-dependent signaling via cyclic AMP response element activation on aromatase up-regulation by o,p'-DDT in human breast cancer cells.

Journal: Toxicology letters 20101020

Title: Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on adipogenic differentiation and insulin-induced glucose uptake in 3T3-L1 cells.

Journal: Journal of hazardous materials 20101015

Title: Radiosensitization of cancer cells by hydroxychalcones.

Journal: Bioorganic & medicinal chemistry letters 20101015

Title: Isoform-selective inhibition of chrysin towards human cytochrome P450 1A2. Kinetics analysis, molecular docking, and molecular dynamics simulations.

Journal: Bioorganic & medicinal chemistry letters 20101015

Title: CH223191 is a ligand-selective antagonist of the Ah (Dioxin) receptor.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20101001

Title: Endotoxin and polycyclic aromatic hydrocarbons in ambient fine particulate matter from Fresno, California initiate human monocyte inflammatory responses mediated by reactive oxygen species.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20101001

Title: A laser flash photolysis and theoretical study of hydrogen abstraction from phenols by triplet alpha-naphthoflavone.

Journal: Physical chemistry chemical physics : PCCP 20100928

Title: Human primordial germ cell formation is diminished by exposure to environmental toxicants acting through the AHR signaling pathway.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20100901

Title: Silymarin protects PBMC against B(a)P induced toxicity by replenishing redox status and modulating glutathione metabolizing enzymes--an in vitro study.

Journal: Toxicology and applied pharmacology 20100901

Title: Phenotypic anchoring of gene expression after developmental exposure to aryl hydrocarbon receptor ligands in zebrafish.

Journal: Aquatic toxicology (Amsterdam, Netherlands) 20100901

Title: Metabolites of galangin by 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible cytochrome P450 1A1 in human intestinal epithelial Caco-2 cells and their antagonistic activity toward aryl hydrocarbon receptor.

Journal: Journal of agricultural and food chemistry 20100714

Title: Extractable organic matter of standard reference material 1649a influences immunological response induced by pathogen-associated molecular patterns.

Journal: Environmental science and pollution research international 20100701

Title: Differential roles of phase I and phase II enzymes in 3,4-methylendioxymethamphetamine-induced cytotoxicity.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20100701

Title: Cytochromes P4501 (CYP1): catalytic activities and inducibility by diesel exhaust particle extract and benzo[a]pyrene in intact human lung ex vivo.

Journal: Toxicology 20100629

Title: Microfluidic-based measurements of cytochrome P450 enzyme activity of primary mammalian hepatocytes.

Journal: The Analyst 20100601

Title: 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx)-induced hepatocarcinogenesis is not enhanced by CYP1A inducers, alpha- and beta-naphthoflavone: relationship to intralobular distribution of CYP1A expression.

Journal: Toxicologic pathology 20100601

Title: Pharmacophore modeling strategies for the development of novel nonsteroidal inhibitors of human aromatase (CYP19).

Journal: Bioorganic & medicinal chemistry letters 20100515

Title: Effects of fish cytochromes P450 inducers and inhibitors on difloxacin N-demethylation in kidney of Chinese idle (Ctenopharyngodon idellus).

Journal: Environmental toxicology and pharmacology 20100501

Title: 2,3,7,8-Tetrachlorodibenzo-p-dioxin induces apoptosis of articular chondrocytes in culture.

Journal: Chemosphere 20100401

Title: 2,3,7,8-Tetrachlorodibenzo-p-dioxin upregulates FoxQ1b in zebrafish jaw primordium.

Journal: Chemical research in toxicology 20100315

Title: 3-Methylindole metabolites induce lung CYP1A1 and CYP2F1 enzymes by AhR and non-AhR mechanisms, respectively.

Journal: Chemical research in toxicology 20100315

Title: Oxidative and conjugative xenobiotic metabolism in zebrafish larvae in vivo.

Journal: Zebrafish 20100301

Title: Membrane remodeling, an early event in benzo[a]pyrene-induced apoptosis.

Journal: Toxicology and applied pharmacology 20100215

Title: High performance liquid chromatography determination of cytochrome P450 1A and 2C activities in bovine liver microsomes.

Journal: Veterinary journal (London, England : 1997) 20100101

Title: Antagonism of aryl hydrocarbon receptor signaling by 6,2',4'-trimethoxyflavone.

Journal: The Journal of pharmacology and experimental therapeutics 20100101

Title: Regulation of aryl hydrocarbon receptor function by selective estrogen receptor modulators.

Journal: Molecular endocrinology (Baltimore, Md.) 20100101

Title: Development of a UGT1A1 reporter gene assay for induction studies: correlation between reporter gene data and regulation of UGT1A1 in human hepatocytes.

Journal: Drug metabolism letters 20100101

Title: Dynamic zebrafish interactome reveals transcriptional mechanisms of dioxin toxicity.

Journal: PloS one 20100101

Title: Mutagenic activation and detoxification of benzo[a]pyrene in vitro by hepatic cytochrome P450 1A1 and phase II enzymes in three meat-producing animals.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20100101

Title: Polycyclic aromatic hydrocarbon components contribute to the mitochondria-antiapoptotic effect of fine particulate matter on human bronchial epithelial cells via the aryl hydrocarbon receptor.

Journal: Particle and fibre toxicology 20100101

Title: Diesel exhaust particles induce CYP1A1 and pro-inflammatory responses via differential pathways in human bronchial epithelial cells.

Journal: Particle and fibre toxicology 20100101

Title: Role of cytochromes P450 and peroxidases in metabolism of the anticancer drug ellipticine: additional evidence of their contribution to ellipticine activation in rat liver, lung and kidney.

Journal: Neuro endocrinology letters 20100101

Title: Hepatic and vascular mRNA expression in adult zebrafish (Danio rerio) following exposure to benzo-a-pyrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Journal: Aquatic toxicology (Amsterdam, Netherlands) 20091213

Title: Inhibitory effects of cigarette smoke extract on neural crest migration occur through suppression of R-spondin1 expression via aryl hydrocarbon receptor.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20091201

Title: Beta-naphthoflavone causes an AhR-independent inhibition of invasion and intracellular multiplication of Listeria monocytogenes in murine hepatocytes.

Journal: Microbial pathogenesis 20091101

Title: The arylhydrocarbon receptor is only marginally involved in the antileukemic effects of its ligand curcumin.

Journal: Anticancer research 20091101

Title: Aryl hydrocarbon receptor facilitates DNA strand breaks and 8-oxo-2'-deoxyguanosine formation by the aldo-keto reductase product benzo[a]pyrene-7,8-dione.

Journal: The Journal of biological chemistry 20091023

Title: UVR exposure sensitizes keratinocytes to DNA adduct formation.

Journal: Cancer prevention research (Philadelphia, Pa.) 20091001

Title: Aryl hydrocarbon receptor-dependent induction of the NADPH oxidase subunit NCF1/p47 phox expression leading to priming of human macrophage oxidative burst.

Journal: Free radical biology & medicine 20090915

Title: PCB126 enhanced the genotoxicity of BaP in HepG2 cells by modulating metabolic enzyme and DNA repair activities.

Journal: Toxicology letters 20090910

Title: Inhibition of human mesenchymal stem cell-derived adipogenesis by the environmental contaminant benzo(a)pyrene.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20090901

Title: Insights into the structure, function, and regulation of human cytochrome P450 1A2.

Journal: Current drug metabolism 20090901

Title: Mixing apples and oranges: Analysis of heterotropic cooperativity in cytochrome P450 3A4.

Journal: Archives of biochemistry and biophysics 20090815

Title: Lack of constitutive and inducible ethoxyresorufin-O-deethylase activity in the liver of suckermouth armored catfish (Hypostomus affinis and Hypostomus auroguttatus, Loricariidae).

Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20090801

Title: TCDD mediates inhibition of p53 and activation of ERalpha signaling in MCF-7 cells at moderate hypoxic conditions.

Journal: International journal of oncology 20090801

Title: Effects of dioxin on vascular endothelial growth factor (VEGF) production in the retina associated with choroidal neovascularization.

Journal: Investigative ophthalmology & visual science 20090701

Title: Vitamin C and alpha-naphthoflavone prevent estrogen-induced mammary tumors and decrease oxidative stress in female ACI rats.

Journal: Carcinogenesis 20090701

Title: Reverse type I binding spectra of human cytochrome P450 1B1 induced by flavonoid, stilbene, pyrene, naphthalene, phenanthrene, and biphenyl derivatives that inhibit catalytic activity: a structure-function relationship study.

Journal: Chemical research in toxicology 20090701

Title: Cytotoxicity of ginkgolic acid in HepG2 cells and primary rat hepatocytes.

Journal: Toxicology letters 20090622

Title: Antioxidant responses and NRF2 in synergistic developmental toxicity of PAHs in zebrafish.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20090601

Title: Ligand diversity of human and chimpanzee CYP3A4: activation of human CYP3A4 by lithocholic acid results from positive selection.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20090601

Title: Up-regulation of endothelial monocyte chemoattractant protein-1 by coplanar PCB77 is caveolin-1-dependent.

Journal: Toxicology and applied pharmacology 20090515

Title: The aryl hydrocarbon receptor activator benzo[a]pyrene enhances vitamin D3 catabolism in macrophages.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20090501

Title: Effect of PCB153 on BaP-induced genotoxicity in HepG2 cells via modulation of metabolic enzymes.

Journal: Mutation research 20090430

Title: [Enzyme kinetics of ligustilide metabolism in rat liver microsomes].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20090401

Title: Comparison of citrus coumarins on carcinogen-detoxifying enzymes in Nrf2 knockout mice.

Journal: Toxicology letters 20090328

Title: The binding of lignans, flavonoids and coumestrol to CYP450 aromatase: a molecular modelling study.

Journal: Molecular and cellular endocrinology 20090325

Title: Quantum-SAR extension of the spectral-SAR algorithm: application to polyphenolic anticancer bioactivity.

Journal: International journal of molecular sciences 20090301

Title: Aryl hydrocarbon receptor-mediated apoptosis of neuronal cells: a possible interaction with estrogen receptor signaling.

Journal: Neuroscience 20090123

Title: Benzo[a]pyrene induces expression of matrix metalloproteinases and cell migration and invasion of vascular smooth muscle cells.

Journal: Toxicology letters 20090110

Title: TCDD induces cell migration via NFATc1/ATX-signaling in MCF-7 cells.

Journal: Toxicology letters 20090110

Title: Retraction notice to 7,8-benzoflavone: a phytotoxin from root exudates of invasive Russian knapweed [Phytochemistry 64 (2003) 493-497].

Journal: Phytochemistry 20090101

Title: Coal dust alters beta-naphthoflavone-induced aryl hydrocarbon receptor nuclear translocation in alveolar type II cells.

Journal: Particle and fibre toxicology 20090101

Title: Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development.

Journal: Current medicinal chemistry 20090101

Title: Prediction of pharmacological and xenobiotic responses to drugs based on time course gene expression profiles.

Journal: PloS one 20090101

Title: Modulation of cytochrome P450 enzyme system by selected flavonoids.

Journal: Neuro endocrinology letters 20090101

Title: Modulatory effects of alpha- and gamma-tocopherols on 4-hydroxyestradiol induced oxidative stresses in MCF-10A breast epithelial cells.

Journal: Nutrition research and practice 20090101

Title: [Comparative effects of flavonoids on cell cycle passage and apoptosis induction in human acute lymphoblastic leukemia MT-4 cells].

Journal: Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20090101

Title: The effect of in vivo co-exposure to estrone and AhR-ligands on estrogenic effect to vitellogenin production and EROD activity.

Journal: Environmental toxicology and pharmacology 20090101

Title: EROD and MROD as Markers of Cytochrome P450 1A Activities in Hepatic Microsomes from Entire and Castrated Male Pigs.

Journal: Sensors (Basel, Switzerland) 20090101

Title: Pharmacologic profiling of human and rat cytochrome P450 1A1 and 1A2 induction and competition.

Journal: Archives of toxicology 20081201

Title: Activation of the aryl hydrocarbon receptor by the calcium/calmodulin-dependent protein kinase kinase inhibitor 7-oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid (STO-609).

Journal: Drug metabolism and disposition: the biological fate of chemicals 20081201

Title: Determination of the inhibitory potential of 6 fluoroquinolones on CYP1A2 and CYP2C9 in human liver microsomes.

Journal: Acta pharmacologica Sinica 20081201

Title: [Inhibition of human cytochrome P-450 CYP1A2 by flavonoids: a quantitative structure-activity relationship study ].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20081201

Title: Induction of human UGT1A1 by bilirubin through AhR dependent pathway.

Journal: Drug metabolism letters 20081201

Title: Allosteric effects on substrate dissociation from cytochrome P450 3A4 in nanodiscs observed by ensemble and single-molecule fluorescence spectroscopy.

Journal: Journal of the American Chemical Society 20081126

Title: BRCA1 transcriptional activity is enhanced by interactions between its AD1 domain and AhR.

Journal: Cancer chemotherapy and pharmacology 20081101

Title: Heat shock protein 90 inhibitors suppress aryl hydrocarbon receptor-mediated activation of CYP1A1 and CYP1B1 transcription and DNA adduct formation.

Journal: Cancer prevention research (Philadelphia, Pa.) 20081101

Title: A human intervention study with foods containing natural Ah-receptor agonists does not significantly show AhR-mediated effects as measured in blood cells and urine.

Journal: Chemico-biological interactions 20081022

Title: Benzo[a]pyrene induces intercellular adhesion molecule-1 through a caveolae and aryl hydrocarbon receptor mediated pathway.

Journal: Toxicology and applied pharmacology 20081015

Title: Pharmacokinetics and bioavailability of the flavonoid 7,8-benzoflavone in rats.

Journal: Journal of pharmaceutical sciences 20081001

Title: Phytotoxic polyacetylenes from roots of Russian knapweed (Acroptilon repens (L.) DC.).

Journal: Phytochemistry 20081001

Title: Dioxin interferes in chromosomal positioning through the aryl hydrocarbon receptor.

Journal: Biochemical and biophysical research communications 20080919

Title: A role for the aryl hydrocarbon receptor and the dioxin TCDD in rheumatoid arthritis.

Journal: Rheumatology (Oxford, England) 20080901

Title: A low halogenated biphenyl (PCB3) increases CYP1A1 expression and activity via the estrogen receptor beta in the porcine ovary.

Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20080901

Title: [Effects of cytochrome P450 isozymes on aristolochic acid renal cytotoxicity].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080901

Title: Experimental approaches to evaluate activities of cytochromes P450 3A.

Journal: Interdisciplinary toxicology 20080901

Title: 2,3,7,8-Tetrachlorodibenzo-p-dioxin modulates the expression of cKrox and Runx3, transcription regulatory factors controlling the lineage commitment of CD4+CD8+ into CD4 and CD8 thymocytes, respectively.

Journal: Toxicology letters 20080828

Title: Cigarette smoke condensate upregulates the gene and protein expression of proinflammatory cytokines in human fibroblast-like synoviocyte line.

Journal: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 20080801

Title: Evidence for multiple mechanisms of toxicity in larval rainbow trout (Oncorhynchus mykiss) co-treated with retene and alpha-naphthoflavone.

Journal: Aquatic toxicology (Amsterdam, Netherlands) 20080707

Title: Genotoxic activation of 2-phenylbenzotriazole-type compounds by human cytochrome P4501A1 and N-acetyltransferase expressed in Salmonella typhimurium umu strains.

Journal: Mutation research 20080630

Title: Cytochrome P450 2C11 5'-flanking region and promoter: regulation by aromatic hydrocarbons in vitro.

Journal: Toxicology 20080627

Title: Identification of human liver cytochrome P450 isoforms involved in autoinduced metabolism of the antiangiogenic agent (Z)-5-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoic acid (TSU-68).

Journal: Drug metabolism and disposition: the biological fate of chemicals 20080601

Title: Primary peripheral T cells become susceptible to 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated apoptosis in vitro upon activation and in the presence of dendritic cells.

Journal: Molecular pharmacology 20080601

Title: Spectral resolution of a second binding site for Nile Red on cytochrome P4503A4.

Journal: Archives of biochemistry and biophysics 20080601

Title: Polychlorinated biphenyl-77 induces adipocyte differentiation and proinflammatory adipokines and promotes obesity and atherosclerosis.

Journal: Environmental health perspectives 20080601

Title: In vitro evaluation of reversible and irreversible cytochrome P450 inhibition: current status on methodologies and their utility for predicting drug-drug interactions.

Journal: The AAPS journal 20080601

Title: Enhanced TGF-beta1 is involved in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induced oxidative stress in C57BL/6 mouse testis.

Journal: Toxicology letters 20080530

Title: Effect of troglitazone on CYP1A1 induction.

Journal: Toxicology 20080418

Title: Biotransformation and pharmacokinetics of the novel anticancer drug, SYUIQ-5, in the rat.

Journal: Investigational new drugs 20080401

Title: Aminoflavone induces oxidative DNA damage and reactive oxidative species-mediated apoptosis in breast cancer cells.

Journal: International journal of cancer 20080401

Title: Aryl hydrocarbon receptor mediates laminar fluid shear stress-induced CYP1A1 activation and cell cycle arrest in vascular endothelial cells.

Journal: Cardiovascular research 20080301

Title: Kinetics of electron transfer in the complex of cytochrome P450 3A4 with the flavin domain of cytochrome P450BM-3 as evidence of functional heterogeneity of the heme protein.

Journal: Archives of biochemistry and biophysics 20080301

Title: Identification of ginkgolide B metabolites in urine and rat liver cytochrome P450 enzymes responsible for their formation in vitro.

Journal: Acta pharmacologica Sinica 20080301

Title: New 7,8-benzoflavanones as potent aromatase inhibitors: synthesis and biological evaluation.

Journal: Bioorganic & medicinal chemistry 20080201

Title: Significance of prolyl hydroxylase 2 in the interference of aryl hydrocarbon receptor and hypoxia-inducible factor-1 alpha signaling.

Journal: Chemical research in toxicology 20080201

Title: Identification of cytochrome P450 enzymes involved in the metabolism of the new designer drug 4'-methyl-alpha-pyrrolidinobutyrophenone.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20080101

Title: Flavonoid treatment of murine macrophages does not alter ingestion or intracellular survival of Listeria monocytogenes.

Journal: Immunopharmacology and immunotoxicology 20080101

Title: Structure-activity relationship and substrate-dependent phenomena in effects of ginsenosides on activities of drug-metabolizing P450 enzymes.

Journal: PloS one 20080101

Title: Cytotoxicity of nitroaromatic explosives and their biodegradation products in mice splenocytes: implications for their immunotoxicity.

Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences 20080101

Title: Synergistic induction of AHR regulated genes in developmental toxicity from co-exposure to two model PAHs in zebrafish.

Journal: Aquatic toxicology (Amsterdam, Netherlands) 20071230

Title: Dioxin affects glucose transport via the arylhydrocarbon receptor signal cascade in pluripotent embryonic carcinoma cells.

Journal: Endocrinology 20071201

Title: Characterization of a 7,8-benzoflavone double effect on CFTR Cl(-) channel activity.

Journal: The Journal of membrane biology 20071201

Title: The involvement of secondary signaling molecules in cytochrome P-450 1A1-mediated inducible nitric oxide synthase expression in benzo(a)pyrene-treated rat polymorphonuclear leukocytes.

Journal: Life sciences 20071130

Title: Human enteric microsomal CYP4F enzymes O-demethylate the antiparasitic prodrug pafuramidine.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20071101

Title: Polychlorinated biphenyls 105 and 118 form thyroid hormone receptor agonists after cytochrome P4501A1 activation in rat pituitary GH3 cells.

Journal: Environmental health perspectives 20071101

Title: Induction of EROD activity by 1-phenylimidazole and beta-naphthoflavone in rainbow trout cultured hepatocytes: a comparative study.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20071001

Title: In vitro metabolism of isoline, a pyrrolizidine alkaloid from Ligularia duciformis, by rodent liver microsomal esterase and enhanced hepatotoxicity by esterase inhibitors.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20071001

Title: Polychlorinated biphenyls alter the expression of endothelial nitric oxide synthase mRNA in human umbilical vein endothelial cells.

Journal: Human & experimental toxicology 20071001

Title: Ligand binding to cytochrome P450 3A4 in phospholipid bilayer nanodiscs: the effect of model membranes.

Journal: The Journal of biological chemistry 20070928

Title: Signaling pathway for 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced TNF-alpha production in differentiated THP-1 human macrophages.

Journal: Experimental & molecular medicine 20070831

Title: 2,3,7,8-Tetrachlorodibenzo-p-dioxin modulates functional differentiation of mouse bone marrow-derived dendritic cells Downregulation of RelB by 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Journal: Toxicology letters 20070830

Title: The environmental carcinogen benzo[a]pyrene induces expression of monocyte-chemoattractant protein-1 in vascular tissue: a possible role in atherogenesis.

Journal: Mutation research 20070801

Title: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) induces oxidative stress, DNA strand breaks, and poly(ADP-ribose) polymerase-1 activation in human breast carcinoma cell lines.

Journal: Toxicology letters 20070801

Title: Energetics of heterotropic cooperativity between alpha-naphthoflavone and testosterone binding to CYP3A4.

Journal: Archives of biochemistry and biophysics 20070701

Title: Involvement of human cytochrome P450 2B6 in the omega- and 4-hydroxylation of the anesthetic agent propofol.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20070701

Title: Abundance of aryl hydrocarbon receptor potentiates benzo[a]pyrene-induced apoptosis in Hepa1c1c7 cells via CYP1A1 activation.

Journal: Toxicology 20070603

Title: Autoradiographic localization of aromatic hydrocarbon receptor (AHR) in rhesus monkey ovary.

Journal: American journal of primatology 20070601

Title: [Simultaneous determination of the inhibitory potency of compounds on the activity of five cytochrome P-450 enzymes using a cocktail probe substrates method].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20070601

Title: Adaptations for the oxidation of polycyclic aromatic hydrocarbons exhibited by the structure of human P450 1A2.

Journal: The Journal of biological chemistry 20070511

Title: Human cytochrome p450 enzyme specificity for the bioactivation of estragole and related alkenylbenzenes.

Journal: Chemical research in toxicology 20070501

Title: TCDD alters PKC signaling pathways in developing neuronal cells in culture.

Journal: Chemosphere 20070401

Title: Expression of zebra fish aromatase cyp19a and cyp19b genes in response to the ligands of estrogen receptor and aryl hydrocarbon receptor.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20070401

Title: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) exposure of normal human dermal fibroblasts results in AhR-dependent and -independent changes in gene expression.

Journal: Toxicology and applied pharmacology 20070401

Title: Role of subunit interactions in P450 oligomers in the loss of homotropic cooperativity in the cytochrome P450 3A4 mutant L211F/D214E/F304W.

Journal: Archives of biochemistry and biophysics 20070401

Title: Genistein inhibits glutamate-induced apoptotic processes in primary neuronal cell cultures: an involvement of aryl hydrocarbon receptor and estrogen receptor/glycogen synthase kinase-3beta intracellular signaling pathway.

Journal: Neuroscience 20070316

Title: Inhibition of CYP1A enzymes by alpha-naphthoflavone causes both synergism and antagonism of retene toxicity to rainbow trout (Oncorhynchus mykiss).

Journal: Aquatic toxicology (Amsterdam, Netherlands) 20070310

Title: Effects of nitrated-polycyclic aromatic hydrocarbons and diesel exhaust particle extracts on cell signalling related to apoptosis: possible implications for their mutagenic and carcinogenic effects.

Journal: Toxicology 20070307

Title: Translocation of PKC-betaII is mediated via RACK-1 in the neuronal cells following dioxin exposure.

Journal: Neurotoxicology 20070301

Title: Polycyclic aromatic hydrocarbon (PAH) metabolizing enzyme activities in human lung, and their inducibility by exposure to naphthalene, phenanthrene, pyrene, chrysene, and benzo(a)pyrene as shown in the rat lung and liver.

Journal: Archives of toxicology 20070301

Title: Involvement of CYP2A6 in the formation of a novel metabolite, 3-hydroxypilocarpine, from pilocarpine in human liver microsomes.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20070301

Title: Targeted salmon gene array (SalArray): a toxicogenomic tool for gene expression profiling of interactions between estrogen and aryl hydrocarbon receptor signalling pathways.

Journal: Chemical research in toxicology 20070301

Title: Potential cancer chemopreventive in vitro activities of monomeric xanthone derivatives from the marine algicolous fungus Monodictys putredinis.

Journal: Journal of natural products 20070301

Title: Benzo(a)pyrene inhibits growth and functional differentiation of mouse bone marrow-derived dendritic cells. Downregulation of RelB and eIF3 p170 by benzo(a)pyrene.

Journal: Toxicology letters 20070227

Title: Dissecting the thermodynamics and cooperativity of ligand binding in cytochrome P450eryF.

Journal: Journal of the American Chemical Society 20070221

Title: Mechanism of interactions of alpha-naphthoflavone with cytochrome P450 3A4 explored with an engineered enzyme bearing a fluorescent probe.

Journal: Biochemistry 20070109

Title: Role of dioxin response element and nuclear factor-kappaB motifs in 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated regulation of Fas and Fas ligand expression.

Journal: Molecular pharmacology 20070101

Title: CYP3A4 mediated in vitro metabolism of vinflunine in human liver microsomes.

Journal: Acta pharmacologica Sinica 20070101

Title: Effect of cytochrome P450 (CYP) inducers on caffeine metabolism in the rat.

Journal: Pharmacological reports : PR 20070101

Title: Antiteratogenic effects of alpha-naphthoflavone on 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposed mice in utero.

Journal: Reproductive toxicology (Elmsford, N.Y.) 20070101

Title: Suppression of T lymphocyte proliferation to antigenic and mitogenic stimuli by Benzo(alpha)pyrene and 2-aminofluorene metabolites.

Journal: Immunopharmacology and immunotoxicology 20070101

Title: Is PPARbeta/delta a Retinoid Receptor?

Journal: PPAR research 20070101

Title: The effect of aryl hydrocarbon receptor ligands on the expression of AhR, AhRR, ARNT, Hif1alpha, CYP1A1 and NQO1 genes in rat liver.

Journal: Toxicology letters 20061215

Title: Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods.

Journal: Journal of molecular graphics & modelling 20061101

Title: Elucidation of the effects of the CYP1A2 deficiency polymorphism in the metabolism of 4-cyclohexyl-1-ethyl-7-methylpyrido[2,3-d]pyrimidine-2-(1h)-one (YM-64227), a phosphodiesterase type 4 inhibitor, and its metabolites in dogs.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20061101

Title: Regioselective 2-hydroxylation of 17beta-estradiol by rat cytochrome P4501B1.

Journal: Toxicology and applied pharmacology 20061101

Title: OPC-67683, a nitro-dihydro-imidazooxazole derivative with promising action against tuberculosis in vitro and in mice.

Journal: PLoS medicine 20061101

Title: Estrogen receptor alpha as a target for indole-3-carbinol.

Journal: The Journal of nutritional biochemistry 20061001

Title: Characterization of CYP1A enzyme in Adélie penguin liver.

Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20061001

Title: Metabolism and metabolic inhibition of gambogic acid in rat liver microsomes.

Journal: Acta pharmacologica Sinica 20060901

Title: Induction of ROS formation, poly(ADP-ribose) polymerase-1 activation, and cell death by PCB126 and PCB153 in human T47D and MDA-MB-231 breast cancer cells.

Journal: Chemico-biological interactions 20060825

Title: Heterotropic and homotropic cooperativity by a drug-metabolising mutant of cytochrome P450 BM3.

Journal: Biochemical and biophysical research communications 20060804

Title: The role of the aryl hydrocarbon receptor pathway in mediating synergistic developmental toxicity of polycyclic aromatic hydrocarbons to zebrafish.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20060801

Title: Effect of cytochromes P450 chemical inhibitors and monoclonal antibodies on human liver microsomal esterase activity.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20060801

Title: Induction of the transferrin receptor gene by benzo[a]pyrene in breast cancer MCF-7 cells: potential as a biomarker of PAH exposure.

Journal: Environmental and molecular mutagenesis 20060801

Title: Induction of propranolol metabolism by Ginkgo biloba extract EGb 761 in rats.

Journal: Current drug metabolism 20060801

Title: Aryl hydrocarbon receptor- and calcium-dependent induction of the chemokine CCL1 by the environmental contaminant benzo[a]pyrene.

Journal: The Journal of biological chemistry 20060721

Title: Naturally occurring coumarins inhibit 7,12-dimethylbenz[a]anthracene DNA adduct formation in mouse mammary gland.

Journal: Carcinogenesis 20060601

Title: Demethylation of the pesticide methoxychlor in liver and intestine from untreated, methoxychlor-treated, and 3-methylcholanthrene-treated channel catfish (Ictalurus punctatus): evidence for roles of CYP1 and CYP3A family isozymes.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20060601

Title: Involvement of endogenous nitric oxide in myeloperoxidase mediated benzo(a)pyrene induced polymorphonuclear leukocytes injury.

Journal: Molecular and cellular biochemistry 20060601

Title: Effect of some carcinogenic and non-carcinogenic polycyclic aromatic hydrocarbons on gap junction intercellular communication in hepatoma cell cultures.

Journal: European journal of cell biology 20060501

Title: Antitumor activity of some natural flavonoids and synthetic derivatives on various human and murine cancer cell lines.

Journal: Bioorganic & medicinal chemistry 20060501

Title: Oxidative metabolism of the alkaloid rutaecarpine by human cytochrome P450.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20060501

Title: Kinetics and thermodynamics of ligand binding by cytochrome P450 3A4.

Journal: The Journal of biological chemistry 20060407

Title: Formation of 4'-carboxyl acid metabolite of imrecoxib by rat liver microsomes.

Journal: Acta pharmacologica Sinica 20060401

Title: Molecular imaging of alkylguanine-DNA alkyltransferase: further evaluation of radioiodinated derivatives of O6-benzylguanine.

Journal: Nuclear medicine and biology 20060401

Title: Preferential inducibility of CYP1A1 and CYP1A2 by TCDD: differential regulation in primary human hepatocytes versus transformed human cells.

Journal: Biochemical and biophysical research communications 20060310

Title: Role of rat liver cytochrome P450 3A and 2D in metabolism of imrecoxib.

Journal: Acta pharmacologica Sinica 20060301

Title: The ligand status of the aromatic hydrocarbon receptor modulates transcriptional activation of BRCA-1 promoter by estrogen.

Journal: Cancer research 20060215

Title: An aryl hydrocarbon receptor agonist amplifies the mitogenic actions of estradiol in granulosa cells: evidence of involvement of the cognate receptors.

Journal: Biology of reproduction 20060201

Title: Characterization of anti-apoptotic action of TCDD as a defensive cellular stress response reaction against the cell damaging action of ultra-violet irradiation in an immortalized normal human mammary epithelial cell line, MCF10A.

Journal: Toxicology 20060116

Title: Effects of endocrine disrupters on the expression of growth hormone and prolactin mRNA in the rainbow trout pituitary.

Journal: General and comparative endocrinology 20060115

Title: Antiproliferative and antiangiogenic effects of 3-methylcholanthrene, an aryl-hydrocarbon receptor agonist, in human umbilical vascular endothelial cells.

Journal: European journal of pharmacology 20060113

Title: Molecular cloning and expression of a novel cytochrome p450 from turkey liver with aflatoxin b1 oxidizing activity.

Journal: Chemical research in toxicology 20060101

Title: Human cytochrome p450 enzymes of importance for the bioactivation of methyleugenol to the proximate carcinogen 1'-hydroxymethyleugenol.

Journal: Chemical research in toxicology 20060101

Title: Growth of a human mammary tumor cell line is blocked by galangin, a naturally occurring bioflavonoid, and is accompanied by down-regulation of cyclins D3, E, and A.

Journal: Breast cancer research : BCR 20060101

Title: Enzymatic characteristics of CYP3A5 and CYP3A4: a comparison of in vitro kinetic and drug-drug interaction patterns.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20060101

Title: Lack of CYP1A1 expression is involved in unresponsiveness of the human hepatoma cell line SK-HEP-1 to dioxin.

Journal: Toxicology letters 20051230

Title: Modulation of human cytochrome P450 1B1 expression by 2,4,3',5'-tetramethoxystilbene.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20051201

Title: CYP1A1-mediated mechanism for atherosclerosis induced by polycyclic aromatic hydrocarbons.

Journal: Biochemical and biophysical research communications 20051118

Title: Cooperative binding of midazolam with testosterone and alpha-naphthoflavone within the CYP3A4 active site: a NMR T1 paramagnetic relaxation study.

Journal: Biochemistry 20051101

Title: Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity.

Journal: Current drug metabolism 20051001

Title: The spectrum of enzymes involved in activation of 2-aminoanthracene varies with the metabolic system applied.

Journal: Mutation research 20050905

Title: Human CD34-positive hematopoietic stem cells constitute targets for carcinogenic polycyclic aromatic hydrocarbons.

Journal: The Journal of pharmacology and experimental therapeutics 20050801

Title: Automated screening with confirmation of mechanism-based inactivation of CYP3A4, CYP2C9, CYP2C19, CYP2D6, and CYP1A2 in pooled human liver microsomes.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20050801

Title: Metabolism of the alpha,beta-unsaturated ketones, chalcone and trans-4-phenyl-3-buten-2-one, by rat liver microsomes and estrogenic activity of the metabolites.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20050801

Title: Role of cytochrome B5 in modulating peroxide-supported cyp3a4 activity: evidence for a conformational transition and cytochrome P450 heterogeneity.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20050801

Title: CYP1A1 and CYP1B1 expressions in medulloblastoma cells are AhR-independent and have no direct link with resveratrol-induced differentiation and apoptosis.

Journal: Neuroscience letters 20050801

Title: Development of a novel cytochrome p450 bioaffinity detection system coupled online to gradient reversed-phase high-performance liquid chromatography.

Journal: Journal of biomolecular screening 20050801

Title: TCDD induces c-jun expression via a novel Ah (dioxin) receptor-mediated p38-MAPK-dependent pathway.

Journal: Oncogene 20050721

Title: The effects of 3-methylcholanthrene on lymphocyte proliferation in the common carp (Cyprinus carpio L.).

Journal: Toxicology 20050701

Title: Tobacco smoke stimulates the transcription of amphiregulin in human oral epithelial cells: evidence of a cyclic AMP-responsive element binding protein-dependent mechanism.

Journal: Cancer research 20050701

Title: alpha-Naphthoflavone, a potent antiplatelet flavonoid, is mediated through inhibition of phospholipase C activity and stimulation of cyclic GMP formation.

Journal: Journal of agricultural and food chemistry 20050629

Title: Altered expression of cytochrome P450 and possible correlation with preneoplastic changes in early stage of rat hepatocarcinogenesis.

Journal: Acta pharmacologica Sinica 20050601

Title: Properties and regional expression of a CYP3A-like protein in channel catfish intestine.

Journal: Aquatic toxicology (Amsterdam, Netherlands) 20050515

Title: Intestinal metabolism of PAH: in vitro demonstration and study of its impact on PAH transfer through the intestinal epithelium.

Journal: Environmental research 20050501

Title: Modulation of Ah receptor and CYP1A1 expression by alpha-naphthoflavone in rainbow trout hepatocytes.

Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20050501

Title: Molecular mechanism of the aryl hydrocarbon receptor activation by the fungicide iprodione in rainbow trout (Oncorhynchus mykiss) hepatocytes.

Journal: Aquatic toxicology (Amsterdam, Netherlands) 20050430

Title: Effects of 3-methylcholanthrene on the transcriptional activity and mRNA accumulation of the oncogene hWAPL.

Journal: Cancer letters 20050418

Title: Ah Receptor-mediated impairment of interrenal steroidogenesis involves StAR protein and P450scc gene attenuation in rainbow trout.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20050401

Title: Flavonoids chrysin and benzoflavone, potent breast cancer resistance protein inhibitors, have no significant effect on topotecan pharmacokinetics in rats or mdr1a/1b (-/-) mice.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20050301

Title: Chemoprotective and toxic potentials of synthetic and natural chalcones and dihydrochalcones in vitro.

Journal: Toxicology 20050301

Title: Differences between rats and mice in the involvement of the aryl hydrocarbon receptor in 4-vinylcyclohexene diepoxide-induced ovarian follicle loss.

Journal: Toxicology and applied pharmacology 20050301

Title: Bisindigotin, a TCDD antagonist from the Chinese medicinal herb Isatis indigotica.

Journal: Journal of natural products 20050301

Title: Molecular cloning and functional analysis of cytochrome P450 1A2 from Japanese monkey liver: comparison with marmoset cytochrome P450 1A2.

Journal: Chemico-biological interactions 20050227

Title: CYP3A4 is a vitamin D-24- and 25-hydroxylase: analysis of structure function by site-directed mutagenesis.

Journal: The Journal of clinical endocrinology and metabolism 20050201

Title: Effects of TCDD and estradiol-17beta on the proliferation and Na+/glucose cotransporter in renal proximal tubule cells.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20050201

Title: Fast-track DRESSA: a bioassay for fast, sensitive, and selective detection of halogenated and polycyclic aromatic hydrocarbons.

Journal: Analytical biochemistry 20050201

Title: A microtiterplate-based screening assay to assess diverse effects on cytochrome P450 enzyme activities in primary rat hepatocytes by various compounds.

Journal: Assay and drug development technologies 20050201

Title: Selective benzopyranone and pyrimido[2,1-a]isoquinolin-4-one inhibitors of DNA-dependent protein kinase: synthesis, structure-activity studies, and radiosensitization of a human tumor cell line in vitro.

Journal: Journal of medicinal chemistry 20050127

Title: Role of cell signaling in B[a]P-induced apoptosis: characterization of unspecific effects of cell signaling inhibitors and apoptotic effects of B[a]P metabolites.

Journal: Chemico-biological interactions 20050115

Title: TCDD activates Mdm2 and attenuates the p53 response to DNA damaging agents.

Journal: Carcinogenesis 20050101

Title: Cytochromes 1A1/1B1- and catechol-O-methyltransferase-derived metabolites mediate estradiol-induced antimitogenesis in human cardiac fibroblast.

Journal: The Journal of clinical endocrinology and metabolism 20050101

Title: Induction of cytochrome P4501A (CYP1A) by clotrimazole, a non-planar aromatic compound. Computational studies on structural features of clotrimazole and related imidazole derivatives.

Journal: Life sciences 20041224

Title: Effects of polybrominated diphenyl ethers on basal and TCDD-induced ethoxyresorufin activity and cytochrome P450-1A1 expression in MCF-7, HepG2, and H4IIE cells.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20041201

Title: Synergistic embryotoxicity of polycyclic aromatic hydrocarbon aryl hydrocarbon receptor agonists with cytochrome P4501A inhibitors in Fundulus heteroclitus.

Journal: Environmental health perspectives 20041201

Title: Expression of the arylhydrocarbon receptor in the peri-implantation period of the mouse uterus and the impact of dioxin on mouse implantation.

Journal: Archives of histology and cytology 20041201

Title: Benzo[a]pyrene-induced immunotoxicity in Japanese medaka (Oryzias latipes): relationship between lymphoid CYP1A activity and humoral immune suppression.

Journal: Toxicology and applied pharmacology 20041115

Title: Roles of reactive oxygen species and heme oxygenase-1 in modulation of alveolar macrophage-mediated pulmonary immune responses to Listeria monocytogenes by diesel exhaust particles.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20041101

Title: Superinduction of CYP1A1 in MCF10A cultures by cycloheximide, anisomycin, and puromycin: a process independent of effects on protein translation and unrelated to suppression of aryl hydrocarbon receptor proteolysis by the proteasome.

Journal: Molecular pharmacology 20041001

Title: Disruption of cell-cell contact maximally but transiently activates AhR-mediated transcription in 10T1/2 fibroblasts.

Journal: Toxicology and applied pharmacology 20040915

Title: TCDD-induced homologous recombination: the role of the Ah receptor versus oxidative DNA damage.

Journal: Mutation research 20040912

Title: TCDD affects DNA double strand-break repair.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20040901

Title: Cytochrome P450 CYP1B1 activity in renal cell carcinoma.

Journal: British journal of cancer 20040831

Title: Drug-drug interactions of Z-338, a novel gastroprokinetic agent, with terfenadine, comparison with cisapride, and involvement of UGT1A9 and 1A8 in the human metabolism of Z-338.

Journal: European journal of pharmacology 20040823

Title: Involvement of cytochrome P450 1A2 in the biotransformation of trans-resveratrol in human liver microsomes.

Journal: Biochemical pharmacology 20040815

Title: 3-aminobenzanthrone, a human metabolite of the environmental pollutant 3-nitrobenzanthrone, forms DNA adducts after metabolic activation by human and rat liver microsomes: evidence for activation by cytochrome P450 1A1 and P450 1A2.

Journal: Chemical research in toxicology 20040801

Title: Specific interactions of steroids, arylhydrocarbons and flavonoids with progesterone receptors from the cytosol of the fungus Rhizopus nigricans.

Journal: The Journal of steroid biochemistry and molecular biology 20040801

Title: Influence of selected inhibitors on the metabolism of the styrene metabolite 4-vinylphenol in wild-type and CYP2E1 knockout mice.

Journal: Journal of toxicology and environmental health. Part A 20040625

Title: Induction of metallothionein I by phenolic antioxidants requires metal-activated transcription factor 1 (MTF-1) and zinc.

Journal: The Biochemical journal 20040615

Title: Interaction between the aryl hydrocarbon receptor and retinoic acid pathways increases matrix metalloproteinase-1 expression in keratinocytes.

Journal: The Journal of biological chemistry 20040611

Title: 2,3,7,8-Tetrachlorodibenzo-p-dioxin inhibits cell proliferation through arylhydrocarbon receptor-mediated G1 arrest in SK-N-SH human neuronal cells.

Journal: Neuroscience letters 20040603

Title: Cytochrome P450-dependent toxicity of environmental polycyclic aromatic hydrocarbons towards human macrophages.

Journal: Biochemical and biophysical research communications 20040507

Title: Polycyclic aromatic hydrocarbons induce both apoptotic and anti-apoptotic signals in Hepa1c1c7 cells.

Journal: Carcinogenesis 20040501

Title: The metabolism of the piperazine-type phenothiazine neuroleptic perazine by the human cytochrome P-450 isoenzymes.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20040501

Title: Benzo[a]pyrene regulates osteoblast proliferation through an estrogen receptor-related cyclooxygenase-2 pathway.

Journal: Chemical research in toxicology 20040501

Title: Retionic acid and its receptors are required for expression of aryl hydrocarbon receptor mRNA and embryonic development of blood vessel and bone in the medaka fish, Oryzias latipes.

Journal: Zoological science 20040501

Title: Antiestrogenic effects of motorcycle exhaust particulate in MCF-7 human breast cancer cells and immature female rats.

Journal: Archives of environmental contamination and toxicology 20040501

Title: beta-Naphthoflavone disrupts cortisol production and liver glucocorticoid responsiveness in rainbow trout.

Journal: Aquatic toxicology (Amsterdam, Netherlands) 20040428

Title: Reduction of androgen receptor expression by benzo[alpha]pyrene and 7,8-dihydro-9,10-epoxy-7,8,9,10-tetrahydrobenzo[alpha]pyrene in human lung cells.

Journal: Biochemical pharmacology 20040415

Title: Constitutive expression of CYP1A1 in bovine cumulus oocyte-complexes in vitro: mechanisms and biological implications.

Journal: Endocrinology 20040401

Title: CYP3A4 is a human microsomal vitamin D 25-hydroxylase.

Journal: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20040401

Title: MAPK signaling pathways modulate IL-1beta expression in human keratinocytes.

Journal: Archives of biochemistry and biophysics 20040401

Title: Induction of diphenytriazol on cytochrome CYP1A.

Journal: Acta pharmacologica Sinica 20040401

Title: Polycyclic aromatic hydrocarbon increases mRNA level for interleukin 1 beta in human fibroblast-like synoviocyte line via aryl hydrocarbon receptor.

Journal: Biological & pharmaceutical bulletin 20040301

Title: 3-Methylcholanthrene induces lymphocyte and phagocyte apoptosis in common carp (Cyprinus carpio L) in vitro.

Journal: Aquatic toxicology (Amsterdam, Netherlands) 20040225

Title: A comparative study on the effects of 2,3,7,8,-tetrachlorodibenzo-p-dioxin polychlorinated biphenyl126 and estrogen in human bronchial epithelial cells.

Journal: Toxicology and applied pharmacology 20040215

Title: Aryl hydrocarbon receptor-mediated posttranscriptional regulation of IL-1beta.

Journal: Archives of biochemistry and biophysics 20040201

Title: Polymorphic expression of CYP1A2 leading to interindividual variability in metabolism of a novel benzodiazepine receptor partial inverse agonist in dogs.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20040201

Title: Characterization of enzymes responsible for biotransformation of the new antileukotrienic drug quinlukast in rat liver microsomes and in primary cultures of rat hepatocytes.

Journal: The Journal of pharmacy and pharmacology 20040201

Title: Biphasic effects of the flavonoids quercetin and naringenin on the metabolic activation of 2-amino-3,5-dimethylimidazo[4,5-f]quinoline by Salmonella typhimurium TA1538 co-expressing human cytochrome P450 1A2, NADPH-cytochrome P450 reductase, and cytochrome b5.

Journal: Mutation research 20040112

Title: Antiproliferative activity of various flavonoids and related compounds: additive effect of interferon-alpha2b.

Journal: Bioorganic & medicinal chemistry letters 20040105

Title: An assessment of udp-glucuronosyltransferase induction using primary human hepatocytes.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20040101

Title: Cytochrome P450 1A1 (CYP1A1) inhibitor alpha-naphthoflavone interferes with UDP-glucuronosyltransferase (UGT) activity in intact but not in permeabilized hepatic microsomes from 3-methylcholanthrene-treated rats: possible involvement of UGT-P450 interactions.

Journal: Biological & pharmaceutical bulletin 20040101

Title: Differential oxidant potential of carcinogenic and weakly carcinogenic estrogens: Involvement of metabolic activation and cytochrome P450.

Journal: Journal of biochemical and molecular toxicology 20040101

Title: Teratogenesis in Fundulus heteroclitus embryos exposed to a creosote-contaminated sediment extract and CYP1A inhibitors.

Journal: Marine environmental research 20040101

Title: Suppressive effects of benzo[a]pyrene upon fish immune function: evolutionarily conserved cellular mechanisms of immunotoxicity.

Journal: Marine environmental research 20040101

Title: Antiandrogenic activities of diesel exhaust particle extracts in PC3/AR human prostate carcinoma cells.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20031201

Title: Bone marrow stromal-B cell interactions in polycyclic aromatic hydrocarbon-induced pro/pre-B cell apoptosis.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20031201

Title: Dietary flavonoids modulate PCB-induced oxidative stress, CYP1A1 induction, and AhR-DNA binding activity in vascular endothelial cells.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20031101

Title: Alpha-naphthoflavone induces vasorelaxation through the induction of extracellular calcium influx and NO formation in endothelium.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20031101

Title: Benzoflavone activators of the cystic fibrosis transmembrane conductance regulator: towards a pharmacophore model for the nucleotide-binding domain.

Journal: Bioorganic & medicinal chemistry 20030901

Title: 7,8-Benzoflavone: a phytotoxin from root exudates of invasive Russian knapweed.

Journal: Phytochemistry 20030901

Title: Demethylation of radiolabelled dextromethorphan in rat microsomes and intact hepatocytes.

Journal: European journal of biochemistry 20030901

Title: Rabbit CYP4B1 engineered for high-level expression in Escherichia coli: ligand stabilization and processing of the N-terminus and heme prosthetic group.

Journal: Archives of biochemistry and biophysics 20030801

Title: 3'-methoxy-4'-nitroflavone, a reported aryl hydrocarbon receptor antagonist, enhances Cyp1a1 transcription by a dioxin responsive element-dependent mechanism.

Journal: Archives of biochemistry and biophysics 20030801

Title: CFTR activation in human bronchial epithelial cells by novel benzoflavone and benzimidazolone compounds.

Journal: American journal of physiology. Lung cellular and molecular physiology 20030701

Title: Cytochrome P450 inhibition using recombinant proteins and mass spectrometry/multiple reaction monitoring technology in a cassette incubation.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20030701

Title: In vitro activation of 7-benzyloxyresorufin O-debenzylation and nifedipine oxidation in human liver microsomes.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20030701

Title: Molecular modelling of human CYP1B1 substrate interactions and investigation of allelic variant effects on metabolism.

Journal: Chemico-biological interactions 20030615

Title: Preclinical factors affecting the interindividual variability in the clearance of the investigational anti-cancer drug 5,6-dimethylxanthenone-4-acetic acid.

Journal: Biochemical pharmacology 20030601

Title: A role of aryl hydrocarbon receptor in the antiandrogenic effects of polycyclic aromatic hydrocarbons in LNCaP human prostate carcinoma cells.

Journal: Archives of toxicology 20030601

Title: In vitro inhibition of human small intestinal and liver microsomal astemizole O-demethylation: different contribution of CYP2J2 in the small intestine and liver.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20030601

Title: Tight-binding inhibition by alpha-naphthoflavone of human cytochrome P450 1A2.

Journal: Biochimica et biophysica acta 20030530

Title: Cytochrome P450 expression and testosterone metabolism in the liver of deer.

Journal: Toxicology 20030501

Title: Frequency of SCEs in Japanese infants exposed to dioxins and PCBs through the breast milk.

Journal: Fukuoka igaku zasshi = Hukuoka acta medica 20030501

Title: Frequency of SCEs in Japanese infants lactationally exposed to organochlorone pesticides.

Journal: Fukuoka igaku zasshi = Hukuoka acta medica 20030501

Title: Homotropic versus heterotopic cooperativity of cytochrome P450eryF: a substrate oxidation and spectral titration study.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20030401

Title: CYP3A4 and CYP3A7-mediated carbamazepine 10,11-epoxidation are activated by differential endogenous steroids.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20030401

Title: Species-specific transcriptional activity of synthetic flavonoids in guinea pig and mouse cells as a result of differential activation of the aryl hydrocarbon receptor to interact with dioxin-responsive elements.

Journal: Molecular pharmacology 20030401

Title: Induction of CYP1A by the N-imidazole derivative, 1-benzylimidazole.

Journal: Environmental toxicology and chemistry 20030401

Title: A study on CYP1A inhibitory action of E-2-(4'-methoxybenzylidene)-1-benzosuberone and some related chalcones and cyclic chalcone analogues.

Journal: Toxicology 20030303

Title: Polycyclic aromatic hydrocarbons inhibit differentiation of human monocytes into macrophages.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20030301

Title: Metabolism and metabolic inhibition of cilnidipine in human liver microsomes.

Journal: Acta pharmacologica Sinica 20030301

Title: CYP450- and COMT-derived estradiol metabolites inhibit activity of human coronary artery SMCs.

Journal: Hypertension (Dallas, Tex. : 1979) 20030301

Title: Flavonoid modulation of ionic currents mediated by GABA(A) and GABA(C) receptors.

Journal: European journal of pharmacology 20030214

Title: In vitro metabolism of fenthion and fenthion sulfoxide by liver preparations of sea bream, goldfish, and rats.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20030201

Title: Aryl hydrocarbon receptor ligands repress T-cadherin expression in vascular smooth muscle cells.

Journal: Biochemical and biophysical research communications 20030124

Title: Human intestinal Caco-2 cells display active transport of benzo[a]pyrene metabolites.

Journal: Chemico-biological interactions 20030106

Title: The presence of inducible cytochrome P450 types 1A1 and 1A2 in the BeWo cell line.

Journal: Placenta 20030101

Title: Role of specific cytochrome P450 enzymes in the N-oxidation of the antiarrhythmic agent mexiletine.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20030101

Title: Catalytic activities of cytochrome P450 enzymes and UDP-glucuronosyltransferases involved in drug metabolism in rat everted sacs and intestinal microsomes.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20030101

Title: Mutagenic activation of arylamines by subcellular fractions of Chamaelea gallina clams exposed to environmental pollutants.

Journal: Environmental and molecular mutagenesis 20030101

Title: Cytochrome P450 1B1: a target for inhibition in anticarcinogenesis strategies.

Journal: Mutation research 20030101

Title: Inhibition of the microsomal metabolism of 1,8-cineole in the common brushtail possum (Trichosurus vulpecula) by terpenes and other chemicals.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20021201

Title: Docetaxel (Taxotere) is not metabolized by recombinant human CYP1B1 in vitro, but acts as an effector of this isozyme.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20021101

Title: Overexpression of the aryl hydrocarbon receptor (AhR) accelerates the cell proliferation of A549 cells.

Journal: Journal of biochemistry 20021101

Title: Induction of cytochrome P4501A1 by autoclavable culture medium change in HepG2 cells.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20021101

Title: The contribution of cytochrome P-450 isoenzymes to the metabolism of phenothiazine neuroleptics.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20021001

Title: Pituitary adenylate cyclase-activating polypeptide induces a sustained increase in intracellular free Ca(2+) concentration and catechol amine release by activating Ca(2+) influx via receptor-stimulated Ca(2+) entry, independent of store-operated Ca(2+) channels, and voltage-dependent Ca(2+) channels in bovine adrenal medullary chromaffin cells.

Journal: The Journal of pharmacology and experimental therapeutics 20020901

Title: 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity in the zebrafish embryo: local circulation failure in the dorsal midbrain is associated with increased apoptosis.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20020901

Title: Characterization of human CYP1A1/1A2 induction by DNA microarray and alpha-naphthoflavone.

Journal: Biochemical and biophysical research communications 20020809

Title: Resistance of MCF-7 cells to dimethylbenz(a)anthracene-induced apoptosis is due to reduced CYP1A1 expression.

Journal: International journal of oncology 20020801

Title: Apoptosis in murine hepatoma hepa 1c1c7 wild-type, C12, and C4 cells mediated by bilirubin.

Journal: Molecular pharmacology 20020801

Title: Target cells for cytochrome p450-catalysed irreversible binding of 7,12-dimethylbenz[a]anthracene (DMBA) in rodent adrenal glands.

Journal: Archives of toxicology 20020801

Title: Membrane-bound progesterone receptors coupled to G proteins in the fungus Rhizopus nigricans.

Journal: FEMS microbiology letters 20020716

Title: Estradiol enhances and estriol inhibits the expression of CYP1A1 induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin in a mouse ovarian cancer cell line.

Journal: Toxicology 20020715

Title: Activation of the antitumor agent aminoflavone (NSC 686288) is mediated by induction of tumor cell cytochrome P450 1A1/1A2.

Journal: Molecular pharmacology 20020701

Title: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) induces plasminogen activator inhibitor-1 through an aryl hydrocarbon receptor-mediated pathway in mouse hepatoma cell lines.

Journal: Archives of toxicology 20020701

Title: 4-Hydroxylation of debrisoquine by human CYP1A1 and its inhibition by quinidine and quinine.

Journal: The Journal of pharmacology and experimental therapeutics 20020601

Title: Polychlorinated biphenyl-induced apoptosis of murine spleen cells is aryl hydrocarbon receptor independent but caspases dependent.

Journal: Toxicology and applied pharmacology 20020601

Title: Aryl hydrocarbon receptor-dependent inhibition of AP-1 activity by 2,3,7,8-tetrachlorodibenzo-p-dioxin in activated B cells.

Journal: Toxicology and applied pharmacology 20020601

Title: Thalidomide metabolism by the CYP2C subfamily.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20020601

Title: 7-Benzyloxyquinoline oxidation by P450eryF A245T: finding of a new fluorescent substrate probe.

Journal: Chemical research in toxicology 20020601

Title: In vitro metabolic characteristics of cytochrome P-450 2A6 in Chinese liver microsomes.

Journal: Acta pharmacologica Sinica 20020501

Title: Benzo(a)pyrene exposure induces CYP1A1 activity and expression in human endometrial cells.

Journal: The Journal of steroid biochemistry and molecular biology 20020501

Title: Acute cytotoxicity of the chemical carcinogen 2-acetylaminofluorene in cultured rat liver epithelial cells.

Journal: Toxicology letters 20020328

Title: Cytochrome P450 1A1/2 mediated metabolism of trans-stilbene in rats and humans.

Journal: Biological & pharmaceutical bulletin 20020301

Title: Aryl hydrocarbon receptor is required for prevention of blood clotting and for the development of vasculature and bone in the embryos of medaka fish, Oryzias latipes.

Journal: Zoological science 20020301

Title: Regio-specific hydroxylation of nonylphenol and the involvement of CYP2K- and CYP2M-like iso-enzymes in Atlantic salmon (Salmo salar).

Journal: Aquatic toxicology (Amsterdam, Netherlands) 20020201

Title: Ligand activation of the aromatic hydrocarbon receptor transcription factor drives Bax-dependent apoptosis in developing fetal ovarian germ cells.

Journal: Endocrinology 20020201

Title: Role of cytochrome P450 1a1 and 1b1 in the metabolic activation of 7,12-dimethylbenz[a]anthracene and the effects of naturally occurring furanocoumarins on skin tumor initiation.

Journal: Chemical research in toxicology 20020201

Title: Increase of CYP1B1 transcription in human keratinocytes and HaCaT cells after UV-B exposure.

Journal: Toxicology and applied pharmacology 20020201

Title: CYP1A-mediated metabolism of the Janus kinase-3 inhibitor 4-(4'-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline: structural basis for inactivation by regioselective O-demethylation.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20020101

Title: Comparative aflatoxin B(1) activation and cytotoxicity in human bronchial cells expressing cytochromes P450 1A2 and 3A4.

Journal: Cancer research 20020101

Title: Epigenetics of breast cancer: polycyclic aromatic hydrocarbons as risk factors.

Journal: Environmental and molecular mutagenesis 20020101

Title: The Japanese medaka (Oryzias latipes) model: applicability for investigating the immunosuppressive effects of the aquatic pollutant benzo[a]pyrene (BaP).

Journal: Marine environmental research 20020101

Title: Kinetic analysis for multiple substrate interaction at the active site of cytochrome P450.

Journal: Methods in enzymology 20020101

Title: Presence on human chromosome 10 of omeprazole-sensitivity gene whose product mediates CYP1A1 induction.

Journal: Cytogenetic and genome research 20020101

Title: A high-throughput cell-based reporter gene system for measurement of CYP1A1 induction.

Journal: Journal of pharmacological and toxicological methods 20020101

Title: Comparative analysis of in vitro and in vivo pharmacokinetic parameters related to individual variability of GTS-21 in canine.

Journal: Drug metabolism and pharmacokinetics 20020101

Title: Estrogen-mediated suppression of cytochrome P4501A (CYP1A) expression in rainbow trout hepatocytes: role of estrogen receptor.

Journal: Chemico-biological interactions 20011221

Title: Induction by xenobiotics of phase I and phase II enzyme activities in the human keratinocyte cell line NCTC 2544.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20011201

Title: The influence of diesel exhaust particles on mononuclear phagocytic cell-derived cytokines: IL-10, TGF-beta and IL-1 beta.

Journal: Clinical and experimental immunology 20011201

Title: Contribution of CYP1A2 in the hepatic metabolism of melatonin: studies with isolated microsomal preparations and liver slices.

Journal: Journal of pineal research 20011101

Title: alpha-Naphthoflavone acts as activator and reversible or irreversible inhibitor of rabbit microsomal CYP3A6.

Journal: Chemico-biological interactions 20011025

Title: Aryl hydrocarbon receptor/dioxin receptor in human monocytes and macrophages.

Journal: Molecular and cellular biochemistry 20011001

Title: Constitutive and inducible expression of Cyp1a1 and Cyp1b1 in vascular smooth muscle cells: role of the Ahr bHLH/PAS transcription factor.

Journal: Circulation research 20010928

Title: Transient expression of CYP1A1 in rat epithelial cells cultured in suspension.

Journal: Archives of biochemistry and biophysics 20010901

Title: A study of the expression of the xenobiotic-metabolising cytochrome P450 proteins and of testosterone metabolism in bovine liver.

Journal: Biochemical pharmacology 20010901

Title: Phenylalanine and tryptophan scanning mutagenesis of CYP3A4 substrate recognition site residues and effect on substrate oxidation and cooperativity.

Journal: Biochemistry 20010828

Title: Human enzymes involved in the metabolic activation of carcinogenic aristolochic acids: evidence for reductive activation by cytochromes P450 1A1 and 1A2.

Journal: Chemical research in toxicology 20010801

Title: Intestinal first-pass metabolism of eperisone in the rat.

Journal: Pharmaceutical research 20010801

Title: Cytochrome P450 CYP1B1 protein expression: a novel mechanism of anticancer drug resistance.

Journal: Biochemical pharmacology 20010715

Title: In vitro metabolism of 14C-moxidectin by hepatic microsomes from various species.

Journal: Veterinary research communications 20010701

Title: Cytochrome P450 1A1 (CYP1A1) in blood lymphocytes evidence for catalytic activity and mRNA expression.

Journal: Life sciences 20010615

Title: Novel CFTR chloride channel activators identified by screening of combinatorial libraries based on flavone and benzoquinolizinium lead compounds.

Journal: The Journal of biological chemistry 20010608

Title: Metabolism of DHEA by cytochromes P450 in rat and human liver microsomal fractions.

Journal: Archives of biochemistry and biophysics 20010515

Title: Inhibitory effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on cAMP-induced differentiation of rat C6 glial cell line.

Journal: Journal of neuroscience research 20010515

Title: 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin induces apoptosis in the dorsal midbrain of zebrafish embryos by activation of arylhydrocarbon receptor.

Journal: Neuroscience letters 20010511

Title: Effect of dioxins in mother's milk on sister chromatid exchange frequency in infant lymphocytes.

Journal: Fukuoka igaku zasshi = Hukuoka acta medica 20010501

Title: Metabolism of amiodarone (Part III): identification of rabbit cytochrome P450 isoforms involved in the hydroxylation of mono-N-desethylamiodarone.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20010501

Title: Cooperativity of alpha-naphthoflavone in cytochrome P450 3A-dependent drug oxidation activities in hepatic and intestinal microsomes from mouse and human.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20010501

Title: Influence of ligand binding to human cytochrome P-450 1A2: conformational activation and stabilization by alpha-naphthoflavone.

Journal: Biochimica et biophysica acta 20010407

Title: Effects of multiple exposures of small doses of Pembina Cardium crude oil and diesel in rats.

Journal: Archives of environmental contamination and toxicology 20010401

Title: Protection against nitrofurantoin-induced oxidative stress by coelenterazine analogues and their oxidation products in rat hepatocytes.

Journal: Free radical research 20010301

Title: Characterization of (+/-)-bufuralol hydroxylation activities in liver microsomes of Japanese and Caucasian subjects genotyped for CYP2D6.

Journal: Pharmacogenetics 20010301

Title: Transcriptional activation of cathepsin D gene expression by 17beta-estradiol: mechanism of aryl hydrocarbon receptor-mediated inhibition.

Journal: Molecular and cellular endocrinology 20010214

Title: CYP3A4 is the major CYP isoform mediating the in vitro hydroxylation and demethylation of flunitrazepam.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20010201

Title: Induction of 7-ethoxyresorufin-O-deethylase activity by planar chlorinated hydrocarbons and polycyclic aromatic hydrocarbons in cell lines from the rainbow trout pituitary.

Journal: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20010201

Title: High-throughput cytochrome P450 (CYP) inhibition screening via a cassette probe-dosing strategy. V. Validation of a direct injection/on-line guard cartridge extraction--tandem mass spectrometry method for CYP1A2 inhibition assessment.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20010201

Title: A kinetic model for the metabolic interaction of two substrates at the active site of cytochrome P450 3A4.

Journal: The Journal of biological chemistry 20010119

Title: Induction of apoptosis in human lymphocytes by the herbicide 2,4-dichlorophenoxyacetic acid.

Journal: Human immunology 20010101

Title: Characterization of xenobiotic-metabolizing cytochrome P450 (CYP) forms in ringed and grey seals from the Baltic Sea and reference sites.

Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20010101

Title: Application of the ethoxyresorufin-O-deethylase (EROD) assay to mixtures of halogenated aromatic compounds.

Journal: Environmental toxicology 20010101

Title: Cytochrome P450 1A expression in midwater fishes: potential effects of chemical contaminants in remote oceanic zones.

Journal: Environmental science & technology 20010101

Title: Effects of donor age and contamination level of dioxins and related chemicals on frequency of sister chromatid exchanges in human lymphocytes cultured in vitro.

Journal: Chemosphere 20010101

Title: Comparison between 'Yusho' patients and healthy Japanese in contamination level of dioxins and related chemicals and frequency of sister chromatid exchanges.

Journal: Chemosphere 20010101

Title: Steroid hormone activity of flavonoids and related compounds.

Journal: Breast cancer research and treatment 20000701

Title: Metabolism of 3-methylindole by porcine liver microsomes: responsible cytochrome P450 enzymes.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20000601

Title: A novel 4 S [3H]beta-naphthoflavone-binding protein in liver cytosol of female Sprague-Dawley rats treated with aryl hydrocarbon receptor agonists.

Journal: The Biochemical journal 20000501

Title: The aryl hydrocarbon receptor interacts with estrogen receptor alpha and orphan receptors COUP-TFI and ERRalpha1.

Journal: Archives of biochemistry and biophysics 20000101

Title: Induction of CYP1A by carbofuran in primary culture of fish hepatocytes.

Journal: Journal of biochemical and molecular toxicology 20000101

Title: Priming effect of benzo[a]pyrene on monocyte oxidative metabolism: possible mechanisms.

Journal: Toxicology letters 19991029

Title: Resveratrol has antagonist activity on the aryl hydrocarbon receptor: implications for prevention of dioxin toxicity.

Journal: Molecular pharmacology 19991001

Title: Transcriptional activation of c-fos protooncogene by 17beta-estradiol: mechanism of aryl hydrocarbon receptor-mediated inhibition.

Journal: Molecular endocrinology (Baltimore, Md.) 19990901

Title: Suppression of cell cycle progression by flavonoids: dependence on the aryl hydrocarbon receptor.

Journal: Carcinogenesis 19990801

Title: Differential regulation of c-fos expression in estrogen-induced hamster renal tumors compared with kidney not due to creation of an estrogen-response element by point mutation in the gene's flanking sequence.

Journal: Molecular carcinogenesis 19990401

Title: Alterations in the growth factor signal transduction pathways and modulators of the cell cycle in endocervical cells from macaques exposed to TCDD.

Journal: Toxicology and applied pharmacology 19980801

Title: Molecular basis of the inhibition of human aromatase (estrogen synthetase) by flavone and isoflavone phytoestrogens: A site-directed mutagenesis study.

Journal: Environmental health perspectives 19980201

Title: 2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced activation of a protein tyrosine kinase, pp60src, in murine hepatic cytosol using a cell-free system.

Journal: Molecular pharmacology 19971001

Title: Identification of enzymes involved in the metabolism of atrazine, terbuthylazine, ametryne, and terbutryne in human liver microsomes.

Journal: Chemical research in toxicology 19970901

Title: Examination of purported probes of human CYP2B6.

Journal: Pharmacogenetics 19970601

Title: Carbaryl induces CYP1A1 gene expression in HepG2 and HaCaT cells but is not a ligand of the human hepatic Ah receptor.

Journal: Toxicology and applied pharmacology 19970501

Title: A benzo[a]pyrene-induced cell cycle checkpoint resulting in p53-independent G1 arrest in 3T3 fibroblasts.

Journal: The Journal of biological chemistry 19970131

Title: Identification of c-Src as the integral component of the cytosolic Ah receptor complex, transducing the signal of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) through the protein phosphorylation pathway.

Journal: Biochemical pharmacology 19961122

Title: Specificity of substrate and inhibitor probes for cytochrome P450s: evaluation of in vitro metabolism using cDNA-expressed human P450s and human liver microsomes.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 19960701

Title: Induction of cytochrome P4501A1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin or indolo(3,2-b)carbazole is associated with oxidative DNA damage.

Journal: Proceedings of the National Academy of Sciences of the United States of America 19960319

Title: Interactions of flavonoids and other phytochemicals with adenosine receptors.

Journal: Journal of medicinal chemistry 19960202

Title: 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) modulates function of human luteinizing granulosa cells via cAMP signaling and early reduction of glucose transporting activity.

Journal: Reproductive toxicology (Elmsford, N.Y.) 19960101

Title: Protective action of dehydroascorbic acid on the Ah receptor-dependent and receptor-independent induction of lipid peroxidation in adipose tissue of male guinea pig caused by TCDD administration.

Journal: Journal of biochemical toxicology 19960101

Title: In vitro inhibition of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced activity by alpha-naphthoflavone and 6-methyl-1,3,8-trichlorodibenzofuran using an aryl hydrocarbon (Ah)-responsive construct.

Journal: Biochemical pharmacology 19950825

Title: Cytochrome P450 forms in the rodent lung involved in the metabolic activation of food-derived heterocyclic amines.

Journal: Carcinogenesis 19930901

Title: Mechanism of action of alpha-naphthoflavone as an Ah receptor antagonist in MCF-7 human breast cancer cells.

Journal: Toxicology and applied pharmacology 19930601

Title: Mechanism of action of aryl hydrocarbon receptor antagonists: inhibition of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced CYP1A1 gene expression.

Journal: Archives of biochemistry and biophysics 19921101

Title: Role of phospholipids in reconstituted cytochrome P450 3A form and mechanism of their activation of catalytic activity.

Journal: Biochemistry 19920707

Title: Metabolism of food-derived heterocyclic amines in human and rabbit tissues by P4503A proteins in the presence of flavonoids.

Journal: Cancer research 19920401

Title: Contributions of human liver cytochrome P450 enzymes to the N-oxidation of 4,4'-methylene-bis(2-chloroaniline).

Journal: Carcinogenesis 19920201

Title: Activation of amino-alpha-carboline, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and a copper phthalocyanine cellulose extract of cigarette smoke condensate by cytochrome P-450 enzymes in rat and human liver microsomes.

Journal: Cancer research 19911001

Title: Catalytic activities of human liver cytochrome P-450 IIIA4 expressed in Saccharomyces cerevisiae.

Journal: Biochemistry 19901225

Title: Inactivation of 1,3-, 1,6-, and 1,8-dinitropyrene by cytochrome P-450 enzymes in human and rat liver microsomes.

Journal: Cancer research 19900401

Title: Effect of benzopyrone derivatives on drug activity and metabolism.

Journal: European journal of drug metabolism and pharmacokinetics 19860101

Title: The influence of simple aromatics on benzene clastogenicity.

Journal: Mutation research 19840901

Title: Inducibility of arylhydrocarbon-hydroxylase activity in human hair follicles by topical application of liquor carbonis detergens (coal tar).

Journal: The British journal of dermatology 19840901

Title: High incidence of hepatocellular carcinomas after synthetic estrogen administration in Syrian golden hamsters fed alpha-naphthoflavone: a new tumor model.

Journal: Journal of the National Cancer Institute 19840801

Title: Campbell DR, et al. Flavonoid inhibition of aromatase enzyme activity in human preadipocytes. J Steroid Biochem Mol Biol. 1993 Sep;46(3):381-8.