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63208-82-2,MFCD00417851
Catalog No.:AA0036TV

63208-82-2 | Pifithrin-alpha

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5mg
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10mg
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25mg
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0036TV
Chemical Name:
Pifithrin-alpha
CAS Number:
63208-82-2
Molecular Formula:
C16H19BrN2OS
Molecular Weight:
367.3039
MDL Number:
MFCD00417851
SMILES:
Cc1ccc(cc1)C(=O)Cn1c(=N)sc2c1CCCC2.Br
Properties
Properties
 
Form:
Solid  
MP:
192.1-192.5 °C(lit.)  
Solubility:
DMSO: 20 mg/mL  
Storage:
Inert atmosphere;-20 ℃;  

Computed Properties
 
Complexity:
449  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
21  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
3  

Literature

Title: Triptolide induces p53-dependent cardiotoxicity through mitochondrial membrane permeabilization in cardiomyocytes.

Journal: Toxicology and applied pharmacology 20180915

Title: Doxorubicin triggers bioenergetic failure and p53 activation in mouse stem cell-derived cardiomyocytes.

Journal: Toxicology and applied pharmacology 20180601

Title: Flavan enantiomers from Daphne giraldii selectively induce apoptotic cell death in p53-null hepatocarcinoma cells in vitro.

Journal: Chemico-biological interactions 20180601

Title: Critical role of p21 on olaquindox-induced mitochondrial apoptosis and S-phase arrest involves activation of PI3K/AKT and inhibition of Nrf2/HO-1pathway.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20171001

Title: Nano-sized iron particles may induce multiple pathways of cell death following generation of mistranscripted RNA in human corneal epithelial cells.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20170801

Title: Long non-coding RNA LINC00672 contributes to p53 protein-mediated gene suppression and promotes endometrial cancer chemosensitivity.

Journal: The Journal of biological chemistry 20170407

Title: Unpredicted Downregulation of RAD51 Suggests Genome Instability Induced by Tetrachlorobenzoquinone.

Journal: Chemical research in toxicology 20161219

Title: Adaptive upregulation of DNA repair genes following benzo(a)pyrene diol epoxide protects against cell death at the expense of mutations.

Journal: Nucleic acids research 20161215

Title: Study of Bioreductive Anticancer Agent RH-1-Induced Signals Leading the Wild-Type p53-Bearing Lung Cancer A549 Cells to Apoptosis.

Journal: Chemical research in toxicology 20160119

Title: Cyclosporine A Suppressed Glucose Oxidase Induced P53 Mitochondrial Translocation and Hepatic Cell Apoptosis through Blocking Mitochondrial Permeability Transition.

Journal: International journal of biological sciences 20160101

Title: Polychlorinated Biphenyl Quinone Metabolite Promotes p53-Dependent DNA Damage Checkpoint Activation, S-Phase Cycle Arrest and Extrinsic Apoptosis in Human Liver Hepatocellular Carcinoma HepG2 Cells.

Journal: Chemical research in toxicology 20151116

Title: Etoposide Induces Necrosis Through p53-Mediated Antiapoptosis in Human Kidney Proximal Tubule Cells.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20151101

Title: Benzo[a]pyrene-induced nitric oxide production acts as a survival signal targeting mitochondrial membrane potential.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20151001

Title: SOX30, a novel epigenetic silenced tumor suppressor, promotes tumor cell apoptosis by transcriptional activating p53 in lung cancer.

Journal: Oncogene 20150813

Title: Arsenic-induced S phase cell cycle lengthening is associated with ROS generation, p53 signaling and CDC25A expression.

Journal: Chemico-biological interactions 20150805

Title: Sestrin2 Protects Dopaminergic Cells against Rotenone Toxicity through AMPK-Dependent Autophagy Activation.

Journal: Molecular and cellular biology 20150801

Title: Hepato-protective effect of resveratrol against acetaminophen-induced liver injury is associated with inhibition of CYP-mediated bioactivation and regulation of SIRT1-p53 signaling pathways.

Journal: Toxicology letters 20150716

Title: FTY720 induces autophagy-related apoptosis and necroptosis in human glioblastoma cells.

Journal: Toxicology letters 20150702

Title: Checkpoint kinase 1 is activated and promotes cell survival after exposure to sulphur mustard.

Journal: Toxicology letters 20150122

Title: Pivotal roles of p53 transcription-dependent and -independent pathways in manganese-induced mitochondrial dysfunction and neuronal apoptosis.

Journal: Toxicology and applied pharmacology 20141215

Title: Translesion polymerase η is upregulated by cancer therapeutics and confers anticancer drug resistance.

Journal: Cancer research 20141001

Title: Detrimental effects of Notch1 signaling activated by cadmium in renal proximal tubular epithelial cells.

Journal: Cell death & disease 20140801

Title: Cordycepin induces apoptosis of C6 glioma cells through the adenosine 2A receptor-p53-caspase-7-PARP pathway.

Journal: Chemico-biological interactions 20140605

Title: Silver nanoparticles induce p53-mediated apoptosis in human bronchial epithelial (BEAS-2B) cells.

Journal: The Journal of toxicological sciences 20140601

Title: The essential role of p53-up-regulated modulator of apoptosis (Puma) and its regulation by FoxO3a transcription factor in β-amyloid-induced neuron death.

Journal: The Journal of biological chemistry 20140411

Title: Quercetin regulates the sestrin 2-AMPK-p38 MAPK signaling pathway and induces apoptosis by increasing the generation of intracellular ROS in a p53-independent manner.

Journal: International journal of molecular medicine 20140401

Title: Differentiation of human placental BeWo cells by the environmental contaminant benzo(a)pyrene.

Journal: Chemico-biological interactions 20140305

Title: Classification of polycyclic aromatic hydrocarbons based on mutagenicity in lung tissue through DNA microarray.

Journal: Environmental toxicology 20131101

Title: p53 activation by Ni(II) is a HIF-1α independent response causing caspases 9/3-mediated apoptosis in human lung cells.

Journal: Toxicology and applied pharmacology 20130615

Title: Autophagy takes place in mutated p53 neuroblastoma cells in response to hypoxia mimetic CoCl(2).

Journal: Biochemical pharmacology 20130415

Title: p53 contributes to quercetin-induced apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes.

Journal: Inflammation 20130401

Title: Cellular mechanisms of the cytotoxic effects of the zearalenone metabolites α-zearalenol and β-zearalenol on RAW264.7 macrophages.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20130401

Title: Marijuana smoke condensate induces p53-mediated apoptosis in human lung epithelial cells.

Journal: The Journal of toxicological sciences 20130101

Title: Hexavalent chromium induces energy metabolism disturbance and p53-dependent cell cycle arrest via reactive oxygen species in L-02 hepatocytes.

Journal: Molecular and cellular biochemistry 20121201

Title: Adenovirus-mediated expression of p33(ING1b) induces apoptosis and inhibits proliferation in gastric adenocarcinoma cells in vitro.

Journal: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 20121001

Title: The synthetic purine reversine selectively induces cell death of cancer cells.

Journal: Journal of cellular biochemistry 20121001

Title: Insulin increases epiblast cell number of in vitro cultured mouse embryos via the PI3K/GSK3/p53 pathway.

Journal: Stem cells and development 20120901

Title: Novel multiple apoptotic mechanism of shikonin in human glioma cells.

Journal: Annals of surgical oncology 20120901

Title: Expression of the polyalanine expansion mutant of nuclear poly(A)-binding protein induces apoptosis via the p53 pathway.

Journal: Cell biology international 20120801

Title: Synergistic interaction between the novel histone deacetylase inhibitor ST2782 and the proteasome inhibitor bortezomib in platinum-sensitive and resistant ovarian carcinoma cells.

Journal: Journal of inorganic biochemistry 20120801

Title: Targets and intracellular signaling mechanisms for deoxynivalenol-induced ribosomal RNA cleavage.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20120601

Title: Alpha-melanocyte-stimulating hormone suppresses oxidative stress through a p53-mediated signaling pathway in human melanocytes.

Journal: Molecular cancer research : MCR 20120601

Title: The p53 inhibitor, pifithrin-α, suppresses self-renewal of embryonic stem cells.

Journal: Biochemical and biophysical research communications 20120413

Title: Dual pathways of p53 mediated glucolipotoxicity-induced apoptosis of rat cardiomyoblast cell: activation of p53 proapoptosis and inhibition of Nrf2-NQO1 antiapoptosis.

Journal: Metabolism: clinical and experimental 20120401

Title: Functional characterization of the p53 binding site in the human PYNOD promoter.

Journal: Human immunology 20120401

Title: p53-induced uncoupling expression of aquaporin-4 and inwardly rectifying K+ 4.1 channels in cytotoxic edema after subarachnoid hemorrhage.

Journal: CNS neuroscience & therapeutics 20120401

Title: XPD could suppress growth of HepG2.2.15 and down-regulate the expression of hepatitis B virus x protein through P53 pathway.

Journal: Biochemical and biophysical research communications 20120323

Title: Role of autophagy in chemoresistance: regulation of the ATM-mediated DNA-damage signaling pathway through activation of DNA-PKcs and PARP-1.

Journal: Biochemical pharmacology 20120315

Title: P53 activation plays a crucial role in silibinin induced ROS generation via PUMA and JNK.

Journal: Free radical research 20120301

Title: MicroRNA-34a upregulation during seizure-induced neuronal death.

Journal: Cell death & disease 20120301

Title: Geranylgeranyl transferase 1 modulates autophagy and apoptosis in human airway smooth muscle.

Journal: American journal of physiology. Lung cellular and molecular physiology 20120215

Title: Moderate dietary restriction reduces p53-mediated neurovascular damage and microglia activation after hypoxic ischemia in neonatal brain.

Journal: Stroke 20120201

Title: Evidence for activation of mutated p53 by apigenin in human pancreatic cancer.

Journal: Biochimica et biophysica acta 20120201

Title: The p53 inhibitor pifithrin-α can stimulate fibrosis in a rat model of ischemic acute kidney injury.

Journal: American journal of physiology. Renal physiology 20120115

Title: p53 acts as a co-repressor to regulate keratin 14 expression during epidermal cell differentiation.

Journal: PloS one 20120101

Title: Transient transfection of a wild-type p53 gene triggers resveratrol-induced apoptosis in cancer cells.

Journal: PloS one 20120101

Title: 2,3,7,8-Tetrachlorodibenzo-p-dioxin's suppression of 1-nitropyrene-induced p53 expression is mediated by cytochrome P450 1A1.

Journal: Chemical research in toxicology 20111219

Title: Study on X-ray-induced apoptosis and chromosomal damage in G2 human lymphocytes in the presence of pifithrin-α, an inhibitor of p53.

Journal: Mutation research 20111127

Title: Id1-induced inhibition of p53 facilitates endothelial cell migration and tube formation by regulating the expression of beta1-integrin.

Journal: Molecular and cellular biochemistry 20111101

Title: NF-κB plays an important role in indoxyl sulfate-induced cellular senescence, fibrotic gene expression, and inhibition of proliferation in proximal tubular cells.

Journal: American journal of physiology. Cell physiology 20111101

Title: [Involvement of p38-p53 signal pathway in resveratrol-induced apoptosis in MCF-7 cells].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20111101

Title: Involvement of phorbol-12-myristate-13-acetate-induced protein 1 in goniothalamin-induced TP53-dependent and -independent apoptosis in hepatocellular carcinoma-derived cells.

Journal: Toxicology and applied pharmacology 20111001

Title: Knockdown of CITED2 using short-hairpin RNA sensitizes cancer cells to cisplatin through stabilization of p53 and enhancement of p53-dependent apoptosis.

Journal: Journal of cellular physiology 20110901

Title: Inhibition of p53-p21 pathway promotes the differentiation of rat bone marrow mesenchymal stem cells into cardiomyocytes.

Journal: Molecular and cellular biochemistry 20110801

Title: SIRT1 activation by resveratrol ameliorates cisplatin-induced renal injury through deacetylation of p53.

Journal: American journal of physiology. Renal physiology 20110801

Title: Targeting the p53 pathway to protect the neonatal ischemic brain.

Journal: Annals of neurology 20110801

Title: PUMA mediates the apoptotic signal of hypoxia/reoxygenation in cardiomyocytes through mitochondrial pathway.

Journal: Shock (Augusta, Ga.) 20110601

Title: [Effects of hot shock protein 70 inhibitor PFTµ on inflammatory response in lipopolysaccharide-stimulated RAW264.7 cells and mice underwent myocardial ischemia-reperfusion injury].

Journal: Zhonghua xin xue guan bing za zhi 20110601

Title: Distinct regulation of p53-mediated apoptosis by protein kinase Cα, δ, ε and ζ: Evidence in yeast for transcription-dependent and -independent p53 apoptotic mechanisms.

Journal: Experimental cell research 20110501

Title: Biological and chemical studies on aryl hydrocarbon receptor induction by the p53 inhibitor pifithrin-α and its condensation product pifithrin-β.

Journal: Life sciences 20110425

Title: Mechanism of anthracycline-mediated down-regulation of GATA4 in the heart.

Journal: Cardiovascular research 20110401

Title: Mild thermotolerance induced at 40°C protects HeLa cells against activation of death receptor-mediated apoptosis by hydrogen peroxide.

Journal: Free radical biology & medicine 20110315

Title: Haploinsufficiency for ribosomal protein genes causes selective activation of p53 in human erythroid progenitor cells.

Journal: Blood 20110303

Title: Inhibition of p53 after acute myocardial infarction: reduction of apoptosis is counteracted by disturbed scar formation and cardiac rupture.

Journal: Journal of molecular and cellular cardiology 20110301

Title: Synthesis and biological evaluation of imidazolo[2,1-b]benzothiazole derivatives, as potential p53 inhibitors.

Journal: Bioorganic & medicinal chemistry 20110301

Title: Human mesenchymal stem cells are sensitive to abnormal gravity and exhibit classic apoptotic features.

Journal: Acta biochimica et biophysica Sinica 20110201

Title: Blocking NF-κB nuclear translocation leads to p53-related autophagy activation and cell apoptosis.

Journal: World journal of gastroenterology 20110128

Title: Critical role of the JNK-p53-GADD45α apoptotic cascade in mediating oxidative cytotoxicity in hippocampal neurons.

Journal: British journal of pharmacology 20110101

Title: p53-Mediated oxidative stress and tubular injury in rats with glycerol-induced acute kidney injury.

Journal: American journal of nephrology 20110101

Title: Enhanced survival of dopaminergic neuronal transplants in hemiparkinsonian rats by the p53 inactivator PFT-α.

Journal: Cell transplantation 20110101

Title: Transcriptional and post-transcriptional mechanisms for oncogenic overexpression of ether à go-go K+ channel.

Journal: PloS one 20110101

Title: Autophagy impairment induces premature senescence in primary human fibroblasts.

Journal: PloS one 20110101

Title: High dose of pyridoxine induces IGFBP-3 mRNA expression in MCF-7 cells and its induction is inhibited by the p53-specific inhibitor pifithrin-α.

Journal: Journal of nutritional science and vitaminology 20110101

Title: Oxaliplatin down-regulates survivin by p38 MAP kinase and proteasome in human colon cancer cells.

Journal: Chemico-biological interactions 20101205

Title: Pifithrin-α as a potential cytoprotective agent in radiotherapy: protection of normal tissue without decreasing therapeutic efficacy in glioma cells.

Journal: Radiation research 20101101

Title: Senescence and dysfunction of proximal tubular cells are associated with activated p53 expression by indoxyl sulfate.

Journal: American journal of physiology. Cell physiology 20101101

Title: Hypoxia downregulates p53 but induces apoptosis and enhances expression of BAD in cultures of human syncytiotrophoblasts.

Journal: American journal of physiology. Cell physiology 20101101

Title: Pharmacological inhibition of Rho-kinase (ROCK) signaling enhances cisplatin resistance in neuroblastoma cells.

Journal: International journal of oncology 20101101

Title: A role for p53 in the beta-amyloid-mediated regulation of the lysosomal system.

Journal: Neurobiology of aging 20101001

Title: Molecular mechanisms of nutlin-induced apoptosis in multiple myeloma: evidence for p53-transcription-dependent and -independent pathways.

Journal: Cancer biology & therapy 20100915

Title: p53 Plays an important role in cell fate determination after exposure to microcystin-LR.

Journal: Environmental health perspectives 20100901

Title: Relation between DNA repair, apoptosis and chromosomal aberrations in presence of pifithrin-alpha, an inhibitor of p53.

Journal: Mutation research 20100814

Title: Enhanced Gadd45 expression and delayed G2/M progression are p53-dependent in zinc-supplemented human bronchial epithelial cells.

Journal: Experimental biology and medicine (Maywood, N.J.) 20100801

Title: Induction of p53-independent apoptosis by a novel synthetic hexahydrocannabinol analog is mediated via Sp1-dependent NSAID-activated gene-1 in colon cancer cells.

Journal: Biochemical pharmacology 20100701

Title: Inhibition of p53 sensitizes MCF-7 cells to ceramide treatment.

Journal: International journal of oncology 20100701

Title: Ursodeoxycholic acid switches oxaliplatin-induced necrosis to apoptosis by inhibiting reactive oxygen species production and activating p53-caspase 8 pathway in HepG2 hepatocellular carcinoma.

Journal: International journal of cancer 20100401

Title: Use of pifithrin to inhibit p53-mediated signalling of TNF in dystrophic muscles of mdx mice.

Journal: Molecular and cellular biochemistry 20100401

Title: Statin-triggered cell death in primary human lung mesenchymal cells involves p53-PUMA and release of Smac and Omi but not cytochrome c.

Journal: Biochimica et biophysica acta 20100401

Title: Transcriptional signature of human macrophages exposed to the environmental contaminant benzo(a)pyrene.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20100401

Title: A small molecule inhibitor of p53 stimulates amplification of hematopoietic stem cells but does not promote tumor development in mice.

Journal: Cell cycle (Georgetown, Tex.) 20100401

Title: 5-Aza-2'-deoxycytidine sensitizes busulfan-resistant myeloid leukemia cells by regulating expression of genes involved in cell cycle checkpoint and apoptosis.

Journal: Leukemia research 20100301

Title: Reduced hippocampal damage and epileptic seizures after status epilepticus in mice lacking proapoptotic Puma.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20100301

Title: Short-term inhibition of p53 combined with keratinocyte growth factor improves thymic epithelial cell recovery and enhances T-cell reconstitution after murine bone marrow transplantation.

Journal: Blood 20100204

Title: Topotecan triggers apoptosis in p53-deficient cells by forcing degradation of XIAP and survivin thereby activating caspase-3-mediated Bid cleavage.

Journal: The Journal of pharmacology and experimental therapeutics 20100101

Title: Cadmium induces intracellular Ca2+- and H2O2-dependent apoptosis through JNK- and p53-mediated pathways in skin epidermal cell line.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20100101

Title: Activation of p53 promotes renal injury in acute aristolochic acid nephropathy.

Journal: Journal of the American Society of Nephrology : JASN 20100101

Title: Inhibiting p53 pathways in microglia attenuates microglial-evoked neurotoxicity following exposure to Alzheimer peptides.

Journal: Journal of neurochemistry 20100101

Title: PFT-alpha inhibits antibody-induced activation of p53 and pro-apoptotic signaling in 1-LN prostate cancer cells.

Journal: Biochemical and biophysical research communications 20100101

Title: Transcriptional regulation of the presenilin-1 gene controls gamma-secretase activity.

Journal: Frontiers in bioscience (Elite edition) 20100101

Title: Sodium orthovanadate inhibits p53-mediated apoptosis.

Journal: Cancer research 20100101

Title: The zebrafish embryo as a model for assessing off-target drug effects.

Journal: Disease models & mechanisms 20100101

Title: Pifithrin-α, an inhibitor of p53 transactivation, up-regulates COX-2 expression through an MAPK-dependent pathway.

Journal: Pharmacology 20100101

Title: Implication of NF-κB and p53 in the expression of TRAIL-death receptors and apoptosis by apple procyanidins in human metastatic SW620 cells.

Journal: Biomedica : revista del Instituto Nacional de Salud 20100101

Title: Angiotensin II-induced p53-dependent cardiac apoptotic cell death: its prevention by metallothionein.

Journal: Toxicology letters 20091215

Title: Oxaliplatin-induced gamma-H2AX activation via both p53-dependent and -independent pathways but is not associated with cell cycle arrest in human colorectal cancer cells.

Journal: Chemico-biological interactions 20091210

Title: Doxorubicin induces senescence or apoptosis in rat neonatal cardiomyocytes by regulating the expression levels of the telomere binding factors 1 and 2.

Journal: American journal of physiology. Heart and circulatory physiology 20091201

Title: p53 induction contributes to excitotoxic neuronal death in rat striatum through apoptotic and autophagic mechanisms.

Journal: The European journal of neuroscience 20091201

Title: Signalling pathways involved in 1-nitropyrene (1-NP)-induced and 3-nitrofluoranthene (3-NF)-induced cell death in Hepa1c1c7 cells.

Journal: Mutagenesis 20091101

Title: NF-kappab facilitates oridonin-induced apoptosis and autophagy in HT1080 cells through a p53-mediated pathway.

Journal: Archives of biochemistry and biophysics 20090901

Title: Cytotoxicity and mitochondrial apoptosis induced by etoposide in melanoma cells.

Journal: Cancer investigation 20090801

Title: Fusarial toxin-induced toxicity in cultured cells and in isolated mitochondria involves PTPC-dependent activation of the mitochondrial pathway of apoptosis.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20090801

Title: Role of p53 in human chondrocyte apoptosis in response to shear strain.

Journal: Arthritis and rheumatism 20090801

Title: Pifithrin-alpha decreases the radioprotective efficacy of a Podophyllum hexandrum Himalayan mayapple fraction REC-2006 in HepG2 cells.

Journal: Biotechnology and applied biochemistry 20090709

Title: Axin induces cell death and reduces cell proliferation in astrocytoma by activating the p53 pathway.

Journal: International journal of oncology 20090701

Title: Humic acid induces G1 phase arrest and apoptosis in cultured vascular smooth muscle cells.

Journal: Environmental toxicology 20090601

Title: Pifithrin-alpha protects against DNA damage-induced apoptosis downstream of mitochondria independent of p53.

Journal: Cell death and differentiation 20090601

Title: The transcription-independent mitochondrial p53 program is a major contributor to nutlin-induced apoptosis in tumor cells.

Journal: Cell cycle (Georgetown, Tex.) 20090601

Title: Differential requirement for nucleostemin in embryonic stem cell and neural stem cell viability.

Journal: Stem cells (Dayton, Ohio) 20090501

Title: Delayed treatment with a p53 inhibitor enhances recovery in stroke brain.

Journal: Annals of neurology 20090501

Title: Divergence to apoptosis from ROS induced cell cycle arrest: effect of cadmium.

Journal: Mutation research 20090426

Title: Rosiglitazone acts as a neuroprotectant in retinal cells via up-regulation of sestrin-1 and SOD-2.

Journal: Journal of neurochemistry 20090401

Title: p53 mediates mitochondria dysfunction-triggered autophagy activation and cell death in rat striatum.

Journal: Autophagy 20090401

Title: Sex-specific differences in fetal germ cell apoptosis induced by ionizing radiation.

Journal: Human reproduction (Oxford, England) 20090301

Title: The essential role of p53 in hyperpigmentation of the skin via regulation of paracrine melanogenic cytokine receptor signaling.

Journal: The Journal of biological chemistry 20090213

Title: Diesel exhaust particles induce apoptosis via p53 and Mdm2 in J774A.1 macrophage cell line.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20090201

Title: Potential role of PUMA in delayed death of hippocampal CA1 neurons after transient global cerebral ischemia.

Journal: Stroke 20090201

Title: Possible involvement of NO in the stimulating effect of pifithrins on survival of hemopoietic clonogenic cells.

Journal: Biochemistry. Biokhimiia 20090201

Title: Bmp2 is required for cephalic neural tube closure in the mouse.

Journal: Developmental dynamics : an official publication of the American Association of Anatomists 20090101

Title: Ammonia-induced activation of p53 in cultured astrocytes: role in cell swelling and glutamate uptake.

Journal: Neurochemistry international 20090101

Title: Enhanced sensitivity of celecoxib in human glioblastoma cells: Induction of DNA damage leading to p53-dependent G1 cell cycle arrest and autophagy.

Journal: Molecular cancer 20090101

Title: p53 Small-molecule inhibitor enhances temozolomide cytotoxic activity against intracranial glioblastoma xenografts.

Journal: Cancer research 20081215

Title: p53 regulates renal expression of HIF-1{alpha} and pVHL under physiological conditions and after ischemia-reperfusion injury.

Journal: American journal of physiology. Renal physiology 20081201

Title: Regulation of Bax activation and apoptotic response to UV irradiation by p53 transcription-dependent and -independent pathways.

Journal: Cancer letters 20081128

Title: Selective activation of p38 mitogen-activated protein kinase in dopaminergic neurons of substantia nigra leads to nuclear translocation of p53 in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20081119

Title: Inhibition of p53 by pifithrin-alpha reduces myocyte apoptosis and leukocyte transmigration in aged rat hearts following 24 hours of reperfusion.

Journal: Shock (Augusta, Ga.) 20081101

Title: Basal and UV-induced MMP-1 expression are inhibited by p53 in human dermal fibroblasts.

Journal: Experimental dermatology 20081101

Title: PCB126 exposure disrupts zebrafish ventricular and branchial but not early neural crest development.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20081101

Title: p53-mediated apoptosis of CLL cells: evidence for a transcription-independent mechanism.

Journal: Blood 20081101

Title: ERKs/p53 signal transduction pathway is involved in doxorubicin-induced apoptosis in H9c2 cells and cardiomyocytes.

Journal: American journal of physiology. Heart and circulatory physiology 20081101

Title: The alpha1D-adrenergic receptor induces vascular smooth muscle apoptosis via a p53-dependent mechanism.

Journal: Molecular pharmacology 20081001

Title: Regulation of MMP-9 by p53 in first trimester cytotrophoblastic cells.

Journal: Human reproduction (Oxford, England) 20081001

Title: Autophagy is cytoprotective during cisplatin injury of renal proximal tubular cells.

Journal: Kidney international 20080901

Title: Inhibition of glycogen synthase kinase or the apoptotic protein p53 lowers the threshold of helium cardioprotection in vivo: the role of mitochondrial permeability transition.

Journal: Anesthesia and analgesia 20080901

Title: Coupling of mutated Met variants to DNA repair via Abl and Rad51.

Journal: Cancer research 20080715

Title: Inhibition of p53 transcriptional activity: a potential target for future development of therapeutic strategies for primary demyelination.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20080611

Title: p21(WAF1/CIP1) induction by 5-azacytosine nucleosides requires DNA damage.

Journal: Oncogene 20080605

Title: Contribution of p53-mediated Bax transactivation in theaflavin-induced mammary epithelial carcinoma cell apoptosis.

Journal: Apoptosis : an international journal on programmed cell death 20080601

Title: Cyclic pifithrin-alpha sensitizes wild type p53 tumor cells to antimicrotubule agent-induced apoptosis.

Journal: Neoplasia (New York, N.Y.) 20080601

Title: Apigenin-induced prostate cancer cell death is initiated by reactive oxygen species and p53 activation.

Journal: Free radical biology & medicine 20080515

Title: Inhibition of p73 function by Pifithrin-alpha as revealed by studies in zebrafish embryos.

Journal: Cell cycle (Georgetown, Tex.) 20080501

Title: Restriction of human herpesvirus 6B replication by p53.

Journal: The Journal of general virology 20080501

Title: HSP27 regulates p53 transcriptional activity in doxorubicin-treated fibroblasts and cardiac H9c2 cells: p21 upregulation and G2/M phase cell cycle arrest.

Journal: American journal of physiology. Heart and circulatory physiology 20080401

Title: Pifithrin-alpha reduces cerebral vasospasm by attenuating apoptosis of endothelial cells in a subarachnoid haemorrhage model of rat.

Journal: Chinese medical journal 20080305

Title: Histone deacetylase inhibitors induce in human hepatoma HepG2 cells acetylation of p53 and histones in correlation with apoptotic effects.

Journal: International journal of oncology 20080101

Title: Cardiac outflow tract septation failure in Pax3-deficient embryos is due to p53-dependent regulation of migrating cardiac neural crest.

Journal: Mechanisms of development 20080101

Title: Simvastatin inhibits cell cycle progression in glucose-stimulated proliferation of aortic vascular smooth muscle cells by up-regulating cyclin dependent kinase inhibitors and p53.

Journal: Pharmacological research 20080101

Title: MAPK inhibitors and pifithrin-alpha block cinnamaldehyde-induced apoptosis in human PLC/PRF/5 cells.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20071201

Title: Bid is not required for Bax translocation during UV-induced apoptosis.

Journal: Cellular signalling 20071201

Title: Increased expression of the pro-apoptotic Bcl2 family member PUMA is required for mitochondrial release of cytochrome C and the apoptosis associated with skeletal myoblast differentiation.

Journal: Apoptosis : an international journal on programmed cell death 20071201

Title: Temozolomide induces senescence but not apoptosis in human melanoma cells.

Journal: British journal of cancer 20071105

Title: Activation and involvement of p53 in cisplatin-induced nephrotoxicity.

Journal: American journal of physiology. Renal physiology 20071001

Title: Involvement of both tumor necrosis factor-alpha-induced necrosis and p53-mediated caspase-dependent apoptosis in nephrotoxicity of cisplatin.

Journal: Apoptosis : an international journal on programmed cell death 20071001

Title: Redox control of G(1)/S cell cycle regulators during nitric oxide-mediated cell cycle arrest.

Journal: Journal of cellular physiology 20070901

Title: Delayed neuronal death after brain trauma involves p53-dependent inhibition of NF-kappaB transcriptional activity.

Journal: Cell death and differentiation 20070801

Title: Transcription factor p53 in degenerating spinal cords.

Journal: Brain research 20070530

Title: NF-kappaB contributes to 6-hydroxydopamine-induced apoptosis of nigral dopaminergic neurons through p53.

Journal: Brain research 20070511

Title: Zebrafish tp53 knockdown extends the survival of irradiated zebrafish embryos more effectively than the p53 inhibitor pifithrin-alpha.

Journal: Cancer biology & therapy 20070501

Title: Endogenously generated hydrogen peroxide induces apoptosis via mitochondrial damage independent of NF-kappaB and p53 activation in bovine embryos.

Journal: Theriogenology 20070415

Title: Dangerous habits of a security guard: the two faces of p53 as a drug target.

Journal: Human molecular genetics 20070415

Title: p21 and mTERT are novel markers for determining different ischemic time periods in renal ischemia-reperfusion injury.

Journal: American journal of physiology. Renal physiology 20070201

Title: Role of p53 in irinotecan-induced intestinal cell death and mucosal damage.

Journal: Anti-cancer drugs 20070201

Title: Pifithrin-alpha, an inhibitor of p53 transactivation, alters the inflammatory process and delays tendon healing following acute injury.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20070101

Title: A novel role for DNA mismatch repair and the autophagic processing of chemotherapy drugs in human tumor cells.

Journal: Autophagy 20070101

Title: Differential protection and transactivation of P53, P21, Bcl2, PCNA, cyclin G, and MDM2 genes in rat liver and the HepG2 cell line upon exposure to pifithrin.

Journal: Biomedical sciences instrumentation 20070101

Title: Protective effect of pifithrin-alpha on brain ischemic reperfusion injury induced by bilateral common carotid arteries occlusion in gerbils.

Journal: Indian journal of physiology and pharmacology 20070101

Title: p53 mediates particulate matter-induced alveolar epithelial cell mitochondria-regulated apoptosis.

Journal: American journal of respiratory and critical care medicine 20061201

Title: Pifithrin-alpha enhances chemosensitivity by a p38 mitogen-activated protein kinase-dependent modulation of the eukaryotic initiation factor 4E in malignant cholangiocytes.

Journal: The Journal of pharmacology and experimental therapeutics 20061201

Title: Pifithrin-alpha attenuates p53-mediated apoptosis and improves cardiac function in response to myocardial ischemia/reperfusion in aged rats.

Journal: Shock (Augusta, Ga.) 20061201

Title: Inhibition of apoptotic protein p53 lowers the threshold of isoflurane-induced cardioprotection during early reperfusion in rabbits.

Journal: Anesthesia and analgesia 20061201

Title: Human herpesvirus 6B inhibits cell proliferation by a p53-independent pathway.

Journal: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20061201

Title: Silibinin activates p53-caspase 2 pathway and causes caspase-mediated cleavage of Cip1/p21 in apoptosis induction in bladder transitional-cell papilloma RT4 cells: evidence for a regulatory loop between p53 and caspase 2.

Journal: Carcinogenesis 20061101

Title: Busulfan selectively induces cellular senescence but not apoptosis in WI38 fibroblasts via a p53-independent but extracellular signal-regulated kinase-p38 mitogen-activated protein kinase-dependent mechanism.

Journal: The Journal of pharmacology and experimental therapeutics 20061101

Title: Inhibition of p53 response in tumor stroma improves efficacy of anticancer treatment by increasing antiangiogenic effects of chemotherapy and radiotherapy in mice.

Journal: Cancer research 20061001

Title: Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation.

Journal: Nature chemical biology 20060901

Title: Primordial germ cell deficiency in the connexin 43 knockout mouse arises from apoptosis associated with abnormal p53 activation.

Journal: Development (Cambridge, England) 20060901

Title: TEL/ETV6 induces apoptosis in 32D cells through p53-dependent pathways.

Journal: Biochemical and biophysical research communications 20060825

Title: Ionizing radiation suppresses FAP-1 mRNA level in A549 cells via p53 activation.

Journal: FEBS letters 20060807

Title: Potent antiproliferative effects of resveratrol on human osteosarcoma SJSA1 cells: Novel cellular mechanisms involving the ERKs/p53 cascade.

Journal: Free radical biology & medicine 20060715

Title: Intestinal mucositis: the role of the Bcl-2 family, p53 and caspases in chemotherapy-induced damage.

Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20060701

Title: Vasospasm and p53-induced apoptosis in an experimental model of subarachnoid hemorrhage.

Journal: Stroke 20060701

Title: Imino-tetrahydro-benzothiazole derivatives as p53 inhibitors: discovery of a highly potent in vivo inhibitor and its action mechanism.

Journal: Journal of medicinal chemistry 20060615

Title: Multiple actions of pifithrin-alpha on doxorubicin-induced apoptosis in rat myoblastic H9c2 cells.

Journal: American journal of physiology. Heart and circulatory physiology 20060601

Title: Evidence for p53-like-mediated stress responses in green algae.

Journal: FEBS letters 20060529

Title: Modulation of p53 transcriptional activity by PRIMA-1 and Pifithrin-alpha on staurosporine-induced apoptosis of wild-type and mutated p53 epithelial cells.

Journal: Apoptosis : an international journal on programmed cell death 20060501

Title: Regulation of p53 and suppression of apoptosis by the soluble guanylyl cyclase/cGMP pathway in human ovarian cancer cells.

Journal: Oncogene 20060406

Title: P53 mediates amosite asbestos-induced alveolar epithelial cell mitochondria-regulated apoptosis.

Journal: American journal of respiratory cell and molecular biology 20060401

Title: [Expression of p53 in neonatal mice following hypoxia-ischemia and effects of its inhibitor on neonatal brain injury].

Journal: Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20060401

Title: Activation of ERK1/2 and p38 kinases by polycyclic aromatic hydrocarbons in rat liver epithelial cells is associated with induction of apoptosis.

Journal: Toxicology and applied pharmacology 20060315

Title: Potent inhibition of carcinogen-bioactivating cytochrome P450 1B1 by the p53 inhibitor pifithrin alpha.

Journal: Carcinogenesis 20060301

Title: Insulin-like growth factor-1 prevents Abeta[25-35]/(H2O2)- induced apoptosis in lymphocytes by reciprocal NF-kappaB activation and p53 inhibition via PI3K-dependent pathway.

Journal: Growth factors (Chur, Switzerland) 20060301

Title: Histone deacetylase inhibitor-mediated radiosensitization of human cancer cells: class differences and the potential influence of p53.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20060201

Title: [Effects of p53 inhibitor-alpha on the proliferation and apoptosis in large intestinal epithelial cells damaged by hyperthermic chemotherapy].

Journal: Zhonghua yi xue za zhi 20060110

Title: Effects of intracellular calcium chelation and pifithrin-alpha on deoxynucleotide metabolism in human lymphocytes.

Journal: Nucleosides, nucleotides & nucleic acids 20060101

Title: Pifithrin-alpha induced p53 inhibition does not affect liver regeneration after partial hepatectomy in mice.

Journal: Journal of hepatology 20051101

Title: Inhibitors of apoptosis in lymphocytes: synthesis and biological evaluation of compounds related to pifithrin-alpha.

Journal: Journal of medicinal chemistry 20051006

Title: p53-dependent caspase-2 activation in mitochondrial release of apoptosis-inducing factor and its role in renal tubular epithelial cell injury.

Journal: The Journal of biological chemistry 20050902

Title: Induction of competing apoptotic and survival signaling pathways in the macrophage by the ribotoxic trichothecene deoxynivalenol.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20050901

Title: Dexamethasone prevents podocyte apoptosis induced by puromycin aminonucleoside: role of p53 and Bcl-2-related family proteins.

Journal: Journal of the American Society of Nephrology : JASN 20050901

Title: Regulation of neuronal P53 activity by CXCR 4.

Journal: Molecular and cellular neurosciences 20050901

Title: An evaluation of the ability of pifithrin-alpha and -beta to inhibit p53 function in two wild-type p53 human tumor cell lines.

Journal: Molecular cancer therapeutics 20050901

Title: Effects of p53 inhibitor on survival and death of cells subjected to oxidative stress.

Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20050901

Title: Pharmaceutical-mediated inactivation of p53 sensitizes U87MG glioma cells to BCNU and temozolomide.

Journal: International journal of cancer 20050820

Title: The p53 inhibitor pifithrin-alpha is a potent agonist of the aryl hydrocarbon receptor.

Journal: The Journal of pharmacology and experimental therapeutics 20050801

Title: Loss of tumor suppressor p53 decreases PTEN expression and enhances signaling pathways leading to activation of activator protein 1 and nuclear factor kappaB induced by UV radiation.

Journal: Cancer research 20050801

Title: p53 mediates cellular dysfunction and behavioral abnormalities in Huntington's disease.

Journal: Neuron 20050707

Title: Prospective therapeutic applications of p53 inhibitors.

Journal: Biochemical and biophysical research communications 20050610

Title: Role of p53 and apoptosis in cerebral vasospasm after experimental subarachnoid hemorrhage.

Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20050501

Title: Activation of p53/p21Waf1/Cip1 pathway by 5-aza-2'-deoxycytidine inhibits cell proliferation, induces pro-apoptotic genes and mitogen-activated protein kinases in human prostate cancer cells.

Journal: International journal of oncology 20050401

Title: Quinolinium salt as a potent inhibitor of lymphocyte apoptosis.

Journal: Bioorganic & medicinal chemistry letters 20050401

Title: Sensitization of cervical cancer cell lines to low-dose radiation by retinoic acid does not require functional p53.

Journal: Gynecologic oncology 20050401

Title: Novel cyclized Pifithrin-alpha p53 inactivators: synthesis and biological studies.

Journal: Bioorganic & medicinal chemistry letters 20050315

Title: Inhibition of P53-related apoptosis had no effect on PrP(Sc) accumulation and prion disease incubation time.

Journal: Neurobiology of disease 20050301

Title: Ellagic acid potentiates the effect of quercetin on p21waf1/cip1, p53, and MAP-kinases without affecting intracellular generation of reactive oxygen species in vitro.

Journal: The Journal of nutrition 20050301

Title: 5-Aza-cytidine is a potent inhibitor of DNA methyltransferase 3a and induces apoptosis in HCT-116 colon cancer cells via Gadd45- and p53-dependent mechanisms.

Journal: The Journal of pharmacology and experimental therapeutics 20050201

Title: Deregulation of cell proliferation by polycyclic aromatic hydrocarbons in human breast carcinoma MCF-7 cells reflects both genotoxic and nongenotoxic events.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20050201

Title: Role of cell signaling in B[a]P-induced apoptosis: characterization of unspecific effects of cell signaling inhibitors and apoptotic effects of B[a]P metabolites.

Journal: Chemico-biological interactions 20050115

Title: DNA damage and nonhomologous end joining in excitotoxicity: neuroprotective role of DNA-PKcs in kainic acid-induced seizures.

Journal: Hippocampus 20050101

Title: The p53 inhibitor pifithrin-alpha forms a sparingly soluble derivative via intramolecular cyclization under physiological conditions.

Journal: Molecular pharmaceutics 20050101

Title: Survivin and p53 modulate quercetin-induced cell growth inhibition and apoptosis in human lung carcinoma cells.

Journal: The Journal of biological chemistry 20041231

Title: Calcitriol-induced prostate-derived factor: autocrine control of prostate cancer cell growth.

Journal: International journal of cancer 20041220

Title: Role of p53 in cisplatin-induced tubular cell apoptosis: dependence on p53 transcriptional activity.

Journal: American journal of physiology. Renal physiology 20041201

Title: Dynamin-2 regulates oxidized low-density lipoprotein-induced apoptosis of vascular smooth muscle cell.

Journal: Circulation 20041123

Title: Selective increase of dATP pools upon activation of deoxycytidine kinase in lymphocytes: implications in apoptosis.

Journal: Nucleosides, nucleotides & nucleic acids 20041001

Title: Pifithrin-alpha inhibits p53 signaling after interaction of the tumor suppressor protein with hsp90 and its nuclear translocation.

Journal: The Journal of biological chemistry 20040716

Title: Selenite-induced p53 Ser-15 phosphorylation and caspase-mediated apoptosis in LNCaP human prostate cancer cells.

Journal: Molecular cancer therapeutics 20040701

Title: The role of p53-induced apoptosis in cerebral ischemia: effects of the p53 inhibitor pifithrin alpha.

Journal: Experimental neurology 20040601

Title: Improvement of rat liver graft quality by pifithrin-alpha-mediated inhibition of hepatocyte necrapoptosis.

Journal: Hepatology (Baltimore, Md.) 20040601

Title: Dual effect of p53 on radiation sensitivity in vivo: p53 promotes hematopoietic injury, but protects from gastro-intestinal syndrome in mice.

Journal: Oncogene 20040422

Title: Differential regulation of signal transduction pathways in wild type and mutated p53 breast cancer epithelial cells by copper and zinc.

Journal: Archives of biochemistry and biophysics 20040315

Title: Pifithrin-alpha protects against doxorubicin-induced apoptosis and acute cardiotoxicity in mice.

Journal: American journal of physiology. Heart and circulatory physiology 20040301

Title: p53-mediated mitochondrial dysfunction by proteasome inhibition in dopaminergic SH-SY5Y cells.

Journal: Neuroscience letters 20040116

Title: Oxidative stress induces p53-mediated apoptosis in glia: p53 transcription-independent way to die.

Journal: Journal of neuroscience research 20040101

Title: p53 down-regulation: a new molecular mechanism involved in ischaemic preconditioning.

Journal: FEBS letters 20031204

Title: Apoptotic mitochondrial dysfunction induced by benzo(a)pyrene in liver epithelial cells: role of p53 and pHi changes.

Journal: Annals of the New York Academy of Sciences 20031201

Title: Involvement of p53 in specific anti-neuroectodermal tumor activity of aloe-emodin.

Journal: International journal of cancer 20031010

Title: Reciprocal inhibition of p53 and nuclear factor-kappaB transcriptional activities determines cell survival or death in neurons.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20030917

Title: Inhibition of p53, p21 and Bax by pifithrin-alpha does not affect UV induced apoptotic response in CS-B cells.

Journal: DNA repair 20030812

Title: Induction of apoptosis by depletion of DNA topoisomerase IIalpha in mammalian cells.

Journal: Biochemical and biophysical research communications 20030725

Title: Multiple signaling events in amyloid beta-induced, oxidative stress-dependent neuronal apoptosis.

Journal: Free radical biology & medicine 20030701

Title: Pifithrin-alpha promotes p53-mediated apoptosis in JB6 cells.

Journal: Molecular carcinogenesis 20030701

Title: p53 inhibitor pifithrin alpha can suppress heat shock and glucocorticoid signaling pathways.

Journal: The Journal of biological chemistry 20030502

Title: p53 inactivation leads to impaired motor synchronization in mice.

Journal: The European journal of neuroscience 20030501

Title: The C-terminal fragment of presenilin 2 triggers p53-mediated staurosporine-induced apoptosis, a function independent of the presenilinase-derived N-terminal counterpart.

Journal: The Journal of biological chemistry 20030404

Title: Inhibition of p53 protects liver tissue against endotoxin-induced apoptotic and necrotic cell death.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030401

Title: Suppression of high-fidelity double-strand break repair in mammalian chromosomes by pifithrin-alpha, a chemical inhibitor of p53.

Journal: DNA repair 20030102

Title: P53 mediates the apoptotic response to GTP depletion after renal ischemia-reperfusion: protective role of a p53 inhibitor.

Journal: Journal of the American Society of Nephrology : JASN 20030101

Title: p53 is present in synapses where it mediates mitochondrial dysfunction and synaptic degeneration in response to DNA damage, and oxidative and excitotoxic insults.

Journal: Neuromolecular medicine 20030101

Title: Pifithrin-alpha suppresses p53 and protects cochlear and vestibular hair cells from cisplatin-induced apoptosis.

Journal: Neuroscience 20030101

Title: The p53-inhibitor pifithrin-alpha inhibits firefly luciferase activity in vivo and in vitro.

Journal: BMC molecular biology 20030101

Title: p53 inhibitors preserve dopamine neurons and motor function in experimental parkinsonism.

Journal: Annals of neurology 20021101

Title: CD40-mediated apoptosis in murine B-lymphoma lines containing mutated p53.

Journal: Experimental cell research 20021101

Title: p53 May positively regulate hepatocyte proliferation in rats.

Journal: Hepatology (Baltimore, Md.) 20020801

Title: Acceleration of cutaneous wound healing by transient p53 inhibition.

Journal: Laboratory investigation; a journal of technical methods and pathology 20020801

Title: Augmented antitumour effects of combination therapy with TNP-470 and chemoimmunotherapy in mice.

Journal: Journal of cancer research and clinical oncology 20020801

Title: Vanadate-induced cell growth arrest is p53-dependent through activation of p21 in C141 cells.

Journal: Journal of inorganic biochemistry 20020410

Title: Doxorubicin induces apoptosis and CD95 gene expression in human primary endothelial cells through a p53-dependent mechanism.

Journal: The Journal of biological chemistry 20020329

Title: Rescue of neural tube defects in Pax-3-deficient embryos by p53 loss of function: implications for Pax-3- dependent development and tumorigenesis.

Journal: Genes & development 20020315

Title: Resveratrol induces apoptosis in thyroid cancer cell lines via a MAPK- and p53-dependent mechanism.

Journal: The Journal of clinical endocrinology and metabolism 20020301

Title: Pifithrin-alpha, an inhibitor of p53, enhances the genetic instability induced by etoposide (VP16) in human lymphoblastoid cells treated in vitro.

Journal: Mutation research 20020220

Title: Polymerase eta and p53 jointly regulate cell survival, apoptosis and Mre11 recombination during S phase checkpoint arrest after UV irradiation.

Journal: DNA repair 20020122

Title: Sodium butyrate induces P53-independent, Fas-mediated apoptosis in MCF-7 human breast cancer cells.

Journal: British journal of pharmacology 20020101

Title: Pifithrin-alpha (PFT-alpha) caused differential protection of rat liver cells and HepG2 cell line in response to the selective cytotoxicity of arsenic and cadmium.

Journal: Biomedical sciences instrumentation 20020101

Title: Regulation of functional nuclear pore size in fibroblasts.

Journal: Journal of cell science 20011201

Title: Neurons are protected from excitotoxic death by p53 antisense oligonucleotides delivered in anionic liposomes.

Journal: The Journal of biological chemistry 20010824

Title: p21 Waf1/Cip1 can protect human colon carcinoma cells against p53-dependent and p53-independent apoptosis induced by natural chemopreventive and therapeutic agents.

Journal: Oncogene 20010607

Title: A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid beta-peptide.

Journal: Journal of neurochemistry 20010401

Title: Suppression of p53: a new approach to overcome side effects of antitumor therapy.

Journal: Biochemistry. Biokhimiia 20000101

Title: Yu W, et al. Cyclosporine A Suppressed Glucose Oxidase Induced P53 Mitochondrial Translocation and Hepatic Cell Apoptosis through Blocking Mitochondrial Permeability Transition. Int J Biol Sci. 2016 Jan 1;12(2):198-209.

Title: Hoagland MS, et al. The p53 Inhibitor Pifithrin-α Is a Potent Agonist of the Aryl Hydrocarbon Receptor. J Pharmacol Exp Ther. 2005 Aug;314(2):603-10.

Title: Kuang SQ, et al. FOXE3 mutations predispose to thoracic aortic aneurysms and dissections. J Clin Invest. 2016 Mar 1;126(3):948-61.

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Tags:63208-82-2 Molecular Formula|63208-82-2 MDL|63208-82-2 SMILES|63208-82-2 Pifithrin-alpha