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Home Nitro Compounds 645-12-5
645-12-5,MFCD00003240
Catalog No.:AA003MU0

645-12-5 | 5-Nitro-2-furoic acid

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1g
95%
in stock  
$19.00   $14.00
- +
5g
95%
in stock  
$49.00   $35.00
- +
25g
95%
in stock  
$245.00   $171.00
- +
100g
98%
in stock  
$926.00   $648.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA003MU0
Chemical Name:
5-Nitro-2-furoic acid
CAS Number:
645-12-5
Molecular Formula:
C5H3NO5
Molecular Weight:
157.0810
MDL Number:
MFCD00003240
SMILES:
OC(=O)c1ccc(o1)[N+](=O)[O-]
NSC Number:
6452
Properties
Properties
 
BP:
332.4°C at 760 mmHg  
Form:
Solid  
MP:
185-189 °C(lit.)  
Refractive Index:
1.4798 (estimate)  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
186  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
11  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
1  
XLogP3:
1  

Downstream Synthesis Route

[1],1959,p.49    Chem.Abstr.,1960,p.6677

[2]JournaloftheAmericanChemicalSociety,1930,vol.52,p.2550,2551

[1]Patent:WO2017/17631,2017,A2.Locationinpatent:Paragraph00312;00314

[2]Patent:US2011/86817,2011,A1.Locationinpatent:Page/Pagecolumn5

[3]CollectionofCzechoslovakChemicalCommunications,1994,vol.59,p.1400-1407

[4]IndianJournalofChemistry-SectionBOrganicandMedicinalChemistry,1987,vol.26,p.856-860

[5]JournalofMedicinalChemistry,2004,vol.47,p.5276-5283

[6]JournaloftheChemicalSociety.PerkinTransactions2(2001),2001,p.2211-2218

[7]BioorganicandMedicinalChemistryLetters,2007,vol.17,p.6714-6719

[8]JournalofMedicinalChemistry,2008,vol.51,p.3094-3103

[9]Patent:WO2005/7625,2005,A2.Locationinpatent:Page47-48

[10]Patent:WO2005/7625,2005,A2.Locationinpatent:Page68

[11]BioorganicandMedicinalChemistry,2011,vol.19,p.816-825

[12]Molecules,2011,vol.16,p.2023-2031

[13]JournalofMedicinalChemistry,2012,vol.55,p.697-708

[14]ChemicalandPharmaceuticalBulletin,2012,vol.60,p.764-771

[15]JournalofMedicinalChemistry,2013,vol.56,p.796-806

[16]BioorganicandMedicinalChemistry,2014,vol.22,p.1938-1947

[17]JournaloftheAmericanChemicalSociety,2015,vol.137,p.1448-1451

[18]EuropeanJournalofMedicinalChemistry,2017,vol.125,p.1088-1097

[19]ScientiaPharmaceutica,2018,vol.86

[20]ChemMedChem,2019,vol.14,p.1227-1231

18638-99-8    645-12-5   
5-nitro-furan-2-carboxylicacid3,4,5-trimethoxy-benzylamide 

[1]JournalofMedicinalChemistry,2004,vol.47,p.5276-5283

[2]Patent:WO2005/7625,2005,A2.Locationinpatent:Page41

[1]JournalofMedicinalChemistry,2004,vol.47,p.5276-5283

[2]Patent:WO2005/7625,2005,A2.Locationinpatent:Page41

372-19-0    645-12-5   
5-nitro-furan-2-carboxylicacid(3-fluoro-phenyl)-amide 

[1]JournalofMedicinalChemistry,2004,vol.47,p.5276-5283

[2]Patent:WO2005/7625,2005,A2.Locationinpatent:Page37

Literature

Title: Synthesis of some new [1,2,4]triazolo[3,4-b][1,3,4]thiadiazines and [1,2,4]triazolo[3,4-b][1,3,4] thiadiazoles starting from 5-nitro-2-furoic acid and evaluation of their antimicrobial activity.

Journal: Bioorganic & medicinal chemistry 20110801

Title: Structural and biochemical study on the inhibitory activity of derivatives of 5-nitro-furan-2-carboxylic acid for RNase H function of HIV-1 reverse transcriptase.

Journal: Bioorganic & medicinal chemistry 20110115

Title: 5-Nitro-2-furoic acid hydrazones: design, synthesis and in vitro antimycobacterial evaluation against log and starved phase cultures.

Journal: Bioorganic & medicinal chemistry letters 20100801

Title: Synthesis of new and potent analogues of anti-tuberculosis agent 5-nitro-furan-2-carboxylic acid 4-(4-benzyl-piperazin-1-yl)-benzylamide with improved bioavailability.

Journal: Bioorganic & medicinal chemistry letters 20060515

Title: Synthesis and evaluation of cyclic secondary amine substituted phenyl and benzyl nitrofuranyl amides as novel antituberculosis agents.

Journal: Journal of medicinal chemistry 20051229

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