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Home Amines 652973-93-8
652973-93-8,MFCD18252543
Catalog No.:AA006TL9

652973-93-8 | Benzamide,4-chloro-N-[(1S,2S)-2-[[(1R)-1-(1-naphthalenyl)ethyl]amino]cyclohexyl]-

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$46.00   $32.00
- +
5mg
≥98%
in stock  
$166.00   $116.00
- +
10mg
≥98%
in stock  
$306.00   $214.00
- +
25mg
≥98%
in stock  
$652.00   $456.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA006TL9
Chemical Name:
Benzamide,4-chloro-N-[(1S,2S)-2-[[(1R)-1-(1-naphthalenyl)ethyl]amino]cyclohexyl]-
CAS Number:
652973-93-8
Molecular Formula:
C25H27ClN2O
Molecular Weight:
406.9477
MDL Number:
MFCD18252543
SMILES:
Clc1ccc(cc1)C(=O)N[C@H]1CCCC[C@@H]1N[C@@H](c1cccc2c1cccc2)C
Properties
Properties
 
Form:
Solid  
MP:
53-55˚C  
Storage:
-20 ℃;  

Computed Properties
 
Complexity:
533  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
3  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
5  
XLogP3:
5.9  

Literature

Title: Extracellular calcium-sensing receptor is critical in hypoxic pulmonary vasoconstriction.

Journal: Antioxidants & redox signaling 20120801

Title: The regulation of K- and L-cell activity by GLUT2 and the calcium-sensing receptor CasR in rat small intestine.

Journal: The Journal of physiology 20120615

Title: Molecular determinants of non-competitive antagonist binding to the mouse GPRC6A receptor.

Journal: Cell calcium 20090101

Title: N1-Benzoyl-N2-[1-(1-naphthyl)ethyl]-trans-1,2-diaminocyclohexanes: Development of 4-chlorophenylcarboxamide (calhex 231) as a new calcium sensing receptor ligand demonstrating potent calcilytic activity.

Journal: Journal of medicinal chemistry 20060824

Title: Evidence in favor of a calcium-sensing receptor in arterial endothelial cells: studies with calindol and Calhex 231.

Journal: Circulation research 20050819

Title: Positive and negative allosteric modulators of the Ca2+-sensing receptor interact within overlapping but not identical binding sites in the transmembrane domain.

Journal: The Journal of biological chemistry 20040430

Title: Modeling and mutagenesis of the binding site of Calhex 231, a novel negative allosteric modulator of the extracellular Ca(2+)-sensing receptor.

Journal: The Journal of biological chemistry 20031205

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SDS
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Tags:652973-93-8 Molecular Formula|652973-93-8 MDL|652973-93-8 SMILES|652973-93-8 Benzamide,4-chloro-N-[(1S,2S)-2-[[(1R)-1-(1-naphthalenyl)ethyl]amino]cyclohexyl]-