Home Fluorides 684-16-2
684-16-2,MFCD00000422
Catalog No.:AA00FR7X

684-16-2 | Hexafluoroacetone

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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00FR7X
Chemical Name:
Hexafluoroacetone
CAS Number:
684-16-2
MDL Number:
MFCD00000422
NSC Number:
202438
UN Number:
2420
Properties
Computed Properties
 
Complexity:
124  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
10  
Hydrogen Bond Acceptor Count:
7  
XLogP3:
1.5  

Literature

Title: Direct measurement of Criegee intermediate (CH2OO) reactions with acetone, acetaldehyde, and hexafluoroacetone.

Journal: Physical chemistry chemical physics : PCCP 20120814

Title: Gas chromatography-mass spectrometry of hexafluoroacetone derivatives: First time utilization of a gaseous phase derivatizing agent for analysis of extraterrestrial amino acids.

Journal: Journal of chromatography. A 20120706

Title: Conformational landscape of N-glycosylated peptides detecting autoantibodies in multiple sclerosis, revealed by Hamiltonian replica exchange.

Journal: The journal of physical chemistry. B 20120510

Title: NADPH oxidase expression in active multiple sclerosis lesions in relation to oxidative tissue damage and mitochondrial injury.

Journal: Brain : a journal of neurology 20120301

Title: A peptide-embedded trifluoromethyl ketone catalyst for enantioselective epoxidation.

Journal: Organic letters 20120217

Title: Inhibition of quorum sensing and efflux pump system by trifluoromethyl ketone proton pump inhibitors.

Journal: In vivo (Athens, Greece) 20120101

Title: Pressure dependence of stabilized Criegee intermediate formation from a sequence of alkenes.

Journal: The journal of physical chemistry. A 20110505

Title: 2,3-Dimethyl-2-butene (TME) ozonolysis: pressure dependence of stabilized Criegee intermediates and evidence of stabilized vinyl hydroperoxides.

Journal: The journal of physical chemistry. A 20110120

Title: Endoplasmic reticulum- and Golgi-localized phospholipase A2 plays critical roles in Arabidopsis pollen development and germination.

Journal: The Plant cell 20110101

Title: Microglial phagocytosis induced by fibrillar β-amyloid is attenuated by oligomeric β-amyloid: implications for Alzheimer's disease.

Journal: Molecular neurodegeneration 20110101

Title: Advances in SXFA-coated SAW chemical sensors for organophosphorous compound detection.

Journal: Sensors (Basel, Switzerland) 20110101

Title: Thermal chemistry and photochemistry of hexafluoroacetone on rutile TiO2(110).

Journal: Physical chemistry chemical physics : PCCP 20100728

Title: Structural optimization of photoswitch ligands for surface attachment of alpha-chymotrypsin and regulation of its surface binding.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20100618

Title: Identification of new non-carboxylic acid containing inhibitors of aldose reductase.

Journal: Bioorganic & medicinal chemistry 20100601

Title: EPR/spin-trapping study of free radical intermediates in the photolysis of trifluoromethyl ketones with initiators.

Journal: Magnetic resonance in chemistry : MRC 20100301

Title: Mechanical properties of regenerated Bombyx mori silk fibers and recombinant silk fibers produced by transgenic silkworms.

Journal: Journal of biomaterials science. Polymer edition 20100101

Title: Application of spectroscopic methods for structural analysis of chitin and chitosan.

Journal: Marine drugs 20100101

Title: Development and biological activity of a new antagonist of the pheromone of the codling moth Cydia pomonella.

Journal: Journal of agricultural and food chemistry 20090923

Title: Direct construction of 1,3-diaxial diol derivatives by C-H hydroxylation.

Journal: Organic letters 20090820

Title: Olfactory proteins mediating chemical communication in the navel orangeworm moth, Amyelois transitella.

Journal: PloS one 20090101

Title: Synthesis of polyfluoro ketones for selective inhibition of human phospholipase A2 enzymes.

Journal: Journal of medicinal chemistry 20081225

Title: Trifluoromethyl ketones from enolizable carboxylic acids via enediolate trifluoroacetylation/decarboxylation.

Journal: The Journal of organic chemistry 20081205

Title: Inhibition of cyclooxygenases 1 and 2 by the phospholipase-blocker, arachidonyl trifluoromethyl ketone.

Journal: British journal of pharmacology 20081101

Title: HKI 46F08, a novel potent histone deacetylase inhibitor, exhibits antitumoral activity against embryonic childhood cancer cells.

Journal: Anti-cancer drugs 20081001

Title: Diethyl [2,2,2-trifluoro-1-phenyl-sulfonyl-amino-1-(trifluoro-meth-yl)eth-yl]phospho-nate.

Journal: Acta crystallographica. Section E, Structure reports online 20080801

Title: Physiologically based pharmacokinetic modeling of persistent organic pollutants for lifetime exposure assessment: a new tool in breast cancer epidemiologic studies.

Journal: Environmental health perspectives 20080701

Title: Synthesis of trifluoromethyl-substituted pyrazoles and 1,2,4-triazines by ring transformation of mesoionic 4-trifluoroacetyl-1,3-oxazolium-5-olates with phenylhydrazine.

Journal: Chemical & pharmaceutical bulletin 20080401

Title: A novel protecting/activating strategy for beta-hydroxy acids and its use in convergent peptide synthesis.

Journal: The Journal of organic chemistry 20080321

Title: Screening of the active site from water by the incoming ligand triggers catalysis and inhibition in serine proteases.

Journal: Proteins 20080301

Title: Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH).

Journal: Bioorganic & medicinal chemistry 20080215

Title: One-pot synthesis of 3-fluoro-4-(trifluoromethyl)quinolines from pentafluoropropen-2-ol and their molecular modification.

Journal: The Journal of organic chemistry 20080215

Title: Silklike materials constructed from sequences of Bombyx mori silk fibroin, fibronectin, and elastin.

Journal: Journal of biomedical materials research. Part A 20080201

Title: Ligand-directed immobilization of proteins through an esterase 2 fusion tag studied by atomic force microscopy.

Journal: Chembiochem : a European journal of chemical biology 20080104

Title: Neutrophil elastase reduces secretion of secretory leukoproteinase inhibitor (SLPI) by lung epithelial cells: role of charge of the proteinase-inhibitor complex.

Journal: Respiratory research 20080101

Title: The cooperative effect between active site ionized groups and water desolvation controls the alteration of acid/base catalysis in serine proteases.

Journal: Chembiochem : a European journal of chemical biology 20070813

Title: Organocatalytic diastereo- and enantioselective Michael addition reactions of 5-aryl-1,3-dioxolan-4-ones.

Journal: Organic letters 20070524

Title: Hepatic sequestration of chlordecone and hexafluoroacetone evaluated by pharmacokinetic modeling.

Journal: Toxicology 20070505

Title: Complex structure of a bacterial class 2 histone deacetylase homologue with a trifluoromethylketone inhibitor.

Journal: Acta crystallographica. Section F, Structural biology and crystallization communications 20070401

Title: Conformational equilibria in formic acid and the adduct of formic acid and hexafluoroacetone, HCO2C(CF3)2OH.

Journal: The Journal of organic chemistry 20070316

Title: Hexafluoroacetone as protecting and activating reagent: new routes to amino, hydroxy, and mercapto acids and their application for peptide and glyco- and depsipeptide modification.

Journal: Chemical reviews 20061101

Title: Structural studies of a potent insect maturation inhibitor bound to the juvenile hormone esterase of Manduca sexta.

Journal: Biochemistry 20060404

Title: A concise asymmetric route for the synthesis of a novel class of glucocorticoid mimetics containing a trifluoromethyl-substituted alcohol.

Journal: Bioorganic & medicinal chemistry letters 20060201

Title: Peptide inhibitors of Dengue virus NS3 protease. Part 1: Warhead.

Journal: Bioorganic & medicinal chemistry letters 20060101

Title: Distinctive influence of two hexafluoro solvents on the structural stabilization of Bombyx mori silk fibroin protein and its derived peptides: 13C NMR and CD studies.

Journal: Biomacromolecules 20060101

Title: Cytotoxic activity of selected trifluoromethyl ketones against oral tumor cells.

Journal: Anticancer research 20060101

Title: Use of lithium hexafluoroisopropoxide as a mild base for Horner-Wadsworth-Emmons olefination of epimerizable aldehydes.

Journal: Organic letters 20050915

Title: A new class of inhibitors of 2-arachidonoylglycerol hydrolysis and invasion of prostate cancer cells.

Journal: Biochemical and biophysical research communications 20050715

Title: Hexafluoroacetone as protecting and activating reagent: site-selective functionalization of iminodiacetic acid.

Journal: Amino acids 20041201

Title: Effects of trifluoromethyl ketones on the motility of Proteus vulgaris.

Journal: Biological & pharmaceutical bulletin 20040901

Title: Responses of the olfactory receptor neurons of the corn stalk borer Sesamia nonagrioides to components of the pheromone blend and their inhibition by a trifluoromethyl ketone analogue of the main component.

Journal: Pest management science 20040701

Title: Structure and solvation of melittin in hexafluoroacetone/water.

Journal: Biopolymers 20040615

Title: Inhibitory action of a new proton pump inhibitor, trifluoromethyl ketone derivative, against the motility of clarithromycin-susceptible and-resistant Helicobacter pylori.

Journal: International journal of antimicrobial agents 20040601

Title: Conformational study of fragments of envelope proteins (gp120: 254-274 and gp41: 519-541) of HIV-1 by NMR and MD simulations.

Journal: Journal of peptide science : an official publication of the European Peptide Society 20040601

Title: The low barrier hydrogen bond (LBHB) proposal revisited: the case of the Asp... His pair in serine proteases.

Journal: Proteins 20040515

Title: Conformation of the cecropin-melittin hybrid, cecropin A(1-8)-melittin (1-18) antibacterial Peptide.

Journal: Protein and peptide letters 20040401

Title: Effect of a trifluoromethyl ketone on the motility of proton pump-deleted mutant of Escherichia coli strain and its wild-type.

Journal: In vivo (Athens, Greece) 20040101

Title: The antimotility action of a trifluoromethyl ketone on some gram-negative bacteria.

Journal: Acta microbiologica et immunologica Hungarica 20040101

Title: Histone deacetylase inhibitors: the Abbott experience.

Journal: Current medicinal chemistry 20031101

Title: Design, synthesis, and biological evaluation of simplified alpha-keto heterocycle, trifluoromethyl ketone, and formyl substituted folate analogues as potential inhibitors of GAR transformylase and AICAR transformylase.

Journal: Bioorganic & medicinal chemistry 20031001

Title: Synthesis of a new potential tridentate anthracene ligand bearing deprotectable methoxymethoxy (OMOM) group at 1,8-positions: attempt to synthesize anionic hypervalent carbon compounds.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20030804

Title: Production of interferon-beta by fibroblast cells on membranes prepared with RGD-containing peptides.

Journal: Journal of biomedical materials research. Part A 20030601

Title: Novel trifluoromethyl ketones as potent gastric lipase inhibitors.

Journal: Chembiochem : a European journal of chemical biology 20030103

Title: Use of ab initio calculations to predict the biological potency of carboxylesterase inhibitors.

Journal: Journal of medicinal chemistry 20021205

Title: A short and efficient synthesis of L-5,5,5,5',5',5'-hexafluoroleucine from N-Cbz-L-serine.

Journal: Organic letters 20021128

Title: Regulation of adhesion of AML14.3D10 cells by surface clustering of beta2-integrin caused by ERK-independent activation of cPLA2.

Journal: Immunology 20020901

Title: Intermolecular Overhauser effects in fluoroalcohol solutions of cyclo-alanylglycine.

Journal: Biopolymers 20020815

Title: 'Entourage' effects of N-acyl ethanolamines at human vanilloid receptors. Comparison of effects upon anandamide-induced vanilloid receptor activation and upon anandamide metabolism.

Journal: British journal of pharmacology 20020601

Title: Environmental mimic of receptor interaction: conformational analysis of CCK-15 in solution.

Journal: Journal of medicinal chemistry 20020214

Title: Conformation of a model peptide of the tandem repeat decapeptide in mussel adhesive protein by NMR and MD simulations.

Journal: Biomaterials 20020101

Title: Synthesis of new carboxylesterase inhibitors and evaluation of potency and water solubility.

Journal: Chemical research in toxicology 20011201

Title: Trifluoromethyl ketone-based inhibitors of apoptosis in cerebellar granule neurons.

Journal: Biological & pharmaceutical bulletin 20011101

Title: Conformation of N-terminal HIV-1 Tat (fragment 1-9) peptide by NMR and MD simulations.

Journal: Journal of peptide science : an official publication of the European Peptide Society 20011101

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Tags:684-16-2 Molecular Formula|684-16-2 MDL|684-16-2 SMILES|684-16-2 Hexafluoroacetone