Home Other Building Blocks 690206-97-4
690206-97-4,MFCD02683969
Catalog No.:AA006DRH

690206-97-4 | Zm-306416

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Purity
Availability
Price(USD)
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1mg
≥98%
in stock  
$63.00   $44.00
- +
5mg
95%
in stock  
$103.00   $72.00
- +
10mg
95%
in stock  
$168.00   $117.00
- +
100mg
97%
in stock  
$366.00   $257.00
- +
250mg
97%
in stock  
$492.00   $344.00
- +
1g
97%
in stock  
$1,154.00   $808.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA006DRH
Chemical Name:
Zm-306416
CAS Number:
690206-97-4
Molecular Formula:
C16H13ClFN3O2
Molecular Weight:
333.7447
MDL Number:
MFCD02683969
SMILES:
COc1cc2c(ncnc2cc1OC)Nc1ccc(cc1F)Cl
Properties
Properties
 
BP:
460.5°C at 760 mmHg  
Form:
Solid  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
392  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
4  
XLogP3:
4.1  

Literature

Title: A high-content biosensor-based screen identifies cell-permeable activators and inhibitors of EGFR function: implications in drug discovery.

Journal: Journal of biomolecular screening 20120801

Title: N⁴-(3-Bromophenyl)-7-(substituted benzyl) pyrrolo[2,3-d]pyrimidines as potent multiple receptor tyrosine kinase inhibitors: design, synthesis, and in vivo evaluation.

Journal: Bioorganic & medicinal chemistry 20120401

Title: N⁴-Aryl-6-substitutedphenylmethyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as receptor tyrosine kinase inhibitors.

Journal: Bioorganic & medicinal chemistry 20120115

Title: The contribution of a 2-amino group on receptor tyrosine kinase inhibition and antiangiogenic activity in 4-anilinosubstituted pyrrolo[2,3-d]pyrimidines.

Journal: Bioorganic & medicinal chemistry letters 20100515

Title: Synthesis and biological activity of N(4)-phenylsubstituted-6-(2,4-dichloro phenylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as vascular endothelial growth factor receptor-2 inhibitors and antiangiogenic and antitumor agents.

Journal: Bioorganic & medicinal chemistry 20100515

Title: Single agents with designed combination chemotherapy potential: synthesis and evaluation of substituted pyrimido[4,5-b]indoles as receptor tyrosine kinase and thymidylate synthase inhibitors and as antitumor agents.

Journal: Journal of medicinal chemistry 20100225

Title: Design, synthesis and biological evaluation of substituted pyrrolo[2,3-d]pyrimidines as multiple receptor tyrosine kinase inhibitors and antiangiogenic agents.

Journal: Bioorganic & medicinal chemistry 20080515

Title: Inhibitor of vascular endothelial growth factor receptor tyrosine kinase attenuates cellular proliferation and differentiation to mature neurons in the hippocampal dentate gyrus after transient forebrain ischemia in the adult rat.

Journal: Neuroscience 20060901

Title: Transactivation of fetal liver kinase-1/kinase-insert domain-containing receptor by lysophosphatidylcholine induces vascular endothelial cell proliferation.

Journal: Endocrinology 20060301

Title: Synthesis of a novel biotin-tagged photoaffinity probe for VEGF receptor tyrosine kinases.

Journal: Bioorganic & medicinal chemistry letters 20060101

Title: Synthesis of the PPARbeta/delta-selective agonist GW501516 and C4-thiazole-substituted analogs.

Journal: Bioorganic & medicinal chemistry letters 20060101

Title: Frontal affinity chromatography with MS detection of EphB2 tyrosine kinase receptor. 2. Identification of small-molecule inhibitors via coupling with virtual screening.

Journal: Journal of medicinal chemistry 20050505

Title: Frontal affinity chromatography with MS detection of EphB2 tyrosine kinase receptor. 1. Comparison with conventional ELISA.

Journal: Journal of medicinal chemistry 20041007

Title: Design and structure-activity relationship of a new class of potent VEGF receptor tyrosine kinase inhibitors.

Journal: Journal of medicinal chemistry 19991230

Title: Han SY, Park SS, Lee WG, Synthesis of a novel biotin-tagged photoaffinity probe for VEGF receptor tyrosine kinases. Bioorg Med Chem Lett. 2006 Jan 1;16(1):129-33.

Title: Antczak C, Mahida JP, Bhinder B, A high-content biosensor-based screen identifies cell-permeable activators and inhibitors of EGFR function: implications in drug discovery. J Biomol Screen. 2012 Aug;17(7):885-99.

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Tags:690206-97-4 Molecular Formula|690206-97-4 MDL|690206-97-4 SMILES|690206-97-4 Zm-306416